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Items: 1 to 50 of 72

1.

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism.

Azatyan A, Gallo-Oller G, Diao Y, Selivanova G, Johnsen JI, Zaphiropoulos PG.

Cancer Lett. 2019 Feb 1;442:341-350. doi: 10.1016/j.canlet.2018.11.005. Epub 2018 Nov 14.

2.

Identification of novel GLI1 target genes and regulatory circuits in human cancer cells.

Diao Y, Rahman MF, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, Zaphiropoulos PG.

Mol Oncol. 2018 Oct;12(10):1718-1734. doi: 10.1002/1878-0261.12366. Epub 2018 Aug 30.

3.

Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells.

Diao Y, Azatyan A, Rahman MF, Zhao C, Zhu J, Dahlman-Wright K, Zaphiropoulos PG.

Oncotarget. 2016 Nov 1;7(44):71580-71593. doi: 10.18632/oncotarget.12259.

4.

Tamoxifen Resistance: Emerging Molecular Targets.

Rondón-Lagos M, Villegas VE, Rangel N, Sánchez MC, Zaphiropoulos PG.

Int J Mol Sci. 2016 Aug 19;17(8). pii: E1357. doi: 10.3390/ijms17081357. Review.

5.

Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling.

Villegas VE, Rondón-Lagos M, Annaratone L, Castellano I, Grismaldo A, Sapino A, Zaphiropoulos PG.

Int J Mol Sci. 2016 Feb 27;17(3):308. doi: 10.3390/ijms17030308.

6.

An updated h-index measures both the primary and total scientific output of a researcher.

Bucur O, Almasan A, Zubarev R, Friedman M, Nicolson GL, Sumazin P, Leabu M, Nikolajczyk BS, Avram D, Kunej T, Calin GA, Godwin AK, Adami HO, Zaphiropoulos PG, Richardson DR, Schmitt-Ulms G, Westerblad H, Keniry M, Grau GE, Carbonetto S, Stan RV, Popa-Wagner A, Takhar K, Baron BW, Galardy PJ, Yang F, Data D, Fadare O, Yeo KJ, Gabreanu GR, Andrei S, Soare GR, Nelson MA, Liehn EA.

Discoveries (Craiova). 2015 Jul-Sep;3(3). pii: e50. Epub 2015 Sep 30.

7.

Neighboring gene regulation by antisense long non-coding RNAs.

Villegas VE, Zaphiropoulos PG.

Int J Mol Sci. 2015 Feb 3;16(2):3251-66. doi: 10.3390/ijms16023251. Review.

8.

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling.

Diao Y, Rahman MF, Villegas VE, Wickström M, Johnsen JI, Zaphiropoulos PG.

BMC Cancer. 2014 Aug 18;14:600. doi: 10.1186/1471-2407-14-600.

9.

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.

Villegas VE, Rahman MF, Fernandez-Barrena MG, Diao Y, Liapi E, Sonkoly E, Ståhle M, Pivarcsi A, Annaratone L, Sapino A, Ramírez Clavijo S, Bürglin TR, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico ME, Zaphiropoulos PG.

Mol Oncol. 2014 Jul;8(5):912-26. doi: 10.1016/j.molonc.2014.03.009. Epub 2014 Mar 22.

10.

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.

Shimokawa T, Rahman MF, Tostar U, Sonkoly E, Ståhle M, Pivarcsi A, Palaniswamy R, Zaphiropoulos PG.

RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.

11.

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.

Int J Cancer. 2013 Apr 1;132(7):1516-24. doi: 10.1002/ijc.27820. Epub 2012 Oct 3.

12.

Genetic variations and alternative splicing: the Glioma associated oncogene 1, GLI1.

Zaphiropoulos PG.

Front Genet. 2012 Jul 6;3:119. doi: 10.3389/fgene.2012.00119. eCollection 2012.

13.

Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.

Tostar U, Finta C, Rahman MF, Shimokawa T, Zaphiropoulos PG.

PLoS One. 2012;7(5):e37761. doi: 10.1371/journal.pone.0037761. Epub 2012 May 29.

14.

Trans-splicing in Higher Eukaryotes: Implications for Cancer Development?

Zaphiropoulos PG.

Front Genet. 2011 Dec 26;2:92. doi: 10.3389/fgene.2011.00092. eCollection 2011.

15.

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma.

Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn J, Hedblad MA, Hippe A, Grandér D, Homey B, Zaphiropoulos PG, Arsenian-Henriksson M, Ståhle M, Pivarcsi A.

Oncogenesis. 2012 Mar 12;1:e3. doi: 10.1038/oncsis.2012.3.

16.

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

Tostar U, Toftgård R, Zaphiropoulos PG, Shimokawa T.

Genes Cancer. 2010 Sep;1(9):941-51. doi: 10.1177/1947601910385449.

17.

PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas.

Santos DC, Zaphiropoulos PG, Neto CF, Pimentel ER, Sanches JA Jr, Ruiz IR.

Int J Dermatol. 2011 Jul;50(7):838-43. doi: 10.1111/j.1365-4632.2010.04866.x.

PMID:
21699520
18.

Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1.

Palaniswamy R, Teglund S, Lauth M, Zaphiropoulos PG, Shimokawa T.

BMC Mol Biol. 2010 Apr 30;11:32. doi: 10.1186/1471-2199-11-32.

19.

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal.

Shimokawa T, Tostar U, Lauth M, Palaniswamy R, Kasper M, Toftgård R, Zaphiropoulos PG.

J Biol Chem. 2008 May 23;283(21):14345-54. doi: 10.1074/jbc.M800299200. Epub 2008 Mar 31.

20.

Lack of aneuploidy for chromosomes 15, 16, and 18 in placentas from small-for-gestational-age liveborn infants.

Papadogiannakis N, Iwarsson E, Taimi T, Zaphiropoulos PG, Westgren M.

Am J Obstet Gynecol. 2008 Feb;198(2):231.e1-7. Epub 2007 Nov 13.

PMID:
17997390
21.

Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling.

Shimokawa T, Svärd J, Heby-Henricson K, Teglund S, Toftgård R, Zaphiropoulos PG.

Oncogene. 2007 Jul 26;26(34):4889-96. Epub 2007 Feb 19.

PMID:
17310997
22.

PTCH mutations: distribution and analyses.

Lindström E, Shimokawa T, Toftgård R, Zaphiropoulos PG.

Hum Mutat. 2006 Mar;27(3):215-9. Review.

PMID:
16419085
23.

Inhibition of GLI1 gene activation by Patched1.

Rahnama F, Shimokawa T, Lauth M, Finta C, Kogerman P, Teglund S, Toftgård R, Zaphiropoulos PG.

Biochem J. 2006 Feb 15;394(Pt 1):19-26.

24.
25.

The FU gene and its possible protein isoforms.

Østerlund T, Everman DB, Betz RC, Mosca M, Nöthen MM, Schwartz CE, Zaphiropoulos PG, Toftgård R.

BMC Genomics. 2004 Jul 22;5(1):49.

26.

Distinct roles of PTCH2 splice variants in Hedgehog signalling.

Rahnama F, Toftgård R, Zaphiropoulos PG.

Biochem J. 2004 Mar 1;378(Pt 2):325-34.

27.

A map of the mouse Cyp3a locus.

Zaphiropoulos PG.

DNA Seq. 2003 Jun;14(3):155-62.

PMID:
14509827
28.

Template switching generated during reverse transcription?

Zaphiropoulos PG.

FEBS Lett. 2002 Sep 11;527(1-3):326. No abstract available.

29.

Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein.

Kogerman P, Krause D, Rahnama F, Kogerman L, Undén AB, Zaphiropoulos PG, Toftgård R.

Oncogene. 2002 Sep 5;21(39):6007-16.

30.

Intergenic mRNAs. Minor gene products or tools of diversity?

Finta C, Warner SC, Zaphiropoulos PG.

Histol Histopathol. 2002 Apr;17(2):677-82. doi: 10.14670/HH-17.677. Review.

PMID:
11962767
31.

Intergenic mRNA molecules resulting from trans-splicing.

Finta C, Zaphiropoulos PG.

J Biol Chem. 2002 Feb 22;277(8):5882-90. Epub 2001 Nov 28.

32.

Intergenic transcripts containing a novel human cytochrome P450 2C exon 1 spliced to sequences from the CYP2C9 gene.

Warner SC, Finta C, Zaphiropoulos PG.

Mol Biol Evol. 2001 Oct;18(10):1841-8.

PMID:
11557791
33.

A statistical view of genome transcription?

Finta C, Zaphiropoulos PG.

J Mol Evol. 2001 Aug;53(2):160-2. No abstract available.

PMID:
11479687
34.

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.

Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG.

Mol Pharmacol. 2001 Feb;59(2):386-92.

PMID:
11160876
35.

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.

Finta C, Zaphiropoulos PG.

Gene. 2000 Dec 30;260(1-2):13-23.

PMID:
11137287
36.

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors.

Jögi A, Abel F, Sjöberg RM, Toftgård R, Zaphiropoulos PG, Påhlman S, Martinsson T, Axelson H.

Int J Oncol. 2000 May;16(5):943-9.

PMID:
10762630
37.

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.

Nilsson M, Undèn AB, Krause D, Malmqwist U, Raza K, Zaphiropoulos PG, Toftgård R.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3438-43.

38.

The human CYP2C locus: a prototype for intergenic and exon repetition splicing events.

Finta C, Zaphiropoulos PG.

Genomics. 2000 Feb 1;63(3):433-8.

PMID:
10704292
39.

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.

Kogerman P, Grimm T, Kogerman L, Krause D, Undén AB, Sandstedt B, Toftgård R, Zaphiropoulos PG.

Nat Cell Biol. 1999 Sep;1(5):312-9.

PMID:
10559945
40.

The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading.

Holla VR, Makita K, Zaphiropoulos PG, Capdevila JH.

J Clin Invest. 1999 Sep;104(6):751-60.

42.

PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas.

Zaphiropoulos PG, Undén AB, Rahnama F, Hollingsworth RE, Toftgård R.

Cancer Res. 1999 Feb 15;59(4):787-92.

44.

Mechanisms of pre-mRNA splicing: classical versus non-classical pathways.

Zaphiropoulos PG.

Histol Histopathol. 1998 Apr;13(2):585-9. doi: 10.14670/HH-13.585. Review.

PMID:
9589911
45.

Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin.

Eklund LK, Lindström E, Undén AB, Lundh-Rozell B, Ståhle-Bäckdahl M, Zaphiropoulos PG, Toftgård R, Söderkvist P.

Mol Carcinog. 1998 Feb;21(2):87-92.

PMID:
9496908
46.

Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma.

Undén AB, Zaphiropoulos PG, Bruce K, Toftgård R, Ståhle-Bäckdahl M.

Cancer Res. 1997 Jun 15;57(12):2336-40.

48.

cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region.

Zaphiropoulos PG, Toftgård R.

DNA Cell Biol. 1996 Dec;15(12):1049-56.

PMID:
8985118
49.

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

Unden AB, Holmberg E, Lundh-Rozell B, Stähle-Bäckdahl M, Zaphiropoulos PG, Toftgård R, Vorechovsky I.

Cancer Res. 1996 Oct 15;56(20):4562-5.

50.

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.

Gailani MR, Ståhle-Bäckdahl M, Leffell DJ, Glynn M, Zaphiropoulos PG, Pressman C, Undén AB, Dean M, Brash DE, Bale AE, Toftgård R.

Nat Genet. 1996 Sep;14(1):78-81.

PMID:
8782823

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