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Items: 1 to 50 of 55

1.

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.

Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HÜ, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, De Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH.

Nat Commun. 2019 Jan 3;10(1):19. doi: 10.1038/s41467-018-07905-4.

2.

Assessing the role of the T-box transcription factor Eomes in B cell differentiation during either Th1 or Th2 cell-biased responses.

Cooper L, Hailes L, Sheikh A, Zaph C, Belz GT, Groom JR, Good-Jacobson KL.

PLoS One. 2018 Dec 6;13(12):e0208343. doi: 10.1371/journal.pone.0208343. eCollection 2018.

3.

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.

Burrows K, Antignano F, Chenery A, Bramhall M, Korinek V, Underhill TM, Zaph C.

PLoS Pathog. 2018 Feb 22;14(2):e1006869. doi: 10.1371/journal.ppat.1006869. eCollection 2018 Feb.

4.

Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Judson RN, Quarta M, Oudhoff MJ, Soliman H, Yi L, Chang CK, Loi G, Vander Werff R, Cait A, Hamer M, Blonigan J, Paine P, Doan LTN, Groppa E, He W, Su L, Zhang RH, Xu P, Eisner C, Low M, Barta I, Lewis CB, Zaph C, Karimi MM, Rando TA, Rossi FM.

Cell Stem Cell. 2018 Feb 1;22(2):177-190.e7. doi: 10.1016/j.stem.2017.12.010. Epub 2018 Jan 25.

5.

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids.

Cait A, Hughes MR, Antignano F, Cait J, Dimitriu PA, Maas KR, Reynolds LA, Hacker L, Mohr J, Finlay BB, Zaph C, McNagny KM, Mohn WW.

Mucosal Immunol. 2018 May;11(3):785-795. doi: 10.1038/mi.2017.75. Epub 2017 Oct 25.

PMID:
29067994
6.

The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.

Sci Immunol. 2016 Sep 2;1(3):eaaf8864. doi: 10.1126/sciimmunol.aaf8864. Epub 2016 Sep 2.

PMID:
28783681
7.

Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):651-661. doi: 10.1165/rcmb.2016-0386OC.

PMID:
28683207
8.

The orphan nuclear receptor ROR alpha and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease.

Lo BC, Gold MJ, Hughes MR, Antignano F, Valdez Y, Zaph C, Harder KW, McNagny KM.

Sci Immunol. 2016 Sep 2;1(3). pii: eaaf8864. doi: 10.1126/sciimmunol.aaf8864.

9.

The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function.

Scheer S, Zaph C.

Front Immunol. 2017 Apr 11;8:429. doi: 10.3389/fimmu.2017.00429. eCollection 2017. Review.

10.

The transcriptional repressor HIC1 regulates intestinal immune homeostasis.

Burrows K, Antignano F, Bramhall M, Chenery A, Scheer S, Korinek V, Underhill TM, Zaph C.

Mucosal Immunol. 2017 Nov;10(6):1518-1528. doi: 10.1038/mi.2017.17. Epub 2017 Mar 22.

PMID:
28327618
11.

Mastering gut permeability: New roles for old friends.

Bramhall M, Zaph C.

Eur J Immunol. 2017 Feb;47(2):236-239. doi: 10.1002/eji.201646842.

12.

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

Scheer S, Medina TS, Murison A, Taves MD, Antignano F, Chenery A, Soma KK, Perona-Wright G, Lupien M, Arrowsmith CH, De Carvalho DD, Zaph C.

J Leukoc Biol. 2017 Apr;101(4):893-900. doi: 10.1189/jlb.3MA0716-334RR. Epub 2016 Dec 29.

PMID:
28034915
13.

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

Chenery AL, Antignano F, Hughes MR, Burrows K, McNagny KM, Zaph C.

Eur J Immunol. 2016 Nov;46(11):2587-2596. doi: 10.1002/eji.201646326. Epub 2016 Sep 26.

14.

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

Oudhoff MJ, Antignano F, Chenery AL, Burrows K, Redpath SA, Braam MJ, Perona-Wright G, Zaph C.

PLoS Pathog. 2016 Sep 6;12(9):e1005876. doi: 10.1371/journal.ppat.1005876. eCollection 2016 Sep.

15.

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

Antignano F, Braam M, Hughes MR, Chenery AL, Burrows K, Gold MJ, Oudhoff MJ, Rattray D, Halim TY, Cait A, Takei F, Rossi FM, McNagny KM, Zaph C.

J Exp Med. 2016 Jun 27;213(7):1153-62. doi: 10.1084/jem.20151646. Epub 2016 Jun 13.

16.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C.

Dev Cell. 2016 Apr 4;37(1):47-57. doi: 10.1016/j.devcel.2016.03.002.

17.

Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.

Chenery AL, Antignano F, Burrows K, Scheer S, Perona-Wright G, Zaph C.

Infect Immun. 2015 Dec 7;84(2):491-501. doi: 10.1128/IAI.01240-15. Print 2016 Feb.

18.

Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.

Gold MJ, Antignano F, Hughes MR, Zaph C, McNagny KM.

Eur J Immunol. 2016 Jan;46(1):122-30. doi: 10.1002/eji.201545628. Epub 2015 Nov 30. Erratum in: Eur J Immunol. 2016 Mar;46(3):782.

19.

Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation.

Bergstrom KS, Morampudi V, Chan JM, Bhinder G, Lau J, Yang H, Ma C, Huang T, Ryz N, Sham HP, Zarepour M, Zaph C, Artis D, Nair M, Vallance BA.

PLoS Pathog. 2015 Aug 18;11(8):e1005108. doi: 10.1371/journal.ppat.1005108. eCollection 2015 Aug.

20.

Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1).

Gold MJ, Hughes MR, Antignano F, Hirota JA, Zaph C, McNagny KM.

J Allergy Clin Immunol. 2015 Sep;136(3):725-736.e2. doi: 10.1016/j.jaci.2015.01.019. Epub 2015 Mar 5.

PMID:
25746967
21.

Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation.

Antignano F, Zaph C.

Immunol Cell Biol. 2015 Mar;93(3):245-52. doi: 10.1038/icb.2014.115. Epub 2015 Jan 13. Review.

PMID:
25582341
22.

Mucosal immune responses following intestinal nematode infection.

Zaph C, Cooper PJ, Harris NL.

Parasite Immunol. 2014 Sep;36(9):439-52. doi: 10.1111/pim.12090. Review.

23.

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8. doi: 10.1073/pnas.1407358111. Epub 2014 Aug 18.

24.

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.

Gold MJ, Antignano F, Halim TY, Hirota JA, Blanchet MR, Zaph C, Takei F, McNagny KM.

J Allergy Clin Immunol. 2014 Apr;133(4):1142-8. doi: 10.1016/j.jaci.2014.02.033.

PMID:
24679471
25.

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, Arrowsmith CH, Lupien M, Levings MK, Zaph C.

J Clin Invest. 2014 May;124(5):1945-55. doi: 10.1172/JCI69592. Epub 2014 Mar 25.

26.

The retinoic acid-metabolizing enzyme Cyp26b1 regulates CD4 T cell differentiation and function.

Chenery A, Burrows K, Antignano F, Underhill TM, Petkovich M, Zaph C.

PLoS One. 2013 Aug 22;8(8):e72308. doi: 10.1371/journal.pone.0072308. eCollection 2013.

27.

Control of the hippo pathway by Set7-dependent methylation of Yap.

Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC, Zaph C.

Dev Cell. 2013 Jul 29;26(2):188-94. doi: 10.1016/j.devcel.2013.05.025. Epub 2013 Jul 11.

28.

Requirement for core 2 O-glycans for optimal resistance to helminth infection.

Mullaly SC, Oudhoff MJ, Min PH, Burrows K, Antignano F, Rattray DG, Chenery A, McNagny KM, Ziltener HJ, Zaph C.

PLoS One. 2013;8(3):e60124. doi: 10.1371/journal.pone.0060124. Epub 2013 Mar 29.

29.

Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection.

Hadidi S, Antignano F, Hughes MR, Wang SK, Snyder K, Sammis GM, Kerr WG, McNagny KM, Zaph C.

Mucosal Immunol. 2012 Sep;5(5):535-43. doi: 10.1038/mi.2012.29. Epub 2012 Apr 25.

PMID:
22535180
30.

Lymph node hypertrophy following Leishmania major infection is dependent on TLR9.

Carvalho LP, Petritus PM, Trochtenberg AL, Zaph C, Hill DA, Artis D, Scott P.

J Immunol. 2012 Feb 1;188(3):1394-401. doi: 10.4049/jimmunol.1101018. Epub 2011 Dec 28.

31.

Trichuris muris infection: a model of type 2 immunity and inflammation in the gut.

Antignano F, Mullaly SC, Burrows K, Zaph C.

J Vis Exp. 2011 May 24;(51). pii: 2774. doi: 10.3791/2774.

32.

Assessing the role of CD103 in immunity to an intestinal helminth parasite.

Mullaly SC, Burrows K, Antignano F, Zaph C.

PLoS One. 2011 May 5;6(5):e19580. doi: 10.1371/journal.pone.0019580.

33.

Which species are in your feces?

Zaph C.

J Clin Invest. 2010 Dec;120(12):4182-5. doi: 10.1172/JCI45263. Epub 2010 Nov 22.

34.

Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A.

Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D.

J Exp Med. 2010 Jun 7;207(6):1293-305. doi: 10.1084/jem.20092054. Epub 2010 May 24.

35.

Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.

Lehnertz B, Northrop JP, Antignano F, Burrows K, Hadidi S, Mullaly SC, Rossi FM, Zaph C.

J Exp Med. 2010 May 10;207(5):915-22. doi: 10.1084/jem.20100363. Epub 2010 Apr 26.

36.

The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.

Naus S, Blanchet MR, Gossens K, Zaph C, Bartsch JW, McNagny KM, Ziltener HJ.

Am J Respir Crit Care Med. 2010 Jun 15;181(12):1318-28. doi: 10.1164/rccm.200909-1396OC. Epub 2010 Mar 1.

PMID:
20194813
37.

IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis.

Troy AE, Zaph C, Du Y, Taylor BC, Guild KJ, Hunter CA, Saris CJ, Artis D.

J Immunol. 2009 Aug 1;183(3):2037-44. doi: 10.4049/jimmunol.0802918. Epub 2009 Jul 13.

38.

MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D.

Nat Immunol. 2009 Jul;10(7):697-705. doi: 10.1038/ni.1740. Epub 2009 May 24.

39.

IL-31-IL-31R interactions limit the magnitude of Th2 cytokine-dependent immunity and inflammation following intestinal helminth infection.

Perrigoue JG, Zaph C, Guild K, Du Y, Artis D.

J Immunol. 2009 May 15;182(10):6088-94. doi: 10.4049/jimmunol.0802459.

40.

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M, Swain GP, Yancopoulos GD, Valenzuela DM, Murphy A, Karow M, Stevens S, Pearce EJ, Artis D.

J Exp Med. 2009 Apr 13;206(4):937-52. doi: 10.1084/jem.20082048. Epub 2009 Apr 6. Erratum in: J Exp Med. 2009 May 11;206(5):1201.

41.

TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis.

Taylor BC, Zaph C, Troy AE, Du Y, Guild KJ, Comeau MR, Artis D.

J Exp Med. 2009 Mar 16;206(3):655-67. doi: 10.1084/jem.20081499. Epub 2009 Mar 9.

42.

Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression.

Perona-Wright G, Mohrs K, Taylor J, Zaph C, Artis D, Pearce EJ, Mohrs M.

J Immunol. 2008 Nov 15;181(10):6697-701.

43.

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation.

Nair MG, Guild KJ, Du Y, Zaph C, Yancopoulos GD, Valenzuela DM, Murphy A, Stevens S, Karow M, Artis D.

J Immunol. 2008 Oct 1;181(7):4709-15.

44.

Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.

Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, Troy AE, Kobuley DE, Kastelein RA, Cua DJ, Yu Y, Artis D.

J Exp Med. 2008 Sep 29;205(10):2191-8. doi: 10.1084/jem.20080720. Epub 2008 Sep 1.

45.
46.

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.

Perrigoue JG, Li J, Zaph C, Goldschmidt M, Scott P, de Sauvage FJ, Pearce EJ, Ghilardi N, Artis D.

J Exp Med. 2007 Mar 19;204(3):481-7. Epub 2007 Mar 12.

47.

Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.

Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D.

Nature. 2007 Mar 29;446(7135):552-6. Epub 2007 Feb 25.

PMID:
17322906
48.

B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses.

Wilson EH, Zaph C, Mohrs M, Welcher A, Siu J, Artis D, Hunter CA.

J Immunol. 2006 Aug 15;177(4):2365-72.

49.

Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth.

Zaph C, Rook KA, Goldschmidt M, Mohrs M, Scott P, Artis D.

J Immunol. 2006 Jul 1;177(1):511-8.

50.

Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.

Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D.

J Exp Med. 2006 Apr 17;203(4):843-9. Epub 2006 Apr 10.

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