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Items: 43

1.

A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties.

Filho RI, Gonzaga DTG, Demaria TM, Leandro JGB, Costa DCS, Ferreira VF, Sola-Penna M, de C da Silva F, Zancan P.

Curr Top Med Chem. 2018;18(17):1483-1493. doi: 10.2174/1568026618666180917100640.

PMID:
30221602
2.

A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis.

Branco JR, Oliveira VG, Esteves AM, Chipoline IC, Lima MFO, Boechat FCS, da Silva FC, Ferreira VF, Sola-Penna M, de Souza MCBV, Zancan P.

Curr Top Med Chem. 2018;18(17):1465-1474. doi: 10.2174/1568026618666180821142458.

PMID:
30129412
3.

Design, Synthesis and Biological Evaluation of 1H-1,2,3-Triazole-Linked-1H-Dibenzo[b,h]xanthenes as Inductors of ROS-Mediated Apoptosis in the Breast Cancer Cell Line MCF-7.

Bortolot CS, da S M Forezi L, Marra RKF, Reis MIP, Sá BVFE, Filho RI, Ghasemishahrestani Z, Sola-Penna M, Zancan P, Ferreira VF, de C da Silva F.

Med Chem. 2019;15(2):119-129. doi: 10.2174/1573406414666180524071409.

PMID:
29792156
4.

Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis.

Machado DE, Perini JA, de Mendonça EM, Branco JR, Rodrigues-Baptista KC, Alessandra-Perini J, Espíndola-Netto JM, Dos Santos TA, Coelho WS, Nasciutti LE, Sola-Penna M, Zancan P.

Mol Cell Endocrinol. 2018 Nov 15;476:17-26. doi: 10.1016/j.mce.2018.04.005. Epub 2018 Apr 22.

5.

Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms.

Ausina P, Da Silva D, Majerowicz D, Zancan P, Sola-Penna M.

Biomed Pharmacother. 2018 Jul;103:228-233. doi: 10.1016/j.biopha.2018.04.033. Epub 2018 Apr 24.

PMID:
29655163
6.

Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway.

Torres RG, Casanova L, Carvalho J, Marcondes MC, Costa SS, Sola-Penna M, Zancan P.

J Bioenerg Biomembr. 2018 Apr;50(2):93-105. doi: 10.1007/s10863-018-9750-3. Epub 2018 Mar 28.

PMID:
29589262
7.

Discrete Fourier Transform-Based Multivariate Image Analysis: Application to Modeling of Aromatase Inhibitory Activity.

Barigye SJ, Freitas MP, Ausina P, Zancan P, Sola-Penna M, Castillo-Garit JA.

ACS Comb Sci. 2018 Feb 12;20(2):75-81. doi: 10.1021/acscombsci.7b00155. Epub 2018 Jan 22.

PMID:
29297675
8.

Effects of Food Additives on Immune Cells As Contributors to Body Weight Gain and Immune-Mediated Metabolic Dysregulation.

Paula Neto HA, Ausina P, Gomez LS, Leandro JGB, Zancan P, Sola-Penna M.

Front Immunol. 2017 Nov 6;8:1478. doi: 10.3389/fimmu.2017.01478. eCollection 2017. Review.

9.

Phosphofructokinase-P Modulates P44/42 MAPK Levels in HeLa Cells.

Cardim Pires TR, Albanese JM, Schwab M, Marette A, Carvalho RS, Sola-Penna M, Zancan P.

J Cell Biochem. 2017 May;118(5):1216-1226. doi: 10.1002/jcb.25774. Epub 2017 Jan 10.

PMID:
27791266
10.

Targeted Nanosystems to Prostate Cancer.

da Silva LC, Carmoa FA, Nasciutti LE, Zancan P, Sathler PC, Cabral LM.

Curr Pharm Des. 2016;22(39):5962-5975. Review.

PMID:
27426128
11.

Exogenous citrate impairs glucose tolerance and promotes visceral adipose tissue inflammation in mice.

Leandro JG, Espindola-Netto JM, Vianna MC, Gomez LS, DeMaria TM, Marinho-Carvalho MM, Zancan P, Paula Neto HA, Sola-Penna M.

Br J Nutr. 2016 Mar 28;115(6):967-73. doi: 10.1017/S0007114516000027. Epub 2016 Feb 11.

PMID:
26863933
12.

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma.

Coelho RG, Calaça IC, Celestrini DM, Correia-Carneiro AH, Costa MM, Zancan P, Sola-Penna M.

Oncotarget. 2015 Oct 6;6(30):29375-87. doi: 10.18632/oncotarget.4910.

13.

Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells.

Marcondes MC, Fernandes AC, Itabaiana I Jr, de Souza RO, Sola-Penna M, Zancan P.

PLoS One. 2015 Jun 22;10(6):e0130555. doi: 10.1371/journal.pone.0130555. eCollection 2015.

14.

Phosphatidylinositol-3-kinase as a putative target for anticancer action of clotrimazole.

Furtado CM, Marcondes MC, Carvalho RS, Sola-Penna M, Zancan P.

Int J Biochem Cell Biol. 2015 May;62:132-41. doi: 10.1016/j.biocel.2015.03.004. Epub 2015 Mar 17.

PMID:
25794423
15.

Therapeutic nanosystems for oral administration of insulin.

do Carmo FA, Sathler PC, Zancan P, Rodrigues CR, Castro HC, de Sousa VP, Sola-Penna M, Cabral LM.

Curr Pharm Biotechnol. 2014;15(7):620-8. Review.

PMID:
25219867
16.

Antidiabetic activity of Sedum dendroideum: metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin.

Da Silva D, Casanova LM, Marcondes MC, Espindola-Netto JM, Paixão LP, De Melo GO, Zancan P, Sola-Penna M, Costa SS.

IUBMB Life. 2014 May;66(5):361-70. doi: 10.1002/iub.1270. Epub 2014 May 10.

17.

Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase.

Gomez LS, Zancan P, Marcondes MC, Ramos-Santos L, Meyer-Fernandes JR, Sola-Penna M, Da Silva D.

Biochimie. 2013 Jun;95(6):1336-43. doi: 10.1016/j.biochi.2013.02.013. Epub 2013 Feb 27.

18.

H3N2 homeopathic influenza virus solution modifies cellular and biochemical aspects of MDCK and J774G8 cell lines.

Siqueira CM, Costa B, Amorim AM, Gonçalves M, Féo da Veiga V, Castelo-Branco M, Takyia C, Zancan P, Câmara FP, Couceiro JN, Holandino C.

Homeopathy. 2013 Jan;102(1):31-40. doi: 10.1016/j.homp.2012.10.003.

PMID:
23290877
19.

Characterization of ecto-ATPase activity in the surface of LLC-PK1 cells and its modulation by ischemic conditions.

Ribeiro MC, Costa-Alves MS, Wengert M, Meyer-Fernandes JR, Zancan P, Caruso-Neves C, Pinheiro AA.

Biochim Biophys Acta. 2012 Dec;1820(12):2030-6. doi: 10.1016/j.bbagen.2012.09.009. Epub 2012 Sep 20.

20.

AMP-activated protein kinase upregulates glucose uptake in thyroid PCCL3 cells independent of thyrotropin.

Andrade BM, Cazarin J, Zancan P, Carvalho DP.

Thyroid. 2012 Oct;22(10):1063-8. doi: 10.1089/thy.2012.0041. Epub 2012 Sep 6.

PMID:
22953992
21.

Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice.

Da Silva D, Ausina P, Alencar EM, Coelho WS, Zancan P, Sola-Penna M.

IUBMB Life. 2012 Sep;64(9):766-74. doi: 10.1002/iub.1063. Epub 2012 Jun 23.

22.

Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis.

Furtado CM, Marcondes MC, Sola-Penna M, de Souza ML, Zancan P.

PLoS One. 2012;7(2):e30462. doi: 10.1371/journal.pone.0030462. Epub 2012 Feb 8.

23.

Muscle-type 6-phosphofructo-1-kinase and aldolase associate conferring catalytic advantages for both enzymes.

Marcondes MC, Sola-Penna M, Torres Rda S, Zancan P.

IUBMB Life. 2011 Jun;63(6):435-45. doi: 10.1002/iub.464.

24.

Glucuronoxylomannan from Cryptococcus neoformans down-regulates the enzyme 6-phosphofructo-1-kinase of macrophages.

Grechi J, Marinho-Carvalho M, Zancan P, Cinelli LP, Gomes AM, Rodrigues ML, Nimrichter L, Sola-Penna M.

J Biol Chem. 2011 Apr 29;286(17):14820-9. doi: 10.1074/jbc.M110.177030. Epub 2011 Mar 9.

25.

Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism.

Sola-Penna M, Da Silva D, Coelho WS, Marinho-Carvalho MM, Zancan P.

IUBMB Life. 2010 Nov;62(11):791-6. doi: 10.1002/iub.393. Review.

26.

Differential expression of phosphofructokinase-1 isoforms correlates with the glycolytic efficiency of breast cancer cells.

Zancan P, Sola-Penna M, Furtado CM, Da Silva D.

Mol Genet Metab. 2010 Aug;100(4):372-8. doi: 10.1016/j.ymgme.2010.04.006. Epub 2010 Apr 18.

PMID:
20483646
27.

Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase.

Marcondes MC, Sola-Penna M, Zancan P.

Arch Biochem Biophys. 2010 May;497(1-2):62-7. doi: 10.1016/j.abb.2010.03.013. Epub 2010 Mar 25.

PMID:
20346906
28.

Filamentous actin and its associated binding proteins are the stimulatory site for 6-phosphofructo-1-kinase association within the membrane of human erythrocytes.

Real-Hohn A, Zancan P, Da Silva D, Martins ER, Salgado LT, Mermelstein CS, Gomes AM, Sola-Penna M.

Biochimie. 2010 May;92(5):538-44. doi: 10.1016/j.biochi.2010.01.023. Epub 2010 Feb 6.

PMID:
20144679
29.

Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse.

Da Silva D, Zancan P, Coelho WS, Gomez LS, Sola-Penna M.

Arch Biochem Biophys. 2010 Apr 1;496(1):53-60. doi: 10.1016/j.abb.2010.01.013. Epub 2010 Feb 1.

PMID:
20117072
30.

Calmodulin upregulates skeletal muscle 6-phosphofructo-1-kinase reversing the inhibitory effects of allosteric modulators.

Marinho-Carvalho MM, Costa-Mattos PV, Spitz GA, Zancan P, Sola-Penna M.

Biochim Biophys Acta. 2009 Aug;1794(8):1175-80. doi: 10.1016/j.bbapap.2009.02.006. Epub 2009 Feb 27.

PMID:
19250982
31.

Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity.

Spitz GA, Furtado CM, Sola-Penna M, Zancan P.

Biochem Pharmacol. 2009 Jan 1;77(1):46-53. doi: 10.1016/j.bcp.2008.09.020. Epub 2008 Sep 21.

PMID:
18851958
32.

Crude ethanol extract from babassu (Orbignya speciosa): cytotoxicity on tumoral and non-tumoral cell lines.

Rennó MN, Barbosa GM, Zancan P, Veiga VF, Alviano CS, Sola-Penna M, Menezes FS, Holandino C.

An Acad Bras Cienc. 2008 Sep;80(3):467-76.

33.

ATP and fructose-2,6-bisphosphate regulate skeletal muscle 6-phosphofructo-1-kinase by altering its quaternary structure.

Zancan P, Marinho-Carvalho MM, Faber-Barata J, Dellias JM, Sola-Penna M.

IUBMB Life. 2008 Aug;60(8):526-33. doi: 10.1002/iub.58.

34.
35.

Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis.

Costa Leite T, Da Silva D, Guimarães Coelho R, Zancan P, Sola-Penna M.

Biochem J. 2007 Nov 15;408(1):123-30.

36.

Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase.

Zancan P, Rosas AO, Marcondes MC, Marinho-Carvalho MM, Sola-Penna M.

Biochem Pharmacol. 2007 May 15;73(10):1520-7. Epub 2007 Jan 14.

PMID:
17291460
37.

Modulation of 6-phosphofructo-1-kinase oligomeric equilibrium by calmodulin: formation of active dimers.

Marinho-Carvalho MM, Zancan P, Sola-Penna M.

Mol Genet Metab. 2006 Mar;87(3):253-61. Epub 2005 Dec 22.

PMID:
16377227
38.

Trehalose and glycerol stabilize and renature yeast inorganic pyrophosphatase inactivated by very high temperatures.

Zancan P, Sola-Penna M.

Arch Biochem Biophys. 2005 Dec 1;444(1):52-60. Epub 2005 Oct 24.

PMID:
16289020
39.
40.
41.

Venous and arterial thrombosis in rat models: dissociation of the antithrombotic effects of glycosaminoglycans.

Zancan P, Mourão PA.

Blood Coagul Fibrinolysis. 2004 Jan;15(1):45-54.

PMID:
15166943
42.

Unbalanced effects of dermatan sulfates with different sulfation patterns on coagulation, thrombosis and bleeding.

Vicente CP, Zancan P, Peixoto LL, Alves-Sá R, Araújo FS, Mourão PA, Pavão MS.

Thromb Haemost. 2001 Nov;86(5):1215-20.

PMID:
11816710
43.

Different antithrombotic mechanisms among glycosaminoglycans revealed with a new fucosylated chondroitin sulfate from an echinoderm.

Pacheco RG, Vicente CP, Zancan P, Mourão PA.

Blood Coagul Fibrinolysis. 2000 Sep;11(6):563-73.

PMID:
10997797

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