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Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.

Bitra A, Doukov T, Croft M, Zajonc DM.

J Biol Chem. 2018 Jun 29;293(26):9958-9969. doi: 10.1074/jbc.RA118.003176. Epub 2018 May 2.


CD1c caves in on lipids.

Zajonc DM.

Nat Immunol. 2018 Apr;19(4):322-324. doi: 10.1038/s41590-018-0074-6. No abstract available.


Characterization of murine antibody responses to vaccinia virus envelope protein A14 reveals an immunodominant antigen lacking of effective neutralization targets.

Meng X, Kaever T, Yan B, Traktman P, Zajonc DM, Peters B, Crotty S, Xiang Y.

Virology. 2018 May;518:284-292. doi: 10.1016/j.virol.2018.03.005. Epub 2018 Mar 17.


A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.

Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A.

Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8.


Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.

Bitra A, Doukov T, Wang J, Picarda G, Benedict CA, Croft M, Zajonc DM.

J Biol Chem. 2018 Jan 26;293(4):1317-1329. doi: 10.1074/jbc.M117.814905. Epub 2017 Dec 14.


Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM.

J Biol Chem. 2018 Jan 5;293(1):390-401. doi: 10.1074/jbc.M117.814541. Epub 2017 Nov 9.


Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.

Madireddi S, Eun SY, Mehta AK, Birta A, Zajonc DM, Niki T, Hirashima M, Podack ER, Schreiber TH, Croft M.

J Immunol. 2017 Oct 15;199(8):2721-2728. doi: 10.4049/jimmunol.1700575. Epub 2017 Sep 6.


Crystal structure of Qa-1a with bound Qa-1 determinant modifier peptide.

Ying G, Wang J, Kumar V, Zajonc DM.

PLoS One. 2017 Aug 2;12(8):e0182296. doi: 10.1371/journal.pone.0182296. eCollection 2017.


Galactosylsphingamides: new α-GalCer analogues to probe the F'-pocket of CD1d.

Guillaume J, Wang J, Janssens J, Remesh SG, Risseeuw MDP, Decruy T, Froeyen M, Elewaut D, Zajonc DM, Calenbergh SV.

Sci Rep. 2017 Jun 27;7(1):4276. doi: 10.1038/s41598-017-04461-7.


Autoreactivity to Sulfatide by Human Invariant NKT Cells.

Stax AM, Tuengel J, Girardi E, Kitano N, Allan LL, Liu V, Zheng D, Panenka WJ, Guillaume J, Wong CH, van Calenbergh S, Zajonc DM, van den Elzen P.

J Immunol. 2017 Jul 1;199(1):97-106. doi: 10.4049/jimmunol.1601976. Epub 2017 May 19.


Antibody Recognition of Immunodominant Vaccinia Virus Envelope Proteins.

Zajonc DM.

Subcell Biochem. 2017;83:103-126. doi: 10.1007/978-3-319-46503-6_4.


N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morlé A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Gharbi T, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O.

Cell Death Differ. 2017 Mar;24(3):500-510. doi: 10.1038/cdd.2016.150. Epub 2017 Feb 10.


Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.

Remesh SG, Andreatta M, Ying G, Kaever T, Nielsen M, McMurtrey C, Hildebrand W, Peters B, Zajonc DM.

J Biol Chem. 2017 Mar 31;292(13):5262-5270. doi: 10.1074/jbc.M117.776542. Epub 2017 Feb 8.


CD1, MR1, NKT, and MAIT: evolution and origins of non-peptidic antigen recognition by T lymphocytes.

Zajonc DM, Flajnik MF.

Immunogenetics. 2016 Aug;68(8):489-90. doi: 10.1007/s00251-016-0941-y. Epub 2016 Aug 1. No abstract available.


The CD1 family: serving lipid antigens to T cells since the Mesozoic era.

Zajonc DM.

Immunogenetics. 2016 Aug;68(8):561-76. doi: 10.1007/s00251-016-0931-0. Epub 2016 Jul 2. Review.


Structure of an α-Helical Peptide and Lipopeptide Bound to the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule CD1d.

Girardi E, Wang J, Zajonc DM.

J Biol Chem. 2016 May 13;291(20):10677-83. doi: 10.1074/jbc.M115.702118. Epub 2016 Mar 22.


Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox.

Kaever T, Matho MH, Meng X, Crickard L, Schlossman A, Xiang Y, Crotty S, Peters B, Zajonc DM.

J Virol. 2016 Apr 14;90(9):4334-4345. doi: 10.1128/JVI.02878-15. Print 2016 May.


Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove.

McMurtrey C, Trolle T, Sansom T, Remesh SG, Kaever T, Bardet W, Jackson K, McLeod R, Sette A, Nielsen M, Zajonc DM, Blader IJ, Peters B, Hildebrand W.

Elife. 2016 Jan 29;5. pii: e12556. doi: 10.7554/eLife.12556.


Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer.

Matho MH, Schlossman A, Meng X, Benhnia MR, Kaever T, Buller M, Doronin K, Parker S, Peters B, Crotty S, Xiang Y, Zajonc DM.

PLoS Pathog. 2015 Sep 1;11(9):e1005148. doi: 10.1371/journal.ppat.1005148. eCollection 2015 Sep.


Recognition of Microbial Glycolipids by Natural Killer T Cells.

Zajonc DM, Girardi E.

Front Immunol. 2015 Aug 4;6:400. doi: 10.3389/fimmu.2015.00400. eCollection 2015. Review.


A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production.

Birkholz AM, Girardi E, Wingender G, Khurana A, Wang J, Zhao M, Zahner S, Illarionov PA, Wen X, Li M, Yuan W, Porcelli SA, Besra GS, Zajonc DM, Kronenberg M.

J Immunol. 2015 Aug 1;195(3):924-33. doi: 10.4049/jimmunol.1500070. Epub 2015 Jun 15.


Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.

Birkholz A, Nemčovič M, Yu ED, Girardi E, Wang J, Khurana A, Pauwels N, Farber E, Chitale S, Franck RW, Tsuji M, Howell A, Van Calenbergh S, Kronenberg M, Zajonc DM.

J Biol Chem. 2015 Jul 10;290(28):17206-17. doi: 10.1074/jbc.M115.654814. Epub 2015 May 27.


Synthesis of C-5″ and C-6″-modified α-GalCer analogues as iNKT-cell agonists.

Guillaume J, Pauwels N, Aspeslagh S, Zajonc DM, Elewaut D, Van Calenbergh S.

Bioorg Med Chem. 2015 Jul 1;23(13):3175-82. doi: 10.1016/j.bmc.2015.04.068. Epub 2015 May 4.


Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E.

Matho MH, de Val N, Miller GM, Brown J, Schlossman A, Meng X, Crotty S, Peters B, Xiang Y, Hsieh-Wilson LC, Ward AB, Zajonc DM.

PLoS Pathog. 2014 Dec 4;10(12):e1004495. doi: 10.1371/journal.ppat.1004495. eCollection 2014 Dec.


The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides.

Kain L, Webb B, Anderson BL, Deng S, Holt M, Costanzo A, Zhao M, Self K, Teyton A, Everett C, Kronenberg M, Zajonc DM, Bendelac A, Savage PB, Teyton L.

Immunity. 2014 Oct 16;41(4):543-54. doi: 10.1016/j.immuni.2014.08.017. Erratum in: Immunity. 2014 Nov 20;41(5):867. Constanzo, Anne [corrected to Costanzo, Anne].


Recognition of lysophosphatidylcholine by type II NKT cells and protection from an inflammatory liver disease.

Maricic I, Girardi E, Zajonc DM, Kumar V.

J Immunol. 2014 Nov 1;193(9):4580-9. doi: 10.4049/jimmunol.1400699. Epub 2014 Sep 26.


Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein.

Kaever T, Meng X, Matho MH, Schlossman A, Li S, Sela-Culang I, Ofran Y, Buller M, Crump RW, Parker S, Frazier A, Crotty S, Zajonc DM, Peters B, Xiang Y.

J Virol. 2014 Oct;88(19):11339-55. doi: 10.1128/JVI.01491-14. Epub 2014 Jul 16.


Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.

Madireddi S, Eun SY, Lee SW, Nemčovičová I, Mehta AK, Zajonc DM, Nishi N, Niki T, Hirashima M, Croft M.

J Exp Med. 2014 Jun 30;211(7):1433-48. doi: 10.1084/jem.20132687. Epub 2014 Jun 23.


Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells.

Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H.

Mucosal Immunol. 2015 Jan;8(1):141-51. doi: 10.1038/mi.2014.51. Epub 2014 Jun 18.


The structure of cytomegalovirus immune modulator UL141 highlights structural Ig-fold versatility for receptor binding.

Nemčovičová I, Zajonc DM.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):851-62. doi: 10.1107/S1399004713033750. Epub 2014 Feb 22.


Helicobacter pylori cholesteryl α-glucosides contribute to its pathogenicity and immune response by natural killer T cells.

Ito Y, Vela JL, Matsumura F, Hoshino H, Tyznik A, Lee H, Girardi E, Zajonc DM, Liddington R, Kobayashi M, Bao X, Bugaytsova J, Borén T, Jin R, Zong Y, Seeberger PH, Nakayama J, Kronenberg M, Fukuda M.

PLoS One. 2013 Dec 2;8(12):e78191. doi: 10.1371/journal.pone.0078191. eCollection 2013.


A γδ T-cell glimpse of glycolipids.

Zajonc DM, Girardi E.

Immunol Cell Biol. 2014 Feb;92(2):99-100. doi: 10.1038/icb.2013.83. Epub 2013 Nov 19. No abstract available.


Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection.

Aspeslagh S, Nemčovič M, Pauwels N, Venken K, Wang J, Calenbergh SV, Zajonc DM, Elewaut D.

J Immunol. 2013 Sep 15;191(6):2916-25. doi: 10.4049/jimmunol.1203134. Epub 2013 Aug 19.


A 'GEM' of a cell.

Kronenberg M, Zajonc DM.

Nat Immunol. 2013 Jul;14(7):694-5. doi: 10.1038/ni.2644. No abstract available.


Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.

Nemčovičová I, Benedict CA, Zajonc DM.

PLoS Pathog. 2013 Mar;9(3):e1003224. doi: 10.1371/journal.ppat.1003224. Epub 2013 Mar 21.


Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemčovičová I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA.

Cell Host Microbe. 2013 Mar 13;13(3):324-35. doi: 10.1016/j.chom.2013.02.003.


Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine.

Benhnia MR, Maybeno M, Blum D, Aguilar-Sino R, Matho M, Meng X, Head S, Felgner PL, Zajonc DM, Koriazova L, Kato S, Burton DR, Xiang Y, Crowe JE Jr, Peters B, Crotty S.

J Virol. 2013 Feb;87(3):1569-85. doi: 10.1128/JVI.02152-12. Epub 2012 Nov 14.


Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids.

Wang J, Guillaume J, Pauwels N, Van Calenbergh S, Van Rhijn I, Zajonc DM.

PLoS One. 2012;7(10):e47989. doi: 10.1371/journal.pone.0047989. Epub 2012 Oct 23.


Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.

Girardi E, Zajonc DM.

Immunol Rev. 2012 Nov;250(1):167-79. doi: 10.1111/j.1600-065X.2012.01166.x. Review.


The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid.

Nguyen TK, Koets AP, Vordermeier M, Jervis PJ, Cox LR, Graham SP, Santema WJ, Moody DB, van Calenbergh S, Zajonc DM, Besra GS, Van Rhijn I.

Int Immunol. 2013 Feb;25(2):91-8. doi: 10.1093/intimm/dxs092. Epub 2012 Sep 11.


Phage display generation of a novel human anti-CD1A monoclonal antibody with potent cytolytic activity.

Bechan GI, Lee DW, Zajonc DM, Heckel D, Xian R, Throsby M, van Meijer M, Germeraad WT, Kruisbeek AM, Egeler RM, Arceci RJ.

Br J Haematol. 2012 Nov;159(3):299-310. doi: 10.1111/bjh.12033. Epub 2012 Aug 30.


Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.

Girardi E, Maricic I, Wang J, Mac TT, Iyer P, Kumar V, Zajonc DM.

Nat Immunol. 2012 Sep;13(9):851-6. doi: 10.1038/ni.2371. Epub 2012 Jul 22.


Structural and biochemical characterization of the vaccinia virus envelope protein D8 and its recognition by the antibody LA5.

Matho MH, Maybeno M, Benhnia MR, Becker D, Meng X, Xiang Y, Crotty S, Peters B, Zajonc DM.

J Virol. 2012 Aug;86(15):8050-8. doi: 10.1128/JVI.00836-12. Epub 2012 May 23.


Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.

Dvir H, Shah M, Girardi E, Guo L, Farquhar MG, Zajonc DM.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6916-21. doi: 10.1073/pnas.1114128109. Epub 2012 Apr 16.


Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties.

Kerzerho J, Yu ED, Barra CM, Alari-Pahissa E, Girardi E, Harrak Y, Lauzurica P, Llebaria A, Zajonc DM, Akbari O, Castaño AR.

J Immunol. 2012 Mar 1;188(5):2254-65. doi: 10.4049/jimmunol.1103049. Epub 2012 Feb 1. Erratum in: J Immunol. 2012 Oct 15;189(8):4194. Alari-Pahisa, Elisenda [corrected to Alari-Pahissa, Elisenda].


Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.

Tyznik AJ, Farber E, Girardi E, Birkholz A, Li Y, Chitale S, So R, Arora P, Khurana A, Wang J, Porcelli SA, Zajonc DM, Kronenberg M, Howell AR.

Chem Biol. 2011 Dec 23;18(12):1620-30. doi: 10.1016/j.chembiol.2011.10.015.


Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.

Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T.

J Clin Invest. 2012 Jan;122(1):218-28. doi: 10.1172/JCI59072. Epub 2011 Dec 1.


Structural basis for the recognition of C20:2-αGalCer by the invariant natural killer T cell receptor-like antibody L363.

Yu ED, Girardi E, Wang J, Mac TT, Yu KO, Van Calenbergh S, Porcelli SA, Zajonc DM.

J Biol Chem. 2012 Jan 6;287(2):1269-78. doi: 10.1074/jbc.M111.308783. Epub 2011 Nov 22.


Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.

Girardi E, Yu ED, Li Y, Tarumoto N, Pei B, Wang J, Illarionov P, Kinjo Y, Kronenberg M, Zajonc DM.

PLoS Biol. 2011 Nov;9(11):e1001189. doi: 10.1371/journal.pbio.1001189. Epub 2011 Nov 1.


Divergent synthetic approach to 6''-modified α-GalCer analogues.

Pauwels N, Aspeslagh S, Vanhoenacker G, Sandra K, Yu ED, Zajonc DM, Elewaut D, Linclau B, Van Calenbergh S.

Org Biomol Chem. 2011 Dec 21;9(24):8413-21. doi: 10.1039/c1ob06235b. Epub 2011 Nov 1.

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