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Items: 1 to 50 of 169

1.

Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability.

Maderuelo C, Lanao JM, Zarzuelo A.

Eur J Pharm Sci. 2019 Oct 1;138:105019. doi: 10.1016/j.ejps.2019.105019. Epub 2019 Jul 30. Review.

PMID:
31374253
2.

Calprotectin protects against experimental colonic inflammation in mice.

Aranda CJ, Ocón B, Arredondo-Amador M, Suárez MD, Zarzuelo A, Chazin WJ, Martínez-Augustin O, Sánchez de Medina F.

Br J Pharmacol. 2018 Oct;175(19):3797-3812. doi: 10.1111/bph.14449. Epub 2018 Sep 2.

3.

A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota.

Rivero-Gutiérrez B, Gámez-Belmonte R, Suárez MD, Lavín JL, Aransay AM, Olivares M, Martínez-Augustin O, Sánchez de Medina F, Zarzuelo A.

Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600622. Epub 2017 Jun 8.

PMID:
28463404
4.

Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis.

Hernández-Chirlaque C, Aranda CJ, Ocón B, Capitán-Cañadas F, Ortega-González M, Carrero JJ, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O.

J Crohns Colitis. 2016 Nov;10(11):1324-1335. Epub 2016 Apr 26.

PMID:
27117829
5.

The Bisphosphonate Pamidronate is an Intestinal Antiinflammatory Agent in Rat and Mouse Experimental Colitis.

López-Posadas R, Mascaraque C, González R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F.

Inflamm Bowel Dis. 2016 Nov;22(11):2549-2561.

PMID:
27760076
6.

The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice.

Ocón B, Aranda CJ, Gámez-Belmonte R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F.

Biochem Pharmacol. 2016 Sep 15;116:73-88. doi: 10.1016/j.bcp.2016.07.010. Epub 2016 Jul 16.

PMID:
27431777
7.

Fructooligosaccharides exert intestinal anti-inflammatory activity in the CD4+ CD62L+ T cell transfer model of colitis in C57BL/6J mice.

Capitán-Cañadas F, Ocón B, Aranda CJ, Anzola A, Suárez MD, Zarzuelo A, de Medina FS, Martínez-Augustin O.

Eur J Nutr. 2016 Jun;55(4):1445-54. doi: 10.1007/s00394-015-0962-6. Epub 2015 Jul 8.

PMID:
26154776
8.

Expression of glucose transporters in the prelaminar region of the optic-nerve head of the pig as determined by immunolabeling and tissue culture.

Carreras FJ, Aranda CJ, Porcel D, Rodriguez-Hurtado F, Martínez-Agustin O, Zarzuelo A.

PLoS One. 2015 Jun 1;10(6):e0128516. doi: 10.1371/journal.pone.0128516. eCollection 2015.

9.

A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii.

Garrido-Mesa J, Algieri F, Rodriguez-Nogales A, Utrilla MP, Rodriguez-Cabezas ME, Zarzuelo A, Ocete MA, Garrido-Mesa N, Galvez J.

Pharmacol Res. 2015 Jul;97:48-63. doi: 10.1016/j.phrs.2015.04.005. Epub 2015 Apr 23.

PMID:
25917208
10.

Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium.

Mascaraque C, González R, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O.

Br J Nutr. 2015 Feb 28;113(4):618-26. doi: 10.1017/S0007114514004292. Epub 2015 Feb 6.

PMID:
25654996
11.

Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis.

Mascaraque C, Aranda C, Ocón B, Monte MJ, Suárez MD, Zarzuelo A, Marín JJ, Martínez-Augustin O, de Medina FS.

Pharmacol Res. 2014 Dec;90:48-57. doi: 10.1016/j.phrs.2014.09.005. Epub 2014 Oct 2.

PMID:
25281414
12.

Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis.

Mascaraque C, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O.

Mol Nutr Food Res. 2014 Dec;58(12):2379-82. doi: 10.1002/mnfr.201400364. Epub 2014 Oct 2.

PMID:
25186628
13.

Intestinal anti-inflammatory effects of oligosaccharides derived from lactulose in the trinitrobenzenesulfonic acid model of rat colitis.

Algieri F, Rodríguez-Nogales A, Garrido-Mesa N, Vezza T, Garrido-Mesa J, Utrilla MP, Montilla A, Cardelle-Cobas A, Olano A, Corzo N, Guerra-Hernández E, Zarzuelo A, Rodriguez-Cabezas ME, Galvez J.

J Agric Food Chem. 2014 May 14;62(19):4285-97. doi: 10.1021/jf500678p. Epub 2014 May 5.

PMID:
24766341
14.

Prebiotic oligosaccharides directly modulate proinflammatory cytokine production in monocytes via activation of TLR4.

Capitán-Cañadas F, Ortega-González M, Guadix E, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O.

Mol Nutr Food Res. 2014 May;58(5):1098-110. doi: 10.1002/mnfr.201300497. Epub 2013 Dec 23.

PMID:
24549946
15.

Validation of bovine glycomacropeptide as an intestinal anti-inflammatory nutraceutical in the lymphocyte-transfer model of colitis.

Ortega-González M, Capitán-Cañadas F, Requena P, Ocón B, Romero-Calvo I, Aranda C, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O.

Br J Nutr. 2014 Apr 14;111(7):1202-12. doi: 10.1017/S0007114513003590. Epub 2013 Nov 14.

PMID:
24229852
16.

Negative clinical outcomes of medication resulting in emergency department visits.

Baena MI, Fajardo PC, Pintor-Mármol A, Faus MJ, Marín R, Zarzuelo A, Martínez-Olmos J, Martínez-Martínez F.

Eur J Clin Pharmacol. 2014 Jan;70(1):79-87. doi: 10.1007/s00228-013-1562-0. Epub 2013 Oct 3.

PMID:
24091839
17.

Nondigestible oligosaccharides exert nonprebiotic effects on intestinal epithelial cells enhancing the immune response via activation of TLR4-NFκB.

Ortega-González M, Ocón B, Romero-Calvo I, Anzola A, Guadix E, Zarzuelo A, Suárez MD, Sánchez de Medina F, Martínez-Augustin O.

Mol Nutr Food Res. 2014 Feb;58(2):384-93. doi: 10.1002/mnfr.201300296. Epub 2013 Sep 3.

PMID:
24039030
18.

Active colitis exacerbates immune response to internalized food antigens in mice.

Cueto-Sola M, Bailon E, Utrilla P, Rodríguez-Ruiz J, Garrido-Mesa N, Zarzuelo A, Xaus J, Gálvez J, Comalada M.

Int Arch Allergy Immunol. 2013;162(3):214-24. doi: 10.1159/000353596. Epub 2013 Sep 6.

PMID:
24021980
19.

Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.

Merroun I, Sánchez-González C, Martínez R, López-Chaves C, Porres JM, Aranda P, Llopis J, Galisteo M, Zarzuelo A, Errami M, López-Jurado M.

Metabolism. 2013 Nov;62(11):1641-50. doi: 10.1016/j.metabol.2013.06.011. Epub 2013 Aug 6.

PMID:
23932644
20.

Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension.

Zarzuelo MJ, Gómez-Guzmán M, Jiménez R, Quintela AM, Romero M, Sánchez M, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J.

Cardiovasc Res. 2013 Sep 1;99(4):622-31. doi: 10.1093/cvr/cvt152. Epub 2013 Jun 10.

PMID:
23752977
21.

Minocycline: far beyond an antibiotic.

Garrido-Mesa N, Zarzuelo A, Gálvez J.

Br J Pharmacol. 2013 May;169(2):337-52. doi: 10.1111/bph.12139. Review.

22.

Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis.

Algieri F, Zorrilla P, Rodriguez-Nogales A, Garrido-Mesa N, Bañuelos O, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, Zarzuelo A, Utrilla MP, Rodriguez-Cabezas ME, Galvez J.

J Ethnopharmacol. 2013 Apr 19;146(3):750-9. doi: 10.1016/j.jep.2013.01.041. Epub 2013 Feb 7.

PMID:
23395625
23.

Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis.

Martínez-Moya P, Romero-Calvo I, Requena P, Hernández-Chirlaque C, Aranda CJ, González R, Zarzuelo A, Suárez MD, Martínez-Augustin O, Marín JJ, de Medina FS.

Int Immunopharmacol. 2013 Feb;15(2):372-80. doi: 10.1016/j.intimp.2012.11.017. Epub 2012 Dec 13.

PMID:
23246254
24.

The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation.

Daddaoua A, Martínez-Plata E, Ortega-González M, Ocón B, Aranda CJ, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O.

Food Chem. 2013 Feb 15;136(3-4):1288-95. doi: 10.1016/j.foodchem.2012.09.039. Epub 2012 Sep 23.

PMID:
23194525
25.

What is behind the non-antibiotic properties of minocycline?

Garrido-Mesa N, Zarzuelo A, Gálvez J.

Pharmacol Res. 2013 Jan;67(1):18-30. doi: 10.1016/j.phrs.2012.10.006. Epub 2012 Oct 17. Review.

PMID:
23085382
26.

Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis.

Ocón B, Anzola A, Ortega-González M, Zarzuelo A, Suárez MD, Sánchez de Medina F, Martínez-Augustin O.

Eur J Nutr. 2013 Mar;52(2):457-66. doi: 10.1007/s00394-012-0347-z. Epub 2012 Sep 1.

PMID:
22941198
27.

Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats.

Martínez-Moya P, Ortega-González M, González R, Anzola A, Ocón B, Hernández-Chirlaque C, López-Posadas R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F.

Pharmacol Res. 2012 Aug;66(2):144-53. doi: 10.1016/j.phrs.2012.04.006. Epub 2012 May 5.

PMID:
22569414
28.

A shorter and more specific oral sensitization-based experimental model of food allergy in mice.

Bailón E, Cueto-Sola M, Utrilla P, Rodríguez-Ruiz J, Garrido-Mesa N, Zarzuelo A, Xaus J, Gálvez J, Comalada M.

J Immunol Methods. 2012 Jul 31;381(1-2):41-9. doi: 10.1016/j.jim.2012.04.007. Epub 2012 Apr 20.

PMID:
22542400
29.

The association of minocycline and the probiotic Escherichia coli Nissle 1917 results in an additive beneficial effect in a DSS model of reactivated colitis in mice.

Garrido-Mesa N, Utrilla P, Comalada M, Zorrilla P, Garrido-Mesa J, Zarzuelo A, Rodríguez-Cabezas ME, Gálvez J.

Biochem Pharmacol. 2011 Dec 15;82(12):1891-900. doi: 10.1016/j.bcp.2011.09.004. Epub 2011 Sep 16.

PMID:
21930116
30.

DNFB-DNS hapten-induced colitis in mice should not be considered a model of inflammatory bowel disease.

Bailón E, Cueto-Sola M, Utrilla P, Nieto A, Garrido-Mesa N, Celada A, Zarzuelo A, Xaus J, Gálvez J, Comalada M.

Inflamm Bowel Dis. 2011 Oct;17(10):2087-101. doi: 10.1002/ibd.21586. Epub 2010 Dec 22.

PMID:
21910170
31.

Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats.

Zarzuelo MJ, Jiménez R, Galindo P, Sánchez M, Nieto A, Romero M, Quintela AM, López-Sepúlveda R, Gómez-Guzmán M, Bailón E, Rodríguez-Gómez I, Zarzuelo A, Gálvez J, Tamargo J, Pérez-Vizcaíno F, Duarte J.

Hypertension. 2011 Oct;58(4):733-43. doi: 10.1161/HYPERTENSIONAHA.111.174490. Epub 2011 Aug 8.

PMID:
21825230
32.

The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis.

Camuesco D, Rodríguez-Cabezas ME, Garrido-Mesa N, Cueto-Sola M, Bailón E, Comalada M, Arribas B, Merlos M, Balsa D, Zarzuelo A, Janer G, Xaus J, Román J, Gálvez J.

Br J Pharmacol. 2012 Feb;165(3):729-40. doi: 10.1111/j.1476-5381.2011.01598.x.

33.

Intestinal inflammation and the enterocyte transportome.

Romero-Calvo I, Mascaraque C, Zarzuelo A, Suárez MD, Martínez-Augustin O, de Medina FS.

Biochem Soc Trans. 2011 Aug;39(4):1096-101. doi: 10.1042/BST0391096. Review.

PMID:
21787355
34.

The immunomodulatory properties of viable Lactobacillus salivarius ssp. salivarius CECT5713 are not restricted to the large intestine.

Arribas B, Garrido-Mesa N, Perán L, Camuesco D, Comalada M, Bailón E, Olivares M, Xaus J, Kruidenier L, Sanderson IR, Zarzuelo A, Rodríguez-Cabezas ME, Gálvez J.

Eur J Nutr. 2012 Apr;51(3):365-74. doi: 10.1007/s00394-011-0221-4. Epub 2011 Jun 19.

PMID:
21688122
35.

Critical factors in the release of drugs from sustained release hydrophilic matrices.

Maderuelo C, Zarzuelo A, Lanao JM.

J Control Release. 2011 Aug 25;154(1):2-19. doi: 10.1016/j.jconrel.2011.04.002. Epub 2011 Apr 8. Review.

PMID:
21497624
36.

Optimization of release kinetics from sustained-release formulations using model-independent pharmacokinetic simulation.

Maderuelo C, Zarzuelo A, Lanao JM.

J Pharm Sci. 2011 Aug;100(8):3260-3267. doi: 10.1002/jps.22565. Epub 2011 Apr 11.

PMID:
21484806
37.

Effects of flavonoids and other polyphenols on inflammation.

González R, Ballester I, López-Posadas R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F.

Crit Rev Food Sci Nutr. 2011 Apr;51(4):331-62. doi: 10.1080/10408390903584094. Review.

PMID:
21432698
38.

The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties.

Garrido-Mesa N, Camuesco D, Arribas B, Comalada M, Bailón E, Cueto-Sola M, Utrilla P, Nieto A, Zarzuelo A, Rodríguez-Cabezas ME, Gálvez J.

Pharmacol Res. 2011 Apr;63(4):308-19. doi: 10.1016/j.phrs.2010.12.011. Epub 2010 Dec 28.

PMID:
21193045
39.

Bovine glycomacropeptide has intestinal antiinflammatory effects in rats with dextran sulfate-induced colitis.

López-Posadas R, Requena P, González R, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O.

J Nutr. 2010 Nov;140(11):2014-9. doi: 10.3945/jn.109.118448. Epub 2010 Sep 29.

PMID:
20881082
40.

Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-kappaB in an intestinal epithelial cell line (IEC18).

López-Posadas R, Ballester I, Mascaraque C, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F.

Br J Pharmacol. 2010 Aug;160(7):1714-26. doi: 10.1111/j.1476-5381.2010.00827.x.

41.

Tissue-nonspecific alkaline phosphatase is activated in enterocytes by oxidative stress via changes in glycosylation.

López-Posadas R, González R, Ballester I, Martínez-Moya P, Romero-Calvo I, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F.

Inflamm Bowel Dis. 2011 Feb;17(2):543-56. doi: 10.1002/ibd.21381.

PMID:
20645320
42.

The combination of fructooligosaccharides and resistant starch shows prebiotic additive effects in rats.

Rodríguez-Cabezas ME, Camuesco D, Arribas B, Garrido-Mesa N, Comalada M, Bailón E, Cueto-Sola M, Utrilla P, Guerra-Hernández E, Pérez-Roca C, Gálvez J, Zarzuelo A.

Clin Nutr. 2010 Dec;29(6):832-9. doi: 10.1016/j.clnu.2010.05.005. Epub 2010 Jun 1.

PMID:
20605664
43.

New insights into the immunological effects of food bioactive peptides in animal models of intestinal inflammation.

de Medina FS, Daddaoua A, Requena P, Capitán-Cañadas F, Zarzuelo A, Dolores Suárez M, Martínez-Augustin O.

Proc Nutr Soc. 2010 Aug;69(3):454-62. doi: 10.1017/S0029665110001783. Epub 2010 Jul 2.

PMID:
20598199
44.

Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation.

Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J.

Atherosclerosis. 2010 Sep;212(1):78-85. doi: 10.1016/j.atherosclerosis.2010.04.031. Epub 2010 May 6.

PMID:
20553682
45.

Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.

Arribas B, Suárez-Pereira E, Ortiz Mellet C, García Fernández JM, Buttersack C, Rodríguez-Cabezas ME, Garrido-Mesa N, Bailon E, Guerra-Hernández E, Zarzuelo A, Gálvez J.

J Agric Food Chem. 2010 May 26;58(10):6476-84. doi: 10.1021/jf100513j.

PMID:
20423151
46.

It may not be intestinal, but tissue non-specific alkaline phosphatase.

Martínez-Augustin O, López-Posadas R, González R, Ballester I, Suárez MD, Zarzuelo A, Sánchez de Medina F.

Gut. 2010 Apr;59(4):560; author reply 560. doi: 10.1136/gut.2009.191957. No abstract available.

PMID:
20332532
47.

[Optimisation of a high-efficiency liquid chromatography technique for measuring lamotrigine in human plasma].

Rivas N, Zarzuelo A, López FG.

Farm Hosp. 2010 Mar-Apr;34(2):85-9. doi: 10.1016/j.farma.2009.09.005. Epub 2010 Feb 6. Spanish.

PMID:
20304367
48.

Reversible Ponceau staining as a loading control alternative to actin in Western blots.

Romero-Calvo I, Ocón B, Martínez-Moya P, Suárez MD, Zarzuelo A, Martínez-Augustin O, de Medina FS.

Anal Biochem. 2010 Jun 15;401(2):318-20. doi: 10.1016/j.ab.2010.02.036. Epub 2010 Mar 3.

PMID:
20206115
49.

The intestinal antiinflammatory agent glycomacropeptide has immunomodulatory actions on rat splenocytes.

Requena P, González R, López-Posadas R, Abadía-Molina A, Suárez MD, Zarzuelo A, de Medina FS, Martínez-Augustin O.

Biochem Pharmacol. 2010 Jun 15;79(12):1797-804. doi: 10.1016/j.bcp.2010.02.008. Epub 2010 Feb 21.

PMID:
20178776
50.

Butyrate in vitro immune-modulatory effects might be mediated through a proliferation-related induction of apoptosis.

Bailón E, Cueto-Sola M, Utrilla P, Rodríguez-Cabezas ME, Garrido-Mesa N, Zarzuelo A, Xaus J, Gálvez J, Comalada M.

Immunobiology. 2010 Nov;215(11):863-73. doi: 10.1016/j.imbio.2010.01.001. Epub 2010 Jan 13.

PMID:
20149475

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