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PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.

Wang S, Chen Z, Zhu S, Lu H, Peng D, Soutto M, Naz H, Peek R Jr, Xu H, Zaika A, Xu Z, El-Rifai W.

Redox Biol. 2019 Sep 5;28:101319. doi: 10.1016/j.redox.2019.101319. [Epub ahead of print]


Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.

Zhu S, Soutto M, Chen Z, Blanca Piazuelo M, Kay Washington M, Belkhiri A, Zaika A, Peng D, El-Rifai W.

Oncogene. 2019 Jul;38(29):5805-5816. doi: 10.1038/s41388-019-0843-1. Epub 2019 Jun 24.


From genetics to signaling pathways: molecular pathogenesis of esophageal adenocarcinoma.

Caspa Gokulan R, Garcia-Buitrago MT, Zaika AI.

Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):37-48. doi: 10.1016/j.bbcan.2019.05.003. Epub 2019 May 30. Review.


NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.

Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, Zaika A, El-Rifai W.

Cancer Lett. 2019 Aug 28;458:46-55. doi: 10.1016/j.canlet.2019.05.031. Epub 2019 May 24.


Gastroesophageal Reflux Induces Protein Adducts in the Esophagus.

Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA Jr, Dikalov SI, Zaika AI.

Cell Mol Gastroenterol Hepatol. 2019;7(2):480-482.e7. doi: 10.1016/j.jcmgh.2018.10.017. Epub 2018 Nov 8. No abstract available.


Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.

Bhat AA, Lu H, Soutto M, Capobianco A, Rai P, Zaika A, El-Rifai W.

Oncogene. 2018 Nov;37(46):6011-6024. doi: 10.1038/s41388-018-0388-8. Epub 2018 Jul 10.


Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells.

Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek RM Jr, Zaika AI.

Oncogene. 2018 Sep;37(37):5054-5065. doi: 10.1038/s41388-018-0343-8. Epub 2018 May 30.


Activation of NADPH oxidases leads to DNA damage in esophageal cells.

Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI.

Sci Rep. 2017 Aug 30;7(1):9956. doi: 10.1038/s41598-017-09620-4.


How does bacterial pathogen Helicobacter pylori control responses to cellular stress?

Horvat A, Zaika AI.

Future Microbiol. 2017 Feb;12:105-108. doi: 10.2217/fmb-2016-0220. Epub 2017 Jan 23. No abstract available.


Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts.

Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI.

Carcinogenesis. 2016 Dec;37(12):1161-1169. Epub 2016 Sep 21.


APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts.

Hong J, Chen Z, Peng D, Zaika A, Revetta F, Washington MK, Belkhiri A, El-Rifai W.

Oncotarget. 2016 Mar 29;7(13):16688-702. doi: 10.18632/oncotarget.7696.


Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma.

Taylor C, Loomans HA, Le Bras GF, Koumangoye RB, Romero-Morales AI, Quast LL, Zaika AI, El-Rifai W, Andl T, Andl CD.

Oncotarget. 2015 Oct 27;6(33):34228-44. doi: 10.18632/oncotarget.5349.


Microbial Regulation of p53 Tumor Suppressor.

Zaika AI, Wei J, Noto JM, Peek RM.

PLoS Pathog. 2015 Sep 17;11(9):e1005099. doi: 10.1371/journal.ppat.1005099. eCollection 2015 Sep. Review.


Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion.

Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G146-61. doi: 10.1152/ajpgi.00462.2014. Epub 2015 Jun 4.


Erratum to: Bacterial Pathogen Helicobacter pylori: A Bad AKTor Inhibits p53 Protein Activity.

Zaika AI.

Dig Dis Sci. 2015 May;60(5):1510. doi: 10.1007/s10620-015-3554-7. No abstract available.


Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway.

Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI.

Oncotarget. 2015 Jan 30;6(3):1531-43.


Bacterial Pathogen Helicobacter pylori: A Bad AKTor Inhibits p53 Protein Activity [corrected].

Zaika AI.

Dig Dis Sci. 2015 Apr;60(4):822-3. doi: 10.1007/s10620-014-3511-x. No abstract available. Erratum in: Dig Dis Sci. 2015 May;60(5):1510.


Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner.

Wei J, Noto JM, Zaika E, Romero-Gallo J, Piazuelo MB, Schneider B, El-Rifai W, Correa P, Peek RM, Zaika AI.

Gut. 2015 Jul;64(7):1040-8. doi: 10.1136/gutjnl-2014-307295. Epub 2014 Jul 30.


TFF1 activates p53 through down-regulation of miR-504 in gastric cancer.

Soutto M, Chen Z, Saleh MA, Katsha A, Zhu S, Zaika A, Belkhiri A, El-Rifai W.

Oncotarget. 2014 Jul 30;5(14):5663-73.


[A complex method for prophylaxis of laparoscopic cholecystectomy complications].

Ioffe IV, Alekseev AV, Pepenin AV, Zaika AV, Torba AV.

Klin Khir. 2013 Jul;(7):9-12. Russian.


HDM2 regulation by AURKA promotes cell survival in gastric cancer.

Sehdev V, Katsha A, Arras J, Peng D, Soutto M, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W.

Clin Cancer Res. 2014 Jan 1;20(1):76-86. doi: 10.1158/1078-0432.CCR-13-1187. Epub 2013 Nov 15. Erratum in: Clin Cancer Res. 2015 Feb 1;21(3):661. Clin Cancer Res. 2015 Feb 1;21(3):661.


Proinflammatory cytokines and bile acids upregulate ΔNp73 protein, an inhibitor of p53 and p73 tumor suppressors.

Zaika E, Bhardwaj V, Wei J, Washington MK, Souza R, El-Rifai W, Zaika A.

PLoS One. 2013 May 22;8(5):e64306. doi: 10.1371/journal.pone.0064306. Print 2013.


Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.

Peng D, Hu T, Soutto M, Belkhiri A, Zaika A, El-Rifai W.

Gut. 2014 Apr;63(4):540-51. doi: 10.1136/gutjnl-2013-304612. Epub 2013 Apr 12.


Regulation of the p53 by Helicobacter pylori.

Zaika A, Wei J, Noto J, Peek R Jr.

Oncotarget. 2012 Oct;3(10):1057-8. No abstract available.


Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses.

Wei J, Noto J, Zaika E, Romero-Gallo J, Correa P, El-Rifai W, Peek RM, Zaika A.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2543-50. Epub 2012 Aug 27.


[Draft macronuclear genome of a ciliate Euplotes crassus].

Vinogradov DV, Tsoĭ OV, Zaika AV, Lobanov AV, Turanov AA, Gladyshev VN, Gel'fand MS.

Mol Biol (Mosk). 2012 Mar-Apr;46(2):361-6. Russian.


The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells.

Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, Zaika A, Rau TT, Schneider-Stock R, Belkhiri A, El-Rifai W.

Mol Cancer Ther. 2012 Mar;11(3):763-74. doi: 10.1158/1535-7163.MCT-11-0623. Epub 2012 Feb 1. Erratum in: Mol Cancer Ther. 2014 Nov;13(11):2765-6.


Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.

Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W.

Gut. 2012 Sep;61(9):1250-60. doi: 10.1136/gutjnl-2011-301078. Epub 2011 Dec 9.


p53 Family: Role of Protein Isoforms in Human Cancer.

Wei J, Zaika E, Zaika A.

J Nucleic Acids. 2012;2012:687359. doi: 10.1155/2012/687359. Epub 2011 Oct 9.


p73 protein regulates DNA damage repair.

Zaika E, Wei J, Yin D, Andl C, Moll U, El-Rifai W, Zaika AI.

FASEB J. 2011 Dec;25(12):4406-14. doi: 10.1096/fj.11-192815. Epub 2011 Sep 2.


Loss of TFF1 is associated with activation of NF-κB-mediated inflammation and gastric neoplasia in mice and humans.

Soutto M, Belkhiri A, Piazuelo MB, Schneider BG, Peng D, Jiang A, Washington MK, Kokoye Y, Crowe SE, Zaika A, Correa P, Peek RM Jr, El-Rifai W.

J Clin Invest. 2011 May;121(5):1753-67. doi: 10.1172/JCI43922. Epub 2011 Apr 1.


[The coordinated interaction of multifunctional members of p53 family determines many key processes in multicellular organisms].

Vilgelm AE, Zaika AI, Prasolov VS.

Mol Biol (Mosk). 2011 Jan-Feb;45(1):180-97. Review. Russian.


Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors.

Vilgelm AE, Hong SM, Washington MK, Wei J, Chen H, El-Rifai W, Zaika A.

Oncogene. 2010 Oct 28;29(43):5861-8. doi: 10.1038/onc.2010.319. Epub 2010 Aug 2.


Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells.

Wei J, Nagy TA, Vilgelm A, Zaika E, Ogden SR, Romero-Gallo J, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A.

Gastroenterology. 2010 Oct;139(4):1333-43. doi: 10.1053/j.gastro.2010.06.018. Epub 2010 Jun 12.


[Postoperative complications after surgical interventions for cancer of proximal regions of the rectum].

Bondar' GV, Basheev VKh, Bondarenko NV, Psaras GG, Zaika AN.

Klin Khir. 2010 Jan;(1):9-12. Russian.


Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors.

Vilgelm AE, Washington MK, Wei J, Chen H, Prassolov VS, Zaika AI.

Mol Cancer Ther. 2010 Mar;9(3):693-705. doi: 10.1158/1535-7163.MCT-09-0912. Epub 2010 Mar 2.


Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.

Lee W, Belkhiri A, Lockhart AC, Merchant N, Glaeser H, Harris EI, Washington MK, Brunt EM, Zaika A, Kim RB, El-Rifai W.

Cancer Res. 2008 Dec 15;68(24):10315-23. doi: 10.1158/0008-5472.CAN-08-1984.


Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells.

Dar AA, Belkhiri A, Ecsedy J, Zaika A, El-Rifai W.

Cancer Res. 2008 Nov 1;68(21):8998-9004. doi: 10.1158/0008-5472.CAN-08-2658.


Therapeutic prospects for p73 and p63: rising from the shadow of p53.

Vilgelm A, El-Rifai W, Zaika A.

Drug Resist Updat. 2008 Aug-Oct;11(4-5):152-63. doi: 10.1016/j.drup.2008.08.001. Epub 2008 Sep 17. Review.


[Insufficience of the large intestine anastomosis sutures. Statistics, causes of occurrence, diagnosis, treatment and prophylaxis].

Bondar' GV, Basheev VKh, Psaras GG, Bondarenko NV, Borota AV, Zolotukhin SE, Zaika AN.

Klin Khir. 2008 Mar;(3):60-4. Russian. No abstract available.


Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family.

Wei J, O'Brien D, Vilgelm A, Piazuelo MB, Correa P, Washington MK, El-Rifai W, Peek RM, Zaika A.

Gastroenterology. 2008 May;134(5):1412-23. doi: 10.1053/j.gastro.2008.01.072. Epub 2008 Jan 31.


Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions.

Dar AA, Zaika A, Piazuelo MB, Correa P, Koyama T, Belkhiri A, Washington K, Castells A, Pera M, El-Rifai W.

Cancer. 2008 Apr 15;112(8):1688-98. doi: 10.1002/cncr.23371.


t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism.

Belkhiri A, Dar AA, Zaika A, Kelley M, El-Rifai W.

Cancer Res. 2008 Jan 15;68(2):395-403. doi: 10.1158/0008-5472.CAN-07-1580.


DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function.

Vilgelm A, Wei JX, Piazuelo MB, Washington MK, Prassolov V, El-Rifai W, Zaika A.

Oncogene. 2008 Apr 3;27(15):2170-6. Epub 2007 Oct 22.


p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.

Hong SM, Cho H, Moskaluk CA, Yu E, Zaika AI.

J Mol Histol. 2007 Jun;38(3):167-75. Epub 2007 Mar 24.


The gastrin gene promoter is regulated by p73 isoforms in tumor cells.

Tomkova K, El-Rifai W, Vilgelm A, Kelly MC, Wang TC, Zaika AI.

Oncogene. 2006 Sep 28;25(44):6032-6. Epub 2006 Apr 24.


The role of p53 protein family in gastrointestinal malignancies.

Zaika AI, El-Rifai W.

Cell Death Differ. 2006 Jun;13(6):935-40. Review. No abstract available.


Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas.

McChesney PA, Aiyar SE, Lee OJ, Zaika A, Moskaluk C, Li R, El-Rifai W.

Cancer Res. 2006 Feb 1;66(3):1346-53.


[Digoxin in treatment of chronic insufficiency and changes of functional state of the pancreas].

Zaïka AV, Zaïka IV.

Lik Sprava. 2005 Jul-Sep;(5-6):69-73. Ukrainian.


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