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Items: 1 to 50 of 96

1.

Metabolomics Identifies a Biomarker Revealing in Vivo Loss of Functional ß-Cell Mass Before Diabetes Onset.

Li L, Krznar P, Erban A, Agazzi A, Martin-Levilain J, Supale S, Kopka J, Zamboni N, Maechler P.

Diabetes. 2019 Sep 19. pii: db190131. doi: 10.2337/db19-0131. [Epub ahead of print]

PMID:
31537525
2.

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors.

Aloia A, Müllhaupt D, Chabbert CD, Eberhart T, Flückiger-Mangual S, Vukolic A, Eichhoff O, Irmisch A, Alexander LT, Scibona E, Frederick DT, Miao B, Tian T, Cheng C, Kwong LN, Wei Z, Sullivan RJ, Boland GM, Herlyn M, Flaherty KT, Zamboni N, Dummer R, Zhang G, Levesque MP, Krek W, Kovacs WJ.

Clin Cancer Res. 2019 Aug 2. doi: 10.1158/1078-0432.CCR-19-0253. [Epub ahead of print]

PMID:
31375515
3.

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.

Zurkirchen L, Varum S, Giger S, Klug A, Häusel J, Bossart R, Zemke M, Cantù C, Atak ZK, Zamboni N, Basler K, Sommer L.

Nat Commun. 2019 May 16;10(1):2192. doi: 10.1038/s41467-019-09823-5.

4.

Metabolomics reveals tepotinib-related mitochondrial dysfunction in MET-activating mutations-driven models.

Poliaková M, Felser A, Pierzchala K, Nuoffer JM, Aebersold DM, Zimmer Y, Zamboni N, Medová M.

FEBS J. 2019 Jul;286(14):2692-2710. doi: 10.1111/febs.14852. Epub 2019 May 11.

PMID:
30993872
5.

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation.

Varum S, Baggiolini A, Zurkirchen L, Atak ZK, Cantù C, Marzorati E, Bossart R, Wouters J, Häusel J, Tuncer E, Zingg D, Veen D, John N, Balz M, Levesque MP, Basler K, Aerts S, Zamboni N, Dummer R, Sommer L.

Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9. doi: 10.1016/j.stem.2019.03.011.

PMID:
30951662
6.

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J.

Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11.

PMID:
30642763
7.

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.

Balaz M, Becker AS, Balazova L, Straub L, Müller J, Gashi G, Maushart CI, Sun W, Dong H, Moser C, Horvath C, Efthymiou V, Rachamin Y, Modica S, Zellweger C, Bacanovic S, Stefanicka P, Varga L, Ukropcova B, Profant M, Opitz L, Amri EZ, Akula MK, Bergo M, Ukropec J, Falk C, Zamboni N, Betz MJ, Burger IA, Wolfrum C.

Cell Metab. 2019 Apr 2;29(4):901-916.e8. doi: 10.1016/j.cmet.2018.11.017. Epub 2018 Dec 20.

PMID:
30581121
8.

Quantification of Cellular Folate Species by LC-MS after Stabilization by Derivatization.

Schittmayer M, Birner-Gruenberger R, Zamboni N.

Anal Chem. 2018 Jun 19;90(12):7349-7356. doi: 10.1021/acs.analchem.8b00650. Epub 2018 Jun 5.

9.

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation.

Muri J, Heer S, Matsushita M, Pohlmeier L, Tortola L, Fuhrer T, Conrad M, Zamboni N, Kisielow J, Kopf M.

Nat Commun. 2018 May 10;9(1):1851. doi: 10.1038/s41467-018-04274-w.

10.

Metabolomics and Transcriptomics Identify Multiple Downstream Targets of Paraburkholderia phymatum σ54 During Symbiosis with Phaseolus vulgaris.

Lardi M, Liu Y, Giudice G, Ahrens CH, Zamboni N, Pessi G.

Int J Mol Sci. 2018 Apr 1;19(4). pii: E1049. doi: 10.3390/ijms19041049.

11.

Liposome-supported peritoneal dialysis in the treatment of severe hyperammonemia: An investigation on potential interactions.

Giacalone G, Matoori S, Agostoni V, Forster V, Kabbaj M, Eggenschwiler S, Lussi M, De Gottardi A, Zamboni N, Leroux JC.

J Control Release. 2018 May 28;278:57-65. doi: 10.1016/j.jconrel.2018.03.030. Epub 2018 Mar 27.

PMID:
29601930
12.

Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.

Lasar D, Rosenwald M, Kiehlmann E, Balaz M, Tall B, Opitz L, Lidell ME, Zamboni N, Krznar P, Sun W, Varga L, Stefanicka P, Ukropec J, Nuutila P, Virtanen K, Amri EZ, Enerbäck S, Wahli W, Wolfrum C.

Cell Rep. 2018 Jan 16;22(3):760-773. doi: 10.1016/j.celrep.2017.12.067.

13.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T.

Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034.

14.

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity.

Knobloch M, Pilz GA, Ghesquière B, Kovacs WJ, Wegleiter T, Moore DL, Hruzova M, Zamboni N, Carmeliet P, Jessberger S.

Cell Rep. 2017 Aug 29;20(9):2144-2155. doi: 10.1016/j.celrep.2017.08.029.

15.

Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection.

Zimmermann M, Kogadeeva M, Gengenbacher M, McEwen G, Mollenkopf HJ, Zamboni N, Kaufmann SHE, Sauer U.

mSystems. 2017 Aug 22;2(4). pii: e00057-17. doi: 10.1128/mSystems.00057-17. eCollection 2017 Jul-Aug.

16.

2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner.

Leni Z, Ćwiek P, Dimitrova V, Dulcey AS, Zamboni N, Simillion C, Rossi G, Leibundgut K, Arcaro A.

Oxid Med Cell Longev. 2017;2017:2487297. doi: 10.1155/2017/2487297. Epub 2017 Jul 26.

17.

Metabolic network segmentation: A probabilistic graphical modeling approach to identify the sites and sequential order of metabolic regulation from non-targeted metabolomics data.

Kuehne A, Mayr U, Sévin DC, Claassen M, Zamboni N.

PLoS Comput Biol. 2017 Jun 9;13(6):e1005577. doi: 10.1371/journal.pcbi.1005577. eCollection 2017 Jun.

18.

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.

Quirós PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J.

J Cell Biol. 2017 Jul 3;216(7):2027-2045. doi: 10.1083/jcb.201702058. Epub 2017 May 31.

19.

Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile.

Palermo A, Botrè F, de la Torre X, Zamboni N.

Anal Chim Acta. 2017 Apr 29;964:112-122. doi: 10.1016/j.aca.2017.01.055. Epub 2017 Jan 31.

PMID:
28351627
20.

An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo.

Kuehne A, Hildebrand J, Soehle J, Wenck H, Terstegen L, Gallinat S, Knott A, Winnefeld M, Zamboni N.

BMC Genomics. 2017 Feb 15;18(1):169. doi: 10.1186/s12864-017-3547-3.

21.

Genomewide landscape of gene-metabolome associations in Escherichia coli.

Fuhrer T, Zampieri M, Sévin DC, Sauer U, Zamboni N.

Mol Syst Biol. 2017 Jan 16;13(1):907. doi: 10.15252/msb.20167150.

22.

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

Ros S, Flöter J, Kaymak I, Da Costa C, Houddane A, Dubuis S, Griffiths B, Mitter R, Walz S, Blake S, Behrens A, Brindle KM, Zamboni N, Rider MH, Schulze A.

Oncogene. 2017 Jun 8;36(23):3287-3299. doi: 10.1038/onc.2016.477. Epub 2017 Jan 16.

PMID:
28092678
23.

Frontiers of high-throughput metabolomics.

Zampieri M, Sekar K, Zamboni N, Sauer U.

Curr Opin Chem Biol. 2017 Feb;36:15-23. doi: 10.1016/j.cbpa.2016.12.006. Epub 2017 Jan 5. Review.

PMID:
28064089
24.

Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics.

Dubuis S, Baenke F, Scherbichler N, Alexander LT, Schulze A, Zamboni N.

Metab Eng. 2017 Sep;43(Pt B):173-186. doi: 10.1016/j.ymben.2016.12.009. Epub 2016 Dec 27.

PMID:
28038952
25.

Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.

Sévin DC, Fuhrer T, Zamboni N, Sauer U.

Nat Methods. 2017 Feb;14(2):187-194. doi: 10.1038/nmeth.4103. Epub 2016 Dec 12.

PMID:
27941785
26.

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity.

Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A.

Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13.

27.

SUMOFLUX: A Generalized Method for Targeted 13C Metabolic Flux Ratio Analysis.

Kogadeeva M, Zamboni N.

PLoS Comput Biol. 2016 Sep 14;12(9):e1005109. doi: 10.1371/journal.pcbi.1005109. eCollection 2016 Sep.

28.

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Xu P, Oosterveer MH, Stein S, Demagny H, Ryu D, Moullan N, Wang X, Can E, Zamboni N, Comment A, Auwerx J, Schoonjans K.

Genes Dev. 2016 Jun 1;30(11):1255-60. doi: 10.1101/gad.277483.116.

29.

Systems proteomics of liver mitochondria function.

Williams EG, Wu Y, Jha P, Dubuis S, Blattmann P, Argmann CA, Houten SM, Amariuta T, Wolski W, Zamboni N, Aebersold R, Auwerx J.

Science. 2016 Jun 10;352(6291):aad0189. doi: 10.1126/science.aad0189.

30.

Metabolomic Profiling of Bradyrhizobium diazoefficiens-Induced Root Nodules Reveals Both Host Plant-Specific and Developmental Signatures.

Lardi M, Murset V, Fischer HM, Mesa S, Ahrens CH, Zamboni N, Pessi G.

Int J Mol Sci. 2016 May 27;17(6). pii: E815. doi: 10.3390/ijms17060815.

31.

A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism.

Gebauer J, Gentsch C, Mansfeld J, Schmeißer K, Waschina S, Brandes S, Klimmasch L, Zamboni N, Zarse K, Schuster S, Ristow M, Schäuble S, Kaleta C.

Cell Syst. 2016 May 25;2(5):312-22. doi: 10.1016/j.cels.2016.04.017. Epub 2016 May 19.

32.

The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression.

Ewald JC, Kuehne A, Zamboni N, Skotheim JM.

Mol Cell. 2016 May 19;62(4):532-45. doi: 10.1016/j.molcel.2016.02.017.

33.

Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet.

Vanderperre B, Herzig S, Krznar P, Hörl M, Ammar Z, Montessuit S, Pierredon S, Zamboni N, Martinou JC.

PLoS Genet. 2016 May 13;12(5):e1006056. doi: 10.1371/journal.pgen.1006056. eCollection 2016 May.

34.

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.

Badertscher L, Wild T, Montellese C, Alexander LT, Bammert L, Sarazova M, Stebler M, Csucs G, Mayer TU, Zamboni N, Zemp I, Horvath P, Kutay U.

Cell Rep. 2015 Dec 29;13(12):2879-91. doi: 10.1016/j.celrep.2015.11.061. Epub 2015 Dec 17.

35.

Climate change and glacier retreat drive shifts in an Antarctic benthic ecosystem.

Sahade R, Lagger C, Torre L, Momo F, Monien P, Schloss I, Barnes DK, Servetto N, Tarantelli S, Tatián M, Zamboni N, Abele D.

Sci Adv. 2015 Nov 13;1(10):e1500050. doi: 10.1126/sciadv.1500050. eCollection 2015 Nov.

36.

Gut Microbiota Orchestrates Energy Homeostasis during Cold.

Chevalier C, Stojanović O, Colin DJ, Suarez-Zamorano N, Tarallo V, Veyrat-Durebex C, Rigo D, Fabbiano S, Stevanović A, Hagemann S, Montet X, Seimbille Y, Zamboni N, Hapfelmeier S, Trajkovski M.

Cell. 2015 Dec 3;163(6):1360-74. doi: 10.1016/j.cell.2015.11.004.

37.

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.

Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M.

Nat Commun. 2015 Dec 1;6:10043. doi: 10.1038/ncomms10043.

38.

Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations.

Rolfs F, Huber M, Kuehne A, Kramer S, Haertel E, Muzumdar S, Wagner J, Tanner Y, Böhm F, Smola S, Zamboni N, Levesque MP, Dummer R, Beer HD, Hohl D, Werner S, Schäfer M.

Cancer Res. 2015 Nov 15;75(22):4817-29. doi: 10.1158/0008-5472.CAN-15-0614. Epub 2015 Nov 3.

39.

Dynamic exometabolome analysis reveals active metabolic pathways in non-replicating mycobacteria.

Zimmermann M, Kuehne A, Boshoff HI, Barry CE 3rd, Zamboni N, Sauer U.

Environ Microbiol. 2015 Nov;17(11):4802-15. doi: 10.1111/1462-2920.13056. Epub 2015 Oct 14.

PMID:
26373870
40.

Real-time metabolome profiling of the metabolic switch between starvation and growth.

Link H, Fuhrer T, Gerosa L, Zamboni N, Sauer U.

Nat Methods. 2015 Nov;12(11):1091-7. doi: 10.1038/nmeth.3584. Epub 2015 Sep 14.

PMID:
26366986
41.

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect.

Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou JC.

Mol Cell. 2015 Aug 6;59(3):491-501. doi: 10.1016/j.molcel.2015.06.035.

42.

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells.

Kuehne A, Emmert H, Soehle J, Winnefeld M, Fischer F, Wenck H, Gallinat S, Terstegen L, Lucius R, Hildebrand J, Zamboni N.

Mol Cell. 2015 Aug 6;59(3):359-71. doi: 10.1016/j.molcel.2015.06.017. Epub 2015 Jul 16.

43.

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.

Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W.

Nature. 2015 Jun 25;522(7557):444-449. doi: 10.1038/nature14508. Epub 2015 Jun 17.

44.

Defining the metabolome: size, flux, and regulation.

Zamboni N, Saghatelian A, Patti GJ.

Mol Cell. 2015 May 21;58(4):699-706. doi: 10.1016/j.molcel.2015.04.021. Review.

45.

Rapid, randomized development of genetically encoded FRET sensors for small molecules.

Peroza EA, Boumezbeur AH, Zamboni N.

Analyst. 2015 Jul 7;140(13):4540-8. doi: 10.1039/c5an00707k.

PMID:
25988853
46.

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.

Baenke F, Dubuis S, Brault C, Weigelt B, Dankworth B, Griffiths B, Jiang M, Mackay A, Saunders B, Spencer-Dene B, Ros S, Stamp G, Reis-Filho JS, Howell M, Zamboni N, Schulze A.

J Pathol. 2015 Oct;237(2):152-65. doi: 10.1002/path.4562. Epub 2015 Jun 4.

PMID:
25965974
47.

A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.

48.

A genetically encoded Förster resonance energy transfer sensor for monitoring in vivo trehalose-6-phosphate dynamics.

Peroza EA, Ewald JC, Parakkal G, Skotheim JM, Zamboni N.

Anal Biochem. 2015 Apr 1;474:1-7. doi: 10.1016/j.ab.2014.12.019. Epub 2015 Jan 9.

49.

Editorial overview: analytical biotechnology.

Sikes HD, Zamboni N.

Curr Opin Biotechnol. 2015 Feb;31:iv-vi. doi: 10.1016/j.copbio.2014.12.001. Epub 2014 Dec 16. No abstract available.

PMID:
25529264
50.

Biological insights through nontargeted metabolomics.

Sévin DC, Kuehne A, Zamboni N, Sauer U.

Curr Opin Biotechnol. 2015 Aug;34:1-8. doi: 10.1016/j.copbio.2014.10.001. Epub 2014 Oct 22. Review.

PMID:
25461505

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