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Items: 1 to 50 of 137

1.

Mechanics-guided developmental fate patterning.

Tewary M, Zandstra PW.

Nat Mater. 2018 Jul;17(7):571-572. doi: 10.1038/s41563-018-0121-6. No abstract available.

PMID:
29941948
2.

Modulating cell state to enhance suspension expansion of human pluripotent stem cells.

Lipsitz YY, Woodford C, Yin T, Hanna JH, Zandstra PW.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6369-6374. doi: 10.1073/pnas.1714099115. Epub 2018 Jun 4.

3.

Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jun;558(7711):E4. doi: 10.1038/s41586-018-0113-3.

PMID:
29769714
4.

Chemically controlled aggregation of pluripotent stem cells.

Lipsitz YY, Tonge PD, Zandstra PW.

Biotechnol Bioeng. 2018 Aug;115(8):2061-2066. doi: 10.1002/bit.26719. Epub 2018 May 1.

PMID:
29679475
5.

Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?

Tedesco S, De Majo F, Kim J, Trenti A, Trevisi L, Fadini GP, Bolego C, Zandstra PW, Cignarella A, Vitiello L.

Front Pharmacol. 2018 Feb 22;9:71. doi: 10.3389/fphar.2018.00071. eCollection 2018.

6.

Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.

Yachie-Kinoshita A, Onishi K, Ostblom J, Langley MA, Posfai E, Rossant J, Zandstra PW.

Mol Syst Biol. 2018 Jan 29;14(1):e7952. doi: 10.15252/msb.20177952.

7.

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Erratum in: Nature. 2018 May 16;:.

PMID:
29342133
8.

Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell-mediated TNFα signaling.

Wang W, Fujii H, Kim HJ, Hermans K, Usenko T, Xie S, Luo ZJ, Ma J, Celso CL, Dick JE, Schroeder T, Krueger J, Wall D, Egeler RM, Zandstra PW.

Sci Transl Med. 2017 Dec 20;9(421). pii: eaag3214. doi: 10.1126/scitranslmed.aag3214.

PMID:
29263228
9.

FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.

Yoon C, Song H, Yin T, Bausch-Fluck D, Frei AP, Kattman S, Dubois N, Witty AD, Hewel JA, Guo H, Emili A, Wollscheid B, Keller G, Zandstra PW.

Stem Cell Reports. 2018 Jan 9;10(1):87-100. doi: 10.1016/j.stemcr.2017.11.008. Epub 2017 Dec 14.

10.

A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning.

Tewary M, Ostblom J, Prochazka L, Zulueta-Coarasa T, Shakiba N, Fernandez-Gonzalez R, Zandstra PW.

Development. 2017 Dec 1;144(23):4298-4312. doi: 10.1242/dev.149658. Epub 2017 Sep 4.

11.

Steric Hindrance Assay for Secreted Factors in Stem Cell Culture.

Zhou W, Mahshid SS, Wang W, Vallée-Bélisle A, Zandstra PW, Sargent EH, Kelley SO.

ACS Sens. 2017 Apr 28;2(4):495-500. doi: 10.1021/acssensors.7b00136. Epub 2017 Apr 17.

PMID:
28723184
12.

Engineering cell fitness: lessons for regenerative medicine.

Shakiba N, Zandstra PW.

Curr Opin Biotechnol. 2017 Oct;47:7-15. doi: 10.1016/j.copbio.2017.05.005. Epub 2017 May 25. Review.

13.

Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence.

Rahman N, Brauer PM, Ho L, Usenko T, Tewary M, Zúñiga-Pflücker JC, Zandstra PW.

Nat Commun. 2017 May 25;8:15380. doi: 10.1038/ncomms15380.

14.

Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1.

Shukla S, Langley MA, Singh J, Edgar JM, Mohtashami M, Zúñiga-Pflücker JC, Zandstra PW.

Nat Methods. 2017 May;14(5):531-538. doi: 10.1038/nmeth.4258. Epub 2017 Apr 10.

PMID:
28394335
15.

Engineering a humanized bone organ model in mice to study bone metastases.

Martine LC, Holzapfel BM, McGovern JA, Wagner F, Quent VM, Hesami P, Wunner FM, Vaquette C, De-Juan-Pardo EM, Brown TD, Nowlan B, Wu DJ, Hutmacher CO, Moi D, Oussenko T, Piccinini E, Zandstra PW, Mazzieri R, Lévesque JP, Dalton PD, Taubenberger AV, Hutmacher DW.

Nat Protoc. 2017 Apr;12(4):639-663. doi: 10.1038/nprot.2017.002. Epub 2017 Mar 2.

PMID:
28253234
16.

Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design.

Lipsitz YY, Bedford P, Davies AH, Timmins NE, Zandstra PW.

Cell Stem Cell. 2017 Jan 5;20(1):13-17. doi: 10.1016/j.stem.2016.12.003.

17.

A 17-gene stemness score for rapid determination of risk in acute leukaemia.

Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC.

Nature. 2016 Dec 15;540(7633):433-437. doi: 10.1038/nature20598. Epub 2016 Dec 7.

PMID:
27926740
18.

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ.

Blood. 2017 Jan 19;129(3):307-318. doi: 10.1182/blood-2016-09-740654. Epub 2016 Nov 8.

19.

Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks.

Yuzwa SA, Yang G, Borrett MJ, Clarke G, Cancino GI, Zahr SK, Zandstra PW, Kaplan DR, Miller FD.

Neuron. 2016 Sep 7;91(5):988-1004. doi: 10.1016/j.neuron.2016.07.037. Epub 2016 Aug 18.

20.

Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform.

Müller E, Wang W, Qiao W, Bornhäuser M, Zandstra PW, Werner C, Pompe T.

Sci Rep. 2016 Aug 18;6:31951. doi: 10.1038/srep31951.

21.

A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production.

Nazareth EJP, Rahman N, Yin T, Zandstra PW.

Stem Cell Reports. 2016 May 10;6(5):679-691. doi: 10.1016/j.stemcr.2016.04.003. Epub 2016 Apr 28.

22.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SWK, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JCY, Naldini L, Dick JE.

Cancer Cell. 2016 Apr 11;29(4):602-606. doi: 10.1016/j.ccell.2016.03.015. No abstract available.

23.

Quality cell therapy manufacturing by design.

Lipsitz YY, Timmins NE, Zandstra PW.

Nat Biotechnol. 2016 Apr;34(4):393-400. doi: 10.1038/nbt.3525.

PMID:
27054995
24.

Two-dimensional arrays of cell-laden polymer hydrogel modules.

Wang Y, Li Y, Thérien-Aubin H, Ma J, Zandstra PW, Kumacheva E.

Biomicrofluidics. 2016 Jan 21;10(1):014110. doi: 10.1063/1.4940430. eCollection 2016 Jan.

25.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE.

Cancer Cell. 2016 Feb 8;29(2):214-28. doi: 10.1016/j.ccell.2015.12.011. Epub 2016 Jan 28. Erratum in: Cancer Cell. 2016 Apr 11;29(4):602-6.

26.

Proportional-Integral-Derivative (PID) Control of Secreted Factors for Blood Stem Cell Culture.

Caldwell J, Wang W, Zandstra PW.

PLoS One. 2015 Sep 8;10(9):e0137392. doi: 10.1371/journal.pone.0137392. eCollection 2015.

27.

LIF signaling in stem cells and development.

Onishi K, Zandstra PW.

Development. 2015 Jul 1;142(13):2230-6. doi: 10.1242/dev.117598. Review.

28.

PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.

Kana K, Song H, Laschinger C, Zandstra PW, Radisic M.

Tissue Eng Part A. 2015 Sep;21(17-18):2379-89. doi: 10.1089/ten.TEA.2014.0412. Epub 2015 Aug 7.

29.

Corrigendum: Genome-wide characterization of the routes to pluripotency.

Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A.

Nature. 2015 Jul 30;523(7562):626. doi: 10.1038/nature14606. Epub 2015 Jun 17. No abstract available.

PMID:
26083747
30.

CD24 tracks divergent pluripotent states in mouse and human cells.

Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SM, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJ, Wollscheid B, Nagy A, Zandstra PW.

Nat Commun. 2015 Jun 16;6:7329. doi: 10.1038/ncomms8329.

31.

Bringing Blood Stem Cell Phenotype, Genotype, and Function Closer Together.

Qiao W, Zandstra PW.

Cell Stem Cell. 2015 Jun 4;16(6):574-5. doi: 10.1016/j.stem.2015.05.001.

32.

The microwell-mesh: A novel device and protocol for the high throughput manufacturing of cartilage microtissues.

Futrega K, Palmer JS, Kinney M, Lott WB, Ungrin MD, Zandstra PW, Doran MR.

Biomaterials. 2015 Sep;62:1-12. doi: 10.1016/j.biomaterials.2015.05.013. Epub 2015 May 20.

33.

Stem cells: Chasing blood.

Goyal S, Zandstra PW.

Nature. 2015 Feb 26;518(7540):488-90. doi: 10.1038/nature14203. Epub 2015 Feb 11. No abstract available.

PMID:
25686602
34.

Genome-wide characterization of the routes to pluripotency.

Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A.

Nature. 2014 Dec 11;516(7530):198-206. doi: 10.1038/nature14046. Erratum in: Nature. 2015 Jul 30;523(7562):626.

PMID:
25503233
35.

Transforming the promise of pluripotent stem cell-derived cardiomyocytes to a therapy: challenges and solutions for clinical trials.

Prowse AB, Timmins NE, Yau TM, Li RK, Weisel RD, Keller G, Zandstra PW.

Can J Cardiol. 2014 Nov;30(11):1335-49. doi: 10.1016/j.cjca.2014.08.005. Epub 2014 Aug 15. Review.

PMID:
25442434
36.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.

37.

Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.

Onishi K, Tonge PD, Nagy A, Zandstra PW.

Stem Cell Reports. 2014 Jun 6;3(1):156-68. doi: 10.1016/j.stemcr.2014.04.019. eCollection 2014 Jul 8.

38.

Intercellular network structure and regulatory motifs in the human hematopoietic system.

Qiao W, Wang W, Laurenti E, Turinsky AL, Wodak SJ, Bader GD, Dick JE, Zandstra PW.

Mol Syst Biol. 2014 Jul 15;10:741. doi: 10.15252/msb.20145141.

39.

A microgroove patterned multiwell cell culture plate for high-throughput studies of cell alignment.

Lücker PB, Javaherian S, Soleas JP, Halverson D, Zandstra PW, McGuigan AP.

Biotechnol Bioeng. 2014 Dec;111(12):2537-48. doi: 10.1002/bit.25298. Epub 2014 Jul 29.

PMID:
24889796
40.

A global assessment of stem cell engineering.

Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM.

Tissue Eng Part A. 2014 Oct;20(19-20):2575-89. doi: 10.1089/ten.TEA.2013.0468. Epub 2014 Feb 28.

41.

Real-time monitoring and control of soluble signaling factors enables enhanced progenitor cell outputs from human cord blood stem cell cultures.

Csaszar E, Chen K, Caldwell J, Chan W, Zandstra PW.

Biotechnol Bioeng. 2014 Jun;111(6):1258-64. doi: 10.1002/bit.25163. Epub 2013 Dec 16.

42.

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues.

Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4698-707. doi: 10.1073/pnas.1311120110. Epub 2013 Nov 19. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3151. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16973.

43.

Oct4 is required ~E7.5 for proliferation in the primitive streak.

DeVeale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D.

PLoS Genet. 2013 Nov;9(11):e1003957. doi: 10.1371/journal.pgen.1003957. Epub 2013 Nov 14.

44.

Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.

Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein ID, Zandstra PW.

Blood. 2014 Jan 30;123(5):650-8. doi: 10.1182/blood-2013-08-520445. Epub 2013 Nov 15.

45.

High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias.

Nazareth EJ, Ostblom JE, Lücker PB, Shukla S, Alvarez MM, Oh SK, Yin T, Zandstra PW.

Nat Methods. 2013 Dec;10(12):1225-31. doi: 10.1038/nmeth.2684. Epub 2013 Oct 20.

46.

Surfaceome profiling reveals regulators of neural stem cell function.

DeVeale B, Bausch-Fluck D, Seaberg R, Runciman S, Akbarian V, Karpowicz P, Yoon C, Song H, Leeder R, Zandstra PW, Wollscheid B, van der Kooy D.

Stem Cells. 2014 Jan;32(1):258-68. doi: 10.1002/stem.1550.

47.

InVERT molding for scalable control of tissue microarchitecture.

Stevens KR, Ungrin MD, Schwartz RE, Ng S, Carvalho B, Christine KS, Chaturvedi RR, Li CY, Zandstra PW, Chen CS, Bhatia SN.

Nat Commun. 2013;4:1847. doi: 10.1038/ncomms2853. Erratum in: Nat Commun. 2014;5:3148.

48.

Integrative network analysis of signaling in human CD34(+) hematopoietic progenitor cells by global phosphoproteomic profiling using TiO2 enrichment combined with 2D LC-MS/MS and pathway mapping.

Guo H, Isserlin R, Chen X, Wang W, Phanse S, Zandstra PW, Paddison PJ, Emili A.

Proteomics. 2013 Apr;13(8):1325-33. doi: 10.1002/pmic.201200369. Epub 2013 Mar 6.

49.

Blood stem cell products: toward sustainable benchmarks for clinical translation.

Csaszar E, Cohen S, Zandstra PW.

Bioessays. 2013 Mar;35(3):201-10. doi: 10.1002/bies.201200118. Epub 2013 Jan 15. Review.

PMID:
23299858
50.

PERT: a method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions.

Qiao W, Quon G, Csaszar E, Yu M, Morris Q, Zandstra PW.

PLoS Comput Biol. 2012;8(12):e1002838. doi: 10.1371/journal.pcbi.1002838. Epub 2012 Dec 20.

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