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Items: 34

1.

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.

Bryan MC, Drobnick J, Gobbi A, Kolesnikov A, Chen Y, Rajapaksa N, Ndubaku C, Feng J, Chang W, Francis R, Yu C, Choo EF, DeMent K, Ran Y, An L, Emson C, Huang Z, Sujatha-Bhaskar S, Brightbill H, DiPasquale A, Maher J, Wai J, McKenzie BS, Lupardus PJ, Zarrin AA, Kiefer JR.

J Med Chem. 2019 Jul 11;62(13):6223-6240. doi: 10.1021/acs.jmedchem.9b00439. Epub 2019 May 24.

PMID:
31082230
2.

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.

Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, Kapoor M, Sun Y, Kapadia SB, Gonzalez L, Zarrin AA, Goate A, Hansen DV, Behrens TW, Graham RR.

PLoS Genet. 2018 Nov 2;14(11):e1007427. doi: 10.1371/journal.pgen.1007427. eCollection 2018 Nov.

3.

TPL2 kinase action and control of inflammation.

Xu D, Matsumoto ML, McKenzie BS, Zarrin AA.

Pharmacol Res. 2018 Mar;129:188-193. doi: 10.1016/j.phrs.2017.11.031. Epub 2017 Nov 26. Review.

4.

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.

Senger K, Pham VC, Varfolomeev E, Hackney JA, Corzo CA, Collier J, Lau VWC, Huang Z, Hamidzhadeh K, Caplazi P, Peng I, Setiadi AF, Francis R, Paler-Martinez A, Kwon YC, Ramirez-Carrozzi V, Sun Y, Grigg PW, Roose-Girma M, Jeet S, Barck KH, Pham A, Ota N, Ha C, Stinson J, Guillory J, Tam L, Modrusan Z, Emson C, McKenzie BS, Townsend MJ, Carano RAD, Warming S, Vucic D, DeVoss J, Lee WP, Lill JR, Zarrin AA.

Sci Signal. 2017 Apr 18;10(475). pii: eaah4273. doi: 10.1126/scisignal.aah4273.

PMID:
28420753
5.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA.

Sci Signal. 2015 Dec 1;8(405):ra122. doi: 10.1126/scisignal.aab0949.

PMID:
26628680
6.

Antibody Isotype Switching in Vertebrates.

Senger K, Hackney J, Payandeh J, Zarrin AA.

Results Probl Cell Differ. 2015;57:295-324. doi: 10.1007/978-3-319-20819-0_13. Review.

PMID:
26537387
7.

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.

Burch JD, Barrett K, Chen Y, DeVoss J, Eigenbrot C, Goldsmith R, Ismaili MH, Lau K, Lin Z, Ortwine DF, Zarrin AA, McEwan PA, Barker JJ, Ellebrandt C, Kordt D, Stein DB, Wang X, Chen Y, Hu B, Xu X, Yuen PW, Zhang Y, Pei Z.

J Med Chem. 2015 May 14;58(9):3806-16. doi: 10.1021/jm501998m. Epub 2015 Apr 16.

PMID:
25844760
8.

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).

Trani G, Barker JJ, Bromidge SM, Brookfield FA, Burch JD, Chen Y, Eigenbrot C, Heifetz A, Ismaili MHA, Johnson A, Krülle TM, MacKinnon CH, Maghames R, McEwan PA, Montalbetti CAGN, Ortwine DF, Pérez-Fuertes Y, Vaidya DG, Wang X, Zarrin AA, Pei Z.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5818-5823. doi: 10.1016/j.bmcl.2014.10.020. Epub 2014 Oct 12.

PMID:
25455497
9.

Dual B cell immunotherapy is superior to individual anti-CD20 depletion or BAFF blockade in murine models of spontaneous or accelerated lupus.

Lin W, Seshasayee D, Lee WP, Caplazi P, McVay S, Suto E, Nguyen A, Lin Z, Sun Y, DeForge L, Balazs M, Martin F, Zarrin AA.

Arthritis Rheumatol. 2015 Jan;67(1):215-24. doi: 10.1002/art.38907.

10.

PILRα negatively regulates mouse inflammatory arthritis.

Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, Luk W, Lu Y, Lin Z, Barck K, Young J, Del Rio M, Lehar S, Asghari V, Lin W, Mariathasan S, DeVoss J, Misaghi S, Balazs M, Sai T, Haley B, Hass PE, Xu M, Ouyang W, Martin F, Lee WP, Zarrin AA.

J Immunol. 2014 Jul 15;193(2):860-70. doi: 10.4049/jimmunol.1400045. Epub 2014 Jun 16.

11.

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

Burch JD, Lau K, Barker JJ, Brookfield F, Chen Y, Chen Y, Eigenbrot C, Ellebrandt C, Ismaili MH, Johnson A, Kordt D, MacKinnon CH, McEwan PA, Ortwine DF, Stein DB, Wang X, Winkler D, Yuen PW, Zhang Y, Zarrin AA, Pei Z.

J Med Chem. 2014 Jul 10;57(13):5714-27. doi: 10.1021/jm500550e. Epub 2014 Jun 27.

PMID:
24918870
12.

The production and regulation of IgE by the immune system.

Wu LC, Zarrin AA.

Nat Rev Immunol. 2014 Apr;14(4):247-59. doi: 10.1038/nri3632. Epub 2014 Mar 14. Review.

PMID:
24625841
13.

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.

Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2644-9. doi: 10.1073/pnas.1324176111. Epub 2014 Feb 3.

14.

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.

Misaghi S, Senger K, Sai T, Qu Y, Sun Y, Hamidzadeh K, Nguyen A, Jin Z, Zhou M, Yan D, Lin WY, Lin Z, Lorenzo MN, Sebrell A, Ding J, Xu M, Caplazi P, Austin CD, Balazs M, Roose-Girma M, DeForge L, Warming S, Lee WP, Dixit VM, Zarrin AA.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15770-5. doi: 10.1073/pnas.1221661110. Epub 2013 Sep 9.

15.

AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.

Kumar R, DiMenna L, Schrode N, Liu TC, Franck P, Muñoz-Descalzo S, Hadjantonakis AK, Zarrin AA, Chaudhuri J, Elemento O, Evans T.

Nature. 2013 Aug 1;500(7460):89-92. doi: 10.1038/nature12299. Epub 2013 Jun 26.

16.

Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.

Sun Y, Peng I, Senger K, Hamidzadeh K, Reichelt M, Baca M, Yeh R, Lorenzo MN, Sebrell A, Dela Cruz C, Tam L, Corpuz R, Wu J, Sai T, Roose-Girma M, Warming S, Balazs M, Gonzalez LC, Caplazi P, Martin F, Devoss J, Zarrin AA.

Autoimmunity. 2013 Mar;46(2):157-67. doi: 10.3109/08916934.2012.750301. Epub 2013 Jan 18.

17.

Origin of immunoglobulin isotype switching.

Zhu C, Lee V, Finn A, Senger K, Zarrin AA, Du Pasquier L, Hsu E.

Curr Biol. 2012 May 22;22(10):872-80. doi: 10.1016/j.cub.2012.03.060. Epub 2012 Apr 26.

18.

Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands.

Sun Y, Senger K, Baginski TK, Mazloom A, Chinn Y, Pantua H, Hamidzadeh K, Ramani SR, Luis E, Tom I, Sebrell A, Quinones G, Ma Y, Mukhyala K, Sai T, Ding J, Haley B, Shadnia H, Kapadia SB, Gonzalez LC, Hass PE, Zarrin AA.

J Biol Chem. 2012 May 4;287(19):15837-50. doi: 10.1074/jbc.M111.286633. Epub 2012 Mar 6.

19.

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW.

PLoS One. 2010 Nov 15;5(11):e13992. doi: 10.1371/journal.pone.0013992.

20.

Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells.

Misaghi S, Garris CS, Sun Y, Nguyen A, Zhang J, Sebrell A, Senger K, Yan D, Lorenzo MN, Heldens S, Lee WP, Xu M, Wu J, DeForge L, Sai T, Dixit VM, Zarrin AA.

J Immunol. 2010 Jul 1;185(1):166-73. doi: 10.4049/jimmunol.1000515. Epub 2010 May 28.

21.

Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.

Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17487-92. doi: 10.1073/pnas.0909723106. Epub 2009 Sep 28.

22.

Mechanisms promoting translocations in editing and switching peripheral B cells.

Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.

Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159.

23.

DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination.

Hackney JA, Misaghi S, Senger K, Garris C, Sun Y, Lorenzo MN, Zarrin AA.

Adv Immunol. 2009;101:163-89. doi: 10.1016/S0065-2776(08)01005-5. Review.

PMID:
19231595
24.

Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.

Zarrin AA, Goff PH, Senger K, Alt FW.

J Exp Med. 2008 Jul 7;205(7):1567-72. doi: 10.1084/jem.20080451. Epub 2008 Jun 9.

25.

IgH class switching and translocations use a robust non-classical end-joining pathway.

Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.

Nature. 2007 Sep 27;449(7161):478-82. Epub 2007 Aug 22.

PMID:
17713479
26.

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW.

Science. 2007 Jan 19;315(5810):377-81. Epub 2006 Dec 14.

27.

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.

Mol Cell. 2006 Jan 20;21(2):201-14.

28.

Influence of switch region length on immunoglobulin class switch recombination.

Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2466-70. Epub 2005 Jan 31.

29.

An evolutionarily conserved target motif for immunoglobulin class-switch recombination.

Zarrin AA, Alt FW, Chaudhuri J, Stokes N, Kaushal D, Du Pasquier L, Tian M.

Nat Immunol. 2004 Dec;5(12):1275-81. Epub 2004 Nov 7.

PMID:
15531884
30.

Internal IgH class switch region deletions are position-independent and enhanced by AID expression.

Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9. Epub 2002 Jul 11.

31.

Functional analysis of the human RAG 2 promoter.

Fong IC, Zarrin AA, Wu GE, Berinstein NL.

Mol Immunol. 2000 May;37(7):391-402.

PMID:
11074256
32.

Comparison of CMV, RSV, SV40 viral and Vlambda1 cellular promoters in B and T lymphoid and non-lymphoid cell lines.

Zarrin AA, Malkin L, Fong I, Luk KD, Ghose A, Berinstein NL.

Biochim Biophys Acta. 1999 Jul 7;1446(1-2):135-9.

PMID:
10395926
33.

Cloning and characterization of the human recombination activating gene 1 (RAG1) and RAG2 promoter regions.

Zarrin AA, Fong I, Malkin L, Marsden PA, Berinstein NL.

J Immunol. 1997 Nov 1;159(9):4382-94.

PMID:
9379036
34.

Clinical, histologic, and ultrastructural evaluation of tattoos treated with three laser systems.

Zelickson BD, Mehregan DA, Zarrin AA, Coles C, Hartwig P, Olson S, Leaf-Davis J.

Lasers Surg Med. 1994;15(4):364-72.

PMID:
7885170

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