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Items: 35


A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family.

Grant EK, Fallon DJ, Eberl HC, Fantom KGM, Zappacosta F, Messenger C, Tomkinson NCO, Bush J.

Angew Chem Int Ed Engl. 2019 Sep 13. doi: 10.1002/anie.201906321. [Epub ahead of print]


Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.

Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP.

Cancer Cell. 2019 Jul 8;36(1):100-114.e25. doi: 10.1016/j.ccell.2019.05.014. Epub 2019 Jun 27.


Detecting the occurrence of indigenous and non-indigenous megafauna through fishermen knowledge: A complementary tool to coastal and port surveys.

Azzurro E, Bolognini L, Dragičević B, Drakulović D, Dulčić J, Fanelli E, Grati F, Kolitari J, Lipej L, Magaletti E, Marković O, Matić-Skoko S, Mavrič B, Milone N, Joksimović A, Tomanić J, Scarpato A, Tutman P, Vrdoljak D, Zappacosta F.

Mar Pollut Bull. 2019 Oct;147:229-236. doi: 10.1016/j.marpolbul.2018.01.016. Epub 2018 Jan 12.


Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.

Van Aller GS, Graves AP, Elkins PA, Bonnette WG, McDevitt PJ, Zappacosta F, Annan RS, Dean TW, Su DS, Carpenter CL, Mohammad HP, Kruger RG.

Structure. 2016 May 3;24(5):774-781. doi: 10.1016/j.str.2016.03.010. Epub 2016 Apr 7.


An optimized platform for hydrophilic interaction chromatography-immobilized metal affinity chromatography enables deep coverage of the rat liver phosphoproteome.

Zappacosta F, Scott GF, Huddleston MJ, Annan RS.

J Proteome Res. 2015 Feb 6;14(2):997-1009. doi: 10.1021/pr501025e. Epub 2015 Jan 26.


Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells.

Li H, Xie W, Gore ER, Montoute MN, Bee WT, Zappacosta F, Zeng X, Wu Z, Kallal L, Ames RS, Pope AJ, Benowitz A, Erickson-Miller CL.

J Biomol Screen. 2013 Dec;18(10):1212-22. doi: 10.1177/1087057113499776. Epub 2013 Oct 25.


Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.

Yang J, Campobasso N, Biju MP, Fisher K, Pan XQ, Cottom J, Galbraith S, Ho T, Zhang H, Hong X, Ward P, Hofmann G, Siegfried B, Zappacosta F, Washio Y, Cao P, Qu J, Bertrand S, Wang DY, Head MS, Li H, Moores S, Lai Z, Johanson K, Burton G, Erickson-Miller C, Simpson G, Tummino P, Copeland RA, Oliff A.

Chem Biol. 2011 Feb 25;18(2):177-86. doi: 10.1016/j.chembiol.2010.12.013.


GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition.

Gilmartin AG, Bleam MR, Groy A, Moss KG, Minthorn EA, Kulkarni SG, Rominger CM, Erskine S, Fisher KE, Yang J, Zappacosta F, Annan R, Sutton D, Laquerre SG.

Clin Cancer Res. 2011 Mar 1;17(5):989-1000. doi: 10.1158/1078-0432.CCR-10-2200. Epub 2011 Jan 18. Erratum in: Clin Cancer Res. 2012 Apr 15;18(8):2413.


Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

Huang H, Hittle J, Zappacosta F, Annan RS, Hershko A, Yen TJ.

J Cell Biol. 2008 Nov 17;183(4):667-80. doi: 10.1083/jcb.200805163.


The catalytic role of INCENP in Aurora B activation and the kinetic mechanism of Aurora B/INCENP.

Yang J, Zappacosta F, Annan RS, Nurse K, Tummino PJ, Copeland RA, Lai Z.

Biochem J. 2009 Jan 1;417(1):355-60. doi: 10.1042/BJ20081365.


A quantitative results-driven approach to analyzing multisite protein phosphorylation: the phosphate-dependent phosphorylation profile of the transcription factor Pho4.

Zappacosta F, Collingwood TS, Huddleston MJ, Annan RS.

Mol Cell Proteomics. 2006 Nov;5(11):2019-30. Epub 2006 Jul 6.


Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.

Yokoyama N, deBakker CD, Zappacosta F, Huddleston MJ, Annan RS, Ravichandran KS, Miller WT.

Biochemistry. 2005 Jun 21;44(24):8841-9.


Interaction between Brk kinase and insulin receptor substrate-4.

Qiu H, Zappacosta F, Su W, Annan RS, Miller WT.

Oncogene. 2005 Aug 25;24(36):5656-64.


Protein posttranslational modifications: phosphorylation site analysis using mass spectrometry.

Annan RS, Zappacosta F.

Methods Biochem Anal. 2005;45:85-106. Review. No abstract available.


Comparative phosphorylation site mapping from gel-derived proteins using a multidimensional ES/MS-based approach.

Zappacosta F, Huddleston MJ, Annan RS.

Methods Mol Biol. 2004;284:91-110.


Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT.

J Biol Chem. 2002 Aug 2;277(31):28238-46. Epub 2002 May 23.


Primary structure of alpha-globin chains from river buffalo (Bubalus bubalis L.) hemoglobins.

Ferranti P, Facchiano A, Zappacosta F, Vincenti D, Rullo R, Masala B, Di Luccia A.

J Protein Chem. 2001 Feb;20(2):171-9.


The srhSR gene pair from Staphylococcus aureus: genomic and proteomic approaches to the identification and characterization of gene function.

Throup JP, Zappacosta F, Lunsford RD, Annan RS, Carr SA, Lonsdale JT, Bryant AP, McDevitt D, Rosenberg M, Burnham MK.

Biochemistry. 2001 Aug 28;40(34):10392-401.


Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.

Karcher RL, Roland JT, Zappacosta F, Huddleston MJ, Annan RS, Carr SA, Gelfand VI.

Science. 2001 Aug 17;293(5533):1317-20.


Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing.

Sun QA, Zappacosta F, Factor VM, Wirth PJ, Hatfield DL, Gladyshev VN.

J Biol Chem. 2001 Feb 2;276(5):3106-14. Epub 2000 Nov 1.


The murine liver-specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire.

Zappacosta F, Tabaczewski P, Parker KC, Coligan JE, Stroynowski I.

J Immunol. 2000 Feb 15;164(4):1906-15.


Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.

Sun QA, Wu Y, Zappacosta F, Jeang KT, Lee BJ, Hatfield DL, Gladyshev VN.

J Biol Chem. 1999 Aug 27;274(35):24522-30.


Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules.

Castellino F, Zappacosta F, Coligan JE, Germain RN.

J Immunol. 1998 Oct 15;161(8):4048-57.


Surface topology of Minibody by selective chemical modifications and mass spectrometry.

Zappacosta F, Ingallinella P, Scaloni A, Pessi A, Bianchi E, Sollazzo M, Tramontano A, Marino G, Pucci P.

Protein Sci. 1997 Sep;6(9):1901-9.


Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis.

Zappacosta F, Borrego F, Brooks AG, Parker KC, Coligan JE.

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6313-8.


Probing the tertiary structure of proteins by limited proteolysis and mass spectrometry: the case of Minibody.

Zappacosta F, Pessi A, Bianchi E, Venturini S, Sollazzo M, Tramontano A, Marino G, Pucci P.

Protein Sci. 1996 May;5(5):802-13.


Amino acid sequence of chicken Cu, Zn-containing superoxide dismutase and identification of glutathionyl adducts at exposed cysteine residues.

Schininà ME, Carlini P, Polticelli F, Zappacosta F, Bossa F, Calabrese L.

Eur J Biochem. 1996 Apr 15;237(2):433-9.


Structural analysis of saposin C and B. Complete localization of disulfide bridges.

Vaccaro AM, Salvioli R, Barca A, Tatti M, Ciaffoni F, Maras B, Siciliano R, Zappacosta F, Amoresano A, Pucci P.

J Biol Chem. 1995 Apr 28;270(17):9953-60.


Physiological concentrations of oxytocin powerfully stimulate insulin secretionin vitro.

Bobbioni-Harsch E, Frütiger S, Hughes G, Panico M, Etienne A, Zappacosta F, Morris HR, Jeanrenaud B.

Endocrine. 1995 Jan;3(1):55-9. doi: 10.1007/BF02917449.


Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector.

Arcone R, Pucci P, Zappacosta F, Fontaine V, Malorni A, Marino G, Ciliberto G.

Eur J Biochem. 1991 Jun 15;198(3):541-7.

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