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Items: 23


Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles.

Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, Cook JM, Savic M, Sibille E.

Mol Neuropsychiatry. 2019 Apr;5(2):84-97. doi: 10.1159/000496086. Epub 2019 Jan 23.


MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression.

Zahn NM, Huber AT, Mikulsky BN, Stepanski ME, Kehoe AS, Li G, Schussman M, Rashid Roni MS, Kodali R, Cook JM, Stafford DC, Steeber DA, Arnold LA.

Basic Clin Pharmacol Toxicol. 2019 Jul;125(1):75-84. doi: 10.1111/bcpt.13206. Epub 2019 Feb 21.


A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.

Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2018 May 7;15(5):1766-1777. doi: 10.1021/acs.molpharmaceut.7b01013. Epub 2018 Apr 2.


Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.

Knutson DE, Kodali R, Divović B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, Mihovilovic MD, Savić MM, Sieghart W, Cook JM.

J Med Chem. 2018 Mar 22;61(6):2422-2446. doi: 10.1021/acs.jmedchem.7b01664. Epub 2018 Mar 6.


Mid-term results of lateral unicondylar mobile bearing knee arthroplasty: a multicentre study of 363 cases.

Walker T, Zahn N, Bruckner T, Streit MR, Mohr G, Aldinger PR, Clarius M, Gotterbarm T.

Bone Joint J. 2018 Jan;100-B(1):42-49. doi: 10.1302/0301-620X.100B1.BJJ-2017-0600.R1.


The Zahn drawings: new illustrations of Xenopus embryo and tadpole stages for studies of craniofacial development.

Zahn N, Levin M, Adams DS.

Development. 2017 Aug 1;144(15):2708-2713. doi: 10.1242/dev.151308.


Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators.

Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2017 Jun 5;14(6):2088-2098. doi: 10.1021/acs.molpharmaceut.7b00183. Epub 2017 May 1.


Optimization of substituted imidazobenzodiazepines as novel asthma treatments.

Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, Arnold LA.

Eur J Med Chem. 2017 Jan 27;126:550-560. doi: 10.1016/j.ejmech.2016.11.045. Epub 2016 Nov 24.


Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.

Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA.

Mol Pharm. 2016 Jun 6;13(6):2026-38. doi: 10.1021/acs.molpharmaceut.6b00159. Epub 2016 May 10.


Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy.

Willems LM, Zahn N, Ferreirós N, Scholich K, Maggio N, Deller T, Vlachos A.

Acta Neuropathol Commun. 2016 Mar 31;4:28. doi: 10.1186/s40478-016-0303-x.


Extrahepatic biliary atresia in a 4-week-old Pug.

Thiel C, Steinbach S, Schmidt M, Amort K, Zahn N, Kramer M, Moritz A.

Vet Surg. 2015 Jan;44(1):35-40. doi: 10.1111/j.1532-950X.2014.12210.x. Epub 2014 Jun 3.


Interaction and UV-Stability of Various Organic Capping Agents on the Surface of Anatase Nanoparticles.

Raza M, Bachinger A, Zahn N, Kickelbick G.

Materials (Basel). 2014 Apr 10;7(4):2890-2912. doi: 10.3390/ma7042890.


Tumor necrosis factor alpha maintains denervation-induced homeostatic synaptic plasticity of mouse dentate granule cells.

Becker D, Zahn N, Deller T, Vlachos A.

Front Cell Neurosci. 2013 Dec 18;7:257. doi: 10.3389/fncel.2013.00257. eCollection 2013. Erratum in: Front Cell Neurosci. 2014 Aug;8:230.


Functional and structural properties of dentate granule cells with hilar basal dendrites in mouse entorhino-hippocampal slice cultures.

Becker D, Willems LM, Vnencak M, Zahn N, Schuldt G, Jedlicka P, Maggio N, Deller T, Vlachos A.

PLoS One. 2012;7(11):e48500. doi: 10.1371/journal.pone.0048500. Epub 2012 Nov 7.


SpineLab: tool for three-dimensional reconstruction of neuronal cell morphology.

Jungblut D, Vlachos A, Schuldt G, Zahn N, Deller T, Wittum G.

J Biomed Opt. 2012 Jul;17(7):076007. doi: 10.1117/1.JBO.17.7.076007.


FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.

Daniel C, Sartory NA, Zahn N, Schmidt R, Geisslinger G, Radeke HH, Stein JM.

Mol Immunol. 2007 Jul;44(13):3305-16. Epub 2007 May 1.


The TGFbeta/Smad 3-signaling pathway is involved in butyrate-mediated vitamin D receptor (VDR)-expression.

Daniel C, Schroder O, Zahn N, Gaschott T, Steinhilber D, Stein JM.

J Cell Biochem. 2007 Dec 15;102(6):1420-31.


FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.

Daniel C, Sartory N, Zahn N, Geisslinger G, Radeke HH, Stein JM.

J Immunol. 2007 Feb 15;178(4):2458-68.


PPARgamma is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2.

Schwab M, Reynders V, Ulrich S, Zahn N, Stein J, Schröder O.

Apoptosis. 2006 Oct;11(10):1801-11.


The new low calcemic vitamin D analog 22-ene-25-oxa-vitamin D prominently ameliorates T helper cell type 1-mediated colitis in mice.

Daniel C, Radeke HH, Sartory NA, Zahn N, Zuegel U, Steinmeyer A, Stein J.

J Pharmacol Exp Ther. 2006 Nov;319(2):622-31. Epub 2006 Aug 16.


15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.

Schröder O, Yudina Y, Sabirsh A, Zahn N, Haeggström JZ, Stein J.

J Lipid Res. 2006 May;47(5):1071-80. Epub 2006 Feb 22.


p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression.

Daniel C, Schröder O, Zahn N, Gaschott T, Stein J.

Biochem Biophys Res Commun. 2004 Nov 26;324(4):1220-6.


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