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Items: 39


-2019 PLOS Genetics Research Prize: Fruit fly school - language and dialects for communicating a threat.

Barsh GS, Copenhaver GP, Prakash ES, Zarnescu DC.

PLoS Genet. 2019 Sep 12;15(9):e1008381. doi: 10.1371/journal.pgen.1008381. eCollection 2019 Sep. No abstract available.


Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).

François-Moutal L, Felemban R, Scott DD, Sayegh MR, Miranda VG, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M.

ACS Chem Biol. 2019 Sep 20;14(9):2006-2013. doi: 10.1021/acschembio.9b00481. Epub 2019 Aug 27.


Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.

Manzo E, Lorenzini I, Barrameda D, O'Conner AG, Barrows JM, Starr A, Kovalik T, Rabichow BE, Lehmkuhl EM, Shreiner DD, Joardar A, Liévens JC, Bowser R, Sattler R, Zarnescu DC.

Elife. 2019 Jun 10;8. pii: e45114. doi: 10.7554/eLife.45114.


Lost in Translation: Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases.

Lehmkuhl EM, Zarnescu DC.

Adv Neurobiol. 2018;20:283-301. doi: 10.1007/978-3-319-89689-2_11. Review.


Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43.

Manzo E, O'Conner AG, Barrows JM, Shreiner DD, Birchak GJ, Zarnescu DC.

Front Mol Neurosci. 2018 May 31;11:182. doi: 10.3389/fnmol.2018.00182. eCollection 2018.


Dynamic duo - FMRP and TDP-43: Regulating common targets, causing different diseases.

Ferro D, Yao S, Zarnescu DC.

Brain Res. 2018 Aug 15;1693(Pt A):37-42. doi: 10.1016/j.brainres.2018.04.034. Epub 2018 Apr 30. Review.


miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila.

Daniel SG, Russ AD, Guthridge KM, Raina AI, Estes PS, Parsons LM, Richardson HE, Schroeder JA, Zarnescu DC.

Biol Open. 2018 Jan 26;7(1). pii: bio027391. doi: 10.1242/bio.027391.


TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.

Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, Cairns NJ, Boylan KB, Dickson DW, Rademakers R, Zhang YJ, Petrucelli L, Sattler R, Zarnescu DC, Glass JD, Rossoll W.

Nat Neurosci. 2018 Feb;21(2):228-239. doi: 10.1038/s41593-017-0047-3. Epub 2018 Jan 8.


Endocytosis regulates TDP-43 toxicity and turnover.

Liu G, Coyne AN, Pei F, Vaughan S, Chaung M, Zarnescu DC, Buchan JR.

Nat Commun. 2017 Dec 12;8(1):2092. doi: 10.1038/s41467-017-02017-x.


Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.

Chu M, Novak SM, Cover C, Wang AA, Chinyere IR, Juneman EB, Zarnescu DC, Wong PK, Gregorio CC.

Circulation. 2018 Feb 6;137(6):605-618. doi: 10.1161/CIRCULATIONAHA.117.028976. Epub 2017 Nov 3.


Metabolic Dysregulation in Amyotrophic Lateral Sclerosis: Challenges and Opportunities.

Joardar A, Manzo E, Zarnescu DC.

Curr Genet Med Rep. 2017 Jun;5(2):108-114. doi: 10.1007/s40142-017-0123-8. Epub 2017 Apr 28.


Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.

Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC.

Cell Rep. 2017 Oct 3;21(1):110-125. doi: 10.1016/j.celrep.2017.09.028.


Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.

Coyne AN, Zaepfel BL, Zarnescu DC.

Front Cell Neurosci. 2017 Aug 17;11:243. doi: 10.3389/fncel.2017.00243. eCollection 2017. Review.


A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes.

Coyne AN, Zarnescu DC.

PLoS Genet. 2016 Nov 17;12(11):e1006419. doi: 10.1371/journal.pgen.1006419. eCollection 2016 Nov. No abstract available.


Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein.

Novak SM, Joardar A, Gregorio CC, Zarnescu DC.

PLoS One. 2015 Nov 16;10(11):e0142836. doi: 10.1371/journal.pone.0142836. eCollection 2015.


Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.

Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC.

Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18.


PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W.

Hum Mol Genet. 2015 Sep 15;24(18):5154-73. doi: 10.1093/hmg/ddv238. Epub 2015 Jun 30.


PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.

Joardar A, Menzl J, Podolsky TC, Manzo E, Estes PS, Ashford S, Zarnescu DC.

Hum Mol Genet. 2015 Mar 15;24(6):1741-54. doi: 10.1093/hmg/ddu587. Epub 2014 Nov 28.


Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.

Coyne AN, Siddegowda BB, Estes PS, Johannesmeyer J, Kovalik T, Daniel SG, Pearson A, Bowser R, Zarnescu DC.

J Neurosci. 2014 Nov 26;34(48):15962-74. doi: 10.1523/JNEUROSCI.2526-14.2014.


Fragile hearts: new insights into translational control in cardiac muscle.

Zarnescu DC, Gregorio CC.

Trends Cardiovasc Med. 2013 Nov;23(8):275-81. doi: 10.1016/j.tcm.2013.03.003. Epub 2013 Apr 10. Review.


Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis.

Estes PS, Daniel SG, McCallum AP, Boehringer AV, Sukhina AS, Zwick RA, Zarnescu DC.

Dis Model Mech. 2013 May;6(3):721-33. doi: 10.1242/dmm.010710. Epub 2013 Feb 1.


Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain.

Callan MA, Clements N, Ahrendt N, Zarnescu DC.

Brain Res. 2012 Jun 26;1462:151-61. doi: 10.1016/j.brainres.2012.03.042. Epub 2012 Mar 27.


Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.

Whitman SA, Cover C, Yu L, Nelson DL, Zarnescu DC, Gregorio CC.

Circ Res. 2011 Jul 22;109(3):262-71. doi: 10.1161/CIRCRESAHA.111.244244. Epub 2011 Jun 9.


Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

Estes PS, Boehringer A, Zwick R, Tang JE, Grigsby B, Zarnescu DC.

Hum Mol Genet. 2011 Jun 15;20(12):2308-21. doi: 10.1093/hmg/ddr124. Epub 2011 Mar 26.


Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells.

Callan MA, Zarnescu DC.

Genesis. 2011 Jun;49(6):424-40. doi: 10.1002/dvg.20745. Epub 2011 May 31. Review.


Fragile X protein controls neural stem cell proliferation in the Drosophila brain.

Callan MA, Cabernard C, Heck J, Luois S, Doe CQ, Zarnescu DC.

Hum Mol Genet. 2010 Aug 1;19(15):3068-79. doi: 10.1093/hmg/ddq213. Epub 2010 May 26.


The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila.

Lee HG, Zarnescu DC, MacIver B, Thomas GH.

J Cell Sci. 2010 Jan 15;123(Pt 2):277-85. doi: 10.1242/jcs.056853.


Ferrying wingless across the synaptic cleft.

Zarnescu DC, Zinsmaier KE.

Cell. 2009 Oct 16;139(2):229-31. doi: 10.1016/j.cell.2009.09.032.


Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary.

Epstein AM, Bauer CR, Ho A, Bosco G, Zarnescu DC.

Dev Biol. 2009 Jun 1;330(1):83-92. doi: 10.1016/j.ydbio.2009.03.011. Epub 2009 Mar 21.


Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.

Bauer CR, Epstein AM, Sweeney SJ, Zarnescu DC, Bosco G.

BMC Syst Biol. 2008 Nov 25;2:101. doi: 10.1186/1752-0509-2-101.


Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons.

Estes PS, O'Shea M, Clasen S, Zarnescu DC.

Mol Cell Neurosci. 2008 Oct;39(2):170-9. doi: 10.1016/j.mcn.2008.06.012. Epub 2008 Jun 28.


Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Chang S, Bray SM, Li Z, Zarnescu DC, He C, Jin P, Warren ST.

Nat Chem Biol. 2008 Apr;4(4):256-63. doi: 10.1038/nchembio.78. Epub 2008 Mar 9.


Come FLY with us: toward understanding fragile X syndrome.

Zarnescu DC, Shan G, Warren ST, Jin P.

Genes Brain Behav. 2005 Aug;4(6):385-92. Review.


Fragile X protein functions with lgl and the par complex in flies and mice.

Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST, Moses K.

Dev Cell. 2005 Jan;8(1):43-52.


Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway.

Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST.

Nat Neurosci. 2004 Feb;7(2):113-7. Epub 2004 Jan 4.


RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila.

Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K, Warren ST.

Neuron. 2003 Aug 28;39(5):739-47.


Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye.

Thomas GH, Zarnescu DC, Juedes AE, Bales MA, Londergan A, Korte CC, Kiehart DP.

Development. 1998 Jun;125(11):2125-34.

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