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Items: 1 to 50 of 144

1.

The optoelectronic microrobot: A versatile toolbox for micromanipulation.

Zhang S, Scott EY, Singh J, Chen Y, Zhang Y, Elsayed M, Chamberlain MD, Shakiba N, Adams K, Yu S, Morshead CM, Zandstra PW, Wheeler AR.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14823-14828. doi: 10.1073/pnas.1903406116. Epub 2019 Jul 9.

PMID:
31289234
2.

Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.

Romagnuolo R, Masoudpour H, Porta-Sánchez A, Qiang B, Barry J, Laskary A, Qi X, Massé S, Magtibay K, Kawajiri H, Wu J, Valdman Sadikov T, Rothberg J, Panchalingam KM, Titus E, Li RK, Zandstra PW, Wright GA, Nanthakumar K, Ghugre NR, Keller G, Laflamme MA.

Stem Cell Reports. 2019 May 14;12(5):967-981. doi: 10.1016/j.stemcr.2019.04.005. Epub 2019 May 2.

3.

Cell competition during reprogramming gives rise to dominant clones.

Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW.

Science. 2019 Apr 26;364(6438). pii: eaan0925. doi: 10.1126/science.aan0925. Epub 2019 Mar 21.

PMID:
30898844
4.

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.

Vigilante A, Laddach A, Moens N, Meleckyte R, Leha A, Ghahramani A, Culley OJ, Kathuria A, Hurling C, Vickers A, Wiseman E, Tewary M, Zandstra PW; HipSci Consortium, Durbin R, Fraternali F, Stegle O, Birney E, Luscombe NM, Danovi D, Watt FM.

Cell Rep. 2019 Feb 19;26(8):2078-2087.e3. doi: 10.1016/j.celrep.2019.01.094.

5.

Context-explorer: Analysis of spatially organized protein expression in high-throughput screens.

Ostblom J, Nazareth EJP, Tewary M, Zandstra PW.

PLoS Comput Biol. 2019 Jan 2;15(1):e1006384. doi: 10.1371/journal.pcbi.1006384. eCollection 2019 Jan.

6.

Patterned Optoelectronic Tweezers: A New Scheme for Selecting, Moving, and Storing Dielectric Particles and Cells.

Zhang S, Shakiba N, Chen Y, Zhang Y, Tian P, Singh J, Chamberlain MD, Satkauskas M, Flood AG, Kherani NP, Yu S, Zandstra PW, Wheeler AR.

Small. 2018 Nov;14(45):e1803342. doi: 10.1002/smll.201803342. Epub 2018 Oct 11.

PMID:
30307718
7.

Stem cell bioengineering: building from stem cell biology.

Tewary M, Shakiba N, Zandstra PW.

Nat Rev Genet. 2018 Oct;19(10):595-614. doi: 10.1038/s41576-018-0040-z. Review.

PMID:
30089805
8.

Mechanics-guided developmental fate patterning.

Tewary M, Zandstra PW.

Nat Mater. 2018 Jul;17(7):571-572. doi: 10.1038/s41563-018-0121-6. No abstract available.

PMID:
29941948
9.

Modulating cell state to enhance suspension expansion of human pluripotent stem cells.

Lipsitz YY, Woodford C, Yin T, Hanna JH, Zandstra PW.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6369-6374. doi: 10.1073/pnas.1714099115. Epub 2018 Jun 4.

10.

Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jun;558(7711):E4. doi: 10.1038/s41586-018-0113-3.

PMID:
29769714
11.

Chemically controlled aggregation of pluripotent stem cells.

Lipsitz YY, Tonge PD, Zandstra PW.

Biotechnol Bioeng. 2018 Aug;115(8):2061-2066. doi: 10.1002/bit.26719. Epub 2018 May 1.

12.

Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?

Tedesco S, De Majo F, Kim J, Trenti A, Trevisi L, Fadini GP, Bolego C, Zandstra PW, Cignarella A, Vitiello L.

Front Pharmacol. 2018 Feb 22;9:71. doi: 10.3389/fphar.2018.00071. eCollection 2018.

13.

Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.

Yachie-Kinoshita A, Onishi K, Ostblom J, Langley MA, Posfai E, Rossant J, Zandstra PW.

Mol Syst Biol. 2018 Jan 29;14(1):e7952. doi: 10.15252/msb.20177952.

14.

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Erratum in: Nature. 2018 May 16;:.

PMID:
29342133
15.

Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFα signaling.

Wang W, Fujii H, Kim HJ, Hermans K, Usenko T, Xie S, Luo ZJ, Ma J, Celso CL, Dick JE, Schroeder T, Krueger J, Wall D, Egeler RM, Zandstra PW.

Sci Transl Med. 2017 Dec 20;9(421). pii: eaag3214. doi: 10.1126/scitranslmed.aag3214.

PMID:
29263228
16.

FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.

Yoon C, Song H, Yin T, Bausch-Fluck D, Frei AP, Kattman S, Dubois N, Witty AD, Hewel JA, Guo H, Emili A, Wollscheid B, Keller G, Zandstra PW.

Stem Cell Reports. 2018 Jan 9;10(1):87-100. doi: 10.1016/j.stemcr.2017.11.008. Epub 2017 Dec 14.

17.

A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning.

Tewary M, Ostblom J, Prochazka L, Zulueta-Coarasa T, Shakiba N, Fernandez-Gonzalez R, Zandstra PW.

Development. 2017 Dec 1;144(23):4298-4312. doi: 10.1242/dev.149658. Epub 2017 Sep 4.

18.

Steric Hindrance Assay for Secreted Factors in Stem Cell Culture.

Zhou W, Mahshid SS, Wang W, Vallée-Bélisle A, Zandstra PW, Sargent EH, Kelley SO.

ACS Sens. 2017 Apr 28;2(4):495-500. doi: 10.1021/acssensors.7b00136. Epub 2017 Apr 17.

PMID:
28723184
19.

Engineering cell fitness: lessons for regenerative medicine.

Shakiba N, Zandstra PW.

Curr Opin Biotechnol. 2017 Oct;47:7-15. doi: 10.1016/j.copbio.2017.05.005. Epub 2017 May 25. Review.

20.

Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence.

Rahman N, Brauer PM, Ho L, Usenko T, Tewary M, Zúñiga-Pflücker JC, Zandstra PW.

Nat Commun. 2017 May 25;8:15380. doi: 10.1038/ncomms15380.

21.

Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1.

Shukla S, Langley MA, Singh J, Edgar JM, Mohtashami M, Zúñiga-Pflücker JC, Zandstra PW.

Nat Methods. 2017 May;14(5):531-538. doi: 10.1038/nmeth.4258. Epub 2017 Apr 10.

PMID:
28394335
22.

Engineering a humanized bone organ model in mice to study bone metastases.

Martine LC, Holzapfel BM, McGovern JA, Wagner F, Quent VM, Hesami P, Wunner FM, Vaquette C, De-Juan-Pardo EM, Brown TD, Nowlan B, Wu DJ, Hutmacher CO, Moi D, Oussenko T, Piccinini E, Zandstra PW, Mazzieri R, Lévesque JP, Dalton PD, Taubenberger AV, Hutmacher DW.

Nat Protoc. 2017 Apr;12(4):639-663. doi: 10.1038/nprot.2017.002. Epub 2017 Mar 2.

PMID:
28253234
23.

Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design.

Lipsitz YY, Bedford P, Davies AH, Timmins NE, Zandstra PW.

Cell Stem Cell. 2017 Jan 5;20(1):13-17. doi: 10.1016/j.stem.2016.12.003.

24.

A 17-gene stemness score for rapid determination of risk in acute leukaemia.

Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC.

Nature. 2016 Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7.

PMID:
27926740
25.

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ.

Blood. 2017 Jan 19;129(3):307-318. doi: 10.1182/blood-2016-09-740654. Epub 2016 Nov 8.

26.

Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.

Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD.

Neuron. 2016 Sep 7;91(5):988-1004. doi: 10.1016/j.neuron.2016.07.037. Epub 2016 Aug 18.

27.

Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform.

Müller E, Wang W, Qiao W, Bornhäuser M, Zandstra PW, Werner C, Pompe T.

Sci Rep. 2016 Aug 18;6:31951. doi: 10.1038/srep31951.

28.

A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production.

Nazareth EJP, Rahman N, Yin T, Zandstra PW.

Stem Cell Reports. 2016 May 10;6(5):679-691. doi: 10.1016/j.stemcr.2016.04.003. Epub 2016 Apr 28.

29.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SWK, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JCY, Naldini L, Dick JE.

Cancer Cell. 2016 Apr 11;29(4):602-606. doi: 10.1016/j.ccell.2016.03.015. No abstract available.

30.

Quality cell therapy manufacturing by design.

Lipsitz YY, Timmins NE, Zandstra PW.

Nat Biotechnol. 2016 Apr;34(4):393-400. doi: 10.1038/nbt.3525.

PMID:
27054995
31.

Two-dimensional arrays of cell-laden polymer hydrogel modules.

Wang Y, Li Y, Thérien-Aubin H, Ma J, Zandstra PW, Kumacheva E.

Biomicrofluidics. 2016 Jan 21;10(1):014110. doi: 10.1063/1.4940430. eCollection 2016 Jan.

32.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE.

Cancer Cell. 2016 Feb 8;29(2):214-28. doi: 10.1016/j.ccell.2015.12.011. Epub 2016 Jan 28. Erratum in: Cancer Cell. 2016 Apr 11;29(4):602-6.

33.

Proportional-Integral-Derivative (PID) Control of Secreted Factors for Blood Stem Cell Culture.

Caldwell J, Wang W, Zandstra PW.

PLoS One. 2015 Sep 8;10(9):e0137392. doi: 10.1371/journal.pone.0137392. eCollection 2015.

34.

LIF signaling in stem cells and development.

Onishi K, Zandstra PW.

Development. 2015 Jul 1;142(13):2230-6. doi: 10.1242/dev.117598. Review.

35.

PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.

Kana K, Song H, Laschinger C, Zandstra PW, Radisic M.

Tissue Eng Part A. 2015 Sep;21(17-18):2379-89. doi: 10.1089/ten.TEA.2014.0412. Epub 2015 Aug 7.

36.

Corrigendum: Genome-wide characterization of the routes to pluripotency.

Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A.

Nature. 2015 Jul 30;523(7562):626. doi: 10.1038/nature14606. Epub 2015 Jun 17. No abstract available.

PMID:
26083747
37.

CD24 tracks divergent pluripotent states in mouse and human cells.

Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SMI, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJR, Wollscheid B, Nagy A, Zandstra PW.

Nat Commun. 2015 Jun 16;6:7329. doi: 10.1038/ncomms8329.

38.

Bringing Blood Stem Cell Phenotype, Genotype, and Function Closer Together.

Qiao W, Zandstra PW.

Cell Stem Cell. 2015 Jun 4;16(6):574-5. doi: 10.1016/j.stem.2015.05.001.

39.

The microwell-mesh: A novel device and protocol for the high throughput manufacturing of cartilage microtissues.

Futrega K, Palmer JS, Kinney M, Lott WB, Ungrin MD, Zandstra PW, Doran MR.

Biomaterials. 2015 Sep;62:1-12. doi: 10.1016/j.biomaterials.2015.05.013. Epub 2015 May 20.

40.

Stem cells: Chasing blood.

Goyal S, Zandstra PW.

Nature. 2015 Feb 26;518(7540):488-90. doi: 10.1038/nature14203. Epub 2015 Feb 11. No abstract available.

PMID:
25686602
41.

Genome-wide characterization of the routes to pluripotency.

Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A.

Nature. 2014 Dec 11;516(7530):198-206. doi: 10.1038/nature14046. Erratum in: Nature. 2015 Jul 30;523(7562):626.

PMID:
25503233
42.

Transforming the promise of pluripotent stem cell-derived cardiomyocytes to a therapy: challenges and solutions for clinical trials.

Prowse AB, Timmins NE, Yau TM, Li RK, Weisel RD, Keller G, Zandstra PW.

Can J Cardiol. 2014 Nov;30(11):1335-49. doi: 10.1016/j.cjca.2014.08.005. Epub 2014 Aug 15. Review.

PMID:
25442434
43.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.

44.

Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.

Onishi K, Tonge PD, Nagy A, Zandstra PW.

Stem Cell Reports. 2014 Jun 6;3(1):156-68. doi: 10.1016/j.stemcr.2014.04.019. eCollection 2014 Jul 8.

45.

Intercellular network structure and regulatory motifs in the human hematopoietic system.

Qiao W, Wang W, Laurenti E, Turinsky AL, Wodak SJ, Bader GD, Dick JE, Zandstra PW.

Mol Syst Biol. 2014 Jul 15;10:741. doi: 10.15252/msb.20145141.

46.

A microgroove patterned multiwell cell culture plate for high-throughput studies of cell alignment.

Lücker PB, Javaherian S, Soleas JP, Halverson D, Zandstra PW, McGuigan AP.

Biotechnol Bioeng. 2014 Dec;111(12):2537-48. doi: 10.1002/bit.25298. Epub 2014 Jul 29.

PMID:
24889796
47.

A global assessment of stem cell engineering.

Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM.

Tissue Eng Part A. 2014 Oct;20(19-20):2575-89. doi: 10.1089/ten.TEA.2013.0468. Epub 2014 Feb 28.

48.

Real-time monitoring and control of soluble signaling factors enables enhanced progenitor cell outputs from human cord blood stem cell cultures.

Csaszar E, Chen K, Caldwell J, Chan W, Zandstra PW.

Biotechnol Bioeng. 2014 Jun;111(6):1258-64. doi: 10.1002/bit.25163. Epub 2013 Dec 16.

49.

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues.

Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4698-707. doi: 10.1073/pnas.1311120110. Epub 2013 Nov 19. Erratum in: Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16973. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3151.

50.

Oct4 is required ~E7.5 for proliferation in the primitive streak.

DeVeale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D.

PLoS Genet. 2013 Nov;9(11):e1003957. doi: 10.1371/journal.pgen.1003957. Epub 2013 Nov 14.

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