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Items: 1 to 50 of 182

1.

β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor.

Klag T, Thomas M, Ehmann D, Courth L, Mailänder-Sanchez D, Weiss TS, Dayoub R, Abshagen K, Vollmar B, Thasler WE, Stange EF, Berg CP, Malek NP, Zanger UM, Wehkamp J.

Front Immunol. 2018 Jul 27;9:1735. doi: 10.3389/fimmu.2018.01735. eCollection 2018.

2.

Epigenetics and MicroRNAs in Pharmacogenetics.

Zanger UM, Klein K, Kugler N, Petrikat T, Ryu CS.

Adv Pharmacol. 2018;83:33-64. doi: 10.1016/bs.apha.2018.02.003. Epub 2018 Apr 23.

PMID:
29801581
3.

Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells.

Knebel C, Neeb J, Zahn E, Schmidt F, Carazo A, Holas O, Pavek P, Püschel GP, Zanger UM, Süssmuth R, Lampen A, Marx-Stoelting P, Braeuning A.

Toxicol Sci. 2018 May 1;163(1):170-181. doi: 10.1093/toxsci/kfy026.

PMID:
29420809
4.

Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates.

Weiß F, Hammer HS, Klein K, Planatscher H, Zanger UM, Norén A, Wegler C, Artursson P, Joos TO, Poetz O.

Drug Metab Dispos. 2018 Apr;46(4):387-396. doi: 10.1124/dmd.117.078626. Epub 2018 Jan 17.

PMID:
29343608
5.

Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells.

Tanner N, Kubik L, Luckert C, Thomas M, Hofmann U, Zanger UM, Böhmert L, Lampen A, Braeuning A.

Drug Metab Dispos. 2018 Apr;46(4):326-335. doi: 10.1124/dmd.117.078675. Epub 2018 Jan 12.

PMID:
29330220
6.

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.

Johänning J, Kröner P, Thomas M, Zanger UM, Nörenberg A, Eichelbaum M, Schwab M, Brauch H, Schroth W, Mürdter TE.

Arch Toxicol. 2018 Mar;92(3):1099-1112. doi: 10.1007/s00204-017-2147-y. Epub 2017 Dec 28.

7.

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function.

Pandey AV, Henderson CJ, Ishii Y, Kranendonk M, Backes WL, Zanger UM.

Front Pharmacol. 2017 Nov 27;8:881. doi: 10.3389/fphar.2017.00881. eCollection 2017. No abstract available.

8.

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.

Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M.

Hepatology. 2018 Apr;67(4):1609-1619. doi: 10.1002/hep.29599. Epub 2018 Mar 2. Review.

PMID:
29059457
9.

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response.

Zhang JE, Klein K, Jorgensen AL, Francis B, Alfirevic A, Bourgeois S, Deloukas P, Zanger UM, Pirmohamed M.

Front Pharmacol. 2017 May 31;8:323. doi: 10.3389/fphar.2017.00323. eCollection 2017.

10.

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450.

Ryu CS, Klein K, Zanger UM.

Front Pharmacol. 2017 Mar 27;8:159. doi: 10.3389/fphar.2017.00159. eCollection 2017. Review.

11.

Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.

12.

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.

Tremmel R, Herrmann K, Engst W, Meinl W, Klein K, Glatt H, Zanger UM.

Arch Toxicol. 2017 Oct;91(10):3329-3339. doi: 10.1007/s00204-017-1955-4. Epub 2017 Mar 22.

PMID:
28326452
13.

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.

Rex J, Albrecht U, Ehlting C, Thomas M, Zanger UM, Sawodny O, Häussinger D, Ederer M, Feuer R, Bode JG.

PLoS Comput Biol. 2016 Jul 27;12(7):e1005018. doi: 10.1371/journal.pcbi.1005018. eCollection 2016 Jul.

14.

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Cho DY, Shen JH, Lemler SM, Skaar TC, Li L, Blievernicht J, Zanger UM, Kim KB, Shin JG, Flockhart DA, Desta Z.

Drug Metab Pharmacokinet. 2016 Apr;31(2):107-16. doi: 10.1016/j.dmpk.2015.07.002. Epub 2015 Jul 29.

15.

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.

Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM.

Biochim Biophys Acta. 2016 Sep;1859(9):1218-1227. doi: 10.1016/j.bbagrm.2016.03.007. Epub 2016 Mar 17.

PMID:
26994748
16.

Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma.

Pellé L, Cipollini M, Tremmel R, Romei C, Figlioli G, Gemignani F, Melaiu O, De Santi C, Barone E, Elisei R, Seiser E, Innocenti F, Zanger UM, Landi S.

Arch Toxicol. 2016 Dec;90(12):3099-3109. Epub 2016 Jan 19.

PMID:
26783003
17.

Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling.

Keller R, Klein M, Thomas M, Dräger A, Metzger U, Templin MF, Joos TO, Thasler WE, Zell A, Zanger UM.

PLoS Comput Biol. 2016 Jan 4;12(1):e1004431. doi: 10.1371/journal.pcbi.1004431. eCollection 2016 Jan.

18.

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data.

Meulendijks D, Henricks LM, Sonke GS, Deenen MJ, Froehlich TK, Amstutz U, Largiadèr CR, Jennings BA, Marinaki AM, Sanderson JD, Kleibl Z, Kleiblova P, Schwab M, Zanger UM, Palles C, Tomlinson I, Gross E, van Kuilenburg AB, Punt CJ, Koopman M, Beijnen JH, Cats A, Schellens JH.

Lancet Oncol. 2015 Dec;16(16):1639-50. doi: 10.1016/S1470-2045(15)00286-7. Epub 2015 Oct 23. Review.

PMID:
26603945
19.

Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice.

Abshagen K, König M, Hoppe A, Müller I, Ebert M, Weng H, Holzhütter HG, Zanger UM, Bode J, Vollmar B, Thomas M, Dooley S.

BMC Syst Biol. 2015 Nov 20;9:83. doi: 10.1186/s12918-015-0229-0.

20.

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

Thomas M, Winter S, Klumpp B, Turpeinen M, Klein K, Schwab M, Zanger UM.

Front Pharmacol. 2015 Nov 4;6:261. doi: 10.3389/fphar.2015.00261. eCollection 2015.

21.

Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1.

Tremmel R, Klein K, Winter S, Schaeffeler E, Zanger UM.

Pharmacogenomics J. 2016 Nov;16(6):551-558. doi: 10.1038/tpj.2015.69. Epub 2015 Oct 27.

PMID:
26503817
22.

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

Kalman LV, Agúndez J, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Caudle K, Coulthard SA, Daly AK, Del Tredici A, den Dunnen JT, Drozda K, Everts RE, Flockhart D, Freimuth RR, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale RF, van Schaik R, Whirl-Carrillo M, Yeo K, Zanger UM.

Clin Pharmacol Ther. 2016 Feb;99(2):172-85. doi: 10.1002/cpt.280. Epub 2015 Nov 20. Review.

23.

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods.

Feuer R, Vlaic S, Arlt J, Sawodny O, Dahmen U, Zanger UM, Thomas M.

PLoS One. 2015 Sep 1;10(9):e0135852. doi: 10.1371/journal.pone.0135852. eCollection 2015.

24.

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.

Braeuning A, Thomas M, Hofmann U, Vetter S, Zeller E, Petzuch B, Johänning J, Schroth W, Weiss TS, Zanger UM, Schwarz M.

Drug Metab Dispos. 2015 Nov;43(11):1781-7. doi: 10.1124/dmd.115.064667. Epub 2015 Aug 26.

25.

Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors.

Emami Riedmaier A, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT.

Pharmacogenomics J. 2016 Aug;16(4):341-51. doi: 10.1038/tpj.2015.55. Epub 2015 Aug 4.

PMID:
26239079
26.

Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease.

Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W.

J Hepatol. 2016 Jan;64(1):44-52. doi: 10.1016/j.jhep.2015.07.022. Epub 2015 Jul 26.

27.

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes.

Thomas M, Bayha C, Klein K, Müller S, Weiss TS, Schwab M, Zanger UM.

BMC Cancer. 2015 Jun 30;15:488. doi: 10.1186/s12885-015-1500-x.

28.

Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

Margaillan G, Rouleau M, Klein K, Fallon JK, Caron P, Villeneuve L, Smith PC, Zanger UM, Guillemette C.

Drug Metab Dispos. 2015 Sep;43(9):1331-5. doi: 10.1124/dmd.115.065391. Epub 2015 Jun 15.

29.

Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained.

Kungulovski G, Nunna S, Thomas M, Zanger UM, Reinhardt R, Jeltsch A.

Epigenetics Chromatin. 2015 Mar 18;8:12. doi: 10.1186/s13072-015-0002-z. eCollection 2015.

30.

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.

Thomas M, Bayha C, Vetter S, Hofmann U, Schwarz M, Zanger UM, Braeuning A.

Mol Pharmacol. 2015 Jun;87(6):1013-20. doi: 10.1124/mol.114.097402. Epub 2015 Mar 30.

31.

Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.

Rieger JK, Reutter S, Hofmann U, Schwab M, Zanger UM.

Drug Metab Dispos. 2015 Jun;43(6):884-8. doi: 10.1124/dmd.114.062844. Epub 2015 Mar 23.

32.

Role of ABC transporters in fluoropyrimidine-based chemotherapy response.

Nies AT, Magdy T, Schwab M, Zanger UM.

Adv Cancer Res. 2015;125:217-43. doi: 10.1016/bs.acr.2014.10.007. Epub 2015 Jan 8. Review.

PMID:
25640272
33.

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O.

Cell Physiol Biochem. 2015;35(2):803-15. doi: 10.1159/000369739. Epub 2015 Jan 30.

34.

Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

Ehlting C, Böhmer O, Hahnel MJ, Thomas M, Zanger UM, Gaestel M, Knoefel WT, Schulte Am Esch J, Häussinger D, Bode JG.

Cell Signal. 2015 Mar;27(3):555-67. doi: 10.1016/j.cellsig.2014.12.016. Epub 2015 Jan 3.

PMID:
25562430
35.

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.

Klein M, Thomas M, Hofmann U, Seehofer D, Damm G, Zanger UM.

Drug Metab Dispos. 2015 Feb;43(2):273-83. doi: 10.1124/dmd.114.060962. Epub 2014 Dec 5.

36.

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

Bitter A, Rümmele P, Klein K, Kandel BA, Rieger JK, Nüssler AK, Zanger UM, Trauner M, Schwab M, Burk O.

Arch Toxicol. 2015 Nov;89(11):2089-103. doi: 10.1007/s00204-014-1348-x. Epub 2014 Sep 3.

PMID:
25182422
37.

Targeting nuclear receptors with lentivirus-delivered small RNAs in primary human hepatocytes.

Thomas M, Rieger JK, Kandel BA, Klein K, Zanger UM.

Cell Physiol Biochem. 2014;33(6):2003-13.

38.

Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.

Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A.

Antimicrob Agents Chemother. 2014 Jul;58(7):4145-52. doi: 10.1128/AAC.02532-14. Epub 2014 May 12.

39.

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.

Rosmarin D, Palles C, Church D, Domingo E, Jones A, Johnstone E, Wang H, Love S, Julier P, Scudder C, Nicholson G, Gonzalez-Neira A, Martin M, Sargent D, Green E, McLeod H, Zanger UM, Schwab M, Braun M, Seymour M, Thompson L, Lacas B, Boige V, Ribelles N, Afzal S, Enghusen H, Jensen SA, Etienne-Grimaldi MC, Milano G, Wadelius M, Glimelius B, Garmo H, Gusella M, Lecomte T, Laurent-Puig P, Martinez-Balibrea E, Sharma R, Garcia-Foncillas J, Kleibl Z, Morel A, Pignon JP, Midgley R, Kerr D, Tomlinson I.

J Clin Oncol. 2014 Apr 1;32(10):1031-9. doi: 10.1200/JCO.2013.51.1857. Epub 2014 Mar 3. Review.

40.

No activation of human pregnane X receptor by hyperforin-related phloroglucinols.

Kandel BA, Ekins S, Leuner K, Thasler WE, Harteneck C, Zanger UM.

J Pharmacol Exp Ther. 2014 Mar;348(3):393-400. doi: 10.1124/jpet.113.209916. Epub 2013 Nov 20.

41.

Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.

Zanger UM, Klein K, Thomas M, Rieger JK, Tremmel R, Kandel BA, Klein M, Magdy T.

Clin Pharmacol Ther. 2014 Mar;95(3):258-61. doi: 10.1038/clpt.2013.220. Epub 2013 Nov 6. Review. No abstract available.

PMID:
24196843
42.

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression.

Magdy T, Arlanov R, Winter S, Lang T, Klein K, Toyoda Y, Ishikawa T, Schwab M, Zanger UM.

Pharmacogenomics. 2013 Sep;14(12):1433-48. doi: 10.2217/pgs.13.139.

PMID:
24024896
43.

Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression.

Rieger JK, Klein K, Winter S, Zanger UM.

Drug Metab Dispos. 2013 Oct;41(10):1752-62. doi: 10.1124/dmd.113.052126. Epub 2013 Jun 3.

44.

The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro.

Li Y, Coller JK, Hutchinson MR, Klein K, Zanger UM, Stanley NJ, Abell AD, Somogyi AA.

Drug Metab Dispos. 2013 Jun;41(6):1264-72. doi: 10.1124/dmd.113.051631. Epub 2013 Apr 2.

45.

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance.

Zanger UM, Klein K.

Front Genet. 2013 Mar 5;4:24. doi: 10.3389/fgene.2013.00024. eCollection 2013.

46.

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Klein K, Zanger UM.

Front Genet. 2013 Feb 25;4:12. doi: 10.3389/fgene.2013.00012. eCollection 2013.

47.

Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools.

Radloff R, Gras A, Zanger UM, Masquelier C, Arumugam K, Karasi JC, Arendt V, Seguin-Devaux C, Klein K.

Hum Mutat. 2013 May;34(5):725-34. doi: 10.1002/humu.22295. Epub 2013 Mar 11.

PMID:
23418033
48.

Molecular Interactions between NAFLD and Xenobiotic Metabolism.

Naik A, Belič A, Zanger UM, Rozman D.

Front Genet. 2013 Jan 22;4:2. doi: 10.3389/fgene.2013.00002. eCollection 2013.

49.

Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples.

Herrmann K, Schumacher F, Engst W, Appel KE, Klein K, Zanger UM, Glatt H.

Carcinogenesis. 2013 May;34(5):1025-30. doi: 10.1093/carcin/bgt013. Epub 2013 Jan 18.

PMID:
23334163
50.

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Zanger UM, Schwab M.

Pharmacol Ther. 2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16. Review.

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