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Items: 1 to 50 of 148

1.

Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae.

Chen CF, Pohl TJ, Pott S, Zakian VA.

Genetics. 2019 Jan;211(1):105-119. doi: 10.1534/genetics.118.301710. Epub 2018 Nov 15.

2.

The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity.

Geronimo CL, Singh SP, Galletto R, Zakian VA.

Nucleic Acids Res. 2018 Sep 19;46(16):8357-8370. doi: 10.1093/nar/gky655.

3.

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.

Tran PLT, Pohl TJ, Chen CF, Chan A, Pott S, Zakian VA.

Nat Commun. 2017 Apr 21;8:15025. doi: 10.1038/ncomms15025.

4.

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

McDonald KR, Guise AJ, Pourbozorgi-Langroudi P, Cristea IM, Zakian VA, Capra JA, Sabouri N.

PLoS Genet. 2016 Sep 9;12(9):e1006238. doi: 10.1371/journal.pgen.1006238. eCollection 2016 Sep.

5.

Telomerase RNA is more than a DNA template.

Webb CJ, Zakian VA.

RNA Biol. 2016 Aug 2;13(8):683-9. doi: 10.1080/15476286.2016.1191725. Epub 2016 May 31. Review.

6.

Getting it done at the ends: Pif1 family DNA helicases and telomeres.

Geronimo CL, Zakian VA.

DNA Repair (Amst). 2016 Aug;44:151-158. doi: 10.1016/j.dnarep.2016.05.021. Epub 2016 May 16. Review.

7.

21st Century Genetics: Mass Spectrometry of Yeast Telomerase.

Lin KW, Zakian VA.

Cold Spring Harb Symp Quant Biol. 2015;80:111-6. doi: 10.1101/sqb.2015.80.027656. Epub 2016 Jan 13.

8.

Telomere les(i/s)ons from a telomerase RNA mutant.

Webb CJ, Zakian VA.

Cell Cycle. 2015;14(24):3769-70. doi: 10.1080/15384101.2015.1105693. Review. No abstract available.

9.
10.

Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length.

Lin KW, McDonald KR, Guise AJ, Chan A, Cristea IM, Zakian VA.

Nat Commun. 2015 Sep 14;6:8290. doi: 10.1038/ncomms9290.

11.

Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Webb CJ, Zakian VA.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11312-7. doi: 10.1073/pnas.1503157112. Epub 2015 Aug 24.

12.

The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres.

Phillips JA, Chan A, Paeschke K, Zakian VA.

PLoS Genet. 2015 Apr 23;11(4):e1005186. doi: 10.1371/journal.pgen.1005186. eCollection 2015 Apr.

13.

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage.

Sabouri N, Capra JA, Zakian VA.

BMC Biol. 2014 Dec 4;12:101. doi: 10.1186/s12915-014-0101-5.

14.

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening.

McDonald KR, Sabouri N, Webb CJ, Zakian VA.

DNA Repair (Amst). 2014 Dec;24:80-86. doi: 10.1016/j.dnarep.2014.09.008. Epub 2014 Oct 7.

15.

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA.

Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T.

Elife. 2014 Apr 29;3:e02190. doi: 10.7554/eLife.02190.

16.

Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.

Bochman ML, Paeschke K, Chan A, Zakian VA.

Cell Rep. 2014 Jan 30;6(2):346-56. doi: 10.1016/j.celrep.2013.12.037. Epub 2014 Jan 16.

17.

DNA repair at telomeres: keeping the ends intact.

Webb CJ, Wu Y, Zakian VA.

Cold Spring Harb Perspect Biol. 2013 Jun 1;5(6). pii: a012666. doi: 10.1101/cshperspect.a012666. Review.

18.

Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency.

Di Domenico EG, Mattarocci S, Cimino-Reale G, Parisi P, Cifani N, D'Ambrosio E, Zakian VA, Ascenzioni F.

Nucleic Acids Res. 2013 Jul;41(13):6490-500. doi: 10.1093/nar/gkt365. Epub 2013 May 15.

19.

Pif1 family helicases suppress genome instability at G-quadruplex motifs.

Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA.

Nature. 2013 May 23;497(7450):458-62. doi: 10.1038/nature12149. Epub 2013 May 8.

20.

Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation.

Wu Y, DiMaggio PA Jr, Perlman DH, Zakian VA, Garcia BA.

J Proteome Res. 2013 Jan 4;12(1):316-27. doi: 10.1021/pr300408v. Epub 2012 Dec 13.

21.

DNA secondary structures: stability and function of G-quadruplex structures.

Bochman ML, Paeschke K, Zakian VA.

Nat Rev Genet. 2012 Nov;13(11):770-80. doi: 10.1038/nrg3296. Epub 2012 Oct 3. Review.

22.

Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.

Wellinger RJ, Zakian VA.

Genetics. 2012 Aug;191(4):1073-105. doi: 10.1534/genetics.111.137851. Review.

23.

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.

Sabouri N, McDonald KR, Webb CJ, Cristea IM, Zakian VA.

Genes Dev. 2012 Mar 15;26(6):581-93. doi: 10.1101/gad.184697.111.

24.

Telomeres: the beginnings and ends of eukaryotic chromosomes.

Zakian VA.

Exp Cell Res. 2012 Jul 15;318(12):1456-60. doi: 10.1016/j.yexcr.2012.02.015. Epub 2012 Feb 25. Review.

25.

A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1.

Chisholm KM, Aubert SD, Freese KP, Zakian VA, King MC, Welcsh PL.

PLoS One. 2012;7(2):e30748. doi: 10.1371/journal.pone.0030748. Epub 2012 Feb 9.

26.
27.

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.

Wu Y, Zakian VA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20362-9. doi: 10.1073/pnas.1100281108. Epub 2011 Oct 3.

28.

The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?

Bochman ML, Judge CP, Zakian VA.

Mol Biol Cell. 2011 Jun 15;22(12):1955-9. doi: 10.1091/mbc.E11-01-0045.

29.

DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase.

Paeschke K, Capra JA, Zakian VA.

Cell. 2011 May 27;145(5):678-91. doi: 10.1016/j.cell.2011.04.015.

30.

The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro.

Tuzon CT, Wu Y, Chan A, Zakian VA.

PLoS Genet. 2011 May;7(5):e1002060. doi: 10.1371/journal.pgen.1002060. Epub 2011 May 5.

31.

Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.

McGee JS, Phillips JA, Chan A, Sabourin M, Paeschke K, Zakian VA.

Nat Struct Mol Biol. 2010 Dec;17(12):1438-45. doi: 10.1038/nsmb.1947. Epub 2010 Nov 7.

32.

Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.

Fachinetti D, Bermejo R, Cocito A, Minardi S, Katou Y, Kanoh Y, Shirahige K, Azvolinsky A, Zakian VA, Foiani M.

Mol Cell. 2010 Aug 27;39(4):595-605. doi: 10.1016/j.molcel.2010.07.024.

33.

G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae.

Capra JA, Paeschke K, Singh M, Zakian VA.

PLoS Comput Biol. 2010 Jul 22;6(7):e1000861. doi: 10.1371/journal.pcbi.1000861.

34.

Telomeres: structures in need of unwinding.

Paeschke K, McDonald KR, Zakian VA.

FEBS Lett. 2010 Sep 10;584(17):3760-72. doi: 10.1016/j.febslet.2010.07.007. Epub 2010 Jul 14. Review.

35.

Characterization of the helicase activity and anti-telomerase properties of yeast Pif1p in vitro.

Boulé JB, Zakian VA.

Methods Mol Biol. 2010;587:359-76. doi: 10.1007/978-1-60327-355-8_25.

36.

Unwinding the functions of the Pif1 family helicases.

Bochman ML, Sabouri N, Zakian VA.

DNA Repair (Amst). 2010 Mar 2;9(3):237-49. doi: 10.1016/j.dnarep.2010.01.008. Epub 2010 Jan 25. Review.

37.

The ends have arrived.

Zakian VA.

Cell. 2009 Dec 11;139(6):1038-40. doi: 10.1016/j.cell.2009.11.033.

38.

Identity crisis when telomeres left unprotected.

Wu Y, Zakian VA.

J Mol Cell Biol. 2010 Feb;2(1):14-6. doi: 10.1093/jmcb/mjp031. Epub 2009 Oct 4.

39.

Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae.

Azvolinsky A, Giresi PG, Lieb JD, Zakian VA.

Mol Cell. 2009 Jun 26;34(6):722-34. doi: 10.1016/j.molcel.2009.05.022.

40.

The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo.

Ribeyre C, Lopes J, Boulé JB, Piazza A, Guédin A, Zakian VA, Mergny JL, Nicolas A.

PLoS Genet. 2009 May;5(5):e1000475. doi: 10.1371/journal.pgen.1000475. Epub 2009 May 8.

41.

Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres.

Chan A, Boulé JB, Zakian VA.

PLoS Genet. 2008 Oct;4(10):e1000236. doi: 10.1371/journal.pgen.1000236. Epub 2008 Oct 24.

42.

The Schizosaccharomyces pombe Pfh1p DNA helicase is essential for the maintenance of nuclear and mitochondrial DNA.

Pinter SF, Aubert SD, Zakian VA.

Mol Cell Biol. 2008 Nov;28(21):6594-608. doi: 10.1128/MCB.00191-08. Epub 2008 Aug 25.

43.

ATM-like kinases and regulation of telomerase: lessons from yeast and mammals.

Sabourin M, Zakian VA.

Trends Cell Biol. 2008 Jul;18(7):337-46. doi: 10.1016/j.tcb.2008.04.004. Epub 2008 May 22. Review.

44.

Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA.

Webb CJ, Zakian VA.

Nat Struct Mol Biol. 2008 Jan;15(1):34-42. Epub 2007 Dec 23.

45.
46.
47.

The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substrates.

Boulé JB, Zakian VA.

Nucleic Acids Res. 2007;35(17):5809-18. Epub 2007 Aug 24.

48.

Telomerase and Tel1p preferentially associate with short telomeres in S. cerevisiae.

Sabourin M, Tuzon CT, Zakian VA.

Mol Cell. 2007 Aug 17;27(4):550-61. Epub 2007 Jul 26.

49.

Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase.

Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA.

PLoS Genet. 2007 Jun;3(6):e105.

50.

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