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Items: 32

1.

Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Barham R, Brennan L, Casavant JM, Ding X, Finegan S, Hardink J, Hoang T, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Subramanyam C, Plotkin M, Reilly U, Schafer J, Stone GG, Uccello DP, Wisialowski T, Yoon K, Zaniewski R, Zook C.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358. doi: 10.1016/j.bmcl.2017.06.009. Epub 2017 Jun 3.

PMID:
28610977
2.

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors.

Montgomery JI, Smith JF, Tomaras AP, Zaniewski R, McPherson CJ, McAllister LA, Hartman-Neumann S, Arcari JT, Lescoe M, Gutierrez J, Yuan Y, Limberakis C, Miller AA.

J Antibiot (Tokyo). 2015 Jun;68(6):361-7. doi: 10.1038/ja.2014.163. Epub 2014 Dec 3.

PMID:
25464974
3.

Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.

Starr J, Brown MF, Aschenbrenner L, Caspers N, Che Y, Gerstenberger BS, Huband M, Knafels JD, Lemmon MM, Li C, McCurdy SP, McElroy E, Rauckhorst MR, Tomaras AP, Young JA, Zaniewski RP, Shanmugasundaram V, Han S.

J Med Chem. 2014 May 8;57(9):3845-55. doi: 10.1021/jm500219c. Epub 2014 Apr 21.

PMID:
24694215
4.

Pyridone-conjugated monobactam antibiotics with gram-negative activity.

Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP.

J Med Chem. 2013 Jul 11;56(13):5541-52. doi: 10.1021/jm400560z. Epub 2013 Jun 27.

PMID:
23755848
5.

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Plotkin M, Reilly U, Robinson S, Schafer J, Shepard RM, Smith JF, Stone GG, Subramanyam C, Yoon K, Yuan W, Zaniewski RP, Zook C.

Bioorg Med Chem Lett. 2013 May 15;23(10):2955-61. doi: 10.1016/j.bmcl.2013.03.047. Epub 2013 Mar 21.

PMID:
23566517
6.

Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.

Papp-Wallace KM, Senkfor B, Gatta J, Chai W, Taracila MA, Shanmugasundaram V, Han S, Zaniewski RP, Lacey BM, Tomaras AP, Skalweit MJ, Harris ME, Rice LB, Buynak JD, Bonomo RA.

Antimicrob Agents Chemother. 2012 Nov;56(11):5687-92. doi: 10.1128/AAC.01027-12. Epub 2012 Aug 20.

7.

Distinctive attributes of β-lactam target proteins in Acinetobacter baumannii relevant to development of new antibiotics.

Han S, Caspers N, Zaniewski RP, Lacey BM, Tomaras AP, Feng X, Geoghegan KF, Shanmugasundaram V.

J Am Chem Soc. 2011 Dec 21;133(50):20536-45. doi: 10.1021/ja208835z. Epub 2011 Nov 28.

PMID:
22050378
8.

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.

Han S, Zaniewski RP, Marr ES, Lacey BM, Tomaras AP, Evdokimov A, Miller JR, Shanmugasundaram V.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22002-7. doi: 10.1073/pnas.1013092107. Epub 2010 Dec 6.

9.

The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A.

Le PT, Brickner SJ, Wade SK, Brighty K, Monahan R, Stone GG, Girard D, Finegan S, Duignan J, Schafer J, Maloney M, Zaniewski RP, Connolly AG, Liras J, Bordner J, Samardjiev I.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):276-9. doi: 10.1016/j.bmcl.2010.11.022. Epub 2010 Nov 10.

PMID:
21115249
10.

Purification of the large ribosomal subunit via its association with the small subunit.

Simons SP, McLellan TJ, Aeed PA, Zaniewski RP, Desbonnet CR, Wondrack LM, Marr ES, Subashi TA, Dougherty TJ, Xu Z, Wang IK, LeMotte PK, Maguire BA.

Anal Biochem. 2009 Dec 1;395(1):77-85. doi: 10.1016/j.ab.2009.07.042. Epub 2009 Jul 30.

PMID:
19646947
11.

In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A.

Stone GG, Girard D, Finegan S, Duignan J, Schafer J, Maloney M, Zaniewski RP, Brickner SJ, Wade SK, Le PT, Huband MD.

Antimicrob Agents Chemother. 2008 Jul;52(7):2663-6. doi: 10.1128/AAC.01326-07. Epub 2008 Apr 21.

12.

Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus.

Kaczmarek FS, Zaniewski RP, Gootz TD, Danley DE, Mansour MN, Griffor M, Kamath AV, Cronan M, Mueller J, Sun D, Martin PK, Benton B, McDowell L, Biek D, Schmid MB.

J Bacteriol. 2001 May;183(10):3016-24.

13.

Action of quinolones against Staphylococcus aureus topoisomerase IV: basis for DNA cleavage enhancement.

Anderson VE, Zaniewski RP, Kaczmarek FS, Gootz TD, Osheroff N.

Biochemistry. 2000 Mar 14;39(10):2726-32.

PMID:
10704224
14.

Quinolones inhibit DNA religation mediated by Staphylococcus aureus topoisomerase IV. Changes in drug mechanism across evolutionary boundaries.

Anderson VE, Zaniewski RP, Kaczmarek FS, Gootz TD, Osheroff N.

J Biol Chem. 1999 Dec 10;274(50):35927-32.

15.

Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.

Gootz TD, Zaniewski RP, Haskell SL, Kaczmarek FS, Maurice AE.

Antimicrob Agents Chemother. 1999 Aug;43(8):1845-55.

16.

Use of Silicon-Based Tethers to Control Diastereofacial Selectivity in Azomethine Ylide Cycloadditions(1).

Garner P, Cox PB, Anderson JT, Protasiewicz J, Zaniewski R.

J Org Chem. 1997 Feb 7;62(3):493-498.

PMID:
11671439
17.

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro.

Gootz TD, Zaniewski R, Haskell S, Schmieder B, Tankovic J, Girard D, Courvalin P, Polzer RJ.

Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.

18.

Protein A immobilized affinity cartridge for immunoglobulin purification.

Hou KC, Zaniewski R, Roy S.

Biotechnol Appl Biochem. 1991 Apr;13(2):257-68.

PMID:
2043281
19.

The effect of hydrophobic interaction on endotoxin adsorption by polymeric affinity matrix.

Hou KC, Zaniewski R.

Biochim Biophys Acta. 1991 Jan 23;1073(1):149-54.

PMID:
1991129
20.

A method for extracorporeal heparin removal from blood by affinity chromatography.

Hou KC, Roy S, Zaniewski R, Shumway E.

Artif Organs. 1990 Dec;14(6):436-42.

PMID:
2281993
21.

Depyrogenation by endotoxin removal with positively charged depth filter cartridge.

Hou KC, Zaniewski R.

J Parenter Sci Technol. 1990 Jul-Aug;44(4):204-9.

PMID:
2213428
22.

Endotoxin removal by anion-exchange polymeric matrix.

Hou KC, Zaniewski R.

Biotechnol Appl Biochem. 1990 Jun;12(3):315-24.

PMID:
1694440
23.

Purification of urokinase by combined cation exchanger and affinity chromatographic cartridges.

Hou KC, Zaniewski R.

J Chromatogr. 1990 Feb 23;525(2):297-306.

PMID:
2329161
24.

RNase T is responsible for the end-turnover of tRNA in Escherichia coli.

Deutscher MP, Marlor CW, Zaniewski R.

Proc Natl Acad Sci U S A. 1985 Oct;82(19):6427-30.

25.

A multiple mutant of Escherichia coli lacking the exoribonucleases RNase II, RNase D, and RNase BN.

Zaniewski R, Petkaitis E, Deutscher MP.

J Biol Chem. 1984 Oct 10;259(19):11651-3.

26.

Ribonuclease T: new exoribonuclease possibly involved in end-turnover of tRNA.

Deutscher MP, Marlor CW, Zaniewski R.

Proc Natl Acad Sci U S A. 1984 Jul;81(14):4290-3.

27.

Ribonuclease BN: identification and partial characterization of a new tRNA processing enzyme.

Asha PK, Blouin RT, Zaniewski R, Deutscher MP.

Proc Natl Acad Sci U S A. 1983 Jun;80(11):3301-4.

29.

Genetic mapping of mutation in Escherichia coli leading to a temperature-sensitive RNase D.

Zaniewski R, Deutscher MP.

Mol Gen Genet. 1982;185(1):142-7.

PMID:
6283310
30.

CDP-diacylglycerol synthase activity in Clostridium perfringens.

Carman GM, Zaniewski RL, Cousminer JJ.

Appl Environ Microbiol. 1982 Jan;43(1):81-5.

31.

Escherichia coli RNase D. Catalytic properties and substrate specificity.

Cudny H, Zaniewski R, Deutscher MP.

J Biol Chem. 1981 Jun 10;256(11):5633-7.

32.

Escherichia coli RNase D. Purification and structural characterization of a putative processing nuclease.

Cudny H, Zaniewski R, Deutscher MP.

J Biol Chem. 1981 Jun 10;256(11):5627-32.

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