Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 296

1.

Peripheral nerve injury-induced alterations in VTA neuron firing properties.

Huang S, Borgland SL, Zamponi GW.

Mol Brain. 2019 Nov 4;12(1):89. doi: 10.1186/s13041-019-0511-y.

2.

Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy.

Souza IA, Gandini MA, Zhang FX, Mitchell WG, Matsumoto J, Lerner J, Pierson TM, Zamponi GW.

Mol Brain. 2019 Oct 24;12(1):86. doi: 10.1186/s13041-019-0509-5.

3.

Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment.

Zamponi GW.

Sci Signal. 2019 Oct 15;12(603). pii: eaay8960. doi: 10.1126/scisignal.aay8960. Review.

PMID:
31615900
4.

A neuronal circuit for activating descending modulation of neuropathic pain.

Huang J, Gadotti VM, Chen L, Souza IA, Huang S, Wang D, Ramakrishnan C, Deisseroth K, Zhang Z, Zamponi GW.

Nat Neurosci. 2019 Oct;22(10):1659-1668. doi: 10.1038/s41593-019-0481-5. Epub 2019 Sep 9.

PMID:
31501573
5.

Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels.

Choi CSW, Souza IA, Sanchez-Arias JC, Zamponi GW, Arbour LT, Swayne LA.

Mol Brain. 2019 Sep 2;12(1):75. doi: 10.1186/s13041-019-0494-8.

6.

Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.

Sahu G, Wazen RM, Colarusso P, Chen SRW, Zamponi GW, Turner RW.

Cell Rep. 2019 Aug 27;28(9):2427-2442.e6. doi: 10.1016/j.celrep.2019.07.075.

7.

SUMOylation regulates USP5-Cav3.2 calcium channel interactions.

Garcia-Caballero A, Zhang FX, Chen L, M'Dahoma S, Huang J, Zamponi GW.

Mol Brain. 2019 Aug 27;12(1):73. doi: 10.1186/s13041-019-0493-9.

8.

Discovery of Michael acceptor containing 1,4-dihydropyridines as first covalent inhibitors of L-/T-type calcium channels.

Aygün Cevher H, Schaller D, Gandini MA, Kaplan O, Gambeta E, Zhang FX, Çelebier M, Tahir MN, Zamponi GW, Wolber G, Gündüz MG.

Bioorg Chem. 2019 Oct;91:103187. doi: 10.1016/j.bioorg.2019.103187. Epub 2019 Aug 7.

PMID:
31419643
9.

A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.

Gaifullina AS, Lazniewska J, Gerasimova EV, Burkhanova GF, Rzhepetskyy Y, Tomin A, Rivas-Ramirez P, Huang J, Cmarko L, Zamponi GW, Sitdikova GF, Weiss N.

Pain. 2019 Dec;160(12):2798-2810. doi: 10.1097/j.pain.0000000000001669.

PMID:
31365467
10.

Interactions of Rabconnectin-3 with Cav2 calcium channels.

Gandini MA, Souza IA, Fan J, Li K, Wang D, Zamponi GW.

Mol Brain. 2019 Jun 28;12(1):62. doi: 10.1186/s13041-019-0483-y.

11.

Genetic T-type calcium channelopathies.

Weiss N, Zamponi GW.

J Med Genet. 2019 Jun 19. pii: jmedgenet-2019-106163. doi: 10.1136/jmedgenet-2019-106163. [Epub ahead of print] Review.

12.

Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis.

Gadotti VM, Andonegui G, Zhang Z, M'Dahoma S, Baggio CH, Chen L, Basso L, Altier C, MacNaughton WK, Kubes P, Zamponi GW.

iScience. 2019 Jun 28;16:12-21. doi: 10.1016/j.isci.2019.05.012. Epub 2019 May 14.

13.

Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers.

Teleb M, Rizk OH, Zhang FX, Fronczek FR, Zamponi GW, Fahmy H.

Bioorg Chem. 2019 Jul;88:102915. doi: 10.1016/j.bioorg.2019.04.009. Epub 2019 Apr 11.

PMID:
31005784
14.

Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels.

Jurkovicova-Tarabova B, Cmarko L, Rehak R, Zamponi GW, Lacinova L, Weiss N.

Mol Brain. 2019 Apr 8;12(1):34. doi: 10.1186/s13041-019-0457-0.

15.

De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias.

Helbig KL, Lauerer RJ, Bahr JC, Souza IA, Myers CT, Uysal B, Schwarz N, Gandini MA, Huang S, Keren B, Mignot C, Afenjar A, Billette de Villemeur T, Héron D, Nava C, Valence S, Buratti J, Fagerberg CR, Soerensen KP, Kibaek M, Kamsteeg EJ, Koolen DA, Gunning B, Schelhaas HJ, Kruer MC, Fox J, Bakhtiari S, Jarrar R, Padilla-Lopez S, Lindstrom K, Jin SC, Zeng X, Bilguvar K, Papavasileiou A, Xing Q, Zhu C, Boysen K, Vairo F, Lanpher BC, Klee EW, Tillema JM, Payne ET, Cousin MA, Kruisselbrink TM, Wick MJ, Baker J, Haan E, Smith N, Sadeghpour A, Davis EE, Katsanis N; Task Force for Neonatal Genomics, Corbett MA, MacLennan AH, Gecz J, Biskup S, Goldmann E, Rodan LH, Kichula E, Segal E, Jackson KE, Asamoah A, Dimmock D, McCarrier J, Botto LD, Filloux F, Tvrdik T, Cascino GD, Klingerman S, Neumann C, Wang R, Jacobsen JC, Nolan MA, Snell RG, Lehnert K, Sadleir LG, Anderlid BM, Kvarnung M, Guerrini R, Friez MJ, Lyons MJ, Leonhard J, Kringlen G, Casas K, El Achkar CM, Smith LA, Rotenberg A, Poduri A, Sanchis-Juan A, Carss KJ, Rankin J, Zeman A, Raymond FL, Blyth M, Kerr B, Ruiz K, Urquhart J, Hughes I, Banka S; Deciphering Developmental Disorders Study, Hedrich UBS, Scheffer IE, Helbig I, Zamponi GW, Lerche H, Mefford HC.

Am J Hum Genet. 2019 Mar 7;104(3):562. doi: 10.1016/j.ajhg.2019.02.015. No abstract available.

16.

Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons.

Candelas M, Reynders A, Arango-Lievano M, Neumayer C, Fruquière A, Demes E, Hamid J, Lemmers C, Bernat C, Monteil A, Compan V, Laffray S, Inquimbert P, Le Feuvre Y, Zamponi GW, Moqrich A, Bourinet E, Méry PF.

Sci Rep. 2019 Feb 28;9(1):3112. doi: 10.1038/s41598-019-39703-3.

17.

Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC.

Garcia-Caballero A, Gandini MA, Huang S, Chen L, Souza IA, Dang YL, Stutts MJ, Zamponi GW.

Mol Brain. 2019 Feb 8;12(1):12. doi: 10.1186/s13041-019-0433-8.

18.

T-Type Channel Druggability at a Crossroads.

Weiss N, Zamponi GW.

ACS Chem Neurosci. 2019 Mar 20;10(3):1124-1126. doi: 10.1021/acschemneuro.9b00031. Epub 2019 Jan 30.

PMID:
30697997
19.

T-type calcium channels: From molecule to therapeutic opportunities.

Weiss N, Zamponi GW.

Int J Biochem Cell Biol. 2019 Mar;108:34-39. doi: 10.1016/j.biocel.2019.01.008. Epub 2019 Jan 14. Review.

PMID:
30648620
20.

Dopaminergic modulation of pain signals in the medial prefrontal cortex: Challenges and perspectives.

Huang S, Borgland SL, Zamponi GW.

Neurosci Lett. 2019 May 29;702:71-76. doi: 10.1016/j.neulet.2018.11.043. Epub 2018 Nov 29. Review.

PMID:
30503912
21.

Design, synthesis and pharmacological evaluation of some substituted dihydropyrimidines with L-/T-type calcium channel blocking activities.

Teleb M, Rizk OH, Zhang FX, Fronczek FR, Zamponi GW, Fahmy H.

Bioorg Chem. 2019 Mar;83:354-366. doi: 10.1016/j.bioorg.2018.10.054. Epub 2018 Nov 1.

PMID:
30408648
22.

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions.

Huang S, Chen L, Bladen C, Stys PK, Zamponi GW.

Mol Brain. 2018 Oct 25;11(1):62. doi: 10.1186/s13041-018-0406-3.

23.

De Novo Pathogenic Variants in CACNA1E Cause Developmental and Epileptic Encephalopathy with Contractures, Macrocephaly, and Dyskinesias.

Helbig KL, Lauerer RJ, Bahr JC, Souza IA, Myers CT, Uysal B, Schwarz N, Gandini MA, Huang S, Keren B, Mignot C, Afenjar A, Billette de Villemeur T, Héron D, Nava C, Valence S, Buratti J, Fagerberg CR, Soerensen KP, Kibaek M, Kamsteeg EJ, Koolen DA, Gunning B, Schelhaas HJ, Kruer MC, Fox J, Bakhtiari S, Jarrar R, Padilla-Lopez S, Lindstrom K, Jin SC, Zeng X, Bilguvar K, Papavasileiou A, Xing Q, Zhu C, Boysen K, Vairo F, Lanpher BC, Klee EW, Tillema JM, Payne ET, Cousin MA, Kruisselbrink TM, Wick MJ, Baker J, Haan E, Smith N, Sadeghpour A, Davis EE, Katsanis N; Task Force for Neonatal Genomics, Corbett MA, MacLennan AH, Gecz J, Biskup S, Goldmann E, Rodan LH, Kichula E, Segal E, Jackson KE, Asamoah A, Dimmock D, McCarrier J, Botto LD, Filloux F, Tvrdik T, Cascino GD, Klingerman S, Neumann C, Wang R, Jacobsen JC, Nolan MA, Snell RG, Lehnert K, Sadleir LG, Anderlid BM, Kvarnung M, Guerrini R, Friez MJ, Lyons MJ, Leonhard J, Kringlen G, Casas K, El Achkar CM, Smith LA, Rotenberg A, Poduri A, Sanchis-Juan A, Carss KJ, Rankin J, Zeman A, Raymond FL, Blyth M, Kerr B, Ruiz K, Urquhart J, Hughes I, Banka S; Deciphering Developmental Disorders Study, Hedrich UBS, Scheffer IE, Helbig I, Zamponi GW, Lerche H, Mefford HC.

Am J Hum Genet. 2018 Nov 1;103(5):666-678. doi: 10.1016/j.ajhg.2018.09.006. Epub 2018 Oct 18. Erratum in: Am J Hum Genet. 2019 Mar 7;104(3):562.

24.

Disrupting USP5/Cav3.2 interactions protects female mice from mechanical hypersensitivity during peripheral inflammation.

Gadotti VM, Zamponi GW.

Mol Brain. 2018 Oct 19;11(1):60. doi: 10.1186/s13041-018-0405-4.

25.

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels.

Bellampalli SS, Ji Y, Moutal A, Cai S, Wijeratne EMK, Gandini MA, Yu J, Chefdeville A, Dorame A, Chew LA, Madura CL, Luo S, Molnar G, Khanna M, Streicher JM, Zamponi GW, Gunatilaka AAL, Khanna R.

Pain. 2019 Jan;160(1):117-135. doi: 10.1097/j.pain.0000000000001385.

PMID:
30169422
26.

A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome.

Zhang Y, Rong H, Zhang FX, Wu K, Mu L, Meng J, Xiao B, Zamponi GW, Shi Y.

Cell Rep. 2018 Aug 28;24(9):2356-2369.e5. doi: 10.1016/j.celrep.2018.07.098.

27.

Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain.

Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM.

Sci Signal. 2018 Aug 28;11(545). pii: eaao4425. doi: 10.1126/scisignal.aao4425.

28.

Microglial pannexin-1 channel activation is a spinal determinant of joint pain.

Mousseau M, Burma NE, Lee KY, Leduc-Pessah H, Kwok CHT, Reid AR, O'Brien M, Sagalajev B, Stratton JA, Patrick N, Stemkowski PL, Biernaskie J, Zamponi GW, Salo P, McDougall JJ, Prescott SA, Matyas JR, Trang T.

Sci Adv. 2018 Aug 8;4(8):eaas9846. doi: 10.1126/sciadv.aas9846. eCollection 2018 Aug.

29.

Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-/T-type calcium channel blocking activity.

Schaller D, Gündüz MG, Zhang FX, Zamponi GW, Wolber G.

Eur J Med Chem. 2018 Jul 15;155:1-12. doi: 10.1016/j.ejmech.2018.05.032. Epub 2018 May 23.

PMID:
29843108
30.

T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.

Garcia-Caballero A, Zhang FX, Hodgkinson V, Huang J, Chen L, Souza IA, Cain S, Kass J, Alles S, Snutch TP, Zamponi GW.

Mol Brain. 2018 May 2;11(1):24. doi: 10.1186/s13041-018-0368-5.

31.

Cav3.1 overexpression is associated with negative characteristics and prognosis in non-small cell lung cancer.

Suo A, Childers A, D'Silva A, Petersen LF, Otsuka S, Dean M, Li H, Enwere EK, Pohorelic B, Klimowicz A, Souza IA, Hamid J, Zamponi GW, Bebb D.

Oncotarget. 2018 Jan 12;9(9):8573-8583. doi: 10.18632/oncotarget.24194. eCollection 2018 Feb 2.

32.

BK Potassium Channels Suppress Cavα2δ Subunit Function to Reduce Inflammatory and Neuropathic Pain.

Zhang FX, Gadotti VM, Souza IA, Chen L, Zamponi GW.

Cell Rep. 2018 Feb 20;22(8):1956-1964. doi: 10.1016/j.celrep.2018.01.073.

33.

A Crash Course in Calcium Channels.

Zamponi GW.

ACS Chem Neurosci. 2017 Dec 20;8(12):2583-2585. doi: 10.1021/acschemneuro.7b00415. Epub 2017 Nov 13. Review.

PMID:
29131938
34.

Activity-Dependent Facilitation of CaV1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons.

Sahu G, Asmara H, Zhang FX, Zamponi GW, Turner RW.

J Neurosci. 2017 Nov 15;37(46):11255-11270. doi: 10.1523/JNEUROSCI.0967-17.2017. Epub 2017 Oct 16.

35.

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels.

Proft J, Rzhepetskyy Y, Lazniewska J, Zhang FX, Cain SM, Snutch TP, Zamponi GW, Weiss N.

Sci Rep. 2017 Sep 14;7(1):11513. doi: 10.1038/s41598-017-11591-5.

36.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.

37.

A T-type channel-calmodulin complex triggers αCaMKII activation.

Asmara H, Micu I, Rizwan AP, Sahu G, Simms BA, Zhang FX, Engbers JDT, Stys PK, Zamponi GW, Turner RW.

Mol Brain. 2017 Aug 11;10(1):37. doi: 10.1186/s13041-017-0317-8.

38.

Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway.

Stemkowski PL, Garcia-Caballero A, Gadotti VM, M'Dahoma S, Chen L, Souza IA, Zamponi GW.

Mol Pain. 2017 Jan-Dec;13:1744806917724698. doi: 10.1177/1744806917724698.

39.

Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects.

Kim JH, Jeong HR, Jung DW, Yoon HB, Kim SY, Kim HJ, Lee KT, Gadotti VM, Huang J, Zhang FX, Zamponi GW, Lee JY.

Bioorg Med Chem. 2017 Sep 1;25(17):4656-4664. doi: 10.1016/j.bmc.2017.07.010. Epub 2017 Jul 8.

PMID:
28720332
40.

Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain.

Rivas-Ramirez P, Gadotti VM, Zamponi GW, Weiss N.

Pflugers Arch. 2017 Oct;469(10):1325-1334. doi: 10.1007/s00424-017-2017-8. Epub 2017 Jun 30.

PMID:
28664409
41.

Recent advances in the development of T-type calcium channel blockers for pain intervention.

Snutch TP, Zamponi GW.

Br J Pharmacol. 2018 Jun;175(12):2375-2383. doi: 10.1111/bph.13906. Epub 2017 Jul 12. Review.

42.

Erratum: Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents.

Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankara JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, DeKoninck Y, Trang T.

Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788c. No abstract available.

43.

Down-regulation of T-type Cav3.2 channels by hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1): Evidence of a signaling complex.

Fan J, Gandini MA, Zhang FX, Chen L, Souza IA, Zamponi GW.

Channels (Austin). 2017 Sep 3;11(5):434-443. doi: 10.1080/19336950.2017.1326233. Epub 2017 May 3.

44.

Synthesis of new N3-substituted dihydropyrimidine derivatives as L-/T- type calcium channel blockers.

Teleb M, Zhang FX, Farghaly AM, Aboul Wafa OM, Fronczek FR, Zamponi GW, Fahmy H.

Eur J Med Chem. 2017 Jul 7;134:52-61. doi: 10.1016/j.ejmech.2017.03.080. Epub 2017 Apr 3.

PMID:
28399450
45.

N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease.

Silva FR, Miranda AS, Santos RPM, Olmo IG, Zamponi GW, Dobransky T, Cruz JS, Vieira LB, Ribeiro FM.

Neurobiol Aging. 2017 Jul;55:1-10. doi: 10.1016/j.neurobiolaging.2017.03.015. Epub 2017 Mar 18.

PMID:
28391067
46.

TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity.

Stemkowski P, García-Caballero A, De Maria Gadotti V, M'Dahoma S, Huang S, Gertrud Black SA, Chen L, Souza IA, Zhang Z, Zamponi GW.

Cell Rep. 2017 Feb 28;18(9):2289-2290. doi: 10.1016/j.celrep.2017.02.050. No abstract available.

47.

Synthesis and biological evaluation of novel N3-substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain.

Teleb M, Zhang FX, Huang J, Gadotti VM, Farghaly AM, AboulWafa OM, Zamponi GW, Fahmy H.

Bioorg Med Chem. 2017 Mar 15;25(6):1926-1938. doi: 10.1016/j.bmc.2017.02.015. Epub 2017 Feb 13.

PMID:
28233679
48.

Carisbamate blockade of T-type voltage-gated calcium channels.

Kim DY, Zhang FX, Nakanishi ST, Mettler T, Cho IH, Ahn Y, Hiess F, Chen L, Sullivan PG, Chen SR, Zamponi GW, Rho JM.

Epilepsia. 2017 Apr;58(4):617-626. doi: 10.1111/epi.13710. Epub 2017 Feb 23.

49.

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents.

Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankara JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T.

Nat Med. 2017 Mar;23(3):355-360. doi: 10.1038/nm.4281. Epub 2017 Jan 30. Erratum in: Nat Med. 2017 Jun 6;23 (6):788.

50.

TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity.

Stemkowski P, García-Caballero A, Gadotti VM, M'Dahoma S, Huang S, Black SAG, Chen L, Souza IA, Zhang Z, Zamponi GW.

Cell Rep. 2016 Dec 13;17(11):2901-2912. doi: 10.1016/j.celrep.2016.11.047. Erratum in: Cell Rep. 2017 Feb 28;18(9):2289-2290.

Supplemental Content

Loading ...
Support Center