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Items: 16

1.

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.

Lensing CJ, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C.

J Med Chem. 2018 May 9. doi: 10.1021/acs.jmedchem.8b00238. [Epub ahead of print]

PMID:
29669202
2.

Identification and analysis of a mercapturic acid conjugate of indole-3-methyl isothiocyanate in the urine of humans who consumed cruciferous vegetables.

Upadhyaya P, Zarth AT, Fujioka N, Fritz VA, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:341-346. doi: 10.1016/j.jchromb.2017.12.001. Epub 2017 Dec 2.

3.

Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Carcinogenesis. 2018 Feb 9;39(2):232-241. doi: 10.1093/carcin/bgx135.

PMID:
29194532
4.
5.

Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2018 Jan 16;31(1):48-57. doi: 10.1021/acs.chemrestox.7b00281. Epub 2017 Nov 30.

6.

Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon.

Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2017 Aug 25;274:80-88. doi: 10.1016/j.cbi.2017.07.005. Epub 2017 Jul 8.

7.

Acrolein Exposure in Hookah Smokers and Non-Smokers Exposed to Hookah Tobacco Secondhand Smoke: Implications for Regulating Hookah Tobacco Products.

Kassem NOF, Kassem NO, Liles S, Zarth AT, Jackson SR, Daffa RM, Chatfield DA, Carmella SG, Hecht SS, Hovell MF.

Nicotine Tob Res. 2018 Mar 6;20(4):492-501. doi: 10.1093/ntr/ntx133.

PMID:
28591850
8.
9.

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.

Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C.

ACS Chem Neurosci. 2017 Jun 21;8(6):1262-1278. doi: 10.1021/acschemneuro.6b00399. Epub 2017 Feb 16.

10.

DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats.

Zarth AT, Upadhyaya P, Yang J, Hecht SS.

Chem Res Toxicol. 2016 Mar 21;29(3):380-9. doi: 10.1021/acs.chemrestox.5b00520. Epub 2016 Feb 9.

11.

Benzene oxide is a substrate for glutathione S-transferases.

Zarth AT, Murphy SE, Hecht SS.

Chem Biol Interact. 2015 Dec 5;242:390-5. doi: 10.1016/j.cbi.2015.11.005. Epub 2015 Nov 7.

12.

Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Villalta PW, Zarth AT, Kotandeniya D, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2015 Nov 16;28(11):2151-9. doi: 10.1021/acs.chemrestox.5b00318. Epub 2015 Oct 12.

13.

Benzene uptake in Hookah smokers and non-smokers attending Hookah social events: regulatory implications.

Kassem NO, Kassem NO, Jackson SR, Liles S, Daffa RM, Zarth AT, Younis MA, Carmella SG, Hofstetter CR, Chatfield DA, Matt GE, Hecht SS, Hovell MF.

Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2793-809.

14.

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.

15.

Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans.

Zarth AT, Cheng G, Zhang Z, Wang M, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2014 May 25;215:40-5. doi: 10.1016/j.cbi.2014.03.002. Epub 2014 Mar 13.

16.

Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide.

Zarth AT, Carmella SG, Le CT, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:126-31. doi: 10.1016/j.jchromb.2014.02.001. Epub 2014 Feb 14.

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