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Items: 1 to 50 of 127

1.

The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets.

Kumm EJ, Pagel O, Gambaryan S, Walter U, Zahedi RP, Smolenski A, Jurk K.

Cells. 2020 Feb 18;9(2). pii: E472. doi: 10.3390/cells9020472.

2.

Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.

Lategahn J, Keul M, Klövekorn P, Tumbrink HL, Niggenaber J, Müller MP, Hodson L, Flaßhoff M, Hardick J, Grabe T, Engel J, Schultz-Fademrecht C, Baumann M, Ketzer J, Mühlenberg T, Hiller W, Günther G, Unger A, Müller H, Heimsoeth A, Golz C, Blank-Landeshammer B, Kollipara L, Zahedi RP, Strohmann C, Hengstler JG, van Otterlo WAL, Bauer S, Rauh D.

Chem Sci. 2019 Oct 4;10(46):10789-10801. doi: 10.1039/c9sc03445e. eCollection 2019 Dec 14.

3.

Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data.

Blank-Landeshammer B, Richard VR, Mitsa G, Marques M, LeBlanc A, Kollipara L, Feldmann I, Couetoux du Tertre M, Gambaro K, McNamara S, Spatz A, Zahedi RP, Sickmann A, Batist G, Borchers CH.

Cancers (Basel). 2019 Dec 1;11(12). pii: E1907. doi: 10.3390/cancers11121907.

4.

The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication.

Czech-Sioli M, Siebels S, Radau S, Zahedi RP, Schmidt C, Dobner T, Grundhoff A, Fischer N.

J Virol. 2020 Feb 14;94(5). pii: e01638-19. doi: 10.1128/JVI.01638-19. Print 2020 Feb 14.

PMID:
31801860
5.

Targeted and Untargeted Proteomics Approaches in Biomarker Development.

Sobsey CA, Ibrahim S, Richard VR, Gaspar V, Mitsa G, Lacasse V, Zahedi RP, Batist G, Borchers CH.

Proteomics. 2019 Nov 15:e1900029. doi: 10.1002/pmic.201900029. [Epub ahead of print] Review.

PMID:
31729135
6.

A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability.

Sirois I, Aguilar-Mahecha A, Lafleur J, Fowler E, Vu V, Scriver M, Buchanan M, Chabot C, Ramanathan A, Balachandran B, Légaré S, Przybytkowski E, Lan C, Krzemien U, Cavallone L, Aleynikova O, Ferrario C, Guilbert MC, Benlimame N, Saad A, Alaoui-Jamali M, Saragovi HU, Josephy S, O'Flanagan C, Hursting SD, Richard VR, Zahedi RP, Borchers CH, Bareke E, Nabavi S, Tonellato P, Roy JA, Robidoux A, Marcus EA, Mihalcioiu C, Majewski J, Basik M.

Mol Cancer Res. 2019 Dec;17(12):2492-2507. doi: 10.1158/1541-7786.MCR-19-0264. Epub 2019 Sep 19.

PMID:
31537618
7.

Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique.

Mnatsakanyan R, Markoutsa S, Walbrunn K, Roos A, Verhelst SHL, Zahedi RP.

Nat Commun. 2019 May 16;10(1):2195. doi: 10.1038/s41467-019-10182-4.

8.

Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow.

Brunoro GVF, Carvalho PC, Barbosa VC, Pagnoncelli D, De Moura Gallo CV, Perales J, Zahedi RP, Valente RH, Neves-Ferreira AGDC.

BMC Cancer. 2019 Apr 18;19(1):365. doi: 10.1186/s12885-019-5547-y.

9.

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation.

Unsworth AJ, Bombik I, Pinto-Fernandez A, McGouran JF, Konietzny R, Zahedi RP, Watson SP, Kessler BM, Pears CJ.

Thromb Haemost. 2019 Jan;119(1):104-116. doi: 10.1055/s-0038-1676344. Epub 2018 Dec 31.

10.

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL.

Siekmann IK, Dierck K, Prall S, Klokow M, Strauss J, Buhs S, Wrzeszcz A, Bockmayr M, Beck F, Trochimiuk M, Gottschling K, Martens V, Khosh-Naucke M, Gerull H, Müller J, Behrmann L, Blohm M, Zahedi RP, Jeremias I, Sickmann A, Nollau P, Horstmann MA.

Blood Adv. 2018 Oct 9;2(19):2554-2567. doi: 10.1182/bloodadvances.2018020693.

11.

Biochemical and pathological changes result from mutated Caveolin-3 in muscle.

González Coraspe JA, Weis J, Anderson ME, Münchberg U, Lorenz K, Buchkremer S, Carr S, Zahedi RP, Brauers E, Michels H, Sunada Y, Lochmüller H, Campbell KP, Freier E, Hathazi D, Roos A.

Skelet Muscle. 2018 Aug 28;8(1):28. doi: 10.1186/s13395-018-0173-y.

12.

Immuno-MALDI-TOF-MS in the Clinic.

Zahedi RP, Parker CE, Borchers CH.

Clin Chem. 2018 Sep;64(9):1271-1272. doi: 10.1373/clinchem.2018.292136. Epub 2018 Jul 17. No abstract available.

PMID:
30018057
13.

Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry.

Mnatsakanyan R, Shema G, Basik M, Batist G, Borchers CH, Sickmann A, Zahedi RP.

Expert Rev Proteomics. 2018 Jun;15(6):515-535. doi: 10.1080/14789450.2018.1483340.

PMID:
29893147
14.

Advanced tools for the analysis of protein phosphorylation in yeast mitochondria.

Walter C, Gonczarowska-Jorge H, Sickmann A, Zahedi RP, Meisinger C, Schmidt O.

Anal Biochem. 2018 Aug 1;554:23-27. doi: 10.1016/j.ab.2018.05.022. Epub 2018 May 24.

PMID:
29803787
15.

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures.

Rodrigues RM, Kollipara L, Chaudhari U, Sachinidis A, Zahedi RP, Sickmann A, Kopp-Schneider A, Jiang X, Keun H, Hengstler J, Oorts M, Annaert P, Hoeben E, Gijbels E, De Kock J, Vanhaecke T, Rogiers V, Vinken M.

Arch Toxicol. 2018 Jun;92(6):1939-1952. doi: 10.1007/s00204-018-2214-z. Epub 2018 May 14.

16.

Effective Assignment of α2,3/α2,6-Sialic Acid Isomers by LC-MS/MS-Based Glycoproteomics.

Pett C, Nasir W, Sihlbom C, Olsson BM, Caixeta V, Schorlemer M, Zahedi RP, Larson G, Nilsson J, Westerlind U.

Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9320-9324. doi: 10.1002/anie.201803540. Epub 2018 Jun 20.

PMID:
29742324
17.

How iMALDI can improve clinical diagnostics.

Popp R, Basik M, Spatz A, Batist G, Zahedi RP, Borchers CH.

Analyst. 2018 May 15;143(10):2197-2203. doi: 10.1039/c8an00094h. Review.

PMID:
29713694
18.

Protease Specificity Profiling in a Pipet Tip Using "Charge-Synchronized" Proteome-Derived Peptide Libraries.

Nguyen MTN, Shema G, Zahedi RP, Verhelst SHL.

J Proteome Res. 2018 May 4;17(5):1923-1933. doi: 10.1021/acs.jproteome.8b00004. Epub 2018 Apr 20.

PMID:
29664642
19.

Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons.

Boczonadi V, Meyer K, Gonczarowska-Jorge H, Griffin H, Roos A, Bartsakoulia M, Bansagi B, Ricci G, Palinkas F, Zahedi RP, Bruni F, Kaspar B, Lochmüller H, Boycott KM, Müller JS, Horvath R.

Hum Mol Genet. 2018 Jun 15;27(12):2187-2204. doi: 10.1093/hmg/ddy127.

20.

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T.

J Cell Biol. 2018 Jun 4;217(6):2167-2184. doi: 10.1083/jcb.201708053. Epub 2018 Apr 3.

21.

Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets.

Makhoul S, Walter E, Pagel O, Walter U, Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K.

Nitric Oxide. 2018 Jun 1;76:71-80. doi: 10.1016/j.niox.2018.03.008. Epub 2018 Mar 14. Review.

PMID:
29550521
22.

pymzML v2.0: introducing a highly compressed and seekable gzip format.

Kösters M, Leufken J, Schulze S, Sugimoto K, Klein J, Zahedi RP, Hippler M, Leidel SA, Fufezan C.

Bioinformatics. 2018 Jul 15;34(14):2513-2514. doi: 10.1093/bioinformatics/bty046.

PMID:
29394323
23.

Simple, scalable, and ultrasensitive tip-based identification of protease substrates.

Shema G, Nguyen MTN, Solari FA, Loroch S, Venne AS, Kollipara L, Sickmann A, Verhelst SHL, Zahedi RP.

Mol Cell Proteomics. 2018 Apr;17(4):826-834. doi: 10.1074/mcp.TIR117.000302. Epub 2018 Jan 22.

24.

Clinical and research strategies for limb-girdle congenital myasthenic syndromes.

O'Connor E, Töpf A, Zahedi RP, Spendiff S, Cox D, Roos A, Lochmüller H.

Ann N Y Acad Sci. 2018 Jan;1412(1):102-112. doi: 10.1111/nyas.13520. Epub 2018 Jan 5. Review.

PMID:
29315608
25.

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.

Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391. Epub 2017 Nov 16.

PMID:
29146750
26.

Quantifying Missing (Phospho)Proteome Regions with the Broad-Specificity Protease Subtilisin.

Gonczarowska-Jorge H, Loroch S, Dell'Aica M, Sickmann A, Roos A, Zahedi RP.

Anal Chem. 2017 Dec 19;89(24):13137-13145. doi: 10.1021/acs.analchem.7b02395. Epub 2017 Nov 28.

PMID:
29136377
27.

Integration of polycarbonate membranes in microfluidic free-flow electrophoresis.

Novo P, Dell'Aica M, Jender M, Höving S, Zahedi RP, Janasek D.

Analyst. 2017 Nov 6;142(22):4228-4239. doi: 10.1039/c7an01514c.

PMID:
29082985
28.

In-depth phenotyping of lymphoblastoid cells suggests selective cellular vulnerability in Marinesco-Sjögren syndrome.

Kollipara L, Buchkremer S, Coraspe JAG, Hathazi D, Senderek J, Weis J, Zahedi RP, Roos A.

Oncotarget. 2017 Jul 28;8(40):68493-68516. doi: 10.18632/oncotarget.19663. eCollection 2017 Sep 15.

29.

Landscape of submitochondrial protein distribution.

Vögtle FN, Burkhart JM, Gonczarowska-Jorge H, Kücükköse C, Taskin AA, Kopczynski D, Ahrends R, Mossmann D, Sickmann A, Zahedi RP, Meisinger C.

Nat Commun. 2017 Aug 18;8(1):290. doi: 10.1038/s41467-017-00359-0.

30.

Combining De Novo Peptide Sequencing Algorithms, A Synergistic Approach to Boost Both Identifications and Confidence in Bottom-up Proteomics.

Blank-Landeshammer B, Kollipara L, Biß K, Pfenninger M, Malchow S, Shuvaev K, Zahedi RP, Sickmann A.

J Proteome Res. 2017 Sep 1;16(9):3209-3218. doi: 10.1021/acs.jproteome.7b00198. Epub 2017 Aug 22.

PMID:
28741358
31.

Mass spectrometry-based protein analysis to unravel the tissue pathophysiology in Duchenne muscular dystrophy.

Carr SJ, Zahedi RP, Lochmüller H, Roos A.

Proteomics Clin Appl. 2018 Mar;12(2). doi: 10.1002/prca.201700071. Epub 2017 Jul 13. Review.

PMID:
28631898
32.

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.

Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, Mrugalla F, Alber Y, Richters A, Engel J, Leenders F, Heuckmann JM, Wolf J, Diebold J, Pall G, Peifer M, Aerts M, Gevaert K, Zahedi RP, Buettner R, Shokat KM, McDonald NQ, Kast SM, Gautschi O, Thomas RK, Sos ML.

Sci Transl Med. 2017 Jun 14;9(394). pii: eaah6144. doi: 10.1126/scitranslmed.aah6144.

33.

The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.

Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4621-E4630. doi: 10.1073/pnas.1617004114. Epub 2017 May 23.

34.

Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level.

Labisch T, Buchkremer S, Phan V, Kollipara L, Gatz C, Lentz C, Nolte K, Vervoorts J, Coraspe JAG, Sickmann A, Carr S, Zahedi RP, Weis J, Roos A.

Mol Neurobiol. 2018 Mar;55(3):2524-2546. doi: 10.1007/s12035-017-0494-6. Epub 2017 Apr 11.

PMID:
28401474
35.

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T.

Nat Cell Biol. 2017 Apr;19(4):318-328. doi: 10.1038/ncb3488. Epub 2017 Mar 13.

PMID:
28288130
36.

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M.

Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051.

37.

Multi-OMICS: a critical technical perspective on integrative lipidomics approaches.

Kopczynski D, Coman C, Zahedi RP, Lorenz K, Sickmann A, Ahrends R.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Aug;1862(8):808-811. doi: 10.1016/j.bbalip.2017.02.003. Epub 2017 Feb 11. Review.

PMID:
28193460
38.

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.

Wiessner M, Roos A, Munn CJ, Viswanathan R, Whyte T, Cox D, Schoser B, Sewry C, Roper H, Phadke R, Marini Bettolo C, Barresi R, Charlton R, Bönnemann CG, Abath Neto O, Reed UC, Zanoteli E, Araújo Martins Moreno C, Ertl-Wagner B, Stucka R, De Goede C, Borges da Silva T, Hathazi D, Dell'Aica M, Zahedi RP, Thiele S, Müller J, Kingston H, Müller S, Curtis E, Walter MC, Strom TM, Straub V, Bushby K, Muntoni F, Swan LE, Lochmüller H, Senderek J.

Am J Hum Genet. 2017 Mar 2;100(3):523-536. doi: 10.1016/j.ajhg.2017.01.024. Epub 2017 Feb 9.

39.

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

Loroch S, Trabold K, Gambaryan S, Reiß C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K.

Thromb Haemost. 2017 Feb 28;117(3):556-569. doi: 10.1160/TH16-07-0515. Epub 2017 Jan 12.

PMID:
28078347
40.

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.

Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Pötz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A.

Blood. 2017 Jan 12;129(2):e1-e12. doi: 10.1182/blood-2016-05-714048. Epub 2016 Nov 9.

41.

Enrichment of Cross-Linked Peptides Using Charge-Based Fractional Diagonal Chromatography (ChaFRADIC).

Tinnefeld V, Venne AS, Sickmann A, Zahedi RP.

J Proteome Res. 2017 Feb 3;16(2):459-469. doi: 10.1021/acs.jproteome.6b00587. Epub 2017 Jan 5.

PMID:
28054782
42.

Taking the stock of granule cargo: Platelet releasate proteomics.

Pagel O, Walter E, Jurk K, Zahedi RP.

Platelets. 2017 Mar;28(2):119-128. doi: 10.1080/09537104.2016.1254762. Epub 2016 Dec 8. Review.

PMID:
27928935
43.

The Caveolin-3 G56S sequence variant of unknown significance: Muscle biopsy findings and functional cell biological analysis.

Brauers E, Roos A, Kollipara L, Zahedi RP, Beckmann A, Mohanadas N, Bauer H, Häusler M, Thoma S, Kress W, Senderek J, Weis J.

Proteomics Clin Appl. 2017 Jan;11(1-2). doi: 10.1002/prca.201600007. Epub 2016 Nov 14.

44.

Bottom-up proteomics suggests an association between differential expression of mitochondrial proteins and chronic fatigue syndrome.

Ciregia F, Kollipara L, Giusti L, Zahedi RP, Giacomelli C, Mazzoni MR, Giannaccini G, Scarpellini P, Urbani A, Sickmann A, Lucacchini A, Bazzichi L.

Transl Psychiatry. 2016 Sep 27;6(9):e904. doi: 10.1038/tp.2016.184.

45.

Joining forces: studying multiple post-translational modifications to understand dynamic disease mechanisms.

Zahedi RP.

Expert Rev Proteomics. 2016 Dec;13(12):1055-1057. Epub 2016 Sep 12. No abstract available.

PMID:
27584944
46.

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome.

Solari FA, Mattheij NJ, Burkhart JM, Swieringa F, Collins PW, Cosemans JM, Sickmann A, Heemskerk JW, Zahedi RP.

Mol Cell Proteomics. 2016 Oct;15(10):3154-3169. Epub 2016 Aug 17.

47.

The proteome of baker's yeast mitochondria.

Gonczarowska-Jorge H, Zahedi RP, Sickmann A.

Mitochondrion. 2017 Mar;33:15-21. doi: 10.1016/j.mito.2016.08.007. Epub 2016 Aug 14. Review.

PMID:
27535110
48.

Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.

Engel J, Becker C, Lategahn J, Keul M, Ketzer J, Mühlenberg T, Kollipara L, Schultz-Fademrecht C, Zahedi RP, Bauer S, Rauh D.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10909-12. doi: 10.1002/anie.201605011. Epub 2016 Aug 5.

PMID:
27496389
49.

Unraveling the Phosphocholination Mechanism of the Legionella pneumophila Enzyme AnkX.

Gavriljuk K, Schartner J, Seidel H, Dickhut C, Zahedi RP, Hedberg C, Kötting C, Gerwert K.

Biochemistry. 2016 Aug 9;55(31):4375-85. doi: 10.1021/acs.biochem.6b00524. Epub 2016 Jul 27.

PMID:
27404583
50.

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.

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