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Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation.

Poupin N, Corlu A, Cabaton NJ, Dubois-Pot-Schneider H, Canlet C, Person E, Bruel S, Frainay C, Vinson F, Maurier F, Morel F, Robin MA, Fromenty B, Zalko D, Jourdan F.

J Proteome Res. 2019 Jan 4;18(1):204-216. doi: 10.1021/acs.jproteome.8b00524. Epub 2018 Nov 19.


Comparison of the metabolism of 10 chemicals in human and pig skin explants.

Géniès C, Jamin EL, Debrauwer L, Zalko D, Person EN, Eilstein J, Grégoire S, Schepky A, Lange D, Ellison C, Roe A, Salhi S, Cubberley R, Hewitt NJ, Rothe H, Klaric M, Duplan H, Jacques-Jamin C.

J Appl Toxicol. 2019 Feb;39(2):385-397. doi: 10.1002/jat.3730. Epub 2018 Oct 21.


An Untargeted Metabolomics Approach to Investigate the Metabolic Modulations of HepG2 Cells Exposed to Low Doses of Bisphenol A and 17β-Estradiol.

Cabaton NJ, Poupin N, Canlet C, Tremblay-Franco M, Audebert M, Cravedi JP, Riu A, Jourdan F, Zalko D.

Front Endocrinol (Lausanne). 2018 Sep 25;9:571. doi: 10.3389/fendo.2018.00571. eCollection 2018.


Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet.

Kopp B, Vignard J, Mirey G, Fessard V, Zalko D, Le Hgarat L, Audebert M.

Environ Mol Mutagen. 2018 Oct;59(8):742-754. doi: 10.1002/em.22214. Epub 2018 Sep 19.


Assessment of a panel of cellular biomarkers and the kinetics of their induction in comparing genotoxic modes of action in HepG2 cells.

Kopp B, Dario M, Zalko D, Audebert M.

Environ Mol Mutagen. 2018 Jul;59(6):516-528. doi: 10.1002/em.22197. Epub 2018 Apr 18.


Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet: evidence from natural isotope abundances of nitrogen and carbon in tissue proteins.

Mantha OL, Polakof S, Huneau JF, Mariotti F, Poupin N, Zalko D, Fouillet H.

Br J Nutr. 2018 May;119(9):981-991. doi: 10.1017/S0007114518000326. Epub 2018 Mar 5.


Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines.

Kopp B, Zalko D, Audebert M.

Environ Mol Mutagen. 2018 Apr;59(3):202-210. doi: 10.1002/em.22157. Epub 2017 Nov 18.


Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles.

Bacqueville D, Jacques C, Duprat L, Jamin EL, Guiraud B, Perdu E, Bessou-Touya S, Zalko D, Duplan H.

Toxicol Appl Pharmacol. 2017 Aug 15;329:190-201. doi: 10.1016/j.taap.2017.05.040. Epub 2017 Jun 7.


Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis.

Desdoits-Lethimonier C, Lesné L, Gaudriault P, Zalko D, Antignac JP, Deceuninck Y, Platel C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B.

Hum Reprod. 2017 Jul 1;32(7):1465-1473. doi: 10.1093/humrep/dex093.


In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays.

Le Fol V, Aït-Aïssa S, Sonavane M, Porcher JM, Balaguer P, Cravedi JP, Zalko D, Brion F.

Ecotoxicol Environ Saf. 2017 Aug;142:150-156. doi: 10.1016/j.ecoenv.2017.04.009. Epub 2017 Apr 11.


Comparison of the In Vivo Biotransformation of Two Emerging Estrogenic Contaminants, BP2 and BPS, in Zebrafish Embryos and Adults.

Le Fol V, Brion F, Hillenweck A, Perdu E, Bruel S, Aït-Aïssa S, Cravedi JP, Zalko D.

Int J Mol Sci. 2017 Mar 25;18(4). pii: E704. doi: 10.3390/ijms18040704.


Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.

Chevereau M, Glatt H, Zalko D, Cravedi JP, Audebert M.

Arch Toxicol. 2017 Sep;91(9):3175-3184. doi: 10.1007/s00204-017-1935-8. Epub 2017 Feb 3.


Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey.

VandeVoort CA, Gerona RR, Vom Saal FS, Tarantal AF, Hunt PA, Hillenweck A, Zalko D.

PLoS One. 2016 Dec 8;11(12):e0165410. doi: 10.1371/journal.pone.0165410. eCollection 2016.


Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure.

Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B.

Environ Toxicol. 2017 Mar;32(3):1024-1036. doi: 10.1002/tox.22301. Epub 2016 Jun 20.


Bisphenol A Exposure Disrupts Neurotransmitters Through Modulation of Transaminase Activity in the Brain of Rodents.

Zalko D, Soto AM, Canlet C, Tremblay-Franco M, Jourdan F, Cabaton NJ.

Endocrinology. 2016 May;157(5):1736-9. doi: 10.1210/en.2016-1207. No abstract available.


Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic.

Lind L, Lind PM, Lejonklou MH, Dunder L, Bergman Å, Guerrero-Bosagna C, Lampa E, Lee HK, Legler J, Nadal A, Pak YK, Phipps RP, Vandenberg LN, Zalko D, Ågerstrand M, Öberg M, Blumberg B, Heindel JJ, Birnbaum LS.

Environ Health Perspect. 2016 May 1;124(5):A81-3. doi: 10.1289/ehp.1511115. No abstract available.


Dynamic Metabolic Disruption in Rats Perinatally Exposed to Low Doses of Bisphenol-A.

Tremblay-Franco M, Cabaton NJ, Canlet C, Gautier R, Schaeberle CM, Jourdan F, Sonnenschein C, Vinson F, Soto AM, Zalko D.

PLoS One. 2015 Oct 30;10(10):e0141698. doi: 10.1371/journal.pone.0141698. eCollection 2015.


Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening.

Khoury L, Zalko D, Audebert M.

Arch Toxicol. 2016 Aug;90(8):1983-95. doi: 10.1007/s00204-015-1599-1. Epub 2015 Sep 24.


Evaluation of four human cell lines with distinct biotransformation properties for genotoxic screening.

Khoury L, Zalko D, Audebert M.

Mutagenesis. 2016 Jan;31(1):83-96. doi: 10.1093/mutage/gev058. Epub 2015 Aug 3.


Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, maternal and cord serum of French women and their newborns.

Cariou R, Veyrand B, Yamada A, Berrebi A, Zalko D, Durand S, Pollono C, Marchand P, Leblanc JC, Antignac JP, Le Bizec B.

Environ Int. 2015 Nov;84:71-81. doi: 10.1016/j.envint.2015.07.014. Epub 2015 Jul 29.


An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes.

Ben Maamar M, Lesné L, Desdoits-Lethimonier C, Coiffec I, Lassurguère J, Lavoué V, Deceuninck Y, Antignac JP, Le Bizec B, Perdu E, Zalko D, Pineau C, Chevrier C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B.

PLoS One. 2015 Feb 23;10(2):e0117226. doi: 10.1371/journal.pone.0117226. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128051.


Cell-specific biotransformation of benzophenone-2 and bisphenol-s in zebrafish and human in vitro models used for toxicity and estrogenicity screening.

Le Fol V, Aït-Aïssa S, Cabaton N, Dolo L, Grimaldi M, Balaguer P, Perdu E, Debrauwer L, Brion F, Zalko D.

Environ Sci Technol. 2015 Mar 17;49(6):3860-8. doi: 10.1021/es505302c. Epub 2015 Mar 2.


Conjugation and deconjugation reactions within the fetoplacental compartment in a sheep model: a key factor determining bisphenol A fetal exposure.

Corbel T, Perdu E, Gayrard V, Puel S, Lacroix MZ, Viguié C, Toutain PL, Zalko D, Picard-Hagen N.

Drug Metab Dispos. 2015 Apr;43(4):467-76. doi: 10.1124/dmd.114.061291. Epub 2015 Jan 9.


Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring.

Byun HM, Benachour N, Zalko D, Frisardi MC, Colicino E, Takser L, Baccarelli AA.

Toxicology. 2015 Feb 3;328:152-9. doi: 10.1016/j.tox.2014.12.019. Epub 2014 Dec 19.


Effect of skin metabolism on dermal delivery of testosterone: qualitative assessment using a new short-term skin model.

Jacques C, Perdu E, Jamin EL, Cravedi JP, Mavon A, Duplan H, Zalko D.

Skin Pharmacol Physiol. 2014;27(4):188. doi: 10.1159/000351683. Epub 2014 Mar 15.


Halogenated bisphenol-A analogs act as obesogens in zebrafish larvae (Danio rerio).

Riu A, McCollum CW, Pinto CL, Grimaldi M, Hillenweck A, Perdu E, Zalko D, Bernard L, Laudet V, Balaguer P, Bondesson M, Gustafsson JA.

Toxicol Sci. 2014 May;139(1):48-58. doi: 10.1093/toxsci/kfu036. Epub 2014 Mar 3.


Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells.

Khoury L, Zalko D, Audebert M.

Environ Mol Mutagen. 2013 Dec;54(9):737-46. doi: 10.1002/em.21817. Epub 2013 Sep 17.


Disposition of fipronil in rats.

Cravedi JP, Delous G, Zalko D, Viguié C, Debrauwer L.

Chemosphere. 2013 Nov;93(10):2276-83. doi: 10.1016/j.chemosphere.2013.07.083. Epub 2013 Sep 6.


Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis.

Jamin EL, Riu A, Douki T, Debrauwer L, Cravedi JP, Zalko D, Audebert M.

PLoS One. 2013;8(3):e58591. doi: 10.1371/journal.pone.0058591. Epub 2013 Mar 6.


Effects of low doses of bisphenol A on the metabolome of perinatally exposed CD-1 mice.

Cabaton NJ, Canlet C, Wadia PR, Tremblay-Franco M, Gautier R, Molina J, Sonnenschein C, Cravedi JP, Rubin BS, Soto AM, Zalko D.

Environ Health Perspect. 2013 May;121(5):586-93. doi: 10.1289/ehp.1205588. Epub 2013 Feb 21.


Characterization of endocrine disruptors from a complex matrix using estrogen receptor affinity columns and high performance liquid chromatography-high resolution mass spectrometry.

Jondeau-Cabaton A, Soucasse A, Jamin EL, Creusot N, Grimaldi M, Jouanin I, Aït-Aïssa S, Balaguer P, Debrauwer L, Zalko D.

Environ Sci Pollut Res Int. 2013 May;20(5):2705-20. doi: 10.1007/s11356-012-1458-z. Epub 2013 Jan 15.


Human testis steroidogenesis is inhibited by phthalates.

Desdoits-Lethimonier C, Albert O, Le Bizec B, Perdu E, Zalko D, Courant F, Lesné L, Guillé F, Dejucq-Rainsford N, Jégou B.

Hum Reprod. 2012 May;27(5):1451-9. doi: 10.1093/humrep/des069. Epub 2012 Mar 8.


Development of a liquid chromatography/atmospheric pressure photo-ionization high-resolution mass spectrometry analytical method for the simultaneous determination of polybrominated diphenyl ethers and their metabolites: application to BDE-47 metabolism in human hepatocytes.

Marteau C, Chevolleau S, Jouanin I, Perdu E, De Sousa G, Rahmani R, Antignac JP, LeBizec B, Zalko D, Debrauwer L.

Rapid Commun Mass Spectrom. 2012 Mar 30;26(6):599-610. doi: 10.1002/rcm.6136.


Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals: Xenopus as a model for endocrine perturbation studies.

Fini JB, Riu A, Debrauwer L, Hillenweck A, Le Mével S, Chevolleau S, Boulahtouf A, Palmier K, Balaguer P, Cravedi JP, Demeneix BA, Zalko D.

Toxicol Sci. 2012 Feb;125(2):359-67. doi: 10.1093/toxsci/kfr312. Epub 2011 Nov 15.


Use of the γH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines.

Audebert M, Dolo L, Perdu E, Cravedi JP, Zalko D.

Arch Toxicol. 2011 Nov;85(11):1463-73. doi: 10.1007/s00204-011-0721-2. Epub 2011 Jun 9.


Characterization of novel ligands of ERα, Erβ, and PPARγ: the case of halogenated bisphenol A and their conjugated metabolites.

Riu A, le Maire A, Grimaldi M, Audebert M, Hillenweck A, Bourguet W, Balaguer P, Zalko D.

Toxicol Sci. 2011 Aug;122(2):372-82. doi: 10.1093/toxsci/kfr132. Epub 2011 May 27.


Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.

Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, Perdu E, Zalko D, Bourguet W, Balaguer P.

Environ Health Perspect. 2011 Sep;119(9):1227-32. doi: 10.1289/ehp.1003328. Epub 2011 May 11.


Active metabolism of thyroid hormone during metamorphosis of amphioxus.

Paris M, Hillenweck A, Bertrand S, Delous G, Escriva H, Zalko D, Cravedi JP, Laudet V.

Integr Comp Biol. 2010 Jul;50(1):63-74. doi: 10.1093/icb/icq052. Epub 2010 May 24.


Bisphenol A induces otolith malformations during vertebrate embryogenesis.

Gibert Y, Sassi-Messai S, Fini JB, Bernard L, Zalko D, Cravedi JP, Balaguer P, Andersson-Lendahl M, Demeneix B, Laudet V.

BMC Dev Biol. 2011 Jan 26;11:4. doi: 10.1186/1471-213X-11-4.


Perinatal exposure to environmentally relevant levels of bisphenol A decreases fertility and fecundity in CD-1 mice.

Cabaton NJ, Wadia PR, Rubin BS, Zalko D, Schaeberle CM, Askenase MH, Gadbois JL, Tharp AP, Whitt GS, Sonnenschein C, Soto AM.

Environ Health Perspect. 2011 Apr;119(4):547-52. doi: 10.1289/ehp.1002559. Epub 2010 Dec 2.


Viable skin efficiently absorbs and metabolizes bisphenol A.

Zalko D, Jacques C, Duplan H, Bruel S, Perdu E.

Chemosphere. 2011 Jan;82(3):424-30. doi: 10.1016/j.chemosphere.2010.09.058. Epub 2010 Oct 27.


Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines.

Audebert M, Riu A, Jacques C, Hillenweck A, Jamin EL, Zalko D, Cravedi JP.

Toxicol Lett. 2010 Nov 30;199(2):182-92. doi: 10.1016/j.toxlet.2010.08.022. Epub 2010 Sep 9.


Disposition and biotransformation of 14C-Benzo(a)pyrene in a pig ear skin model: ex vivo and in vitro approaches.

Jacques C, Perdu E, Duplan H, Jamin EL, Canlet C, Debrauwer L, Cravedi JP, Mavon A, Zalko D.

Toxicol Lett. 2010 Nov 10;199(1):22-33. doi: 10.1016/j.toxlet.2010.08.001. Epub 2010 Aug 7.


Time-of-flight secondary ion mass spectrometry imaging demonstrates the specific localization of deca-bromo-diphenyl-ether residues in the ovaries and adrenal glands of exposed rats.

Seyer A, Riu A, Debrauwer L, Bourgès-Abella N, Brunelle A, Laprévote O, Zalko D.

J Am Soc Mass Spectrom. 2010 Nov;21(11):1836-45. doi: 10.1016/j.jasms.2010.06.019. Epub 2010 Jul 7.


Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining.

Jourdan F, Cottret L, Huc L, Wildridge D, Scheltema R, Hillenweck A, Barrett MP, Zalko D, Watson DG, Debrauwer L.

Metabolomics. 2010 Jun;6(2):312-321. Epub 2010 Jan 6.


Percutaneous absorption and metabolism of [14C]-ethoxycoumarin in a pig ear skin model.

Jacques C, Perdu E, Dorio C, Bacqueville D, Mavon A, Zalko D.

Toxicol In Vitro. 2010 Aug;24(5):1426-34. doi: 10.1016/j.tiv.2010.04.006. Epub 2010 Apr 22.


Characterisation of B(a)P metabolites formed in an ex vivo pig skin model using three complementary analytical methods.

Jacques C, Jamin EL, Perdu E, Duplan H, Mavon A, Zalko D, Debrauwer L.

Anal Bioanal Chem. 2010 Mar;396(5):1691-701. doi: 10.1007/s00216-009-3389-1. Epub 2010 Jan 18.


A CASCADE of effects of bisphenol A.

Bondesson M, Jönsson J, Pongratz I, Olea N, Cravedi JP, Zalko D, Håkansson H, Halldin K, Di Lorenzo D, Behl C, Manthey D, Balaguer P, Demeneix B, Fini JB, Laudet V, Gustafsson JA.

Reprod Toxicol. 2009 Dec;28(4):563-7. doi: 10.1016/j.reprotox.2009.06.014. Epub 2009 Jul 3. No abstract available.


Metabolism of the endocrine disruptor BPA by Xenopus laevis tadpoles.

Fini JB, Dolo L, Cravedi JP, Demeneix B, Zalko D.

Ann N Y Acad Sci. 2009 Apr;1163:394-7. doi: 10.1111/j.1749-6632.2008.03655.x.


Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line.

Cabaton N, Dumont C, Severin I, Perdu E, Zalko D, Cherkaoui-Malki M, Chagnon MC.

Toxicology. 2009 Jan 8;255(1-2):15-24. doi: 10.1016/j.tox.2008.09.024. Epub 2008 Oct 7.


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