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TRPV4 deletion protects against hypokalemia during systemic K+ deficiency.

Tomilin V, Mamenko M, Zaika O, Wingo CS, Pochynyuk O.

Am J Physiol Renal Physiol. 2019 May 1;316(5):F948-F956. doi: 10.1152/ajprenal.00043.2019. Epub 2019 Mar 6.


Urinary concentrating defect in mice lacking Epac1 or Epac2.

Cherezova A, Tomilin V, Buncha V, Zaika O, Ortiz PA, Mei F, Cheng X, Mamenko M, Pochynyuk O.

FASEB J. 2019 Feb;33(2):2156-2170. doi: 10.1096/fj.201800435R. Epub 2018 Sep 25.


Compromised regulation of the collecting duct ENaC activity in mice lacking AT1a receptor.

Mamenko M, Zaika O, Tomilin V, Jensen VB, Pochynyuk O.

J Cell Physiol. 2018 Sep;233(9):7217-7225. doi: 10.1002/jcp.26552. Epub 2018 Mar 25.


Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca2+]i homeostasis in human autosomal-dominant polycystic kidney disease cells.

Tomilin V, Reif GA, Zaika O, Wallace DP, Pochynyuk O.

FASEB J. 2018 Aug;32(8):4612-4623. doi: 10.1096/fj.201701535RR. Epub 2018 Mar 19.


Rapid risk assessment during the early weeks of the 2015-2016 influenza season in Ukraine.

Newitt S, Mironenko A, Holubka O, Zaika O, Gubar O, Jalava K, Brown C, Demchyshyna I, Dykhanovska T.

Influenza Other Respir Viruses. 2018 Mar;12(2):241-249. doi: 10.1111/irv.12526. Epub 2018 Jan 15.


Dietary K+ and Cl- independently regulate basolateral conductance in principal and intercalated cells of the collecting duct.

Tomilin VN, Zaika O, Subramanya AR, Pochynyuk O.

Pflugers Arch. 2018 Feb;470(2):339-353. doi: 10.1007/s00424-017-2084-x. Epub 2017 Nov 13.


The renal TRPV4 channel is essential for adaptation to increased dietary potassium.

Mamenko MV, Boukelmoune N, Tomilin VN, Zaika OL, Jensen VB, O'Neil RG, Pochynyuk OM.

Kidney Int. 2017 Jun;91(6):1398-1409. doi: 10.1016/j.kint.2016.12.010. Epub 2017 Feb 7.


Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y.

Cell Rep. 2016 Jun 28;16(1):106-119. doi: 10.1016/j.celrep.2016.05.080. Epub 2016 Jun 16.


Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus and perirhinal cortex-mediated object memory.

Mitchnick KA, Creighton SD, Cloke JM, Wolter M, Zaika O, Christen B, Van Tiggelen M, Kalisch BE, Winters BD.

Genes Brain Behav. 2016 Jul;15(6):542-57. doi: 10.1111/gbb.12303.


Correction: Emerging Role of the Calcium-Activated, Small Conductance, SK3 K+ Channel in Distal Tubule Function: Regulation by TRPV4.

Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG.

PLoS One. 2016 May 19;11(5):e0156368. doi: 10.1371/journal.pone.0156368. eCollection 2016.


Evaluation of User Performance in Simulation-Based Diagnostic Cerebral Angiography Training.

Zaika O, Nguyen N, Boulton M, Eagleson R, de Ribaupierre S.

Stud Health Technol Inform. 2016;220:465-8.


New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule.

Zaika O, Tomilin V, Mamenko M, Bhalla V, Pochynyuk O.

Am J Physiol Renal Physiol. 2016 May 15;310(10):F923-30. doi: 10.1152/ajprenal.00577.2015. Epub 2016 Jan 20. Review.


Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage.

Zaika O, Palygin O, Tomilin V, Mamenko M, Staruschenko A, Pochynyuk O.

Am J Physiol Renal Physiol. 2016 Feb 15;310(4):F311-21. doi: 10.1152/ajprenal.00436.2015. Epub 2015 Dec 2.


Defective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes Insipidus.

Mamenko M, Dhande I, Tomilin V, Zaika O, Boukelmoune N, Zhu Y, Gonzalez-Garay ML, Pochynyuk O, Doris PA.

J Am Soc Nephrol. 2016 Jul;27(7):2035-48. doi: 10.1681/ASN.2014121200. Epub 2015 Nov 16.


Role of renal TRP channels in physiology and pathology.

Tomilin V, Mamenko M, Zaika O, Pochynyuk O.

Semin Immunopathol. 2016 May;38(3):371-83. doi: 10.1007/s00281-015-0527-z. Epub 2015 Sep 18. Review.


Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin.

Mamenko M, Zaika O, Boukelmoune N, Madden E, Pochynyuk O.

Vitam Horm. 2015;98:137-54. doi: 10.1016/bs.vh.2014.12.005. Epub 2015 Feb 14. Review.


Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.

Mamenko M, Zaika O, Boukelmoune N, O'Neil RG, Pochynyuk O.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F275-86. doi: 10.1152/ajprenal.00485.2014. Epub 2014 Dec 10. Review.


IGF-1 and insulin exert opposite actions on ClC-K2 activity in the cortical collecting ducts.

Zaika O, Mamenko M, Boukelmoune N, Pochynyuk O.

Am J Physiol Renal Physiol. 2015 Jan 1;308(1):F39-48. doi: 10.1152/ajprenal.00545.2014. Epub 2014 Oct 22.


Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4.

Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG.

PLoS One. 2014 Apr 24;9(4):e95149. doi: 10.1371/journal.pone.0095149. eCollection 2014. Erratum in: PLoS One. 2016;11(5):e0156368.


Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling.

Mamenko M, Zaika O, Pochynyuk O.

Curr Opin Nephrol Hypertens. 2014 Mar;23(2):122-9. doi: 10.1097/01.mnh.0000441053.81339.61. Review.


Chronic angiotensin II infusion drives extensive aldosterone-independent epithelial Na+ channel activation.

Mamenko M, Zaika O, Prieto MC, Jensen VB, Doris PA, Navar LG, Pochynyuk O.

Hypertension. 2013 Dec;62(6):1111-1122. doi: 10.1161/HYPERTENSIONAHA.113.01797. Epub 2013 Sep 23.


Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine.

Zaika OL, Mamenko M, Palygin O, Boukelmoune N, Staruschenko A, Pochynyuk O.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1277-87. doi: 10.1152/ajprenal.00363.2013. Epub 2013 Aug 28.


Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.

Mamenko M, Zaika OL, Boukelmoune N, Berrout J, O'Neil RG, Pochynyuk O.

J Biol Chem. 2013 Jul 12;288(28):20306-14. doi: 10.1074/jbc.M113.466797. Epub 2013 May 24.


Ca2+ Imaging as a tool to assess TRP channel function in murine distal nephrons.

Mamenko M, Zaika O, O'Neil RG, Pochynyuk O.

Methods Mol Biol. 2013;998:371-84. doi: 10.1007/978-1-62703-351-0_29.


Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, Zaika OL, Mamenko M, Kayashima Y, Matsuki K, Hiller S, Li F, Xu L, Grant R, Bertorello AM, Smithies O.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5600-5. doi: 10.1073/pnas.1302641110. Epub 2013 Mar 15.


TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease.

Zaika O, Mamenko M, Berrout J, Boukelmoune N, O'Neil RG, Pochynyuk O.

J Am Soc Nephrol. 2013 Mar;24(4):604-16. doi: 10.1681/ASN.2012050442. Epub 2013 Feb 14.


Novel insights into TRPV4 function in the kidney.

Pochynyuk O, Zaika O, O'Neil RG, Mamenko M.

Pflugers Arch. 2013 Feb;465(2):177-86. doi: 10.1007/s00424-012-1190-z. Epub 2012 Dec 4. Review.


Direct activation of ENaC by angiotensin II: recent advances and new insights.

Zaika O, Mamenko M, Staruschenko A, Pochynyuk O.

Curr Hypertens Rep. 2013 Feb;15(1):17-24. doi: 10.1007/s11906-012-0316-1. Review.


Salt-dependent inhibition of epithelial Na+ channel-mediated sodium reabsorption in the aldosterone-sensitive distal nephron by bradykinin.

Mamenko M, Zaika O, Doris PA, Pochynyuk O.

Hypertension. 2012 Nov;60(5):1234-41. doi: 10.1161/HYPERTENSIONAHA.112.200469. Epub 2012 Oct 1.


Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system.

Berrout J, Jin M, Mamenko M, Zaika O, Pochynyuk O, O'Neil RG.

J Biol Chem. 2012 Mar 16;287(12):8782-91. doi: 10.1074/jbc.M111.308411. Epub 2012 Feb 1.


Angiotensin II increases activity of the epithelial Na+ channel (ENaC) in distal nephron additively to aldosterone.

Mamenko M, Zaika O, Ilatovskaya DV, Staruschenko A, Pochynyuk O.

J Biol Chem. 2012 Jan 2;287(1):660-71. doi: 10.1074/jbc.M111.298919. Epub 2011 Nov 15.


Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron.

Mamenko M, Zaika O, Jin M, O'Neil RG, Pochynyuk O.

PLoS One. 2011;6(8):e22824. doi: 10.1371/journal.pone.0022824. Epub 2011 Aug 5.


AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.

Zhang J, Bal M, Bierbower S, Zaika O, Shapiro MS.

J Neurosci. 2011 May 11;31(19):7199-211. doi: 10.1523/JNEUROSCI.4446-10.2011.


Af17 deficiency increases sodium excretion and decreases blood pressure.

Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W.

J Am Soc Nephrol. 2011 Jun;22(6):1076-86. doi: 10.1681/ASN.2010121270. Epub 2011 May 5.


Functional role of M-type (KCNQ) K⁺ channels in adrenergic control of cardiomyocyte contraction rate by sympathetic neurons.

Zaika O, Zhang J, Shapiro MS.

J Physiol. 2011 May 15;589(Pt 10):2559-68. doi: 10.1113/jphysiol.2010.204768. Epub 2011 Mar 21.


Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Zaika O, Mamenko M, O'Neil RG, Pochynyuk O.

Am J Physiol Renal Physiol. 2011 May;300(5):F1105-15. doi: 10.1152/ajprenal.00606.2010. Epub 2011 Feb 16.


Combined phosphoinositide and Ca2+ signals mediating receptor specificity toward neuronal Ca2+ channels.

Zaika O, Zhang J, Shapiro MS.

J Biol Chem. 2011 Jan 7;286(1):830-41. doi: 10.1074/jbc.M110.166033. Epub 2010 Nov 4.


Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels.

Bal M, Zhang J, Hernandez CC, Zaika O, Shapiro MS.

J Neurosci. 2010 Feb 10;30(6):2311-23. doi: 10.1523/JNEUROSCI.5175-09.2010.


[Participation of synaptotagmin in release of catecholamines in rat adrenal chromaffin cells].

Pochyniuk OV, Zaïka OL, Sadovyĭ OV, Iavors'ka OM, Kostiuk PH, Luk'ianets OO.

Fiziol Zh. 2010;56(6):31-8. Ukrainian.


Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.

Zaika O, Hernandez CC, Bal M, Tolstykh GP, Shapiro MS.

Biophys J. 2008 Dec;95(11):5121-37. doi: 10.1529/biophysj.108.137604. Epub 2008 Sep 12.


Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.

Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS.

J Biol Chem. 2008 Nov 7;283(45):30668-76. doi: 10.1074/jbc.M805216200. Epub 2008 Sep 11.


A carboxy-terminal inter-helix linker as the site of phosphatidylinositol 4,5-bisphosphate action on Kv7 (M-type) K+ channels.

Hernandez CC, Zaika O, Shapiro MS.

J Gen Physiol. 2008 Sep;132(3):361-81. doi: 10.1085/jgp.200810007.


Calmodulin binding to M-type K+ channels assayed by TIRF/FRET in living cells.

Bal M, Zaika O, Martin P, Shapiro MS.

J Physiol. 2008 May 1;586(9):2307-20. doi: 10.1113/jphysiol.2008.152777. Epub 2008 Mar 13.


Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications.

Hernandez CC, Zaika O, Tolstykh GP, Shapiro MS.

J Physiol. 2008 Apr 1;586(7):1811-21. doi: 10.1113/jphysiol.2007.148304. Epub 2008 Jan 31. Review.


Inositol triphosphate-mediated Ca2+ signals direct purinergic P2Y receptor regulation of neuronal ion channels.

Zaika O, Tolstykh GP, Jaffe DB, Shapiro MS.

J Neurosci. 2007 Aug 15;27(33):8914-26.


Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing.

Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS.

EMBO J. 2006 Oct 18;25(20):4996-5004. Epub 2006 Oct 5.


Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels.

Zaika O, Lara LS, Gamper N, Hilgemann DW, Jaffe DB, Shapiro MS.

J Physiol. 2006 Aug 15;575(Pt 1):49-67. Epub 2006 Jun 15.


Acetylcholine-induced calcium signalling in adrenaline- and noradrenaline-containing adrenal chromaffin cells.

Zaika OL, Pochynyuk OM, Kostyuk PG, Yavorskaya EN, Lukyanetz EA.

Arch Biochem Biophys. 2004 Apr 1;424(1):23-32.


[Electrochemical studies of induced secretion of catecholamines from individual vesicles of rat chromaffin cells].

Zaika OL, Pochiniuk OM, Luk'ianets EA.

Ukr Biokhim Zh (1999). 2001 Jul-Aug;73(4):69-72. Russian.


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