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J Res Med Sci. 2017 May 30;22:70. doi: 10.4103/jrms.JRMS_788_16. eCollection 2017.

Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease.

Author information

1
Department of Nutrition and Food Sciences, Pregnancy Health Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
2
Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
3
Department of Nutrition and Food Sciences, Health Promotion Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
4
Department of Nutrition and Food Sciences, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract

BACKGROUND:

Omentin-1, vaspin, and apelin are novel adipokines which closely associate with obesity, nonalcoholic fatty liver disease (NAFLD), and inflammation. The aim of this study was to investigate the circulating levels of omentin-1, vaspin, and apelin in NAFLD patients and to clarify their relationship with biochemical parameters, abdominal obesity, and high sensitive C-reactive protein.

MATERIALS AND METHODS:

In a case-control study, serum levels of omentin-1, vaspin, and apelin were measured in 41 NAFLD patients and 41 healthy volunteers. The study was performed in the outpatients' clinic of Imam-Ali Hospital in Zahedan, Iran, during February to July 2015. Fatty liver was confirmed by ultrasonography. The association of the adipokines with lipid profile and anthropometric parameters was assessed using multivariable linear regression models. In this model, those variables that showed P < 0.05 were included in the study.

RESULTS:

NAFLD patients presented a significantly higher apelin levels compared to the controls (P < 0.01), whereas serum omentin-1 and vaspin levels did not differ between two groups (both P > 0.05). Multiple regression analysis showed that the serum levels of apelin and vaspin correlated positively with waist circumference (WC) (P < 0.01 and P < 0.05, respectively) and low-density lipoprotein (P < 0.05 and P < 0.01, respectively) while serum omentin-1 was inversely correlated with WC (P < 0.01) and positively corrected with high-density lipoprotein (P < 0.05).

CONCLUSION:

The findings showed that among the analyzed adipokines only apelin was different in patients with NAFLD when compared to controls. Considering the multivariate regression analysis, apelin seems be more suitable diagnostic marker in predicting of NAFLD and omentin might be considered as a protective factor in occurrence of NAFLD, particularly in those with central obesity.

KEYWORDS:

Adipokines; apelin; central obesity; nonalcoholic fatty liver disease; omentin; vaspin

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