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Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E467-71. doi: 10.1073/pnas.1418264112. Epub 2014 Dec 22.

Fear and C-reactive protein cosynergize annual pulse increases in healthy adults.

Author information

1
The Edmond and Lily Safra Center of Brain Science and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel;
2
Department of Internal Medicine "D&E," Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel;
3
Faculty of Management, Tel Aviv University, Tel Aviv 69978, Israel; and.
4
Department of Statistics and the Center for Rationality, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
5
The Edmond and Lily Safra Center of Brain Science and the Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; soreq@cc.huji.ac.il.

Abstract

Recent international terror outbreaks notably involve long-term mental health risks to the exposed population, but whether physical health risks are also anticipated has remained unknown. Here, we report fear of terror-induced annual increases in resting heart rate (pulse), a notable risk factor of all-cause mortality. Partial least squares analysis based on 325 measured parameters successfully predicted annual pulse increases, inverse to the expected age-related pulse decline, in approximately 4.1% of a cohort of 17,380 apparently healthy active Israeli adults. Nonbiased hierarchical regression analysis among 27 of those parameters identified pertinent fear of terror combined with the inflammatory biomarker C-reactive protein as prominent coregulators of the observed annual pulse increases. In comparison, basal pulse primarily depended on general physiological parameters and reduced cholinergic control over anxiety and inflammation, together indicating that consistent exposure to terror threats ignites fear-induced exacerbation of preexisting neuro-immune risks of all-cause mortality.

KEYWORDS:

C-reactive protein; acetylcholinesterase; cholinergic status; pulse; terror

Comment in

PMID:
25535364
PMCID:
PMC4321278
DOI:
10.1073/pnas.1418264112
[Indexed for MEDLINE]
Free PMC Article

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