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Items: 1 to 50 of 101

1.

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.

de Castro-Jorge LA, de Carvalho RVH, Klein TM, Hiroki CH, Lopes AH, Guimarães RM, Fumagalli MJ, Floriano VG, Agostinho MR, Slhessarenko RD, Ramalho FS, Cunha TM, Cunha FQ, da Fonseca BAL, Zamboni DS.

PLoS Pathog. 2019 Sep 3;15(9):e1007934. doi: 10.1371/journal.ppat.1007934. eCollection 2019 Sep.

2.

Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis.

Ketelut-Carneiro N, Souza COS, Benevides L, Gardinassi LG, Silva MC, Tavares LA, Zamboni DS, Silva JS.

PLoS Pathog. 2019 Aug 19;15(8):e1007990. doi: 10.1371/journal.ppat.1007990. eCollection 2019 Aug.

3.

Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout.

Tavares LD, Galvão I, Costa VV, Batista NV, Rossi LCR, Brito CB, Reis AC, Queiroz-Junior CM, Braga AD, Coelho FM, Dias AC, Zamboni DS, Pinho V, Teixeira MM, Amaral FA, Souza DG.

J Leukoc Biol. 2019 Sep;106(3):619-629. doi: 10.1002/JLB.MA1118-470RR. Epub 2019 Aug 8.

PMID:
31392775
4.

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

Gonçalves AV, Margolis SR, Quirino GFS, Mascarenhas DPA, Rauch I, Nichols RD, Ansaldo E, Fontana MF, Vance RE, Zamboni DS.

PLoS Pathog. 2019 Jun 28;15(6):e1007886. doi: 10.1371/journal.ppat.1007886. eCollection 2019 Jun.

5.

Inflammasomes and Leishmania: in good times or bad, in sickness or in health.

Zamboni DS, Sacks DL.

Curr Opin Microbiol. 2019 Jun 20;52:70-76. doi: 10.1016/j.mib.2019.05.005. [Epub ahead of print] Review.

PMID:
31229882
6.

Systems analysis of subjects acutely infected with the Chikungunya virus.

Soares-Schanoski A, Baptista Cruz N, de Castro-Jorge LA, de Carvalho RVH, Santos CAD, Rós ND, Oliveira Ú, Costa DD, Santos CLSD, Cunha MDP, Oliveira MLS, Alves JC, Océa RALC, Ribeiro DR, Gonçalves ANA, Gonzalez-Dias P, Suhrbier A, Zanotto PMA, Azevedo IJ, Zamboni DS, Almeida RP, Ho PL, Kalil J, Nishiyama MY Junior, Nakaya HI.

PLoS Pathog. 2019 Jun 18;15(6):e1007880. doi: 10.1371/journal.ppat.1007880. eCollection 2019 Jun.

7.

Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication.

de Carvalho RVH, Silva ALN, Santos LL, Andrade WA, de Sá KSG, Zamboni DS.

J Leukoc Biol. 2019 Sep;106(3):631-640. doi: 10.1002/JLB.MA1118-471R. Epub 2019 May 7.

PMID:
31063608
8.

Inflammasome Activation in Legionella-Infected Macrophages.

Mascarenhas DPA, Zamboni DS.

Methods Mol Biol. 2019;1921:305-319. doi: 10.1007/978-1-4939-9048-1_20.

PMID:
30694501
9.

NLRP12 Attenuates Inflammatory Bone Loss in Experimental Apical Periodontitis.

Taira TM, Lima V, Prado DS, Silva TA, Issa JPM, da Silva LAB, Zamboni DS, Cunha FQ, Fukada SY.

J Dent Res. 2019 Apr;98(4):476-484. doi: 10.1177/0022034518820289. Epub 2019 Jan 25.

PMID:
30681895
10.

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome.

de Carvalho RVH, Andrade WA, Lima-Junior DS, Dilucca M, de Oliveira CV, Wang K, Nogueira PM, Rugani JN, Soares RP, Beverley SM, Shao F, Zamboni DS.

Cell Rep. 2019 Jan 8;26(2):429-437.e5. doi: 10.1016/j.celrep.2018.12.047.

11.

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.

Cerqueira DM, Gomes MTR, Silva ALN, Rungue M, Assis NRG, Guimarães ES, Morais SB, Broz P, Zamboni DS, Oliveira SC.

PLoS Pathog. 2018 Dec 27;14(12):e1007519. doi: 10.1371/journal.ppat.1007519. eCollection 2018 Dec.

12.

Inhibition of inflammasome activation by a clinical strain of Klebsiella pneumoniae impairs efferocytosis and leads to bacterial dissemination.

Codo AC, Saraiva AC, Dos Santos LL, Visconde MF, Gales AC, Zamboni DS, Medeiros AI.

Cell Death Dis. 2018 Dec 5;9(12):1182. doi: 10.1038/s41419-018-1214-5.

13.

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.

Santa-Cecília FV, Ferreira DW, Guimaraes RM, Cecilio NT, Fonseca MM, Lopes AH, Davoli-Ferreira M, Kusuda R, Souza GR, Nachbur U, Alves-Filho JC, Teixeira MM, Zamboni DS, Cunha FQ, Cunha TM.

Pain. 2019 Jan;160(1):102-116. doi: 10.1097/j.pain.0000000000001383.

PMID:
30169421
14.

Absence of NOD2 receptor predisposes to intestinal inflammation by a deregulation in the immune response in hosts that are unable to control gut dysbiosis.

de Souza PR, Guimarães FR, Sales-Campos H, Bonfá G, Nardini V, Chica JEL, Turato WM, Silva JS, Zamboni DS, Cardoso CRB.

Immunobiology. 2018 Oct;223(10):577-585. doi: 10.1016/j.imbio.2018.07.003. Epub 2018 Jul 6.

PMID:
30041769
15.

The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88.

Sônego F, Castanheira FVS, Horta CV, Kanashiro A, Czaikoski PG, Zamboni DS, Alves-Filho JC, Cunha FQ.

Inflamm Res. 2018 May;67(5):435-443. doi: 10.1007/s00011-018-1135-x. Epub 2018 Feb 15.

PMID:
29450586
16.

IL-1β Production by Intermediate Monocytes Is Associated with Immunopathology in Cutaneous Leishmaniasis.

Santos D, Campos TM, Saldanha M, Oliveira SC, Nascimento M, Zamboni DS, Machado PR, Arruda S, Scott P, Carvalho EM, Carvalho LP.

J Invest Dermatol. 2018 May;138(5):1107-1115. doi: 10.1016/j.jid.2017.11.029. Epub 2017 Dec 12.

17.

The P2X7 Receptor Mediates Toxoplasma gondii Control in Macrophages through Canonical NLRP3 Inflammasome Activation and Reactive Oxygen Species Production.

Moreira-Souza ACA, Almeida-da-Silva CLC, Rangel TP, Rocha GDC, Bellio M, Zamboni DS, Vommaro RC, Coutinho-Silva R.

Front Immunol. 2017 Oct 12;8:1257. doi: 10.3389/fimmu.2017.01257. eCollection 2017.

18.

Inflammasome-dependent Mechanisms Involved in Sensing and Restriction of Bacterial Replication.

Andrade WA, Zamboni DS.

Curr Issues Mol Biol. 2018;25:99-132. doi: 10.21775/cimb.025.099. Epub 2017 Sep 6. Review.

PMID:
28875942
19.

Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication.

Lima-Junior DS, Mineo TWP, Calich VLG, Zamboni DS.

J Immunol. 2017 Sep 15;199(6):2055-2068. doi: 10.4049/jimmunol.1700258. Epub 2017 Aug 7.

20.

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.

Mascarenhas DPA, Cerqueira DM, Pereira MSF, Castanheira FVS, Fernandes TD, Manin GZ, Cunha LD, Zamboni DS.

PLoS Pathog. 2017 Aug 3;13(8):e1006502. doi: 10.1371/journal.ppat.1006502. eCollection 2017 Aug.

21.

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome.

Cunha LD, Silva ALN, Ribeiro JM, Mascarenhas DPA, Quirino GFS, Santos LL, Flavell RA, Zamboni DS.

Cell Rep. 2017 Jul 25;20(4):794-805. doi: 10.1016/j.celrep.2017.06.086.

22.

NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis.

Feriotti C, de Araújo EF, Loures FV, da Costa TA, Galdino NAL, Zamboni DS, Calich VLG.

Front Immunol. 2017 Jul 10;8:786. doi: 10.3389/fimmu.2017.00786. eCollection 2017.

23.

Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection.

Franco LH, Fleuri AKA, Pellison NC, Quirino GFS, Horta CV, de Carvalho RVH, Oliveira SC, Zamboni DS.

J Biol Chem. 2017 Aug 11;292(32):13087-13096. doi: 10.1074/jbc.M117.780981. Epub 2017 Jun 12.

24.

Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine.

Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogolín M, Zamboni DS, Ferreira G, Cairoli E, Hill M.

Sci Rep. 2017 May 15;7(1):1892. doi: 10.1038/s41598-017-01836-8.

25.

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.

Nascimento DC, Melo PH, Piñeros AR, Ferreira RG, Colón DF, Donate PB, Castanheira FV, Gozzi A, Czaikoski PG, Niedbala W, Borges MC, Zamboni DS, Liew FY, Cunha FQ, Alves-Filho JC.

Nat Commun. 2017 Apr 4;8:14919. doi: 10.1038/ncomms14919.

26.

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model.

Carlos D, Costa FR, Pereira CA, Rocha FA, Yaochite JN, Oliveira GG, Carneiro FS, Tostes RC, Ramos SG, Zamboni DS, Camara NO, Ryffel B, Silva JS.

Front Immunol. 2017 Feb 27;8:164. doi: 10.3389/fimmu.2017.00164. eCollection 2017.

27.

The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.

Gonçalves AC, Ferreira LS, Manente FA, de Faria CMQG, Polesi MC, de Andrade CR, Zamboni DS, Carlos IZ.

Immunology. 2017 Jun;151(2):154-166. doi: 10.1111/imm.12719. Epub 2017 Mar 3.

28.

Inflammasome biology taught by Legionella pneumophila.

Mascarenhas DP, Zamboni DS.

J Leukoc Biol. 2017 Apr;101(4):841-849. doi: 10.1189/jlb.3MR0916-380R. Epub 2016 Dec 20. Review.

PMID:
27999148
29.

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

Massis LM, Assis-Marques MA, Castanheira FV, Capobianco YJ, Balestra AC, Escoll P, Wood RE, Manin GZ, Correa VM, Alves-Filho JC, Cunha FQ, Buchrieser C, Borges MC, Newton HJ, Zamboni DS.

J Infect Dis. 2017 Feb 1;215(3):440-451. doi: 10.1093/infdis/jiw560.

PMID:
27932612
30.

NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model.

Chaves de Souza JA, Frasnelli SC, Curylofo-Zotti FA, Ávila-Campos MJ, Spolidório LC, Zamboni DS, Graves DT, Rossa C Jr.

Immunology. 2016 Dec;149(4):374-385. doi: 10.1111/imm.12654. Epub 2016 Sep 6.

31.

NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage.

Bruder-Nascimento T, Ferreira NS, Zanotto CZ, Ramalho F, Pequeno IO, Olivon VC, Neves KB, Alves-Lopes R, Campos E, Silva CA, Fazan R, Carlos D, Mestriner FL, Prado D, Pereira FV, Braga T, Luiz JP, Cau SB, Elias PC, Moreira AC, Câmara NO, Zamboni DS, Alves-Filho JC, Tostes RC.

Circulation. 2016 Dec 6;134(23):1866-1880. Epub 2016 Nov 1.

PMID:
27803035
32.

NOD2-RIP2-Mediated Signaling Helps Shape Adaptive Immunity in Visceral Leishmaniasis.

Nascimento MS, Ferreira MD, Quirino GF, Maruyama SR, Krishnaswamy JK, Liu D, Berlink J, Fonseca DM, Zamboni DS, Carregaro V, Almeida RP, Cunha TM, Eisenbarth SS, Silva JS.

J Infect Dis. 2016 Dec 1;214(11):1647-1657. Epub 2016 Sep 20.

PMID:
27651416
33.

Role of NOD2 and RIP2 in host-microbe interactions with Gram-negative bacteria: insights from the periodontal disease model.

Souza JA, Medeiros MC, Rocha FR, de Aquino SG, Ávila-Campos MJ, Spolidorio LC, Zamboni DS, Graves DT, Rossa C Junior.

Innate Immun. 2016 Nov;22(8):598-611. doi: 10.1177/1753425916666652. Epub 2016 Sep 22.

34.

Nucleotide-binding oligomerization domain-containing protein 2 prompts potent inflammatory stimuli during Neospora caninum infection.

Davoli-Ferreira M, Fonseca DM, Mota CM, Dias MS, Lima-Junior DS, da Silva MV, Quirino GF, Zamboni DS, Silva JS, Mineo TW.

Sci Rep. 2016 Jul 5;6:29289. doi: 10.1038/srep29289.

35.

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset.

Costa FR, Françozo MC, de Oliveira GG, Ignacio A, Castoldi A, Zamboni DS, Ramos SG, Câmara NO, de Zoete MR, Palm NW, Flavell RA, Silva JS, Carlos D.

J Exp Med. 2016 Jun 27;213(7):1223-39. doi: 10.1084/jem.20150744. Epub 2016 Jun 20.

36.

Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase II In Vitro.

Fernandes TD, Cunha LD, Ribeiro JM, Massis LM, Lima-Junior DS, Newton HJ, Zamboni DS.

Infect Immun. 2016 Aug 19;84(9):2439-48. doi: 10.1128/IAI.00411-16. Print 2016 Sep.

37.

Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.

Zoccal KF, Sorgi CA, Hori JI, Paula-Silva FW, Arantes EC, Serezani CH, Zamboni DS, Faccioli LH.

Nat Commun. 2016 Feb 23;7:10760. doi: 10.1038/ncomms10760.

38.

Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages.

Bradley WP, Boyer MA, Nguyen HT, Birdwell LD, Yu J, Ribeiro JM, Weiss SR, Zamboni DS, Roy CR, Shin S.

Infect Immun. 2016 Mar 24;84(4):998-1015. doi: 10.1128/IAI.01536-15. Print 2016 Apr.

39.

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA.

Cunha LD, Ribeiro JM, Fernandes TD, Massis LM, Khoo CA, Moffatt JH, Newton HJ, Roy CR, Zamboni DS.

Nat Commun. 2015 Dec 21;6:10205. doi: 10.1038/ncomms10205.

40.

Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo.

Cerqueira DM, Pereira MS, Silva AL, Cunha LD, Zamboni DS.

J Immunol. 2015 Sep 1;195(5):2303-11. doi: 10.4049/jimmunol.1501223. Epub 2015 Jul 31.

41.

Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis.

Franca R, Vieira SM, Talbot J, Peres RS, Pinto LG, Zamboni DS, Louzada-Junior P, Cunha FQ, Cunha TM.

Scand J Rheumatol. 2016 Jan;45(1):8-12. doi: 10.3109/03009742.2015.1047403. Epub 2015 Jul 23.

PMID:
26202066
42.

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection.

Ramos-Junior ES, Morandini AC, Almeida-da-Silva CL, Franco EJ, Potempa J, Nguyen KA, Oliveira AC, Zamboni DS, Ojcius DM, Scharfstein J, Coutinho-Silva R.

J Dent Res. 2015 Sep;94(9):1233-42. doi: 10.1177/0022034515593465. Epub 2015 Jul 7.

43.

Inflammasomes in host response to protozoan parasites.

Zamboni DS, Lima-Junior DS.

Immunol Rev. 2015 May;265(1):156-71. doi: 10.1111/imr.12291. Review.

PMID:
25879291
44.

IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection.

Ketelut-Carneiro N, Silva GK, Rocha FA, Milanezi CM, Cavalcanti-Neto FF, Zamboni DS, Silva JS.

J Immunol. 2015 May 1;194(9):4507-17. doi: 10.4049/jimmunol.1402321. Epub 2015 Mar 30.

45.

Nucleotide-binding oligomerization domain-2 (NOD2) regulates type-1 cytokine responses to Mycobacterium avium but is not required for host control of infection.

Carvalho NB, Oliveira FS, Marinho FA, de Almeida LA, Fahel JS, Báfica A, Rothfuchs AG, Zamboni DS, Caliari MV, Oliveira SC.

Microbes Infect. 2015 May;17(5):337-44. doi: 10.1016/j.micinf.2015.03.009. Epub 2015 Mar 27.

PMID:
25817335
46.

Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain.

Lopes AH, Talbot J, Silva RL, Lima JB, França RO, Verri WA Jr, Mascarenhas DP, Ryffel B, Cunha FQ, Zamboni DS, Cunha TM.

Pain. 2015 Mar;156(3):451-9. doi: 10.1097/01.j.pain.0000460322.72396.53.

PMID:
25687541
47.

Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.

Galvani RG, Lemos R, Areal RB, Salvador PA, Zamboni DS, Wanderley JL, Bonomo A.

PLoS One. 2015 Feb 2;10(2):e0118079. doi: 10.1371/journal.pone.0118079. eCollection 2015.

48.

Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma.

Gasparoto TH, de Oliveira CE, de Freitas LT, Pinheiro CR, Hori JI, Garlet GP, Cavassani KA, Schillaci R, da Silva JS, Zamboni DS, Campanelli AP.

PLoS One. 2014 Sep 30;9(9):e107170. doi: 10.1371/journal.pone.0107170. eCollection 2014.

49.

NOD2 contributes to Porphyromonas gingivalis-induced bone resorption.

Prates TP, Taira TM, Holanda MC, Bignardi LA, Salvador SL, Zamboni DS, Cunha FQ, Fukada SY.

J Dent Res. 2014 Nov;93(11):1155-62. doi: 10.1177/0022034514551770. Epub 2014 Sep 19.

50.

Hemolysis-induced lethality involves inflammasome activation by heme.

Dutra FF, Alves LS, Rodrigues D, Fernandez PL, de Oliveira RB, Golenbock DT, Zamboni DS, Bozza MT.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4110-8. doi: 10.1073/pnas.1405023111. Epub 2014 Sep 15.

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