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Items: 34

1.

Repurposing of the CDK inhibitor PHA-767491 as a NRF2 inhibitor drug candidate for cancer therapy via redox modulation.

Liu HY, Tuckett AZ, Fennell M, Garippa R, Zakrzewski JL.

Invest New Drugs. 2018 Aug;36(4):590-600. doi: 10.1007/s10637-017-0557-6. Epub 2018 Jan 3.

PMID:
29297149
2.

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor.

Vaisitti T, Gaudino F, Ouk S, Moscvin M, Vitale N, Serra S, Arruga F, Zakrzewski JL, Liou HC, Allan JN, Furman RR, Deaglio S.

Haematologica. 2017 Nov;102(11):1878-1889. doi: 10.3324/haematol.2017.173419. Epub 2017 Aug 31.

3.

Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency.

Tuckett AZ, Thornton RH, O'Reilly RJ, van den Brink MRM, Zakrzewski JL.

J Hematol Oncol. 2017 May 16;10(1):109. doi: 10.1186/s13045-017-0478-z.

4.

Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.

Ghosh A, Smith M, James SE, Davila ML, Velardi E, Argyropoulos KV, Gunset G, Perna F, Kreines FM, Levy ER, Lieberman S, Jay HV, Tuckett AZ, Zakrzewski JL, Tan L, Young LF, Takvorian K, Dudakov JA, Jenq RR, Hanash AM, Motta AC, Murphy GF, Liu C, Schietinger A, Sadelain M, van den Brink MR.

Nat Med. 2017 Feb;23(2):242-249. doi: 10.1038/nm.4258. Epub 2017 Jan 9.

5.

Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses.

Shono Y, Tuckett AZ, Liou HC, Doubrovina E, Derenzini E, Ouk S, Tsai JJ, Smith OM, Levy ER, Kreines FM, Ziegler CG, Scallion MI, Doubrovin M, Heller G, Younes A, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Res. 2016 Jan 15;76(2):377-89. doi: 10.1158/0008-5472.CAN-14-2814. Epub 2016 Jan 7.

6.

Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice.

Tuckett AZ, Zakrzewski JL, Li D, van den Brink MR, Thornton RH.

Ultrasound Med Biol. 2015 Apr;41(4):1105-11. doi: 10.1016/j.ultrasmedbio.2014.11.011. Epub 2015 Feb 17.

7.

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.

Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MR.

J Exp Med. 2014 Nov 17;211(12):2341-9. doi: 10.1084/jem.20131289. Epub 2014 Oct 20.

8.

Overcoming immunological barriers in regenerative medicine.

Zakrzewski JL, van den Brink MR, Hubbell JA.

Nat Biotechnol. 2014 Aug;32(8):786-94. doi: 10.1038/nbt.2960.

9.

Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy.

Tuckett AZ, Thornton RH, Shono Y, Smith OM, Levy ER, Kreines FM, van den Brink MR, Zakrzewski JL.

Blood. 2014 May 1;123(18):2797-805. doi: 10.1182/blood-2013-10-535401. Epub 2014 Mar 20.

10.

A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.

Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Discov. 2014 May;4(5):578-91. doi: 10.1158/2159-8290.CD-13-0585. Epub 2014 Feb 18.

11.

Additive antileukemia effects by GFI1B- and BCR-ABL-specific siRNA in advanced phase chronic myeloid leukemic cells.

Koldehoff M, Zakrzewski JL, Beelen DW, Elmaagacli AH.

Cancer Gene Ther. 2013 Jul;20(7):421-7. doi: 10.1038/cgt.2013.31. Epub 2013 Jun 21.

PMID:
23788109
12.

Extrathymic development of murine T cells after bone marrow transplantation.

Holland AM, Zakrzewski JL, Tsai JJ, Hanash AM, Dudakov JA, Smith OM, West ML, Singer NV, Brill J, Sun JC, van den Brink MR.

J Clin Invest. 2012 Dec;122(12):4716-26. doi: 10.1172/JCI60630. Epub 2012 Nov 19.

13.

Transforming lymph nodes into tissue factories.

Zakrzewski JL, Tuckett AZ, van den Brink MR.

Nat Biotechnol. 2012 Oct;30(10):958-9. doi: 10.1038/nbt.2388. No abstract available.

PMID:
23051813
14.

Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease.

Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR.

J Immunol. 2010 Aug 1;185(3):1912-9. doi: 10.4049/jimmunol.0903148. Epub 2010 Jul 9.

15.

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man.

Holland AM, Zakrzewski JL, Goldberg GL, Ghosh A, van den Brink MR.

Semin Immunopathol. 2008 Dec;30(4):479-87. doi: 10.1007/s00281-008-0138-z. Epub 2008 Nov 15. Review.

16.

Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation.

Jenq RR, King CG, Volk C, Suh D, Smith OM, Rao UK, Yim NL, Holland AM, Lu SX, Zakrzewski JL, Goldberg GL, Diab A, Alpdogan O, Penack O, Na IK, Kappel LW, Wolchok JD, Houghton AN, Perales MA, van den Brink MR.

Blood. 2009 Feb 12;113(7):1574-80. doi: 10.1182/blood-2008-05-155697. Epub 2008 Nov 14.

17.

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease.

Lu SX, Alpdogan O, Lin J, Balderas R, Campos-Gonzalez R, Wang X, Gao GJ, Suh D, King C, Chow M, Smith OM, Hubbard VM, Bautista JL, Cabrera-Perez J, Zakrzewski JL, Kochman AA, Chow A, Altan-Bonnet G, van den Brink MR.

Blood. 2008 Dec 15;112(13):5254-8. doi: 10.1182/blood-2008-03-147322. Epub 2008 Oct 6.

18.

Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors.

Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R, Holland AM, Grubin J, Cabrera-Perez J, Brentjens RJ, Lu SX, Rizzuto G, Sant'Angelo DB, Riviere I, Sadelain M, Heller G, Zúñiga-Pflücker JC, Lu C, van den Brink MR.

Nat Biotechnol. 2008 Apr;26(4):453-61. doi: 10.1038/nbt1395. Epub 2008 Mar 30.

19.

Gene profiling of growth factor independence 1B gene (Gfi-1B) in leukemic cells.

Koldehoff M, Zakrzewski JL, Klein-Hitpass L, Beelen DW, Elmaagacli AH.

Int J Hematol. 2008 Jan;87(1):39-47. doi: 10.1007/s12185-007-0013-z. Epub 2007 Dec 6.

PMID:
18224412
20.

Organ-derived dendritic cells have differential effects on alloreactive T cells.

Kim TD, Terwey TH, Zakrzewski JL, Suh D, Kochman AA, Chen ME, King CG, Borsotti C, Grubin J, Smith OM, Heller G, Liu C, Murphy GF, Alpdogan O, van den Brink MR.

Blood. 2008 Mar 1;111(5):2929-40. doi: 10.1182/blood-2007-06-096602. Epub 2008 Jan 4.

21.

Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines.

Stephan H, Zakrzewski JL, Bölöni R, Grasemann C, Lohmann DR, Eggert A.

Pediatr Blood Cancer. 2008 Feb;50(2):218-22.

PMID:
17973327
22.

Clinical strategies to enhance T cell reconstitution.

Goldberg GL, Zakrzewski JL, Perales MA, van den Brink MR.

Semin Immunol. 2007 Oct;19(5):289-96. Epub 2007 Oct 26. Review.

23.

Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends.

Zakrzewski JL, Goldberg GL, Smith OM, van den Brink MR.

Blood Cells Mol Dis. 2008 Jan-Feb;40(1):44-7. Epub 2007 Oct 1. Review.

24.

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation.

Zakrzewski JL, Holland AM, van den Brink MR.

J Mol Med (Berl). 2007 Aug;85(8):837-43. Epub 2007 Feb 28. Review.

PMID:
17333096
25.

Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate.

Elmaagacli AH, Koldehoff M, Zakrzewski JL, Steckel NK, Ottinger H, Beelen DW.

Br J Haematol. 2007 Jan;136(2):212-9. Epub 2006 Dec 8.

PMID:
17156408
26.

Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.

Zakrzewski JL, Kochman AA, Lu SX, Terwey TH, Kim TD, Hubbard VM, Muriglan SJ, Suh D, Smith OM, Grubin J, Patel N, Chow A, Cabrera-Perez J, Radhakrishnan R, Diab A, Perales MA, Rizzuto G, Menet E, Pamer EG, Heller G, Zúñiga-Pflücker JC, Alpdogan O, van den Brink MR.

Nat Med. 2006 Sep;12(9):1039-47. Epub 2006 Aug 27.

PMID:
16936725
27.

CCR2 is required for CD8-induced graft-versus-host disease.

Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-Montagut T, Eng JM, Muriglan SJ, Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MR.

Blood. 2005 Nov 1;106(9):3322-30. Epub 2005 Jul 21.

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32.

Successful management of impending late graft failure in a thalassemic bone marrow transplant recipient.

Zakrzewski JL.

Haematologica. 2002 Oct;87(10):ECR32. No abstract available.

PMID:
12368175
33.

Toxic epidermal necrolysis: differential diagnosis of an epidermolytic dermopathy in a hematopoietic stem cell transplant recipient.

Zakrzewski JL, Lentini G, Such U, Duerr A, Tran V, Guenzelmann S, Braunschweig T, Riede UN, Koldehoff M.

Bone Marrow Transplant. 2002 Sep;30(5):331-3.

34.

Epidermal naevus and segmental hypermelanosis associated with an intraspinal mass: overlap between different mosaic neuroectodermal syndromes.

Zakrzewski JL, Luecke T, Bentele KH, Hoeger PH.

Eur J Pediatr. 2001 Oct;160(10):603-6. Review.

PMID:
11686504

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