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Items: 31


Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes.

Sands AT, Zambrowicz BP, Rosenstock J, Lapuerta P, Bode BW, Garg SK, Buse JB, Banks P, Heptulla R, Rendell M, Cefalu WT, Strumph P.

Diabetes Care. 2015 Jul;38(7):1181-8. doi: 10.2337/dc14-2806. Epub 2015 Jun 6.


Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

Salojin KV, Hamman BD, Chang WC, Jhaver KG, Al-Shami A, Crisostomo J, Wilkins C, Digeorge-Foushee AM, Allen J, Patel N, Gopinathan S, Zhou J, Nouraldeen A, Jessop TC, Bagdanoff JT, Augeri DJ, Read R, Vogel P, Swaffield J, Wilson A, Platt KA, Carson KG, Main A, Zambrowicz BP, Oravecz T.

PLoS One. 2014 May 22;9(5):e98151. doi: 10.1371/journal.pone.0098151. eCollection 2014.


Keratinocyte migration in the developing eyelid requires LIMK2.

Rice DS, Hansen GM, Liu F, Crist MJ, Newhouse MM, Potter D, Xu N, Abuin A, Vogel PJ, Zambrowicz BP.

PLoS One. 2012;7(10):e47168. doi: 10.1371/journal.pone.0047168. Epub 2012 Oct 5.


Congenital hydrocephalus in genetically engineered mice.

Vogel P, Read RW, Hansen GM, Payne BJ, Small D, Sands AT, Zambrowicz BP.

Vet Pathol. 2012 Jan;49(1):166-81. doi: 10.1177/0300985811415708. Epub 2011 Jul 11.


A mouse knockout library for secreted and transmembrane proteins.

Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ.

Nat Biotechnol. 2010 Jul;28(7):749-55. doi: 10.1038/nbt.1644. Epub 2010 Jun 20.


Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.

Vogel P, Read R, Hansen GM, Freay LC, Zambrowicz BP, Sands AT.

Vet Pathol. 2010 Jan;47(1):120-31. doi: 10.1177/0300985809353553.


GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4.

Sonnenburg WK, Yu D, Lee EC, Xiong W, Gololobov G, Key B, Gay J, Wilganowski N, Hu Y, Zhao S, Schneider M, Ding ZM, Zambrowicz BP, Landes G, Powell DR, Desai U.

J Lipid Res. 2009 Dec;50(12):2421-9. doi: 10.1194/jlr.M900145-JLR200. Epub 2009 Jun 21.


Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

Lee EC, Desai U, Gololobov G, Hong S, Feng X, Yu XC, Gay J, Wilganowski N, Gao C, Du LL, Chen J, Hu Y, Zhao S, Kirkpatrick L, Schneider M, Zambrowicz BP, Landes G, Powell DR, Sonnenburg WK.

J Biol Chem. 2009 May 15;284(20):13735-45. doi: 10.1074/jbc.M807899200. Epub 2009 Mar 23.


Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.

Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A.

Genome Res. 2008 Oct;18(10):1670-9. doi: 10.1101/gr.078352.108. Epub 2008 Sep 17.


High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.

Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, Platt KA, Suwanichkul A, Hansen GM, Sands AT, Zambrowicz BP, Powell DR.

Obesity (Silver Spring). 2008 Oct;16(10):2362-7. doi: 10.1038/oby.2008.361. Epub 2008 Jul 31.


Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.

Wong RL, Wlodarczyk BJ, Min KS, Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP, Finnell RH.

Hum Mol Genet. 2008 Feb 15;17(4):587-601. Epub 2007 Nov 13.


Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.

Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, Wingert J, Zambrowicz BP, Landes G, Powell DR.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71. Epub 2007 Jul 3.


High-throughput mouse knockouts provide a functional analysis of the genome.

Friddle CJ, Abuin A, Ramirez-Solis R, Richter LJ, Buxton EC, Edwards J, Finch RA, Gupta A, Hansen G, Holt KH, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Newhouse M, Perry T, Platt KA, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Tran D, Wann ER, Walke W, Wallace JD, Xu N, Zhu Q, Person C, Sands AT, Zambrowicz BP.

Cold Spring Harb Symp Quant Biol. 2003;68:311-5. No abstract available.


Severe retinal degeneration associated with disruption of semaphorin 4A.

Rice DS, Huang W, Jones HA, Hansen G, Ye GL, Xu N, Wilson EA, Troughton K, Vaddi K, Newton RC, Zambrowicz BP, Sands AT.

Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2767-77.


Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.

Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14. Epub 2003 Nov 10.


Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry.

Zambrowicz BP, Turner CA, Sands AT.

Curr Opin Pharmacol. 2003 Oct;3(5):563-70. Review.


Knockouts model the 100 best-selling drugs--will they model the next 100?

Zambrowicz BP, Sands AT.

Nat Rev Drug Discov. 2003 Jan;2(1):38-51. doi: 10.1038/nrd987. Review.


mdmx is a negative regulator of p53 activity in vivo.

Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, Zhang N.

Cancer Res. 2002 Jun 1;62(11):3221-5.


Full-speed mammalian genetics: in vivo target validation in the drug discovery process.

Abuin A, Holt KH, Platt KA, Sands AT, Zambrowicz BP.

Trends Biotechnol. 2002 Jan;20(1):36-42. Review.


Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN.

Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR.

Mol Cell Biol. 2001 Jul;21(14):4829-36.


Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice.

Guidi CJ, Sands AT, Zambrowicz BP, Turner TK, Demers DA, Webster W, Smith TW, Imbalzano AN, Jones SN.

Mol Cell Biol. 2001 May;21(10):3598-603.


Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse.

Zambrowicz BP, Friedrich GA.

Int J Dev Biol. 1998;42(7):1025-36. Review.


Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.

Zambrowicz BP, Friedrich GA, Buxton EC, Lilleberg SL, Person C, Sands AT.

Nature. 1998 Apr 9;392(6676):608-11.


Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells.

Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, Soriano P.

Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3789-94.


Characterization of the murine Zfy1 and Zfy2 promoters.

Zambrowicz BP, Findley SD, Simpson EM, Page DC, Palmiter RD.

Genomics. 1994 Nov 15;24(2):406-8. No abstract available.


Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles.

Masters BA, Quaife CJ, Erickson JC, Kelly EJ, Froelick GJ, Zambrowicz BP, Brinster RL, Palmiter RD.

J Neurosci. 1994 Oct;14(10):5844-57.


Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia.

Quaife CJ, Findley SD, Erickson JC, Froelick GJ, Kelly EJ, Zambrowicz BP, Palmiter RD.

Biochemistry. 1994 Jun 14;33(23):7250-9.


Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis.

Zambrowicz BP, Zimmermann JW, Harendza CJ, Simpson EM, Page DC, Brinster RL, Palmiter RD.

Development. 1994 Jun;120(6):1549-59.


Analysis of the mouse protamine 1 promoter in transgenic mice.

Zambrowicz BP, Harendza CJ, Zimmermann JW, Brinster RL, Palmiter RD.

Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5071-5.

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