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Items: 27


ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells.

Chen W, Nyuydzefe MS, Weiss JM, Zhang J, Waksal SD, Zanin-Zhorov A.

Sci Rep. 2018 Nov 9;8(1):16636. doi: 10.1038/s41598-018-35109-9.


The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6.

Tengesdal IW, Kitzenberg D, Li S, Nyuydzefe MS, Chen W, Weiss JM, Zhang J, Waksal SD, Zanin-Zhorov A, Dinarello CA.

Eur J Immunol. 2018 Oct;48(10):1679-1686. doi: 10.1002/eji.201847652. Epub 2018 Sep 21.


Heat shock protein 60 enhances CD4+CD25+ regulatory T cell function via innate TLR2 signaling.

Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR.

J Clin Invest. 2018 Jun 1;128(6):2651. doi: 10.1172/JCI121856. Epub 2018 May 7. No abstract available.


Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity.

Zanin-Zhorov A, Kumari S, Hippen KL, Merkel SC, MacMillan ML, Blazar BR, Dustin ML.

Sci Rep. 2017 Jun 26;7(1):4258. doi: 10.1038/s41598-017-04053-5.


Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10.

Zanin-Zhorov A, Weiss JM, Trzeciak A, Chen W, Zhang J, Nyuydzefe MS, Arencibia C, Polimera S, Schueller O, Fuentes-Duculan J, Bonifacio KM, Kunjravia N, Cueto I, Soung J, Fleischmann RM, Kivitz A, Lebwohl M, Nunez M, Woodson J, Smith SL, West RF, Berger M, Krueger JG, Ryan JL, Waksal SD.

J Immunol. 2017 May 15;198(10):3809-3814. doi: 10.4049/jimmunol.1602142. Epub 2017 Apr 7.


ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings.

Weiss JM, Chen W, Nyuydzefe MS, Trzeciak A, Flynn R, Tonra JR, Marusic S, Blazar BR, Waksal SD, Zanin-Zhorov A.

Sci Signal. 2016 Jul 19;9(437):ra73. doi: 10.1126/scisignal.aad8953.


Isoform-specific targeting of ROCK proteins in immune cells.

Zanin-Zhorov A, Flynn R, Waksal SD, Blazar BR.

Small GTPases. 2016 Jul 2;7(3):173-7. doi: 10.1080/21541248.2016.1181698. Epub 2016 Jun 2. Review.


Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

Flynn R, Paz K, Du J, Reichenbach DK, Taylor PA, Panoskaltsis-Mortari A, Vulic A, Luznik L, MacDonald KK, Hill GR, Nyuydzefe MS, Weiss JM, Chen W, Trzeciak A, Serody JS, Aguilar EG, Murphy WJ, Maillard I, Munn D, Koreth J, Cutler CS, Antin JH, Ritz J, Waksal SD, Zanin-Zhorov A, Blazar BR.

Blood. 2016 Apr 28;127(17):2144-54. doi: 10.1182/blood-2015-10-678706. Epub 2016 Mar 16.


ROCKing cytokine secretion balance in human T cells.

Zanin-Zhorov A, Waksal SD.

Cytokine. 2015 Apr;72(2):224-5. doi: 10.1016/j.cyto.2014.12.025. Epub 2015 Jan 31.


Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.

Zanin-Zhorov A, Weiss JM, Nyuydzefe MS, Chen W, Scher JU, Mo R, Depoil D, Rao N, Liu B, Wei J, Lucas S, Koslow M, Roche M, Schueller O, Weiss S, Poyurovsky MV, Tonra J, Hippen KL, Dustin ML, Blazar BR, Liu CJ, Waksal SD.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9. doi: 10.1073/pnas.1414189111. Epub 2014 Nov 10.


Signaling via TLR2 and TLR4 Directly Down-Regulates T Cell Effector Functions: The Regulatory Face of Danger Signals.

Zanin-Zhorov A, Cohen IR.

Front Immunol. 2013 Jul 25;4:211. doi: 10.3389/fimmu.2013.00211. eCollection 2013.


Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.

Zanin-Zhorov A, Lin J, Scher J, Kumari S, Blair D, Hippen KL, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1625-30. doi: 10.1073/pnas.1110120109. Epub 2012 Jan 17.


PKC-θ function at the immunological synapse: prospects for therapeutic targeting.

Zanin-Zhorov A, Dustin ML, Blazar BR.

Trends Immunol. 2011 Aug;32(8):358-63. doi: 10.1016/ Epub 2011 Jul 4. Review.


The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ.

Science. 2011 Apr 22;332(6028):478-84. doi: 10.1126/science.1199214. Epub 2011 Mar 10.


Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells.

Rosenblat G, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.

Arch Dermatol Res. 2011 May;303(4):239-46. doi: 10.1007/s00403-010-1088-6. Epub 2010 Oct 27. Erratum in: Arch Dermatol Res. 2011 May;303(4):299.


Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.

Science. 2010 Apr 16;328(5976):372-6. doi: 10.1126/science.1186068. Epub 2010 Mar 25. Erratum in: Science. 2010 May 21;328(5981):974.


Functional anatomy of T cell activation and synapse formation.

Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair DA, Waite J, Sacristán C, Victora GD, Zanin-Zhorov A, Dustin ML.

Annu Rev Immunol. 2010;28:79-105. doi: 10.1146/annurev-immunol-030409-101308. Review.


Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling.

Zanin-Zhorov A, Tal-Lapidot G, Cahalon L, Cohen-Sfady M, Pevsner-Fischer M, Lider O, Cohen IR.

J Immunol. 2007 Jul 1;179(1):41-4.


Toll-like receptors and their ligands control mesenchymal stem cell functions.

Pevsner-Fischer M, Morad V, Cohen-Sfady M, Rousso-Noori L, Zanin-Zhorov A, Cohen S, Cohen IR, Zipori D.

Blood. 2007 Feb 15;109(4):1422-32. Epub 2006 Oct 12.


Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis.

Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR.

Int Immunol. 2006 Oct;18(10):1413-9. Epub 2006 Aug 7.


Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.

Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A.

J Leukoc Biol. 2006 Aug;80(2):399-406. Epub 2006 Jun 12.


Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.

Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR.

J Clin Invest. 2006 Jul;116(7):2022-32. Epub 2006 Jun 8. Retraction in: J Clin Invest. 2018 Jun 1;128(6):2651.


Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway.

Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, Mor F, Carmi P, Zanin-Zhorov A, Lider O, Cohen IR.

J Immunol. 2005 Sep 15;175(6):3594-602.


Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation.

Zanin-Zhorov A, Tal G, Shivtiel S, Cohen M, Lapidot T, Nussbaum G, Margalit R, Cohen IR, Lider O.

J Immunol. 2005 Jul 1;175(1):276-85.


Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.

Zanin-Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, Cohen IR, Lider O.

J Immunol. 2005 Mar 15;174(6):3227-36.


Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells.

Zanin-Zhorov A, Hershkoviz R, Hecht I, Cahalon L, Lider O.

J Immunol. 2003 Dec 1;171(11):5882-9.


T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors.

Zanin-Zhorov A, Nussbaum G, Franitza S, Cohen IR, Lider O.

FASEB J. 2003 Aug;17(11):1567-9. Epub 2003 Jun 17. Retraction in: FASEB J. 2018 Apr;32(4):2315-2316.


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