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Items: 41


Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms

Zannas AS.

Dialogues Clin Neurosci. 2019 Dec;21(4):389-396. doi: 10.31887/DCNS.2019.21.4/azannas.


Literature review and methodological considerations for understanding circulating risk biomarkers following trauma exposure.

Linnstaedt SD, Zannas AS, McLean SA, Koenen KC, Ressler KJ.

Mol Psychiatry. 2019 Dec 20. doi: 10.1038/s41380-019-0636-5. [Epub ahead of print] Review.


SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection.

Gassen NC, Niemeyer D, Muth D, Corman VM, Martinelli S, Gassen A, Hafner K, Papies J, Mösbauer K, Zellner A, Zannas AS, Herrmann A, Holsboer F, Brack-Werner R, Boshart M, Müller-Myhsok B, Drosten C, Müller MA, Rein T.

Nat Commun. 2019 Dec 18;10(1):5770. doi: 10.1038/s41467-019-13659-4.


Decoding the life story of our epigenome.

Zannas AS.

Epigenomics. 2019 Aug;11(11):1233-1236. doi: 10.2217/epi-2019-0155. Epub 2019 Sep 6. No abstract available.


Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.

Zannas AS, Jia M, Hafner K, Baumert J, Wiechmann T, Pape JC, Arloth J, Ködel M, Martinelli S, Roitman M, Röh S, Haehle A, Emeny RT, Iurato S, Carrillo-Roa T, Lahti J, Räikkönen K, Eriksson JG, Drake AJ, Waldenberger M, Wahl S, Kunze S, Lucae S, Bradley B, Gieger C, Hausch F, Smith AK, Ressler KJ, Müller-Myhsok B, Ladwig KH, Rein T, Gassen NC, Binder EB.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11370-11379. doi: 10.1073/pnas.1816847116. Epub 2019 May 21.


Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene.

Palma-Gudiel H, Eixarch E, Crispi F, Morán S, Zannas AS, Fañanás L.

Clin Epigenetics. 2019 May 9;11(1):73. doi: 10.1186/s13148-019-0674-5.


Resilience as a translational endpoint in the treatment of PTSD.

Rakesh G, Morey RA, Zannas AS, Malik Z, Marx CE, Clausen AN, Kritzer MD, Szabo ST.

Mol Psychiatry. 2019 Sep;24(9):1268-1283. doi: 10.1038/s41380-019-0383-7. Epub 2019 Mar 13. Review.


DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder.

Pape JC, Carrillo-Roa T, Rothbaum BO, Nemeroff CB, Czamara D, Zannas AS, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Dunlop BW, Binder EB.

Clin Epigenetics. 2018 Nov 3;10(1):136. doi: 10.1186/s13148-018-0569-x.


Correction to: Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.

Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D.

Genome Biol. 2018 May 23;19(1):61. doi: 10.1186/s13059-018-1441-1.


Lithium treatment and mechanisms of aging.

Zannas AS.

Mol Psychiatry. 2018 Nov;23(11):2112-2113. doi: 10.1038/s41380-018-0024-6. Epub 2018 Feb 8. No abstract available.


Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.

Zannas AS.

Curr Neuropharmacol. 2018 Mar 5;16(3):327-333. doi: 10.2174/1570159X15666171109121452. Review.


Strategies for dementia prevention: latest evidence and implications.

Rakesh G, Szabo ST, Alexopoulos GS, Zannas AS.

Ther Adv Chronic Dis. 2017 Aug;8(8-9):121-136. doi: 10.1177/2040622317712442. Epub 2017 Jun 27. Review.


Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.

Emeny RT, Baumert J, Zannas AS, Kunze S, Wahl S, Iurato S, Arloth J, Erhardt A, Balsevich G, Schmidt MV, Weber P, Kretschmer A, Pfeiffer L, Kruse J, Strauch K, Roden M, Herder C, Koenig W, Gieger C, Waldenberger M, Peters A, Binder EB, Ladwig KH.

Neuropsychopharmacology. 2018 Jan;43(2):342-353. doi: 10.1038/npp.2017.102. Epub 2017 May 25.


Epigenetic programming by stress and glucocorticoids along the human lifespan.

Zannas AS, Chrousos GP.

Mol Psychiatry. 2017 May;22(5):640-646. doi: 10.1038/mp.2017.35. Epub 2017 Mar 14.


Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice.

Zannas AS, Kim JH, West AE.

Psychopharmacology (Berl). 2017 Mar;234(6):913-923. doi: 10.1007/s00213-017-4527-7. Epub 2017 Jan 23.


Comparison of two biventricular infarct patterns with respect to the infarct burden required to induce cardiogenic shock: An experimental study.

Koudoumas D, Terrovitis J, Glentis P, Ntalianis A, Tsolakis E, Zannas AS, Tseliou E, Papalois A, Drakos S, Nanas JN.

Hellenic J Cardiol. 2017 Jul - Aug;58(4):306-309. doi: 10.1016/j.hjc.2016.11.035. Epub 2016 Dec 5. No abstract available.


Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.

Volk N, Pape JC, Engel M, Zannas AS, Cattane N, Cattaneo A, Binder EB, Chen A.

Cell Rep. 2016 Nov 8;17(7):1882-1891. doi: 10.1016/j.celrep.2016.10.038.


The emerging role of FKBP5 in the regulation of metabolism and body weight.

Zannas AS, Balsevich G, Gassen NC.

Surg Obes Relat Dis. 2016 Sep - Oct;12(8):1560-1561. doi: 10.1016/j.soard.2016.05.016. Epub 2016 May 16. No abstract available.


Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases.

Gassen NC, Chrousos GP, Binder EB, Zannas AS.

Neurosci Biobehav Rev. 2017 Mar;74(Pt B):356-365. doi: 10.1016/j.neubiorev.2016.06.003. Epub 2016 Jun 23. Review.


Freud and the human connectome.

Zannas AS.

Acta Psychiatr Scand. 2016 Sep;134(3):275. doi: 10.1111/acps.12598. Epub 2016 Jun 2. No abstract available.


Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent?

Zannas AS.

J Child Psychol Psychiatry. 2016 Jun;57(6):674-5. doi: 10.1111/jcpp.12535.


Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder.

Kao CY, He Z, Zannas AS, Hahn O, Kühne C, Reichel JM, Binder EB, Wotjak CT, Khaitovich P, Turck CW.

J Psychiatr Res. 2016 May;76:74-83. doi: 10.1016/j.jpsychires.2016.02.003. Epub 2016 Feb 8.


Heritability and reliability of automatically segmented human hippocampal formation subregions.

Whelan CD, Hibar DP, van Velzen LS, Zannas AS, Carrillo-Roa T, McMahon K, Prasad G, Kelly S, Faskowitz J, deZubiracay G, Iglesias JE, van Erp TGM, Frodl T, Martin NG, Wright MJ, Jahanshad N, Schmaal L, Sämann PG, Thompson PM; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2016 Mar;128:125-137. doi: 10.1016/j.neuroimage.2015.12.039. Epub 2015 Dec 30.


Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.

Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D.

Genome Biol. 2015 Dec 17;16:266. doi: 10.1186/s13059-015-0828-5. Erratum in: Genome Biol. 2018 May 23;19(1):61.


Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.

Gassen NC, Fries GR, Zannas AS, Hartmann J, Zschocke J, Hafner K, Carrillo-Roa T, Steinbacher J, Preißinger SN, Hoeijmakers L, Knop M, Weber F, Kloiber S, Lucae S, Chrousos GP, Carell T, Ising M, Binder EB, Schmidt MV, Rüegg J, Rein T.

Sci Signal. 2015 Nov 24;8(404):ra119. doi: 10.1126/scisignal.aac7695.


Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition.

Zannas AS, Chrousos GP.

Sci Signal. 2015 Oct 27;8(400):fs19. doi: 10.1126/scisignal.aad3022. Review.


Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications.

Zannas AS, Wiechmann T, Gassen NC, Binder EB.

Neuropsychopharmacology. 2016 Jan;41(1):261-74. doi: 10.1038/npp.2015.235. Epub 2015 Aug 13. Review.


Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions.

Zannas AS, Provençal N, Binder EB.

Biol Psychiatry. 2015 Sep 1;78(5):327-35. doi: 10.1016/j.biopsych.2015.04.003. Epub 2015 Apr 7. Review.


FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.

Gassen NC, Hartmann J, Zannas AS, Kretzschmar A, Zschocke J, Maccarrone G, Hafner K, Zellner A, Kollmannsberger LK, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, Holsboer F, Binder EB, Ising M, Schmidt MV, Rein T.

Mol Psychiatry. 2016 Feb;21(2):277-89. doi: 10.1038/mp.2015.38. Epub 2015 Apr 7.


Selective inhibitors of the FK506-binding protein 51 by induced fit.

Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F.

Nat Chem Biol. 2015 Jan;11(1):33-7. doi: 10.1038/nchembio.1699. Epub 2014 Dec 1.


Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age.

Zannas AS, McQuoid DR, Payne ME, MacFall JR, Ashley-Koch A, Steffens DC, Potter GG, Taylor WD.

Am J Psychiatry. 2014 Nov 1;171(11):1214-21. doi: 10.1176/appi.ajp.2014.13111543.


The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival.

Wijayatunge R, Chen LF, Cha YM, Zannas AS, Frank CL, West AE.

Mol Cell Neurosci. 2014 Jul;61:187-200. doi: 10.1016/j.mcn.2014.06.008. Epub 2014 Jun 28.


Hippocampus atrophy and the longitudinal course of late-life depression.

Taylor WD, McQuoid DR, Payne ME, Zannas AS, MacFall JR, Steffens DC.

Am J Geriatr Psychiatry. 2014 Dec;22(12):1504-12. doi: 10.1016/j.jagp.2013.11.004. Epub 2013 Nov 22.


Epigenetics and the regulation of stress vulnerability and resilience.

Zannas AS, West AE.

Neuroscience. 2014 Apr 4;264:157-70. doi: 10.1016/j.neuroscience.2013.12.003. Epub 2013 Dec 13. Review.


Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.

Pelton GH, Andrews H, Roose SP, Marcus SM, D'Antonio K, Husn H, Petrella JR, Zannas AS, Doraiswamy PM, Devanand DP.

Contemp Clin Trials. 2014 Mar;37(2):200-8. doi: 10.1016/j.cct.2013.11.015. Epub 2013 Dec 5.


Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism.

Zannas AS, Binder EB.

Genes Brain Behav. 2014 Jan;13(1):25-37. doi: 10.1111/gbb.12104. Epub 2013 Dec 2. Review.


Cholinesterase inhibitors and Pisa syndrome: a pharmacovigilance study.

Zannas AS, Okuno Y, Doraiswamy PM.

Pharmacotherapy. 2014 Mar;34(3):272-8. doi: 10.1002/phar.1359. Epub 2013 Oct 11.


Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.

Zannas AS, Doraiswamy PM, Shpanskaya KS, Murphy KR, Petrella JR, Burke JR, Wong TZ.

Neurocase. 2014 Aug;20(4):466-73. doi: 10.1080/13554794.2013.791867. Epub 2013 May 14.


Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression.

Zannas AS, McQuoid DR, Payne ME, Steffens DC, MacFall JR, Ashley-Koch A, Taylor WD.

J Psychiatr Res. 2013 Jun;47(6):829-34. doi: 10.1016/j.jpsychires.2013.02.008. Epub 2013 Mar 8.


How much is a picture worth? Putting amyloid imaging to the test.

Zannas AS, Wong TZ, Doraiswamy PM.

Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):649-51. doi: 10.1159/000345982. Epub 2012 Dec 14. No abstract available.


Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.

Zannas AS, McQuoid DR, Steffens DC, Chrousos GP, Taylor WD.

Stress. 2012 Jul;15(4):425-34. doi: 10.3109/10253890.2011.634263. Epub 2012 Jan 4.

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