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Items: 39

1.

Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.

Kugeratski FG, Atkinson SJ, Neilson LJ, Lilla S, Knight JRP, Serneels J, Juin A, Ismail S, Bryant DM, Markert EK, Machesky LM, Mazzone M, Sansom OJ, Zanivan S.

Sci Signal. 2019 Feb 5;12(567). pii: eaan8247. doi: 10.1126/scisignal.aan8247.

PMID:
30723174
2.

The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108.

Unbekandt M, Lilla S, Zanivan S, Olson MF.

Small GTPases. 2019 Jan 22:1-10. doi: 10.1080/21541248.2018.1564472. [Epub ahead of print]

PMID:
30667325
3.

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.

Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, Secklehner J, Kruiswijk F, Vousden K, Macpherson IR, Blyth K, Bailey P, Yin H, Carlin LM, Morton J, Zanivan S, Norman JC.

Nat Commun. 2018 Nov 29;9(1):5069. doi: 10.1038/s41467-018-07339-y.

4.

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM.

Nat Cell Biol. 2018 Oct;20(10):1159-1171. doi: 10.1038/s41556-018-0198-9. Epub 2018 Sep 24.

PMID:
30250061
5.

Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis.

Dandoulaki M, Petsalaki E, Sumpton D, Zanivan S, Zachos G.

J Cell Biol. 2018 Sep 3;217(9):3071-3089. doi: 10.1083/jcb.201802102. Epub 2018 Jun 28.

PMID:
29954829
6.

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress.

van der Reest J, Lilla S, Zheng L, Zanivan S, Gottlieb E.

Nat Commun. 2018 Apr 20;9(1):1581. doi: 10.1038/s41467-018-04003-3.

7.

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.

Port J, Muthalagu N, Raja M, Ceteci F, Monteverde T, Kruspig B, Hedley A, Kalna G, Lilla S, Neilson L, Brucoli M, Gyuraszova K, Tait-Mulder J, Mezna M, Svambaryte S, Bryson A, Sumpton D, McVie A, Nixon C, Drysdale M, Esumi H, Murray GI, Sansom OJ, Zanivan SR, Murphy DJ.

Cancer Discov. 2018 May;8(5):632-647. doi: 10.1158/2159-8290.CD-17-0533. Epub 2018 Mar 2.

8.

Cancer Associated Fibroblasts: The Architects of Stroma Remodeling.

Santi A, Kugeratski FG, Zanivan S.

Proteomics. 2018 Mar;18(5-6):e1700167. doi: 10.1002/pmic.201700167. Epub 2018 Feb 1. Review.

9.

Tumor stiffness extends its grip on the metastatic microenvironment.

Reid SE, Zanivan S.

Mol Cell Oncol. 2017 Oct 16;4(6):e1372866. doi: 10.1080/23723556.2017.1372866. eCollection 2017.

10.

Mitogen-Activated Protein Kinase Kinase 5 Regulates Proliferation and Biosynthetic Processes in Procyclic Forms of Trypanosoma brucei.

Kugeratski FG, Batista M, Lima CVP, Neilson LJ, da Cunha ES, de Godoy LM, Zanivan S, Krieger MA, Marchini FK.

J Proteome Res. 2018 Jan 5;17(1):108-118. doi: 10.1021/acs.jproteome.7b00415. Epub 2017 Nov 7.

PMID:
29043805
11.

Chloride intracellular channel 3: A secreted pro-invasive oxidoreductase.

Norman J, Zanivan S.

Cell Cycle. 2017;16(21):1993-1994. doi: 10.1080/15384101.2017.1377031. Epub 2017 Sep 29. No abstract available.

12.

Paradigm of Biased PAR1 (Protease-Activated Receptor-1) Activation and Inhibition in Endothelial Cells Dissected by Phosphoproteomics.

van den Eshof BL, Hoogendijk AJ, Simpson PJ, van Alphen FPJ, Zanivan S, Mertens K, Meijer AB, van den Biggelaar M.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1891-1902. doi: 10.1161/ATVBAHA.117.309926. Epub 2017 Aug 17.

PMID:
28818855
13.

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S.

EMBO J. 2017 Aug 15;36(16):2373-2389. doi: 10.15252/embj.201694912. Epub 2017 Jul 10.

14.

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson IR, McNeish I, Ennis D, Ali H, Kugeratski FG, Al Khamici H, van den Biggelaar M, van den Berghe PV, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC, Zanivan S.

Nat Commun. 2017 Feb 15;8:14206. doi: 10.1038/ncomms14206.

15.

A proteomic approach to identify endosomal cargoes controlling cancer invasiveness.

Diaz-Vera J, Palmer S, Hernandez-Fernaud JR, Dornier E, Mitchell LE, Macpherson I, Edwards J, Zanivan S, Norman JC.

J Cell Sci. 2017 Feb 15;130(4):697-711. doi: 10.1242/jcs.190835. Epub 2017 Jan 6.

16.

In-Depth Proteomics Identifies a Role for Autophagy in Controlling Reactive Oxygen Species Mediated Endothelial Permeability.

Patella F, Neilson LJ, Athineos D, Erami Z, Anderson KI, Blyth K, Ryan KM, Zanivan S.

J Proteome Res. 2016 Jul 1;15(7):2187-97. doi: 10.1021/acs.jproteome.6b00166. Epub 2016 Jun 15.

PMID:
27246970
17.

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.

Clarke CJ, Berg TJ, Birch J, Ennis D, Mitchell L, Cloix C, Campbell A, Sumpton D, Nixon C, Campbell K, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Jones JL, Haywood L, Pulleine E, Yin H, Strathdee D, Sansom O, Blyth K, McNeish I, Zanivan S, Reynolds AR, Norman JC.

Curr Biol. 2016 Mar 21;26(6):755-65. doi: 10.1016/j.cub.2016.01.045. Epub 2016 Mar 3.

18.

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M.

EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492.

19.

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts.

Kuchnio A, Moens S, Bruning U, Kuchnio K, Cruys B, Thienpont B, Broux M, Ungureanu AA, Leite de Oliveira R, Bruyère F, Cuervo H, Manderveld A, Carton A, Hernandez-Fernaud JR, Zanivan S, Bartic C, Foidart JM, Noel A, Vinckier S, Lambrechts D, Dewerchin M, Mazzone M, Carmeliet P.

Cell Rep. 2015 Aug 11;12(6):992-1005. doi: 10.1016/j.celrep.2015.07.010. Epub 2015 Jul 30.

20.

Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.

Patella F, Schug ZT, Persi E, Neilson LJ, Erami Z, Avanzato D, Maione F, Hernandez-Fernaud JR, Mackay G, Zheng L, Reid S, Frezza C, Giraudo E, Fiorio Pla A, Anderson K, Ruppin E, Gottlieb E, Zanivan S.

Mol Cell Proteomics. 2015 Mar;14(3):621-34. doi: 10.1074/mcp.M114.045575. Epub 2015 Jan 8.

21.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R.

Sci Signal. 2014 Dec 2;7(354):rs7. doi: 10.1126/scisignal.2005473.

22.

In vivo quantitative proteomics for the study of oncometabolism.

Reid S, Hernandez-Fernaud JR, Zanivan S.

Methods Enzymol. 2014;543:235-59. doi: 10.1016/B978-0-12-801329-8.00012-X.

PMID:
24924136
23.

Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells.

van den Biggelaar M, Hernández-Fernaud JR, van den Eshof BL, Neilson LJ, Meijer AB, Mertens K, Zanivan S.

Blood. 2014 Mar 20;123(12):e22-36. doi: 10.1182/blood-2013-12-546036. Epub 2014 Feb 5.

24.

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.

Zanivan S, Maione F, Hein MY, Hernández-Fernaud JR, Ostasiewicz P, Giraudo E, Mann M.

Mol Cell Proteomics. 2013 Dec;12(12):3599-611. doi: 10.1074/mcp.M113.031344. Epub 2013 Aug 26.

25.

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments.

Schiller HB, Hermann MR, Polleux J, Vignaud T, Zanivan S, Friedel CC, Sun Z, Raducanu A, Gottschalk KE, Théry M, Mann M, Fässler R.

Nat Cell Biol. 2013 Jun;15(6):625-36. doi: 10.1038/ncb2747. Epub 2013 May 26.

PMID:
23708002
26.

High performance computational analysis of large-scale proteome data sets to assess incremental contribution to coverage of the human genome.

Neuhauser N, Nagaraj N, McHardy P, Zanivan S, Scheltema R, Cox J, Mann M.

J Proteome Res. 2013 Jun 7;12(6):2858-68. doi: 10.1021/pr400181q. Epub 2013 May 6.

27.

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M.

Cell Rep. 2013 Feb 21;3(2):552-66. doi: 10.1016/j.celrep.2013.01.003. Epub 2013 Jan 31.

28.

Quantitative mass spectrometry-based proteomics in angiogenesis.

Hernandez-Fernaud JR, Reid SE, Neilson LJ, Zanivan S.

Proteomics Clin Appl. 2013 Aug;7(7-8):464-76. doi: 10.1002/prca.201200055. Epub 2013 Jan 15. Review.

29.

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.

Muller PA, Trinidad AG, Timpson P, Morton JP, Zanivan S, van den Berghe PV, Nixon C, Karim SA, Caswell PT, Noll JE, Coffill CR, Lane DP, Sansom OJ, Neilsen PM, Norman JC, Vousden KH.

Oncogene. 2013 Mar 7;32(10):1252-65. doi: 10.1038/onc.2012.148. Epub 2012 May 14.

30.

Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.

Azimifar SB, Böttcher RT, Zanivan S, Grashoff C, Krüger M, Legate KR, Mann M, Fässler R.

J Cell Sci. 2012 Jan 15;125(Pt 2):435-48. doi: 10.1242/jcs.091652.

31.

In vivo quantitative proteomics: the SILAC mouse.

Zanivan S, Krueger M, Mann M.

Methods Mol Biol. 2012;757:435-50. doi: 10.1007/978-1-61779-166-6_25.

PMID:
21909926
32.

Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation.

Meves A, Geiger T, Zanivan S, DiGiovanni J, Mann M, Fässler R.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15213-8. doi: 10.1073/pnas.1105689108. Epub 2011 Aug 29.

33.

In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse.

Scholten A, Mohammed S, Low TY, Zanivan S, van Veen TA, Delanghe B, Heck AJ.

Mol Cell Proteomics. 2011 Oct;10(10):O111.008474. doi: 10.1074/mcp.O111.008474. Epub 2011 Jun 24.

34.

Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics.

Geiger T, Wisniewski JR, Cox J, Zanivan S, Kruger M, Ishihama Y, Mann M.

Nat Protoc. 2011 Feb;6(2):147-57. doi: 10.1038/nprot.2010.192.

PMID:
21293456
35.

Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.

Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M.

J Proteome Res. 2008 Dec;7(12):5314-26.

PMID:
19367708
36.

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function.

Krüger M, Moser M, Ussar S, Thievessen I, Luber CA, Forner F, Schmidt S, Zanivan S, Fässler R, Mann M.

Cell. 2008 Jul 25;134(2):353-64. doi: 10.1016/j.cell.2008.05.033.

37.

A new computational approach to analyze human protein complexes and predict novel protein interactions.

Zanivan S, Cascone I, Peyron C, Molineris I, Marchio S, Caselle M, Bussolino F.

Genome Biol. 2007;8(12):R256.

38.

Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors.

Parsons-Wingerter P, Kasman IM, Norberg S, Magnussen A, Zanivan S, Rissone A, Baluk P, Favre CJ, Jeffry U, Murray R, McDonald DM.

Am J Pathol. 2005 Jul;167(1):193-211.

39.

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function.

Serini G, Valdembri D, Zanivan S, Morterra G, Burkhardt C, Caccavari F, Zammataro L, Primo L, Tamagnone L, Logan M, Tessier-Lavigne M, Taniguchi M, Püschel AW, Bussolino F.

Nature. 2003 Jul 24;424(6947):391-7. Erratum in: Nature. 2003 Aug 21;424(6951):974.

PMID:
12879061

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