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IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.

Poholek CH, Dulson SJ, Zajac AJ, Harrington LE.

Immunohorizons. 2019 Jun 4;3(6):194-202. doi: 10.4049/immunohorizons.1900005.


Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus.

Kahan SM, Zajac AJ.

Viruses. 2019 Feb 13;11(2). pii: E156. doi: 10.3390/v11020156. Review.


Inscribing the core memories of killers.

Dulson SJ, Harrington LE, Zajac AJ.

Cell Mol Immunol. 2019 Feb;16(2):104-105. doi: 10.1038/s41423-018-0178-9. Epub 2018 Nov 7. No abstract available.


Late arising T follicular helper cells cultivate the B cell crop during chronic infections.

Kahan SM, Zajac AJ.

Sci Immunol. 2017 Dec 1;2(18). pii: eaap9339. doi: 10.1126/sciimmunol.aap9339. Review.


Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.

Botta D, Fuller MJ, Marquez-Lago TT, Bachus H, Bradley JE, Weinmann AS, Zajac AJ, Randall TD, Lund FE, León B, Ballesteros-Tato A.

Nat Immunol. 2017 Nov;18(11):1249-1260. doi: 10.1038/ni.3837. Epub 2017 Sep 11.


IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection.

Tian Y, Mollo SB, Harrington LE, Zajac AJ.

J Immunol. 2016 Aug 15;197(4):1308-21. doi: 10.4049/jimmunol.1502481. Epub 2016 Jul 8.


IL-21 and T Cell Differentiation: Consider the Context.

Tian Y, Zajac AJ.

Trends Immunol. 2016 Aug;37(8):557-568. doi: 10.1016/ Epub 2016 Jul 4. Review.


Editorial overview: Viral immunology.

Selin LK, Zajac AJ.

Curr Opin Virol. 2016 Feb;16:vii-ix. doi: 10.1016/j.coviro.2016.01.012. Epub 2016 Mar 12. No abstract available.


A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets.

Tian Y, Cox MA, Kahan SM, Ingram JT, Bakshi RK, Zajac AJ.

J Immunol. 2016 Mar 1;196(5):2153-66. doi: 10.4049/jimmunol.1401236. Epub 2016 Jan 29.


A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control.

Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W.

Cell Rep. 2015 Nov 10;13(6):1118-1124. doi: 10.1016/j.celrep.2015.09.069. Epub 2015 Oct 29.


T cell exhaustion during persistent viral infections.

Kahan SM, Wherry EJ, Zajac AJ.

Virology. 2015 May;479-480:180-93. doi: 10.1016/j.virol.2014.12.033. Epub 2015 Jan 22. Review.


Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients.

Overton ET, Sterrett S, Westfall AO, Kahan SM, Burkholder G, Zajac AJ, Goepfert PA, Bansal A.

AIDS. 2014 Nov 13;28(17):2627-2631. doi: 10.1097/QAD.0000000000000475.


A stay of execution: type I interferons pardon T cells from death by natural killers.

Kahan SM, Zajac AJ.

Immunity. 2014 Jun 19;40(6):861-2. doi: 10.1016/j.immuni.2014.05.009.


Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.

Ding Y, Li J, Yang P, Luo B, Wu Q, Zajac AJ, Wildner O, Hsu HC, Mountz JD.

Arthritis Rheumatol. 2014 Sep;66(9):2601-12. doi: 10.1002/art.38735.


Tissue-resident T cells lose their S1P1 exit visas.

Zajac AJ, Harrington LE.

Cell Mol Immunol. 2014 May;11(3):221-3. doi: 10.1038/cmi.2014.7. Epub 2014 Feb 24. No abstract available.


Virus-specific CD4 and CD8 T cell responses in the absence of Th1-associated transcription factors.

Mollo SB, Ingram JT, Kress RL, Zajac AJ, Harrington LE.

J Leukoc Biol. 2014 May;95(5):705-713. Epub 2013 Nov 14.


Temporal requirements for B cells in the establishment of CD4 T cell memory.

Mollo SB, Zajac AJ, Harrington LE.

J Immunol. 2013 Dec 15;191(12):6052-9. doi: 10.4049/jimmunol.1302033. Epub 2013 Nov 11.


IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.

Phares TW, DiSano KD, Hinton DR, Hwang M, Zajac AJ, Stohlman SA, Bergmann CC.

J Neuroimmunol. 2013 Oct 15;263(1-2):43-54. doi: 10.1016/j.jneuroim.2013.07.019. Epub 2013 Aug 6.


IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.

Ding Y, Li J, Wu Q, Yang P, Luo B, Xie S, Druey KM, Zajac AJ, Hsu HC, Mountz JD.

J Immunol. 2013 Aug 15;191(4):1614-24. doi: 10.4049/jimmunol.1300479. Epub 2013 Jul 15.


ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection.

Cox MA, Barnum SR, Bullard DC, Zajac AJ.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1416-21. doi: 10.1073/pnas.1213480110. Epub 2013 Jan 7.


Anti-viral CD8 T cells and the cytokines that they love.

Cox MA, Kahan SM, Zajac AJ.

Virology. 2013 Jan 5;435(1):157-69. doi: 10.1016/j.virol.2012.09.012. Review.


IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.

Petrelli A, Carvello M, Vergani A, Lee KM, Tezza S, Du M, Kleffel S, Chengwen L, Mfarrej BG, Hwu P, Secchi A, Leonard WJ, Young D, Sayegh MH, Markmann JF, Zajac AJ, Fiorina P.

Diabetes. 2011 Dec;60(12):3223-34. doi: 10.2337/db11-0880. Epub 2011 Oct 19.


Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.

Ingram JT, Yi JS, Zajac AJ.

PLoS Pathog. 2011 Sep;7(9):e1002273. doi: 10.1371/journal.ppat.1002273. Epub 2011 Sep 29.


Cytokines and the inception of CD8 T cell responses.

Cox MA, Harrington LE, Zajac AJ.

Trends Immunol. 2011 Apr;32(4):180-6. doi: 10.1016/ Epub 2011 Mar 2. Review.


Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers.

Williams LD, Bansal A, Sabbaj S, Heath SL, Song W, Tang J, Zajac AJ, Goepfert PA.

J Virol. 2011 Mar;85(5):2316-24. doi: 10.1128/JVI.01476-10. Epub 2010 Dec 15.


IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.

Yi JS, Ingram JT, Zajac AJ.

J Immunol. 2010 Oct 15;185(8):4835-45. doi: 10.4049/jimmunol.1001032. Epub 2010 Sep 15.


Interleukin-21: a multifunctional regulator of immunity to infections.

Yi JS, Cox MA, Zajac AJ.

Microbes Infect. 2010 Dec;12(14-15):1111-9. doi: 10.1016/j.micinf.2010.08.008. Epub 2010 Sep 9. Review.


Pronounced virus-dependent activation drives exhaustion but sustains IFN-γ transcript levels.

Mackerness KJ, Cox MA, Lilly LM, Weaver CT, Harrington LE, Zajac AJ.

J Immunol. 2010 Sep 15;185(6):3643-51. doi: 10.4049/jimmunol.1000841. Epub 2010 Aug 18.


Shaping successful and unsuccessful CD8 T cell responses following infection.

Cox MA, Zajac AJ.

J Biomed Biotechnol. 2010;2010:159152. doi: 10.1155/2010/159152. Epub 2010 Mar 31. Review.


T-cell exhaustion: characteristics, causes and conversion.

Yi JS, Cox MA, Zajac AJ.

Immunology. 2010 Apr;129(4):474-81. doi: 10.1111/j.1365-2567.2010.03255.x. Epub 2010 Feb 23. Review.


A vital role for interleukin-21 in the control of a chronic viral infection.

Yi JS, Du M, Zajac AJ.

Science. 2009 Jun 19;324(5934):1572-6. doi: 10.1126/science.1175194. Epub 2009 May 14.


Memory CD4 T cells emerge from effector T-cell progenitors.

Harrington LE, Janowski KM, Oliver JR, Zajac AJ, Weaver CT.

Nature. 2008 Mar 20;452(7185):356-60. doi: 10.1038/nature06672. Epub 2008 Mar 5.


HIV-1(89.6) Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in mice.

Parker SD, Rottinghaus ST, Zajac AJ, Yue L, Hunter E, Whitley RJ, Parker JN.

Vaccine. 2007 Sep 17;25(37-38):6764-73. Epub 2007 Jul 27.


Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment.

Sabbaj S, Heath SL, Bansal A, Vohra S, Kilby JM, Zajac AJ, Goepfert PA.

J Infect Dis. 2007 Jan 1;195(1):108-17. Epub 2006 Nov 20.


In vivo analysis of adenovirus-specific cytotoxic T lymphocyte response in mice deficient in CD28, fas ligand, and perforin.

Chen J, Hsu HC, Zajac AJ, Wu Q, Yang P, Xu X, McPherson SA, Li J, Curiel DT, Mountz JD.

Hum Gene Ther. 2006 Jun;17(6):669-82.


Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.

Wojciechowski S, Jordan MB, Zhu Y, White J, Zajac AJ, Hildeman DA.

Eur J Immunol. 2006 Jul;36(7):1694-706.


Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses.

Tebo AE, Fuller MJ, Gaddis DE, Kojima K, Rehani K, Zajac AJ.

J Virol. 2005 Oct;79(20):12703-13.


Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help.

Fuller MJ, Hildeman DA, Sabbaj S, Gaddis DE, Tebo AE, Shang L, Goepfert PA, Zajac AJ.

J Immunol. 2005 May 15;174(10):5926-30.


Primary adenovirus-specific cytotoxic T lymphocyte response occurs after viral clearance and liver enzyme elevation.

Chen J, Zajac AJ, McPherson SA, Hsu HC, Yang P, Wu Q, Xu X, Wang X, Fujihashi K, Curiel DT, Mountz JD.

Gene Ther. 2005 Jul;12(13):1079-88.


Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections.

Fuller MJ, Khanolkar A, Tebo AE, Zajac AJ.

J Immunol. 2004 Apr 1;172(7):4204-14.


CD4 T cell-dependent CD8 T cell maturation.

Khanolkar A, Fuller MJ, Zajac AJ.

J Immunol. 2004 Mar 1;172(5):2834-44.


Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice.

Gao F, Li Y, Decker JM, Peyerl FW, Bibollet-Ruche F, Rodenburg CM, Chen Y, Shaw DR, Allen S, Musonda R, Shaw GM, Zajac AJ, Letvin N, Hahn BH.

AIDS Res Hum Retroviruses. 2003 Sep;19(9):817-23.


Ablation of CD8 and CD4 T cell responses by high viral loads.

Fuller MJ, Zajac AJ.

J Immunol. 2003 Jan 1;170(1):477-86.


T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus.

Khanolkar A, Fuller MJ, Zajac AJ.

Immunol Res. 2002;26(1-3):309-21. Review.


Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome.

Davis IC, Zajac AJ, Nolte KB, Botten J, Hjelle B, Matalon S.

J Virol. 2002 Aug;76(16):8347-59.


Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells.

McMahon CW, Zajac AJ, Jamieson AM, Corral L, Hammer GE, Ahmed R, Raulet DH.

J Immunol. 2002 Aug 1;169(3):1444-52.


In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb.

Puglielli MT, Zajac AJ, van der Most RG, Dzuris JL, Sette A, Altman JD, Ahmed R.

J Virol. 2001 Jun;75(11):5099-107.


Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells.

Grayson JM, Zajac AJ, Altman JD, Ahmed R.

J Immunol. 2000 Apr 15;164(8):3950-4.


Impaired anti-viral T cell responses due to expression of the Ly49A inhibitory receptor.

Zajac AJ, Vance RE, Held W, Sourdive DJ, Altman JD, Raulet DH, Ahmed R.

J Immunol. 1999 Nov 15;163(10):5526-34.

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