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Items: 1 to 50 of 61

1.

Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase.

Berhe S, Slupe A, Luster C, Charlier HA Jr, Warner DL, Zalkow LH, Burgess EM, Enwerem NM, Bakare O.

Bioorg Med Chem. 2010 Jan 1;18(1):134-41. doi: 10.1016/j.bmc.2009.11.011. Epub 2009 Nov 10.

2.

Synthesis and MEK1 inhibitory activities of imido-substituted 2-chloro-1,4-naphthoquinones.

Bakare O, Ashendel CL, Peng H, Zalkow LH, Burgess EM.

Bioorg Med Chem. 2003 Jul 17;11(14):3165-70.

PMID:
12818679
3.

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases.

Peng H, Kim DI, Sarkaria JN, Cho YS, Abraham RT, Zalkow LH.

Bioorg Med Chem. 2002 Jan;10(1):167-74.

PMID:
11738618
4.

Structure-activity relationship of aza-steroids as PI-PLC inhibitors.

Xie W, Peng H, Kim DI, Kunkel M, Powis G, Zalkow LH.

Bioorg Med Chem. 2001 May;9(5):1073-83.

PMID:
11377165
5.

Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase.

Peng H, Xie W, Otterness DM, Cogswell JP, McConnell RT, Carter HL, Powis G, Abraham RT, Zalkow LH.

J Med Chem. 2001 Mar 1;44(5):834-48.

PMID:
11262093
6.

3Beta-hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity.

Xie W, Peng H, Zalkow LH, Li YH, Zhu C, Powis G, Kunkel M.

Bioorg Med Chem. 2000 Apr;8(4):699-706.

PMID:
10819158
7.

Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase.

Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham RT.

Bioorg Med Chem. 2000 Feb;8(2):299-306.

PMID:
10722152
8.

Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-alpha-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel.

Peng H, Zalkow LH, Abraham RT, Powis G.

J Med Chem. 1999 May 6;42(9):1682. No abstract available.

PMID:
10229637
9.

Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel.

Peng H, Zalkow LH, Abraham RT, Powis G.

J Med Chem. 1998 Nov 19;41(24):4677-80. No abstract available.

PMID:
9822537
10.

Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.

Farnet CM, Wang B, Hansen M, Lipford JR, Zalkow L, Robinson WE Jr, Siegel J, Bushman F.

Antimicrob Agents Chemother. 1998 Sep;42(9):2245-53.

11.

Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.

Rice WG, Turpin JA, Huang M, Clanton D, Buckheit RW Jr, Covell DG, Wallqvist A, McDonnell NB, DeGuzman RN, Summers MF, Zalkow L, Bader JP, Haugwitz RD, Sausville EA.

Nat Med. 1997 Mar;3(3):341-5.

PMID:
9055865
12.

Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues.

Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Dorr R, Dvorakova K, Salmon S, Harrison S, Worzalla J.

Cancer Chemother Pharmacol. 1997;41(1):22-8.

PMID:
9443610
13.

Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobene.

Halliday SM, Lackman-Smith C, Bader JP, Rice WG, Clanton DJ, Zalkow LH, Buckheit RW Jr.

Antiviral Res. 1996 Dec;33(1):41-53.

PMID:
8955852
14.

Antiviral activity of a derivative of the photosensitive compound Hypericin.

Yip L, Hudson JB, Gruszecka-Kowalik E, Zalkow LH, Neil Towers GH.

Phytomedicine. 1996 Sep;3(2):185-90. doi: 10.1016/S0944-7113(96)80034-1.

PMID:
23194968
15.

Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds.

Brunner G, Zalkow L, Burgess E, Rifkin DB, Wilson EL, Gruszecka-Kowalik E, Powis G.

Anticancer Res. 1996 Sep-Oct;16(5A):2513-6.

PMID:
8917344
16.

Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase.

Frew T, Powis G, Berggren M, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Gruszecka-Kowalik E, Burgess EM, et al.

Anticancer Drug Des. 1995 Jun;10(4):347-59.

PMID:
7786399
17.

Molecular similarity from atomic electrostatic multipole comparisons. Application to anti-HIV drugs.

Burgess EM, Ruell JA, Zalkow LH, Haugwitz RD.

J Med Chem. 1995 May 12;38(10):1635-40.

PMID:
7752188
18.

Advances with phospholipid signalling as a target for anticancer drug development.

Powis G, Berggren M, Gallegos A, Frew T, Hill S, Kozikowski A, Bonjouklian R, Zalkow L, Abraham R, Ashendel C, et al.

Acta Biochim Pol. 1995;42(4):395-403. Review.

19.

A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.

Frew T, Powis G, Berggren M, Abraham RT, Ashendel CL, Zalkow LH, Hudson C, Qazia S, Gruszecka-Kowalik E, Merriman R, et al.

Anticancer Res. 1994 Nov-Dec;14(6B):2425-8.

PMID:
7872663
20.

A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity.

Hill SR, Bonjouklian R, Powis G, Abraham RT, Ashendel CL, Zalkow LH.

Anticancer Drug Des. 1994 Aug;9(4):353-61.

PMID:
7916901
21.

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

Powis G, Bonjouklian R, Berggren MM, Gallegos A, Abraham R, Ashendel C, Zalkow L, Matter WF, Dodge J, Grindey G, et al.

Cancer Res. 1994 May 1;54(9):2419-23.

22.

Synthesis of 2-methyl-(Z)-4-(phenylimino)naphth[2,3-d]oxazol-9-one , a monoimine quinone with selective cytotoxicity toward cancer cells.

Benedetti-Doctorovich V, Burgess EM, Lambropoulos J, Lednicer D, Van Derveer D, Zalkow LH.

J Med Chem. 1994 Mar 4;37(5):710-2.

PMID:
8126711
23.

Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues.

Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R.

Cancer Chemother Pharmacol. 1994;34(4):344-50.

PMID:
8033301
24.

Quinobene, a new potent anti-HIV agent.

Gruszecka-Kowalik E, Haugwitz RD, Zalkow LH.

Biochem Biophys Res Commun. 1992 Sep 30;187(3):1409-17.

PMID:
1417817
25.

Synthesis and pharmacology of irreversible affinity labels as potential cocaine antagonists: aryl 1,4-dialkylpiperazines related to GBR-12783.

Deutsch HM, Schweri MM, Culbertson CT, Zalkow LH.

Eur J Pharmacol. 1992 Sep 22;220(2-3):173-80.

PMID:
1425990
26.

Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.

Zembower DE, Kam CM, Powers JC, Zalkow LH.

J Med Chem. 1992 May 1;35(9):1597-605.

PMID:
1578486
27.

Acetylanonamine, a new secopyrrolizidine alkaloid from Senecio anonymus.

Asibal CF, Zalkow LH, Gelbaum LT.

J Nat Prod. 1991 Sep-Oct;54(5):1425-6.

PMID:
1800641
28.
29.

Model systems for detecting the hepatic toxicity of pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides.

Moore DJ, Batts KP, Zalkow LL, Fortune GT Jr, Powis G.

Toxicol Appl Pharmacol. 1989 Nov;101(2):271-84.

PMID:
2815083
30.

Pyrrolizidine alkaloids from Heliotropium rotundifolium.

Asibal CF, Gelbaum LT, Zalkow LH.

J Nat Prod. 1989 Jul-Aug;52(4):726-31.

PMID:
2809605
31.

Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity.

Deutsch HM, Glinski JA, Hernandez M, Haugwitz RD, Narayanan VL, Suffness M, Zalkow LH.

J Med Chem. 1989 Apr;32(4):788-92.

PMID:
2564894
32.

Pyrrolizidine alkaloids from Cynoglossum creticum. Synthesis of the pyrrolizidine alkaloids echinatine, rinderine, and analogues.

Asibal CF, Glinski JA, Gelbaum LT, Zalkow LH.

J Nat Prod. 1989 Jan-Feb;52(1):109-18.

PMID:
2597280
33.
34.

Semisynthetic pyrrolizidine alkaloid N-oxide antitumor agents. Esters of heliotridine.

Zalkow LH, Glinski JA, Gelbaum LT, Moore D, Melder D, Powis G.

J Med Chem. 1988 Aug;31(8):1520-6.

PMID:
3397989
35.

Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.

Zalkow LH, Asibal CF, Glinski JA, Bonetti SJ, Gelbaum LT, VanDerveer D, Powis G.

J Nat Prod. 1988 Jul-Aug;51(4):690-702.

PMID:
3210016
36.

Capillary supercritical fluid chromatography of pyrrolizidine alkaloids.

Holzer G, Zalkow LH, Asibal CF.

J Chromatogr. 1987 Jul 29;400:317-22.

PMID:
3117819
38.

Prostaglandin involvement in the responses of the rabbit eye to water-soluble marihuana-derived material.

Green K, Cheeks KE, Watkins L, Bowman KA, McDonald TF, Ocasio H, Deutsch HM, Hodges LC, Zalkow LH.

Curr Eye Res. 1987 Feb;6(2):337-44.

PMID:
3568747
39.

Synthesis of congeners and prodrugs of the benzene maleimide photoadduct mitindomide as potential antitumor agents. 2.

Deutsch HM, Gelbaum LT, McLaughlin M, Fleischmann TJ, Earnhart LL, Haugwitz RD, Zalkow LH.

J Med Chem. 1986 Nov;29(11):2164-70.

PMID:
3783577
40.

Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogues and their N-oxides. Potential antitumor agents.

Zalkow LH, Glinski JA, Gelbaum LT, Fleischmann TJ, McGowan LS, Gordon MM.

J Med Chem. 1985 Jun;28(6):687-94.

PMID:
4009589
41.

Marihuana-derived material: biochemical studies of the ocular responses.

Green K, Cheeks K, Mittag T, Riley MV, Symonds CM, Deutsch HM, Hodges LC, Zalkow LH.

Curr Eye Res. 1985 May;4(5):631-9.

PMID:
3160544
42.

Marihuana-derived material: distribution and effects after systemic administration.

Green K, Cheeks K, Bowman KA, Hodges LC, Deutsch HM, Zalkow LH.

Curr Eye Res. 1984 May;3(5):751-61.

PMID:
6734256
43.

Induction by carrot allelochemicals of insecticide-metabolising enzymes in the southern armyworm (Spodoptera eridania).

Brattsten LB, Evans CK, Bonetti S, Zalkow LH.

Comp Biochem Physiol C. 1984;77(1):29-37.

PMID:
6141878
44.

Cuticular hydrocarbons ofReticulitermes virginicus (Banks) and their role as potential species- and caste-recognition cues.

Howard RW, McDaniel CA, Nelson DR, Blomquist GJ, Gelbaum LT, Zalkow LH.

J Chem Ecol. 1982 Sep;8(9):1227-39. doi: 10.1007/BF00990755.

PMID:
24413965
45.

Synthesis of naphthoquinoles as potential antitumor agents related to jacaranone.

Deutsch HM, Zalkow LH.

J Nat Prod. 1982 Jul-Aug;45(4):390-2.

PMID:
7130984
46.

Cytotoxic agent from Senecio anonymus wood.

Gelbaum LT, Zalkow LH, Hamilton D.

J Nat Prod. 1982 May-Jun;45(3):370-2. No abstract available.

PMID:
7119810
47.

Isolation of ocular hypotensive agents from Cannabis sativa.

Deutsch HM, Green K, Zalkow LH.

J Clin Pharmacol. 1981 Aug-Sep;21(S1):479S-485S.

PMID:
7298874
48.

Chemical ecology ofReticulitermes flavipes (Kollar) andR. virginicus (Banks) (Rhinotermitidae) : Chemistry of the soldier cephalic secretions.

Zalkow LH, Howard RW, Gelbaum LT, Gordon MM, Deutsch HM, Blum MS.

J Chem Ecol. 1981 Jul;7(4):717-31. doi: 10.1007/BF00990304.

PMID:
24420686
49.

Water soluble marihuana-derived material: pharmacological actions in rabbit and primate.

Green K, Symonds CM, Elijah RD, Zalkow LH, Deutsch HM, Bowman KA, Morgan TR.

Curr Eye Res. 1981-1982;1(10):599-608.

PMID:
7344831
50.

Ocular and systemic responses to water soluble material derived from Cannabis sativa (marihuana).

Green K, Zalkow LH, Deutsch HM, Yablonski ME, Oliver N, Symonds CM, Elijah RD.

Curr Eye Res. 1981;1(2):65-75.

PMID:
6117418

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