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Items: 29

1.

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.

Engers DW, Bollinger SR, Engers JL, Panarese JD, Breiner MM, Gregro A, Blobaum AL, Bronson JJ, Wu YJ, Macor JE, Rodriguez AL, Zamorano R, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

Bioorg Med Chem Lett. 2018 Aug 15;28(15):2641-2646. doi: 10.1016/j.bmcl.2018.06.034. Epub 2018 Jun 19.

PMID:
29958762
2.

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Fisher NM, Adams J, Zamorano R, Walker AG, Blobaum AL, Engers DW, Hopkins CR, Daniels JS, Jones CK, Lindsley CW, Xiang Z, Conn PJ, Niswender CM.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaai7459. doi: 10.1126/scitranslmed.aai7459.

3.

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Rook JM, Ghoshal A, Zamorano R, Malosh C, Stauffer SR, Bridges TM, Bartolome JM, Daniels JS, Jones CK, Lindsley CW, Conn PJ, Niswender CM.

Hum Mol Genet. 2016 May 15;25(10):1990-2004. Epub 2016 Mar 2.

4.

The discovery and characterization of a centrally penetrant (ML396) and a peripherally restricted (ML397) pan-Group III mGlu positive allosteric modulators.

Jalan-Sakrikar N, Roper-Field J, Klar R, Mattman M, Walker AG, Zamorano R, Xiang Z, Byers CF, Blobaum AL, Engers D, Weaver CD, Days E, Utley TJ, Melancon B, Daniels JS, Wood MR, Lindsley CW, Conn PJ, Hopkins CR, Niswender CM.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

5.

Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.

Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM.

ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. doi: 10.1021/cn500153z. Epub 2014 Oct 9.

6.

Randomised clinical trial to compare total contact casts, healing sandals and a shear-reducing removable boot to heal diabetic foot ulcers.

Lavery LA, Higgins KR, La Fontaine J, Zamorano RG, Constantinides GP, Kim PJ.

Int Wound J. 2015 Dec;12(6):710-5. doi: 10.1111/iwj.12213. Epub 2014 Feb 21.

PMID:
24618113
7.

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.

Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM.

J Neurosci. 2014 Jan 1;34(1):79-94. doi: 10.1523/JNEUROSCI.1129-13.2014.

8.

Determination of the variability of both hydrophilic and lipophilic toxins in endemic wild bivalves and carnivorous gastropods from the southern part of Chile.

Zamorano R, Marín M, Cabrera F, Figueroa D, Contreras C, Barriga A, Lagos N, García C.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(9):1660-77. doi: 10.1080/19440049.2013.805438. Epub 2013 Jul 4.

PMID:
23822152
9.

Discovery of a novel metabotropic glutamate receptor 4 (mGlu4) positive allosteric modulator (PAM) extended probe: Characterization of ML292, a potent and selective mGlu4 PAM which produces efficacy alone or in combination with L-DOPA in preclinical rodent models of Parkinson's disease.

Engers DW, Jones CK, Bubser M, Thompson AD, Blobaum AL, Sheffler DJ, Zamorano R, Carrington SJS, Bridges TM, Morrison RD, Daniels JS, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 2 [updated 2013 Feb 25].

10.

Functional selectivity induced by mGlu₄ receptor positive allosteric modulation and concomitant activation of Gq coupled receptors.

Yin S, Zamorano R, Conn PJ, Niswender CM.

Neuropharmacology. 2013 Mar;66:122-32. doi: 10.1016/j.neuropharm.2012.03.003. Epub 2012 Mar 9.

11.

[Kawasaki disease: a clinical serie].

Budnik O I, Hirsch B T, Fernández C C, Yánez P L, Zamorano R J.

Rev Chilena Infectol. 2011 Oct;28(5):416-22. doi: /S0716-10182011000600005. Epub 2011 Oct 19. Spanish.

12.

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.

Utley T, Haddenham D, Salovich JM, Zamorano R, Vinson PN, Lindsley CW, Hopkins CR, Niswender CM.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):6955-9. doi: 10.1016/j.bmcl.2011.09.131. Epub 2011 Oct 8.

13.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model.

Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

J Med Chem. 2011 Nov 10;54(21):7639-47. doi: 10.1021/jm200956q. Epub 2011 Oct 19.

14.

Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄.

Cheung YY, Zamorano R, Blobaum AL, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

ACS Comb Sci. 2011 Mar 14;13(2):159-65. doi: 10.1021/co1000508. Epub 2011 Feb 21.

15.

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

Engers DW, Field JR, Le U, Zhou Y, Bolinger JD, Zamorano R, Blobaum AL, Jones CK, Jadhav S, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR.

J Med Chem. 2011 Feb 24;54(4):1106-10. doi: 10.1021/jm101271s. Epub 2011 Jan 19.

16.

[Infections in patients with Systemic Lupus Erythematosus].

Enberg G M, Kahn Ch M, Goity F C, Villalón S MV, Zamorano R J, Figueroa E F.

Rev Med Chil. 2009 Oct;137(10):1367-74. doi: /S0034-98872009001000014. Review. Spanish.

17.

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR.

J Med Chem. 2009 Jul 23;52(14):4115-8. doi: 10.1021/jm9005065.

18.

Preventing diabetic foot ulcer recurrence in high-risk patients: use of temperature monitoring as a self-assessment tool.

Lavery LA, Higgins KR, Lanctot DR, Constantinides GP, Zamorano RG, Athanasiou KA, Armstrong DG, Agrawal CM.

Diabetes Care. 2007 Jan;30(1):14-20.

PMID:
17192326
19.

[Neonatal meningitis caused by atypical Streptococcus pneumoniae: case report and review].

Silva B V, Castillo F F, O Reilly F P, Araya B I, Porte T L, Ulloa F MT, Varela A C, Zamorano R J.

Rev Chilena Infectol. 2006 Dec;23(4):346-50. Epub 2006 Nov 23. Review. Spanish.

20.

3'-Untranslated region of the type 2 bradykinin receptor is a potent regulator of gene expression.

Zamorano R, Suchindran S, Gainer JV.

Am J Physiol Renal Physiol. 2006 Feb;290(2):F456-64. Epub 2005 Sep 6.

21.

Wear and biomechanical characteristics of a novel shear-reducing insole with implications for high-risk persons with diabetes.

Lavery LA, Lanctot DR, Constantinides G, Zamorano RG, Athanasiou KA, Agrawal CM.

Diabetes Technol Ther. 2005 Aug;7(4):638-46.

PMID:
16120040
22.

Home monitoring of foot skin temperatures to prevent ulceration.

Lavery LA, Higgins KR, Lanctot DR, Constantinides GP, Zamorano RG, Armstrong DG, Athanasiou KA, Agrawal CM.

Diabetes Care. 2004 Nov;27(11):2642-7.

PMID:
15504999
23.

Different arrangement of human papillomavirus E2 binding sites distinguishes cutaneous types from those associated with mucosal lesions.

Garrido-Guerrero E, Carrillo E, Guido M, Zamorano R, García-Carranca A, Gariglio P.

Arch Med Res. 1996 Autumn;27(3):389-94.

PMID:
8854400
24.

Early promoters of genital and cutaneous human papillomaviruses are differentially regulated by the bovine papillomavirus type 1 E2 gene product.

Guido MC, Zamorano R, Garrido-Guerrero E, Gariglio P, García-Carrancá A.

J Gen Virol. 1992 Jun;73 ( Pt 6):1395-400.

PMID:
1318941
25.

Captopril does not scavenge superoxide: captopril prevents O2-. production by chelating copper.

Jay D, Cuéllar A, Zamorano R, Muñoz E, Gleason R.

Arch Biochem Biophys. 1991 Nov 1;290(2):463-7.

PMID:
1656879
26.

[An in vitro study of the mechanism by which captopril attenuates myocardial reperfusion damage].

Jay D, Zamorano R, Cuéllar A, Muñoz E, Gleason R.

Arch Inst Cardiol Mex. 1991 Jul-Aug;61(4):303-7. Spanish.

PMID:
1953205
27.

Study of the interaction of cadmium with membrane-bound succinate dehydrogenase.

Jay D, Zamorano R, Muñoz E, Gleason R, Boldu JL.

J Bioenerg Biomembr. 1991 Apr;23(2):381-9.

PMID:
2050657
28.

Electron paramagnetic resonance of the mitochondrial respiratory chain in the presence of phenazine methosulfate.

Jay D, Zamorano R, Muñoz E, Gleason R, Boldu JL.

Bol Estud Med Biol. 1990 Jan-Jun;38(1-2):16-21.

PMID:
1963304
29.

[Combined therapy of advanced gastric cancer].

Fodor M, Tampier C, Zamorano R.

Rev Med Chil. 1982 Mar;110(3):293. Spanish. No abstract available.

PMID:
7156581

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