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Items: 1 to 50 of 278

1.

The Role of Nitric Oxide in Preventing Cardiopulmonary Bypass-associated Acute Kidney Injury.

Lama TT, Berra L, Zapol WM.

J Cardiothorac Vasc Anesth. 2019 Sep 18. pii: S1053-0770(19)30977-2. doi: 10.1053/j.jvca.2019.09.016. [Epub ahead of print] No abstract available.

PMID:
31606280
2.

Phototherapy and extracorporeal membrane oxygenation facilitate removal of carbon monoxide in rats.

Zazzeron L, Fischbach A, Franco W, Farinelli WA, Ichinose F, Bloch DB, Anderson RR, Zapol WM.

Sci Transl Med. 2019 Oct 9;11(513). pii: eaau4217. doi: 10.1126/scitranslmed.aau4217.

PMID:
31597752
3.

Electrically generated nitric oxide from air: a safe and economical treatment for pulmonary hypertension.

Yu B, Zapol WM, Berra L.

Intensive Care Med. 2019 Aug 26. doi: 10.1007/s00134-019-05756-1. [Epub ahead of print] No abstract available.

PMID:
31451859
4.

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK.

Cell Metab. 2019 Oct 1;30(4):824-832.e3. doi: 10.1016/j.cmet.2019.07.006. Epub 2019 Aug 8.

PMID:
31402314
5.

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.

Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.

Cell. 2019 May 30;177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. Epub 2019 Apr 25.

PMID:
31031004
6.

Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.

Hindle AG, Allen KN, Batten AJ, Hückstädt LA, Turner-Maier J, Schulberg SA, Johnson J, Karlsson E, Lindblad-Toh K, Costa DP, Bloch DB, Zapol WM, Buys ES.

Am J Physiol Regul Integr Comp Physiol. 2019 Jun 1;316(6):R704-R715. doi: 10.1152/ajpregu.00283.2018. Epub 2019 Mar 20.

PMID:
30892912
7.

Reply to Coutrot et al.: Is Nitric Oxide Nephro- or Cardioprotective?

Lei C, Berra L, Xiong L, Zapol WM.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1442-1443. doi: 10.1164/rccm.201901-0089LE. No abstract available.

8.

Nitric Oxide Story.

Zapol WM.

Anesthesiology. 2019 Mar;130(3):435-440. doi: 10.1097/ALN.0000000000002579.

PMID:
30664059
9.

Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome.

Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM.

Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L391-L399. doi: 10.1152/ajplung.00419.2018. Epub 2018 Dec 6.

10.

Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation.

Wang A, Singh S, Yu B, Bloch DB, Zapol WM, Kluger R.

Transfusion. 2019 Jan;59(1):359-370. doi: 10.1111/trf.15003. Epub 2018 Nov 15.

PMID:
30444016
11.

Inhaled nitric oxide.

Yu B, Ichinose F, Bloch DB, Zapol WM.

Br J Pharmacol. 2019 Jan;176(2):246-255. doi: 10.1111/bph.14512. Epub 2018 Nov 16. Review.

PMID:
30288739
12.

Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites.

Nagasaka Y, Fernandez BO, Steinbicker AU, Spagnolli E, Malhotra R, Bloch DB, Bloch KD, Zapol WM, Feelisch M.

Nitric Oxide. 2018 Nov 1;80:52-60. doi: 10.1016/j.niox.2018.08.006. Epub 2018 Aug 13.

13.

Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin.

Goldstein SR, Liu C, Safo MK, Nakagawa A, Zapol WM, Winkler JD.

ACS Med Chem Lett. 2018 May 11;9(7):714-718. doi: 10.1021/acsmedchemlett.8b00166. eCollection 2018 Jul 12.

14.

Reducing the Incidence of Substance Use Disorders in Anesthesiology Residents: 13 Years of Comprehensive Urine Drug Screening.

Fitzsimons MG, Baker K, Malhotra R, Gottlieb A, Lowenstein E, Zapol WM.

Anesthesiology. 2018 Oct;129(4):821-828. doi: 10.1097/ALN.0000000000002348.

PMID:
30020101
15.

Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery.

Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, Hou L, Chen M, Chen W, Wang H, Zheng Q, Shen J, Jin Z, Chen T, Zhao R, Christie E, Sabbisetti VS, Nordio F, Bonventre JV, Xiong L, Zapol WM.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1279-1287. doi: 10.1164/rccm.201710-2150OC.

PMID:
29932345
16.

A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM.

Mol Pharm. 2018 May 7;15(5):1954-1963. doi: 10.1021/acs.molpharmaceut.8b00108. Epub 2018 Apr 18.

17.

Development of a portable mini-generator to safely produce nitric oxide for the treatment of infants with pulmonary hypertension.

Yu B, Ferrari M, Schleifer G, Blaesi AH, Wepler M, Zapol WM, Bloch DB.

Nitric Oxide. 2018 May 1;75:70-76. doi: 10.1016/j.niox.2018.02.006. Epub 2018 Feb 24.

18.

Pulmonary Delivery of Therapeutic and Diagnostic Gases.

Zapol WM, Charles HC, Martin AR, Sá RC, Yu B, Ichinose F, MacIntyre N, Mammarappallil J, Moon R, Chen JZ, Geier ET, Darquenne C, Prisk GK, Katz I.

J Aerosol Med Pulm Drug Deliv. 2018 Apr;31(2):78-87. doi: 10.1089/jamp.2017.1431. Epub 2018 Feb 16.

19.

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.

Kassa T, Strader MB, Nakagawa A, Zapol WM, Alayash AI.

Metallomics. 2017 Sep 20;9(9):1260-1270. doi: 10.1039/c7mt00104e.

20.

Inhaled Pulmonary Vasodilators in Cardiac Surgery Patients: Correct Answer Is "NO".

Ichinose F, Zapol WM.

Anesth Analg. 2017 Aug;125(2):375-377. doi: 10.1213/ANE.0000000000002239. No abstract available.

21.

Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha.

Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM.

BMC Anesthesiol. 2017 Jun 14;17(1):76. doi: 10.1186/s12871-017-0368-5.

22.

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.

Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4241-E4250. doi: 10.1073/pnas.1621511114. Epub 2017 May 8. Erratum in: Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4894-E4896. Proc Natl Acad Sci U S A. 2018 Jan 30;:.

23.

Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension.

Graw JA, Yu B, Rezoagli E, Warren HS, Buys ES, Bloch DB, Zapol WM.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1120-H1127. doi: 10.1152/ajpheart.00851.2016. Epub 2017 Mar 17.

24.

Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats.

Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM.

Shock. 2017 Jun;47(6):735-742. doi: 10.1097/SHK.0000000000000797.

25.

Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge.

Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1213-L1221. doi: 10.1152/ajplung.00394.2016. Epub 2016 Nov 4.

26.

Electric Plasma-generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension.

Berra L, Rodriguez-Lopez J, Rezoagli E, Yu B, Fisher DF, Semigran MJ, Bloch DB, Channick RN, Zapol WM.

Am J Respir Crit Care Med. 2016 Nov 1;194(9):1168-1170. No abstract available.

27.

Detection and removal of impurities in nitric oxide generated from air by pulsed electrical discharge.

Yu B, Blaesi AH, Casey N, Raykhtsaum G, Zazzeron L, Jones R, Morrese A, Dobrynin D, Malhotra R, Bloch DB, Goldstein LE, Zapol WM.

Nitric Oxide. 2016 Nov 30;60:16-23. doi: 10.1016/j.niox.2016.08.005. Epub 2016 Aug 31.

28.

Exposure of Stored Packed Erythrocytes to Nitric Oxide Prevents Transfusion-associated Pulmonary Hypertension.

Muenster S, Beloiartsev A, Yu B, Du E, Abidi S, Dao M, Fabry G, Graw JA, Wepler M, Malhotra R, Fernandez BO, Feelisch M, Bloch KD, Bloch DB, Zapol WM.

Anesthesiology. 2016 Nov;125(5):952-963.

29.

Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis.

Rezoagli E, Ichinose F, Strelow S, Roy N, Shelton K, Matsumine R, Chen L, Bittner EA, Bloch DB, Zapol WM, Berra L.

J Cardiothorac Vasc Anesth. 2017 Apr;31(2):505-515. doi: 10.1053/j.jvca.2016.06.009. Epub 2016 Jun 8.

PMID:
27590461
30.

Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells.

Graw JA, Mayeur C, Rosales I, Liu Y, Sabbisetti VS, Riley FE, Rechester O, Malhotra R, Warren HS, Colvin RB, Bonventre JV, Bloch DB, Zapol WM.

Circulation. 2016 Sep 27;134(13):945-60. doi: 10.1161/CIRCULATIONAHA.115.019955. Epub 2016 Aug 11.

31.

Hypoxia as a therapy for mitochondrial disease.

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK.

Science. 2016 Apr 1;352(6281):54-61. doi: 10.1126/science.aad9642. Epub 2016 Feb 25.

32.

BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.

Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB.

Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.

33.

"Treating Lungs": The Scientific Contributions of Dr. Theodor Kolobow.

Trahanas JM, Kolobow MA, Hardy MA, Berra L, Zapol WM, Bartlett RH.

ASAIO J. 2016 Mar-Apr;62(2):203-10. doi: 10.1097/MAT.0000000000000323.

34.

Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial.

Mwanga-Amumpaire J, Carroll RW, Baudin E, Kemigisha E, Nampijja D, Mworozi K, Santorino D, Nyehangane D, Nathan DI, De Beaudrap P, Etard JF, Feelisch M, Fernandez BO, Berssenbrugge A, Bangsberg D, Bloch KD, Boum Y 2nd, Zapol WM.

Open Forum Infect Dis. 2015 Jul 24;2(3):ofv111. doi: 10.1093/ofid/ofv111. eCollection 2015 Sep. Erratum in: Open Forum Infect Dis. 2015 Sep;2(3):ofv132.

35.

Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning.

Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM.

Am J Respir Crit Care Med. 2015 Nov 15;192(10):1191-9. doi: 10.1164/rccm.201503-0609OC.

36.

Producing nitric oxide by pulsed electrical discharge in air for portable inhalation therapy.

Yu B, Muenster S, Blaesi AH, Bloch DB, Zapol WM.

Sci Transl Med. 2015 Jul 1;7(294):294ra107. doi: 10.1126/scitranslmed.aaa3097.

PMID:
26136478
37.

Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j.

Beloiartsev A, da Glória Rodrigues-Machado M, Zhou GL, Tan TC, Zazzeron L, Tainsh RE, Leyton P, Jones RC, Scherrer-Crosbie M, Zapol WM.

Am J Respir Cell Mol Biol. 2015 May;52(5):563-70. doi: 10.1165/rcmb.2013-0482OC.

38.

Our paper 20 years later: Inhaled nitric oxide for the acute respiratory distress syndrome--discovery, current understanding, and focussed targets of future applications.

Rossaint R, Lewandowski K, Zapol WM.

Intensive Care Med. 2014 Nov;40(11):1649-58. doi: 10.1007/s00134-014-3458-6. Epub 2014 Sep 9.

PMID:
25201565
39.

Autologous transfusion of stored red blood cells increases pulmonary artery pressure.

Berra L, Pinciroli R, Stowell CP, Wang L, Yu B, Fernandez BO, Feelisch M, Mietto C, Hod EA, Chipman D, Scherrer-Crosbie M, Bloch KD, Zapol WM.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):800-7. doi: 10.1164/rccm.201405-0850OC.

40.

Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling.

Nakagawa A, Lui FE, Wassaf D, Yefidoff-Freedman R, Casalena D, Palmer MA, Meadows J, Mozzarelli A, Ronda L, Abdulmalik O, Bloch KD, Safo MK, Zapol WM.

ACS Chem Biol. 2014 Oct 17;9(10):2318-25. doi: 10.1021/cb500230b. Epub 2014 Aug 11.

41.

Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia.

Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD.

PLoS Genet. 2013 Nov;9(11):e1003950. doi: 10.1371/journal.pgen.1003950. Epub 2013 Nov 21.

42.

Adverse effects of hemorrhagic shock resuscitation with stored blood are ameliorated by inhaled nitric oxide in lambs*.

Baron DM, Beloiartsev A, Nakagawa A, Martyn T, Stowell CP, Malhotra R, Mayeur C, Bloch KD, Zapol WM.

Crit Care Med. 2013 Nov;41(11):2492-501. doi: 10.1097/CCM.0b013e31828cf456.

43.

Hemoglobin infusion does not alter murine pulmonary vascular tone.

Beloiartsev A, Baron DM, Yu B, Bloch KD, Zapol WM.

Nitric Oxide. 2013 Apr 1;30:1-8. doi: 10.1016/j.niox.2012.12.007. Epub 2013 Jan 8.

44.

Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock.

Lei C, Yu B, Shahid M, Beloiartsev A, Bloch KD, Zapol WM.

Anesthesiology. 2012 Dec;117(6):1190-202. doi: 10.1097/ALN.0b013e318272d866.

45.

Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury.

Vaporidi K, Vergadi E, Kaniaris E, Hatziapostolou M, Lagoudaki E, Georgopoulos D, Zapol WM, Bloch KD, Iliopoulos D.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L199-207. doi: 10.1152/ajplung.00370.2011. Epub 2012 Jun 1.

46.

Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.

Berra L, Coppadoro A, Yu B, Lei C, Spagnolli E, Steinbicker AU, Bloch KD, Lin T, Sammy FY, Warren HS, Fernandez BO, Feelisch M, Dzik WH, Stowell CP, Zapol WM.

Anesthesiology. 2012 Jul;117(1):56-63. doi: 10.1097/ALN.0b013e31825575e6.

47.

Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide.

Baron DM, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker AU, Malhotra R, Bloch KD, Zapol WM.

Anesthesiology. 2012 Mar;116(3):637-47. doi: 10.1097/ALN.0b013e318246ef77.

48.

Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice.

Yu B, Lei C, Baron DM, Steinbicker AU, Bloch KD, Zapol WM.

Transfusion. 2012 Jul;52(7):1410-22. doi: 10.1111/j.1537-2995.2011.03473.x. Epub 2012 Jan 10.

49.

Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis.

Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):613-22. doi: 10.1161/ATVBAHA.111.242594. Epub 2012 Jan 5.

50.

Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria.

Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC.

PLoS One. 2011;6(11):e27714. doi: 10.1371/journal.pone.0027714. Epub 2011 Nov 16.

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