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The cone opsin repertoire of osteoglossomorph fishes: gene loss in mormyrid electric fish and a long wave-length sensitive cone opsin that survived 3R.

Liu DW, Wang FY, Lin JJ, Thompson A, Lu Y, Vo D, Yan HY, Zakon H.

Mol Biol Evol. 2018 Dec 27. doi: 10.1093/molbev/msy241. [Epub ahead of print]


Electrostatic Tuning of a Potassium Channel in Electric Fish.

Swapna I, Ghezzi A, York JM, Markham MR, Halling DB, Lu Y, Gallant JR, Zakon HH.

Curr Biol. 2018 Jul 9;28(13):2094-2102.e5. doi: 10.1016/j.cub.2018.05.012. Epub 2018 Jun 21.


Rapid evolution of a voltage-gated sodium channel gene in a lineage of electric fish leads to a persistent sodium current.

Thompson A, Infield DT, Smith AR, Smith GT, Ahern CA, Zakon HH.

PLoS Biol. 2018 Mar 27;16(3):e2004892. doi: 10.1371/journal.pbio.2004892. eCollection 2018 Mar.


Stronger selective constraint on downstream genes in the oxidative phosphorylation pathway of cetaceans.

Tian R, Xu S, Chai S, Yin D, Zakon H, Yang G.

J Evol Biol. 2018 Feb;31(2):217-228. doi: 10.1111/jeb.13213. Epub 2017 Dec 8.


Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance.

Tarvin RD, Borghese CM, Sachs W, Santos JC, Lu Y, O'Connell LA, Cannatella DC, Harris RA, Zakon HH.

Science. 2017 Sep 22;357(6357):1261-1266. doi: 10.1126/science.aan5061.


Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene.

Zakon HH, Li W, Pillai NE, Tohari S, Shingate P, Ren J, Venkatesh B.

Proc Biol Sci. 2017 Sep 27;284(1863). pii: 20170824. doi: 10.1098/rspb.2017.0824.


Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome.

Modrell MS, Lyne M, Carr AR, Zakon HH, Buckley D, Campbell AS, Davis MC, Micklem G, Baker CV.

Elife. 2017 Mar 27;6. pii: e24197. doi: 10.7554/eLife.24197.


Molecular evolution of globin genes in Gymnotiform electric fishes: relation to hypoxia tolerance.

Tian R, Losilla M, Lu Y, Yang G, Zakon H.

BMC Evol Biol. 2017 Feb 13;17(1):51. doi: 10.1186/s12862-017-0893-3.


South American Weakly Electric Fish (Gymnotiformes) Are Long-Wavelength-Sensitive Cone Monochromats.

Liu DW, Lu Y, Yan HY, Zakon HH.

Brain Behav Evol. 2016;88(3-4):204-212. doi: 10.1159/000450746. Epub 2016 Nov 8.


Electric fields of flowers stimulate the sensory hairs of bumble bees.

Zakon HH.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7020-1. doi: 10.1073/pnas.1607426113. Epub 2016 Jun 20. No abstract available.


Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.

Tarvin RD, Santos JC, O'Connell LA, Zakon HH, Cannatella DC.

Mol Biol Evol. 2016 Apr;33(4):1068-81. doi: 10.1093/molbev/msv350. Epub 2016 Jan 18.


Complex Homology and the Evolution of Nervous Systems.

Liebeskind BJ, Hillis DM, Zakon HH, Hofmann HA.

Trends Ecol Evol. 2016 Feb;31(2):127-135. doi: 10.1016/j.tree.2015.12.005. Epub 2015 Dec 30. Review.


Compensatory Drift and the Evolutionary Dynamics of Dosage-Sensitive Duplicate Genes.

Thompson A, Zakon HH, Kirkpatrick M.

Genetics. 2016 Feb;202(2):765-74. doi: 10.1534/genetics.115.178137. Epub 2015 Dec 12.


Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus).

Traeger LL, Volkening JD, Moffett H, Gallant JR, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Güth R, Unguez GA, Albert JS, Zakon H, Sussman MR, Samanta MP.

BMC Genomics. 2015 Mar 26;16:243. doi: 10.1186/s12864-015-1288-8.


Emerging from the bottleneck: benefits of the comparative approach to modern neuroscience.

Brenowitz EA, Zakon HH.

Trends Neurosci. 2015 May;38(5):273-8. doi: 10.1016/j.tins.2015.02.008. Epub 2015 Mar 21. Review.


Evolution of voltage-gated ion channels at the emergence of Metazoa.

Moran Y, Barzilai MG, Liebeskind BJ, Zakon HH.

J Exp Biol. 2015 Feb 15;218(Pt 4):515-25. doi: 10.1242/jeb.110270. Review.


Convergence of ion channel genome content in early animal evolution.

Liebeskind BJ, Hillis DM, Zakon HH.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E846-51. doi: 10.1073/pnas.1501195112. Epub 2015 Feb 9.


Nonhuman genetics. Genomic basis for the convergent evolution of electric organs.

Gallant JR, Traeger LL, Volkening JD, Moffett H, Chen PH, Novina CD, Phillips GN Jr, Anand R, Wells GB, Pinch M, Güth R, Unguez GA, Albert JS, Zakon HH, Samanta MP, Sussman MR.

Science. 2014 Jun 27;344(6191):1522-5. doi: 10.1126/science.1254432.


Hibernating mammals pass the acid test: multiple independent evolutions of enhanced proton block of sodium channels in acid-sensing pain receptors.

Zakon H.

Brain Behav Evol. 2014;83(4):245-6. doi: 10.1159/000361037. Epub 2014 Jun 18. No abstract available.


Human impact on fish sensory systems in the long term: an evolutionary perspective.

Zakon HH.

Integr Zool. 2015 Jan;10(1):83-90. doi: 10.1111/1749-4877.12097. Review.


Ionic mechanisms of microsecond-scale spike timing in single cells.

Markham MR, Zakon HH.

J Neurosci. 2014 May 7;34(19):6668-78. doi: 10.1523/JNEUROSCI.0615-14.2014.


Expression evolution facilitated the convergent neofunctionalization of a sodium channel gene.

Thompson A, Vo D, Comfort C, Zakon HH.

Mol Biol Evol. 2014 Aug;31(8):1941-55. doi: 10.1093/molbev/msu145. Epub 2014 Apr 29.


Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals.

Ghezzi A, Liebeskind BJ, Thompson A, Atkinson NS, Zakon HH.

Front Mol Neurosci. 2014 Mar 7;7:15. doi: 10.3389/fnmol.2014.00015. eCollection 2014.


Independent acquisition of sodium selectivity in bacterial and animal sodium channels.

Liebeskind BJ, Hillis DM, Zakon HH.

Curr Biol. 2013 Nov 4;23(21):R948-9. doi: 10.1016/j.cub.2013.09.025. No abstract available.


Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.

Rowe AH, Xiao Y, Rowe MP, Cummins TR, Zakon HH.

Science. 2013 Oct 25;342(6157):441-446. doi: 10.1126/science.1236451.


A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.

Wu M, Ye N, Sengupta B, Zakon HH.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2013 Oct;199(10):829-42. doi: 10.1007/s00359-013-0845-3. Epub 2013 Aug 25.


Sensory plasticity: seasonal regulation of hearing by a potassium channel.

Zakon H.

Curr Biol. 2013 Apr 22;23(8):R321-2. doi: 10.1016/j.cub.2013.02.053.


A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude.

Markham MR, Kaczmarek LK, Zakon HH.

J Neurophysiol. 2013 Apr;109(7):1713-23. doi: 10.1152/jn.00875.2012. Epub 2013 Jan 16.


Phylogeny unites animal sodium leak channels with fungal calcium channels in an ancient, voltage-insensitive clade.

Liebeskind BJ, Hillis DM, Zakon HH.

Mol Biol Evol. 2012 Dec;29(12):3613-6. doi: 10.1093/molbev/mss182. Epub 2012 Jul 19.


Adaptive evolution of voltage-gated sodium channels: the first 800 million years.

Zakon HH.

Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1:10619-25. doi: 10.1073/pnas.1201884109. Epub 2012 Jun 20. Review.


Isolation and characterization of CvIV4: a pain inducing α-scorpion toxin.

Rowe AH, Xiao Y, Scales J, Linse KD, Rowe MP, Cummins TR, Zakon HH.

PLoS One. 2011;6(8):e23520. doi: 10.1371/journal.pone.0023520. Epub 2011 Aug 24.


Evolution of sodium channels predates the origin of nervous systems in animals.

Liebeskind BJ, Hillis DM, Zakon HH.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9154-9. doi: 10.1073/pnas.1106363108. Epub 2011 May 16.


Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.

George AA, Macleod GT, Zakon HH.

J Neurophysiol. 2011 Jul;106(1):319-31. doi: 10.1152/jn.00741.2010. Epub 2011 Apr 27.


Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexity.

Zakon HH, Jost MC, Lu Y.

Mol Biol Evol. 2011 Apr;28(4):1415-24. doi: 10.1093/molbev/msq325. Epub 2010 Dec 9.


Old gene duplication facilitates origin and diversification of an innovative communication system--twice.

Arnegard ME, Zwickl DJ, Lu Y, Zakon HH.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22172-7. doi: 10.1073/pnas.1011803107. Epub 2010 Dec 2.


Calcium dynamics encode the magnitude of a graded memory underlying sensorimotor adaptation.

Dembrow NC, Pettit DL, Zakon HH.

J Neurophysiol. 2010 May;103(5):2372-81. doi: 10.1152/jn.00109.2010. Epub 2010 Feb 24.


Circadian and social cues regulate ion channel trafficking.

Markham MR, McAnelly ML, Stoddard PK, Zakon HH.

PLoS Biol. 2009 Sep;7(9):e1000203. doi: 10.1371/journal.pbio.1000203. Epub 2009 Sep 29.


Molecular evolution of Na+ channels in teleost fishes.

Zakon HH, Jost MC, Zwickl DJ, Lu Y, Hillis DM.

Integr Zool. 2009 Mar;4(1):64-74. doi: 10.1111/j.1749-4877.2008.00136.x. Review.


A novel Na+ channel splice form contributes to the regulation of an androgen-dependent social signal.

Liu H, Wu MM, Zakon HH.

J Neurosci. 2008 Sep 10;28(37):9173-82. doi: 10.1523/JNEUROSCI.2783-08.2008.


Molecular evolution of communication signals in electric fish.

Zakon HH, Zwickl DJ, Lu Y, Hillis DM.

J Exp Biol. 2008 Jun;211(Pt 11):1814-8. doi: 10.1242/jeb.015982. Review.


Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.

Jost MC, Hillis DM, Lu Y, Kyle JW, Fozzard HA, Zakon HH.

Mol Biol Evol. 2008 Jun;25(6):1016-24. doi: 10.1093/molbev/msn025. Epub 2008 Feb 6.


Gene duplications and evolution of vertebrate voltage-gated sodium channels.

Novak AE, Jost MC, Lu Y, Taylor AD, Zakon HH, Ribera AB.

J Mol Evol. 2006 Aug;63(2):208-21. Epub 2006 Jul 7.


Divide and conquer: Cell addition and aggressive signaling in electric fish.

Zakon HH.

Horm Behav. 2006 Jun;50(1):8-9. Epub 2006 May 3. No abstract available.


Sodium channel genes and the evolution of diversity in communication signals of electric fishes: convergent molecular evolution.

Zakon HH, Lu Y, Zwickl DJ, Hillis DM.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3675-80. Epub 2006 Feb 27.


Regulation and modulation of electric waveforms in gymnotiform electric fish.

Stoddard PK, Zakon HH, Markham MR, McAnelly L.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Jun;192(6):613-24. Epub 2006 Jan 26. Review.

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