Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 73

1.

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.

Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D; New York Genome Center ALS Consortium, Phatnani H, Kwan J, Sareen D, Broach JR, Simmons Z, Arcila-Londono X, Lee EB, Van Deerlin VM, Shneider NA, Fraenkel E, Ostrow LW, Baas F, Zaitlen N, Berry JD, Malaspina A, Fratta P, Cox GA, Thompson LM, Finkbeiner S, Dardiotis E, Miller TM, Chandran S, Pal S, Hornstein E, MacGowan DJ, Heiman-Patterson T, Hammell MG, Patsopoulos NA, Dubnau J, Nath A, Phatnani H, Shneider NA, Manley JL.

Elife. 2018 Jul 13;7. pii: e37754. doi: 10.7554/eLife.37754.

2.

An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures.

Kang EY, Lee CH, Furlotte NA, Joo JWJ, Kostem E, Zaitlen N, Eskin E, Han B.

Genetics. 2018 Jul;209(3):685-698. doi: 10.1534/genetics.117.300501. Epub 2018 May 11.

PMID:
29752291
3.

ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.

Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N.

Genome Biol. 2018 Feb 15;19(1):36. doi: 10.1186/s13059-018-1403-7.

4.

Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.

Mak ACY, White MJ, Eckalbar WL, Szpiech ZA, Oh SS, Pino-Yanes M, Hu D, Goddard P, Huntsman S, Galanter J, Wu AC, Himes BE, Germer S, Vogel JM, Bunting KL, Eng C, Salazar S, Keys KL, Liberto J, Nuckton TJ, Nguyen TA, Torgerson DG, Kwok PY, Levin AM, Celedón JC, Forno E, Hakonarson H, Sleiman PM, Dahlin A, Tantisira KG, Weiss ST, Serebrisky D, Brigino-Buenaventura E, Farber HJ, Meade K, Lenoir MA, Avila PC, Sen S, Thyne SM, Rodriguez-Cintron W, Winkler CA, Moreno-Estrada A, Sandoval K, Rodriguez-Santana JR, Kumar R, Williams LK, Ahituv N, Ziv E, Seibold MA, Darnell RB, Zaitlen N, Hernandez RD, Burchard EG; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1552-1564. doi: 10.1164/rccm.201712-2529OC.

PMID:
29509491
5.

Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression.

Peterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS.

Am J Psychiatry. 2018 Jun 1;175(6):545-554. doi: 10.1176/appi.ajp.2017.17060621. Epub 2018 Mar 2.

PMID:
29495898
6.

Dual gene activation and knockout screen reveals directional dependencies in genetic networks.

Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT.

Nat Biotechnol. 2018 Feb;36(2):170-178. doi: 10.1038/nbt.4062. Epub 2018 Jan 15.

7.

Multiplexed droplet single-cell RNA-sequencing using natural genetic variation.

Kang HM, Subramaniam M, Targ S, Nguyen M, Maliskova L, McCarthy E, Wan E, Wong S, Byrnes L, Lanata CM, Gate RE, Mostafavi S, Marson A, Zaitlen N, Criswell LA, Ye CJ.

Nat Biotechnol. 2018 Jan;36(1):89-94. doi: 10.1038/nbt.4042. Epub 2017 Dec 11.

8.

An ancestry-based approach for detecting interactions.

Park DS, Eskin I, Kang EY, Gamazon ER, Eng C, Gignoux CR, Galanter JM, Burchard E, Ye CJ, Aschard H, Eskin E, Halperin E, Zaitlen N.

Genet Epidemiol. 2018 Feb;42(1):49-63. doi: 10.1002/gepi.22087. Epub 2017 Nov 8.

PMID:
29114909
9.

Covariate selection for association screening in multiphenotype genetic studies.

Aschard H, Guillemot V, Vilhjalmsson B, Patel CJ, Skurnik D, Ye CJ, Wolpin B, Kraft P, Zaitlen N.

Nat Genet. 2017 Dec;49(12):1789-1795. doi: 10.1038/ng.3975. Epub 2017 Oct 16.

10.

CRISPR-Cas9-mediated functional dissection of 3'-UTRs.

Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ.

Nucleic Acids Res. 2017 Oct 13;45(18):10800-10810. doi: 10.1093/nar/gkx675.

11.

Heritable natural variation of an anxiety-like behavior in larval zebrafish.

Wagle M, Nguyen J, Lee S, Zaitlen N, Guo S.

J Neurogenet. 2017 Sep;31(3):138-148. doi: 10.1080/01677063.2017.1343827. Epub 2017 Jul 5.

12.

Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism.

Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Hertz-Picciotto I, Fallin MD, Weiss LA.

PLoS Genet. 2017 Jun 7;13(6):e1006831. doi: 10.1371/journal.pgen.1006831. eCollection 2017 Jun.

13.

Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk.

Hoffman JD, Graff RE, Emami NC, Tai CG, Passarelli MN, Hu D, Huntsman S, Hadley D, Leong L, Majumdar A, Zaitlen N, Ziv E, Witte JS.

PLoS Genet. 2017 Mar 31;13(3):e1006690. doi: 10.1371/journal.pgen.1006690. eCollection 2017 Mar.

14.

Correcting for cell-type heterogeneity in DNA methylation: a comprehensive evaluation.

Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard EG, Eskin E, Zou J, Halperin E.

Nat Methods. 2017 Feb 28;14(3):218-219. doi: 10.1038/nmeth.4190. No abstract available.

15.

GLINT: a user-friendly toolset for the analysis of high-throughput DNA-methylation array data.

Rahmani E, Yedidim R, Shenhav L, Schweiger R, Weissbrod O, Zaitlen N, Halperin E.

Bioinformatics. 2017 Jun 15;33(12):1870-1872. doi: 10.1093/bioinformatics/btx059.

16.

Genome-wide methylation data mirror ancestry information.

Rahmani E, Shenhav L, Schweiger R, Yousefi P, Huen K, Eskenazi B, Eng C, Huntsman S, Hu D, Galanter J, Oh SS, Waldenberger M, Strauch K, Grallert H, Meitinger T, Gieger C, Holland N, Burchard EG, Zaitlen N, Halperin E.

Epigenetics Chromatin. 2017 Jan 3;10:1. doi: 10.1186/s13072-016-0108-y. eCollection 2017.

17.

Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures.

Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodríguez-Cintrón W, Kumar R, Rodríguez-Santana JR, Seibold MA, Borrell LN, Burchard EG, Zaitlen N.

Elife. 2017 Jan 3;6. pii: e20532. doi: 10.7554/eLife.20532.

18.

Mixed Model Association with Family-Biased Case-Control Ascertainment.

Hayeck TJ, Loh PR, Pollack S, Gusev A, Patterson N, Zaitlen NA, Price AL.

Am J Hum Genet. 2017 Jan 5;100(1):31-39. doi: 10.1016/j.ajhg.2016.11.015. Epub 2016 Dec 22.

19.

Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.

Traglia M, Bseiso D, Gusev A, Adviento B, Park DS, Mefford JA, Zaitlen N, Weiss LA.

Genetics. 2017 Feb;205(2):979-992. doi: 10.1534/genetics.116.193623. Epub 2016 Dec 14.

20.

The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium.

Zaitlen N, Huntsman S, Hu D, Spear M, Eng C, Oh SS, White MJ, Mak A, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Burchard EG, Halperin E.

Genetics. 2017 Jan;205(1):375-383. doi: 10.1534/genetics.116.192138. Epub 2016 Nov 22.

21.

Pleiotropic Mechanisms Indicated for Sex Differences in Autism.

Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Hertz-Picciotto I, Fallin MD, Weiss LA.

PLoS Genet. 2016 Nov 15;12(11):e1006425. doi: 10.1371/journal.pgen.1006425. eCollection 2016 Nov. Erratum in: PLoS Genet. 2017 Jun 7;13(6):e1006831.

22.

DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome.

Joshi RS, Garg P, Zaitlen N, Lappalainen T, Watson CT, Azam N, Ho D, Li X, Antonarakis SE, Brunner HG, Buiting K, Cheung SW, Coffee B, Eggermann T, Francis D, Geraedts JP, Gimelli G, Jacobson SG, Le Caignec C, de Leeuw N, Liehr T, Mackay DJ, Montgomery SB, Pagnamenta AT, Papenhausen P, Robinson DO, Ruivenkamp C, Schwartz C, Steiner B, Stevenson DA, Surti U, Wassink T, Sharp AJ.

Am J Hum Genet. 2016 Sep 1;99(3):555-566. doi: 10.1016/j.ajhg.2016.06.032. Epub 2016 Aug 25.

23.

Transethnic Genetic-Correlation Estimates from Summary Statistics.

Brown BC; Asian Genetic Epidemiology Network Type 2 Diabetes Consortium, Ye CJ, Price AL, Zaitlen N.

Am J Hum Genet. 2016 Jul 7;99(1):76-88. doi: 10.1016/j.ajhg.2016.05.001. Epub 2016 Jun 16.

24.

Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.

Uricchio LH, Zaitlen NA, Ye CJ, Witte JS, Hernandez RD.

Genome Res. 2016 Jul;26(7):863-73. doi: 10.1101/gr.202440.115. Epub 2016 May 18.

25.

Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies.

Brown BC, Price AL, Patsopoulos NA, Zaitlen N.

Genetics. 2016 Jul;203(3):1105-16. doi: 10.1534/genetics.116.188292. Epub 2016 May 6.

26.

Massively Parallel Identification of Regulatory Variants in Asthma.

Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S104. doi: 10.1513/AnnalsATS.201508-523MG. No abstract available.

27.

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies.

Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard EG, Eskin E, Zou J, Halperin E.

Nat Methods. 2016 May;13(5):443-5. doi: 10.1038/nmeth.3809. Epub 2016 Mar 28.

28.

A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.

Balliu B, Zaitlen N.

Genetics. 2016 Apr;202(4):1289-97. doi: 10.1534/genetics.115.179846. Epub 2016 Feb 10.

29.

Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns.

Zou JY, Park DS, Burchard EG, Torgerson DG, Pino-Yanes M, Song YS, Sankararaman S, Halperin E, Zaitlen N.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13621-6. doi: 10.1073/pnas.1501741112. Epub 2015 Oct 19. Erratum in: Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4432.

30.

Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.

Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Zaitlen N, Goga A, Ziv E.

Hum Mol Genet. 2015 Dec 20;24(25):7421-31. doi: 10.1093/hmg/ddv432. Epub 2015 Oct 15.

31.

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, Kathiresan S, Pato M, Pato C, Tamimi R, Stahl E, Zaitlen N, Pasaniuc B, Belbin G, Kenny EE, Schierup MH, De Jager P, Patsopoulos NA, McCarroll S, Daly M, Purcell S, Chasman D, Neale B, Goddard M, Visscher PM, Kraft P, Patterson N, Price AL.

Am J Hum Genet. 2015 Oct 1;97(4):576-92. doi: 10.1016/j.ajhg.2015.09.001.

32.

Adapt-Mix: learning local genetic correlation structure improves summary statistics-based analyses.

Park DS, Brown B, Eng C, Huntsman S, Hu D, Torgerson DG, Burchard EG, Zaitlen N.

Bioinformatics. 2015 Jun 15;31(12):i181-9. doi: 10.1093/bioinformatics/btv230.

33.

The landscape of genomic imprinting across diverse adult human tissues.

Baran Y, Subramaniam M, Biton A, Tukiainen T, Tsang EK, Rivas MA, Pirinen M, Gutierrez-Arcelus M, Smith KS, Kukurba KR, Zhang R, Eng C, Torgerson DG, Urbanek C; GTEx Consortium, Li JB, Rodriguez-Santana JR, Burchard EG, Seibold MA, MacArthur DG, Montgomery SB, Zaitlen NA, Lappalainen T.

Genome Res. 2015 Jul;25(7):927-36. doi: 10.1101/gr.192278.115. Epub 2015 May 7.

34.

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.

Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C; Baylor-Hopkins Center for Mendelian Genomics, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK.

Nat Genet. 2015 Jun;47(6):654-60. doi: 10.1038/ng.3279. Epub 2015 Apr 20.

35.

Mixed model with correction for case-control ascertainment increases association power.

Hayeck TJ, Zaitlen NA, Loh PR, Vilhjalmsson B, Pollack S, Gusev A, Yang J, Chen GB, Goddard ME, Visscher PM, Patterson N, Price AL.

Am J Hum Genet. 2015 May 7;96(5):720-30. doi: 10.1016/j.ajhg.2015.03.004. Epub 2015 Apr 16.

36.

PIGS: improved estimates of identity-by-descent probabilities by probabilistic IBD graph sampling.

Park DS, Baran Y, Hormozdiari F, Eng C, Torgerson DG, Burchard EG, Zaitlen N.

BMC Bioinformatics. 2015;16 Suppl 5:S9. doi: 10.1186/1471-2105-16-S5-S9. Epub 2015 Mar 18.

37.

Assessing allele-specific expression across multiple tissues from RNA-seq read data.

Pirinen M, Lappalainen T, Zaitlen NA; GTEx Consortium, Dermitzakis ET, Donnelly P, McCarthy MI, Rivas MA.

Bioinformatics. 2015 Aug 1;31(15):2497-504. doi: 10.1093/bioinformatics/btv074. Epub 2015 Mar 27.

38.

Genetic and environmental components of family history in type 2 diabetes.

Cornelis MC, Zaitlen N, Hu FB, Kraft P, Price AL.

Hum Genet. 2015 Feb;134(2):259-67. doi: 10.1007/s00439-014-1519-0. Epub 2014 Dec 30.

39.

Leveraging population admixture to characterize the heritability of complex traits.

Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ, Hsing A, Ingles SA, Isaacs W, Kittles RA, Klein EA, Lange LA, Nemesure B, Patterson N, Reich D, Rybicki BA, Stanford JL, Stevens VL, Strom SS, Whitsel EA, Witte JS, Xu J, Haiman C, Wilson JG, Kooperberg C, Stram D, Reiner AP, Tang H, Price AL.

Nat Genet. 2014 Dec;46(12):1356-62. doi: 10.1038/ng.3139. Epub 2014 Nov 10.

40.

Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age.

Aschard H, Zaitlen N, Lindström S, Kraft P.

Epidemiology. 2015 Jan;26(1):51-8. doi: 10.1097/EDE.0000000000000195.

41.

Intersection of population variation and autoimmunity genetics in human T cell activation.

Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, Regev A, Benoist C.

Science. 2014 Sep 12;345(6202):1254665. doi: 10.1126/science.1254665.

42.

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.

Pasaniuc B, Zaitlen N, Shi H, Bhatia G, Gusev A, Pickrell J, Hirschhorn J, Strachan DP, Patterson N, Price AL.

Bioinformatics. 2014 Oct 15;30(20):2906-14. doi: 10.1093/bioinformatics/btu416. Epub 2014 Jul 1.

43.

Massively parallel functional annotation of 3' untranslated regions.

Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ.

Nat Biotechnol. 2014 Apr;32(4):387-91. doi: 10.1038/nbt.2851. Epub 2014 Mar 16.

44.

Advantages and pitfalls in the application of mixed-model association methods.

Yang J, Zaitlen NA, Goddard ME, Visscher PM, Price AL.

Nat Genet. 2014 Feb;46(2):100-6. doi: 10.1038/ng.2876.

45.

Quantifying missing heritability at known GWAS loci.

Gusev A, Bhatia G, Zaitlen N, Vilhjalmsson BJ, Diogo D, Stahl EA, Gregersen PK, Worthington J, Klareskog L, Raychaudhuri S, Plenge RM, Pasaniuc B, Price AL.

PLoS Genet. 2013;9(12):e1003993. doi: 10.1371/journal.pgen.1003993. Epub 2013 Dec 26.

46.

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.

Chimusa ER, Zaitlen N, Daya M, Möller M, van Helden PD, Mulder NJ, Price AL, Hoal EG.

Hum Mol Genet. 2014 Feb 1;23(3):796-809. doi: 10.1093/hmg/ddt462. Epub 2013 Sep 20.

47.

Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits.

Zaitlen N, Kraft P, Patterson N, Pasaniuc B, Bhatia G, Pollack S, Price AL.

PLoS Genet. 2013 May;9(5):e1003520. doi: 10.1371/journal.pgen.1003520. Epub 2013 May 30.

48.

Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation.

Pasaniuc B, Sankararaman S, Torgerson DG, Gignoux C, Zaitlen N, Eng C, Rodriguez-Cintron W, Chapela R, Ford JG, Avila PC, Rodriguez-Santana J, Chen GK, Le Marchand L, Henderson B, Reich D, Haiman CA, Gonzàlez Burchard E, Halperin E.

Bioinformatics. 2013 Jun 1;29(11):1407-15. doi: 10.1093/bioinformatics/btt166. Epub 2013 Apr 9.

49.

A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes.

Aschard H, Zaitlen N, Tamimi RM, Lindström S, Kraft P.

Genet Epidemiol. 2013 May;37(4):323-33. doi: 10.1002/gepi.21716. Epub 2013 Mar 19.

50.

Response to Sul and Eskin.

Price AL, Zaitlen NA, Reich D, Patterson N.

Nat Rev Genet. 2013 Apr;14(4):300. doi: 10.1038/nrg2813-c2. Epub 2013 Feb 26. No abstract available.

Supplemental Content

Loading ...
Support Center