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Items: 1 to 50 of 138

1.

Benzanthric Acid, a Novel Metabolite From Streptomyces albus Del14 Expressing the Nybomycin Gene Cluster.

Rodríguez Estévez M, Gummerlich N, Myronovskyi M, Zapp J, Luzhetskyy A.

Front Chem. 2020 Jan 10;7:896. doi: 10.3389/fchem.2019.00896. eCollection 2019.

2.

Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters.

Ahmed Y, Rebets Y, Estévez MR, Zapp J, Myronovskyi M, Luzhetskyy A.

Microb Cell Fact. 2020 Jan 9;19(1):5. doi: 10.1186/s12934-020-1277-8.

3.

Multiple Ether-Functionalized Phosphonium Ionic Liquids as Highly Fluid Electrolytes.

Philippi F, Rauber D, Zapp J, Präsang C, Scheschkewitz D, Hempelmann R.

Chemphyschem. 2019 Feb 4;20(3):443-455. doi: 10.1002/cphc.201800939. Epub 2018 Dec 5.

PMID:
30480374
4.

New Alpiniamides From Streptomyces sp. IB2014/011-12 Assembled by an Unusual Hybrid Non-ribosomal Peptide Synthetase Trans-AT Polyketide Synthase Enzyme.

Paulus C, Rebets Y, Zapp J, Rückert C, Kalinowski J, Luzhetskyy A.

Front Microbiol. 2018 Aug 22;9:1959. doi: 10.3389/fmicb.2018.01959. eCollection 2018.

5.

Diffusion parameter mapping with the combined intravoxel incoherent motion and kurtosis model using artificial neural networks at 3 T.

Bertleff M, Domsch S, Weingärtner S, Zapp J, O'Brien K, Barth M, Schad LR.

NMR Biomed. 2017 Dec;30(12). doi: 10.1002/nbm.3833. Epub 2017 Sep 28.

PMID:
28960549
6.

Transport properties and ionicity of phosphonium ionic liquids.

Philippi F, Rauber D, Zapp J, Hempelmann R.

Phys Chem Chem Phys. 2017 Aug 30;19(34):23015-23023. doi: 10.1039/c7cp04552b.

PMID:
28816321
7.

Oxygen extraction fraction mapping at 3 Tesla using an artificial neural network: A feasibility study.

Domsch S, Mürle B, Weingärtner S, Zapp J, Wenz F, Schad LR.

Magn Reson Med. 2018 Feb;79(2):890-899. doi: 10.1002/mrm.26749. Epub 2017 May 14.

PMID:
28504360
8.

The steroid metabolite 16(β)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1.

Neunzig J, Milhim M, Schiffer L, Khatri Y, Zapp J, Sánchez-Guijo A, Hartmann MF, Wudy SA, Bernhardt R.

J Steroid Biochem Mol Biol. 2017 Mar;167:182-191. doi: 10.1016/j.jsbmb.2017.01.002. Epub 2017 Jan 5.

PMID:
28065637
9.

Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D3 hydroxylase.

Abdulmughni A, Jóźwik IK, Putkaradze N, Brill E, Zapp J, Thunnissen AW, Hannemann F, Bernhardt R.

J Biotechnol. 2017 Feb 10;243:38-47. doi: 10.1016/j.jbiotec.2016.12.023. Epub 2016 Dec 30.

PMID:
28043840
10.

Biotransformation of prednisone and dexamethasone by cytochrome P450 based systems - Identification of new potential drug candidates.

Putkaradze N, Kiss FM, Schmitz D, Zapp J, Hutter MC, Bernhardt R.

J Biotechnol. 2017 Jan 20;242:101-110. doi: 10.1016/j.jbiotec.2016.12.011. Epub 2016 Dec 14.

PMID:
27988215
11.

Magnetic resonance fingerprinting using echo-planar imaging: Joint quantification of T1 and T2∗ relaxation times.

Rieger B, Zimmer F, Zapp J, Weingärtner S, Schad LR.

Magn Reson Med. 2017 Nov;78(5):1724-1733. doi: 10.1002/mrm.26561. Epub 2016 Dec 16.

PMID:
27981641
12.

Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium.

Jóźwik IK, Kiss FM, Gricman Ł, Abdulmughni A, Brill E, Zapp J, Pleiss J, Bernhardt R, Thunnissen AW.

FEBS J. 2016 Nov;283(22):4128-4148. doi: 10.1111/febs.13911. Epub 2016 Oct 17.

13.

Gaussian signal relaxation around spin echoes: Implications for precise reversible transverse relaxation quantification of pulmonary tissue at 1.5 and 3 Tesla.

Zapp J, Domsch S, Weingärtner S, Schad LR.

Magn Reson Med. 2017 May;77(5):1938-1945. doi: 10.1002/mrm.26280. Epub 2016 Jun 25.

PMID:
27343149
14.

Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation.

Schiffer L, Müller AR, Hobler A, Brixius-Anderko S, Zapp J, Hannemann F, Bernhardt R.

J Steroid Biochem Mol Biol. 2016 Oct;163:68-76. doi: 10.1016/j.jsbmb.2016.04.004. Epub 2016 Apr 25.

PMID:
27125452
15.

Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progestogens 17α,20β-di- and 17α,20β,21α-trihydroxy-4-pregnen-3-one.

Gerber A, Milhim M, Hartz P, Zapp J, Bernhardt R.

Metab Eng. 2016 Jul;36:19-27. doi: 10.1016/j.ymben.2016.02.010. Epub 2016 Mar 11.

PMID:
26976492
16.

Human CYP27A1 catalyzes hydroxylation of β-sitosterol and ergosterol.

Ehrhardt M, Gerber A, Zapp J, Hannemann F, Bernhardt R.

Biol Chem. 2016 Jun 1;397(6):513-8. doi: 10.1515/hsz-2016-0111.

PMID:
26891232
17.

Diphenidine, a new psychoactive substance: metabolic fate elucidated with rat urine and human liver preparations and detectability in urine using GC-MS, LC-MSn , and LC-HR-MSn.

Wink CS, Michely JA, Jacobsen-Bauer A, Zapp J, Maurer HH.

Drug Test Anal. 2016 Oct;8(10):1005-1014. doi: 10.1002/dta.1946. Epub 2016 Jan 26.

PMID:
26811026
18.

Metabolism of Oral Turinabol by Human Steroid Hormone-Synthesizing Cytochrome P450 Enzymes.

Schiffer L, Brixius-Anderko S, Hannemann F, Zapp J, Neunzig J, Thevis M, Bernhardt R.

Drug Metab Dispos. 2016 Feb;44(2):227-37. doi: 10.1124/dmd.115.066829. Epub 2015 Dec 9.

PMID:
26658226
19.

Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.

Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R.

Chembiochem. 2016 Jan 1;17(1):90-101. doi: 10.1002/cbic.201500420. Epub 2015 Nov 20.

PMID:
26478560
20.

A two-color fluorogenic carbene complex for tagging olefins via metathesis reaction.

Wirtz M, Grüter A, Heib F, Huch V, Zapp J, Herten DP, Schmitt M, Jung G.

Methods Appl Fluoresc. 2015 Sep 8;3(4):044001. doi: 10.1088/2050-6120/3/4/044001.

PMID:
29148507
21.

Steering the azido-tetrazole equilibrium of 4-azidopyrimidines via substituent variation - implications for drug design and azide-alkyne cycloadditions.

Thomann A, Zapp J, Hutter M, Empting M, Hartmann RW.

Org Biomol Chem. 2015 Nov 21;13(43):10620-30. doi: 10.1039/c5ob01006c.

PMID:
26340222
22.

Squalenoylation of Chitosan: A Platform for Drug Delivery?

Lepeltier E, Loretz B, Desmaële D, Zapp J, Herrmann J, Couvreur P, Lehr CM.

Biomacromolecules. 2015 Sep 14;16(9):2930-9. doi: 10.1021/acs.biomac.5b00840. Epub 2015 Aug 6.

PMID:
26221873
23.

Identification of new substrates for the CYP106A1-mediated 11-oxidation and investigation of the reaction mechanism.

Kiss FM, Khatri Y, Zapp J, Bernhardt R.

FEBS Lett. 2015 Aug 19;589(18):2320-6. doi: 10.1016/j.febslet.2015.07.011. Epub 2015 Jul 17.

24.

Regioselective Acetylation of C21 Hydroxysteroids by the Bacterial Chloramphenicol Acetyltransferase I.

Mosa A, Hutter MC, Zapp J, Bernhardt R, Hannemann F.

Chembiochem. 2015 Jul 27;16(11):1670-9. doi: 10.1002/cbic.201500125. Epub 2015 Jun 12.

PMID:
25999128
25.

Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-oxidase activity.

Kiss FM, Schmitz D, Zapp J, Dier TK, Volmer DA, Bernhardt R.

Appl Microbiol Biotechnol. 2015 Oct;99(20):8495-514. doi: 10.1007/s00253-015-6563-8. Epub 2015 Apr 24.

PMID:
25904128
26.

Process development for the production of 15β-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst.

Kiss FM, Lundemo MT, Zapp J, Woodley JM, Bernhardt R.

Microb Cell Fact. 2015 Mar 5;14:28. doi: 10.1186/s12934-015-0210-z.

27.

2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation.

Mosa A, Neunzig J, Gerber A, Zapp J, Hannemann F, Pilak P, Bernhardt R.

J Steroid Biochem Mol Biol. 2015 Jun;150:1-10. doi: 10.1016/j.jsbmb.2015.02.014. Epub 2015 Mar 3.

PMID:
25746800
28.
29.

Characterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: biosynthesis of (+)-eremophilene and its hydroxylation.

Schifrin A, Ly TT, Günnewich N, Zapp J, Thiel V, Schulz S, Hannemann F, Khatri Y, Bernhardt R.

Chembiochem. 2015 Jan 19;16(2):337-44. doi: 10.1002/cbic.201402443. Epub 2014 Dec 12.

PMID:
25504914
30.

Optimized protocol for high resolution functional magnetic resonance imaging at 3T using single-shot echo planar imaging.

Domsch S, Zapp J, Schad LR, Nees F, Hill H, Hermann D, Mann K, Vollstädt-Klein S.

J Neurosci Methods. 2015 Jan 15;239:170-82. doi: 10.1016/j.jneumeth.2014.10.014. Epub 2014 Oct 29.

PMID:
25445785
31.
32.

Steroid conversion with CYP106A2 - production of pharmaceutically interesting DHEA metabolites.

Schmitz D, Zapp J, Bernhardt R.

Microb Cell Fact. 2014 Jun 5;13:81. doi: 10.1186/1475-2859-13-81.

33.

Substrate-assisted O2 activation in a cofactor-independent dioxygenase.

Thierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S.

Chem Biol. 2014 Feb 20;21(2):217-25. doi: 10.1016/j.chembiol.2013.11.013. Epub 2014 Jan 2.

34.

Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse.

Meyer GM, Meyer MR, Wink CS, Zapp J, Maurer HH.

Biochem Pharmacol. 2013 Nov 15;86(10):1497-506. doi: 10.1016/j.bcp.2013.08.025. Epub 2013 Aug 26.

PMID:
23988488
35.

A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA).

Brill E, Hannemann F, Zapp J, Brüning G, Jauch J, Bernhardt R.

Appl Microbiol Biotechnol. 2014 Feb;98(4):1701-17. Epub 2013 Jun 25.

PMID:
23797329
36.

Norditerpenoid alkaloids from Delphinium flexuosum Bieb.

Pirildar S, Unsal-Gürer C, Koçyiğit M, Zapp J, Kiemer AK, Meriçli AH.

Z Naturforsch C J Biosci. 2012 Nov-Dec;67(11-12):541-4.

PMID:
23413746
37.

Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids.

Janocha S, Zapp J, Hutter M, Kleser M, Bohlmann J, Bernhardt R.

Chembiochem. 2013 Mar 4;14(4):467-73. doi: 10.1002/cbic.201200729. Epub 2013 Feb 1.

PMID:
23371760
38.

Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions.

Ringle M, Khatri Y, Zapp J, Hannemann F, Bernhardt R.

Appl Microbiol Biotechnol. 2013 Sep;97(17):7741-54. doi: 10.1007/s00253-012-4612-0. Epub 2012 Dec 20.

PMID:
23254762
39.

Memory stabilization with targeted reactivation during human slow-wave sleep.

van Dongen EV, Takashima A, Barth M, Zapp J, Schad LR, Paller KA, Fernández G.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10575-80. doi: 10.1073/pnas.1201072109. Epub 2012 Jun 12.

40.

Diterpenoid alkaloids of Aconitum vulparia Rchb.

Kurtoğlu S, Sen B, Melikoğlu G, Becker H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH.

Z Naturforsch C J Biosci. 2012 Mar-Apr;67(3-4):103-7.

PMID:
22624325
41.

Sinusoidal echo-planar imaging with parallel acquisition technique for reduced acoustic noise in auditory fMRI.

Zapp J, Schmitter S, Schad LR.

J Magn Reson Imaging. 2012 Sep;36(3):581-8. doi: 10.1002/jmri.23699. Epub 2012 May 14.

PMID:
22585371
42.
43.

Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium.

Schmitz D, Zapp J, Bernhardt R.

FEBS J. 2012 May;279(9):1663-74. doi: 10.1111/j.1742-4658.2012.08503.x. Epub 2012 Feb 24.

44.

Production and NMR analysis of the human ibuprofen metabolite 3-hydroxyibuprofen.

Neunzig I, Göhring A, Drăgan CA, Zapp J, Peters FT, Maurer HH, Bureik M.

J Biotechnol. 2012 Feb 10;157(3):417-20. doi: 10.1016/j.jbiotec.2011.12.016. Epub 2011 Dec 27.

PMID:
22226725
45.

CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase.

Ly TT, Khatri Y, Zapp J, Hutter MC, Bernhardt R.

Appl Microbiol Biotechnol. 2012 Jul;95(1):123-33. doi: 10.1007/s00253-011-3727-z. Epub 2012 Jan 6.

PMID:
22223101
46.

CYP105A1 mediated 3-hydroxylation of glimepiride and glibenclamide using a recombinant Bacillus megaterium whole-cell catalyst.

Kleser M, Hannemann F, Hutter M, Zapp J, Bernhardt R.

J Biotechnol. 2012 Feb 10;157(3):405-12. doi: 10.1016/j.jbiotec.2011.12.006. Epub 2011 Dec 21.

PMID:
22202177
47.

Immunoinhibitory effect of teuclatriol a guaiane sesquiterpene from Salvia mirzayanii.

Ziaei A, Amirghofran Z, Zapp J, Ramezani M.

Iran J Immunol. 2011 Dec;8(4):226-35. doi: IJIv8i4A5.

48.

Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography-linear ion trap-mass spectrometry (LC-MS(n)).

Meyer MR, Dinger J, Schwaninger AE, Wissenbach DK, Zapp J, Fritschi G, Maurer HH.

Anal Bioanal Chem. 2012 Jan;402(3):1249-55. doi: 10.1007/s00216-011-5528-8. Epub 2011 Nov 8.

PMID:
22065349
49.

A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system.

Bleif S, Hannemann F, Zapp J, Hartmann D, Jauch J, Bernhardt R.

Appl Microbiol Biotechnol. 2012 Feb;93(3):1135-46. doi: 10.1007/s00253-011-3467-0. Epub 2011 Jul 22.

PMID:
21779845
50.

Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography-linear ion trap-mass spectrometry.

Philipp AA, Wissenbach DK, Weber AA, Zapp J, Maurer HH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1049-55. doi: 10.1016/j.jchromb.2011.03.005. Epub 2011 Mar 29.

PMID:
21450536

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