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The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization.

Dai G, Aman TK, DiMaio F, Zagotta WN.

Nat Struct Mol Biol. 2019 Aug;26(8):686-694. doi: 10.1038/s41594-019-0259-1. Epub 2019 Jul 8.


Functional characterization and optimization of a bacterial cyclic nucleotide-gated channel.

Morgan JLW, Evans EGB, Zagotta WN.

J Biol Chem. 2019 May 3;294(18):7503-7515. doi: 10.1074/jbc.RA119.007699. Epub 2019 Mar 18.


Correction: Visualizing conformational dynamics of proteins in solution and at the cell membrane.

Gordon SE, Munari M, Zagotta WN.

Elife. 2018 Nov 30;7. pii: e44029. doi: 10.7554/eLife.44029.


Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels.

Flynn GE, Zagotta WN.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8086-E8095. doi: 10.1073/pnas.1805596115. Epub 2018 Aug 3.


Visualizing conformational dynamics of proteins in solution and at the cell membrane.

Gordon SE, Munari M, Zagotta WN.

Elife. 2018 Jun 20;7. pii: e37248. doi: 10.7554/eLife.37248. Erratum in: Elife. 2018 Nov 30;7:.


Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels.

Dai G, James ZM, Zagotta WN.

J Gen Physiol. 2018 Apr 2;150(4):625-635. doi: 10.1085/jgp.201711989. Epub 2018 Mar 22.


Structural insights into the mechanisms of CNBD channel function.

James ZM, Zagotta WN.

J Gen Physiol. 2018 Feb 5;150(2):225-244. doi: 10.1085/jgp.201711898. Epub 2017 Dec 12. Review.


The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance.

Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D.

Structure. 2017 Nov 7;25(11):1732-1739.e5. doi: 10.1016/j.str.2017.09.007. Epub 2017 Oct 12.


Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b.

Bankston JR, DeBerg HA, Stoll S, Zagotta WN.

J Biol Chem. 2017 Oct 27;292(43):17794-17803. doi: 10.1074/jbc.M117.800722. Epub 2017 Sep 1.


Rates and equilibrium constants of the ligand-induced conformational transition of an HCN ion channel protein domain determined by DEER spectroscopy.

Collauto A, DeBerg HA, Kaufmann R, Zagotta WN, Stoll S, Goldfarb D.

Phys Chem Chem Phys. 2017 Jun 14;19(23):15324-15334. doi: 10.1039/c7cp01925d.


Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels.

Dai G, Zagotta WN.

Elife. 2017 Apr 27;6. pii: e26355. doi: 10.7554/eLife.26355.


CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel.

James ZM, Borst AJ, Haitin Y, Frenz B, DiMaio F, Zagotta WN, Veesler D.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4430-4435. doi: 10.1073/pnas.1700248114. Epub 2017 Apr 10.


Regulation of CNGA1 Channel Gating by Interactions with the Membrane.

Aman TK, Gordon SE, Zagotta WN.

J Biol Chem. 2016 May 6;291(19):9939-47. doi: 10.1074/jbc.M116.723932. Epub 2016 Mar 11.


Transition metal ion FRET to measure short-range distances at the intracellular surface of the plasma membrane.

Gordon SE, Senning EN, Aman TK, Zagotta WN.

J Gen Physiol. 2016 Feb;147(2):189-200. doi: 10.1085/jgp.201511530. Epub 2016 Jan 11.


Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET.

Zagotta WN, Gordon MT, Senning EN, Munari MA, Gordon SE.

J Gen Physiol. 2016 Feb;147(2):201-16. doi: 10.1085/jgp.201511531. Epub 2016 Jan 11.


Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.

DeBerg HA, Brzovic PS, Flynn GE, Zagotta WN, Stoll S.

J Biol Chem. 2016 Jan 1;291(1):371-81. doi: 10.1074/jbc.M115.696450. Epub 2015 Nov 11.


Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b.

DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S.

Structure. 2015 Apr 7;23(4):734-44. doi: 10.1016/j.str.2015.02.007. Epub 2015 Mar 19.


Double electron-electron resonance reveals cAMP-induced conformational change in HCN channels.

Puljung MC, DeBerg HA, Zagotta WN, Stoll S.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9816-21. doi: 10.1073/pnas.1405371111. Epub 2014 Jun 23.


Crystal structure of the plant dual-affinity nitrate transporter NRT1.1.

Sun J, Bankston JR, Payandeh J, Hinds TR, Zagotta WN, Zheng N.

Nature. 2014 Mar 6;507(7490):73-7. doi: 10.1038/nature13074. Epub 2014 Feb 26.


Flavonoid regulation of HCN2 channels.

Carlson AE, Rosenbaum JC, Brelidze TI, Klevit RE, Zagotta WN.

J Biol Chem. 2013 Nov 15;288(46):33136-45. doi: 10.1074/jbc.M113.501759. Epub 2013 Oct 1.


The structural mechanism of KCNH-channel regulation by the eag domain.

Haitin Y, Carlson AE, Zagotta WN.

Nature. 2013 Sep 19;501(7467):444-8. doi: 10.1038/nature12487. Epub 2013 Aug 25.


Structure of the C-terminal region of an ERG channel and functional implications.

Brelidze TI, Gianulis EC, DiMaio F, Trudeau MC, Zagotta WN.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11648-53. doi: 10.1073/pnas.1306887110. Epub 2013 Jun 25.


A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channels.

Puljung MC, Zagotta WN.

J Biol Chem. 2013 May 3;288(18):12944-56. doi: 10.1074/jbc.M113.464123. Epub 2013 Mar 22.


Flavonoid regulation of EAG1 channels.

Carlson AE, Brelidze TI, Zagotta WN.

J Gen Physiol. 2013 Mar;141(3):347-58. doi: 10.1085/jgp.201210900.


Fluorescent labeling of specific cysteine residues using CyMPL.

Puljung MC, Zagotta WN.

Curr Protoc Protein Sci. 2012 Nov;Chapter 14:Unit14.14. doi: 10.1002/0471140864.ps1414s70.


Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.

Bankston JR, Camp SS, DiMaio F, Lewis AS, Chetkovich DM, Zagotta WN.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7899-904. doi: 10.1073/pnas.1201997109. Epub 2012 May 1.


Structure of the carboxy-terminal region of a KCNH channel.

Brelidze TI, Carlson AE, Sankaran B, Zagotta WN.

Nature. 2012 Jan 9;481(7382):530-3. doi: 10.1038/nature10735.


Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels.

Shuart NG, Haitin Y, Camp SS, Black KD, Zagotta WN.

Nat Commun. 2011 Aug 30;2:457. doi: 10.1038/ncomms1466.


Labeling of specific cysteines in proteins using reversible metal protection.

Puljung MC, Zagotta WN.

Biophys J. 2011 May 18;100(10):2513-21. doi: 10.1016/j.bpj.2011.03.063.


Molecular mechanism underlying phosphatidylinositol 4,5-bisphosphate-induced inhibition of SpIH channels.

Flynn GE, Zagotta WN.

J Biol Chem. 2011 Apr 29;286(17):15535-42. doi: 10.1074/jbc.M110.214650. Epub 2011 Mar 7.


Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate.

Mercado J, Gordon-Shaag A, Zagotta WN, Gordon SE.

J Neurosci. 2010 Oct 6;30(40):13338-47. doi: 10.1523/JNEUROSCI.2108-10.2010.


Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen.

Brelidze TI, Carlson AE, Davies DR, Stewart LJ, Zagotta WN.

PLoS One. 2010 Sep 2;5(9). pii: e12523. doi: 10.1371/journal.pone.0012523.


Flow of energy in the outer retina in darkness and in light.

Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R, Pluk H, Seeliger MW, Tanimoto N, Fong K, Bolton L, Kuok DL, Sweet IR, Bartoletti TM, Radu RA, Travis GH, Zagotta WN, Townes-Anderson E, Parker E, Van der Zee CE, Sampath AP, Sokolov M, Thoreson WB, Hurley JB.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8599-604. doi: 10.1073/pnas.1002471107. Epub 2010 May 5.


Fluorescence applications in molecular neurobiology.

Taraska JW, Zagotta WN.

Neuron. 2010 Apr 29;66(2):170-89. doi: 10.1016/j.neuron.2010.02.002. Review.


Short-distance probes for protein backbone structure based on energy transfer between bimane and transition metal ions.

Taraska JW, Puljung MC, Zagotta WN.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16227-32. doi: 10.1073/pnas.0905207106. Epub 2009 Sep 10.


Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods.

Brelidze TI, Carlson AE, Zagotta WN.

J Biol Chem. 2009 Oct 9;284(41):27989-97. doi: 10.1074/jbc.M109.016337. Epub 2009 Aug 11.


Mapping the structure and conformational movements of proteins with transition metal ion FRET.

Taraska JW, Puljung MC, Olivier NB, Flynn GE, Zagotta WN.

Nat Methods. 2009 Jul;6(7):532-7. doi: 10.1038/nmeth.1341. Epub 2009 Jun 14.


Mechanism of Ca(2+)-dependent desensitization in TRP channels.

Gordon-Shaag A, Zagotta WN, Gordon SE.

Channels (Austin). 2008 Mar-Apr;2(2):125-9. Epub 2008 Mar 16. Review.


C-terminal movement during gating in cyclic nucleotide-modulated channels.

Craven KB, Olivier NB, Zagotta WN.

J Biol Chem. 2008 May 23;283(21):14728-38. doi: 10.1074/jbc.M710463200. Epub 2008 Mar 26.


Cyclic nucleotide-regulated ion channels: spotlight on symmetry.

Taraska JW, Zagotta WN.

Structure. 2007 Sep;15(9):1023-4.


Structural dynamics in the gating ring of cyclic nucleotide-gated ion channels.

Taraska JW, Zagotta WN.

Nat Struct Mol Biol. 2007 Sep;14(9):854-60. Epub 2007 Aug 12.


Structure and rearrangements in the carboxy-terminal region of SpIH channels.

Flynn GE, Black KD, Islas LD, Sankaran B, Zagotta WN.

Structure. 2007 Jun;15(6):671-82.


Membrane biology: permutations of permeability.

Zagotta WN.

Nature. 2006 Mar 23;440(7083):427-9. No abstract available.


CNG and HCN channels: two peas, one pod.

Craven KB, Zagotta WN.

Annu Rev Physiol. 2006;68:375-401. Review.


The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.

Johnson JP Jr, Zagotta WN.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2742-7. Epub 2005 Feb 14.


Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.

Craven KB, Zagotta WN.

J Gen Physiol. 2004 Dec;124(6):663-77.


Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels.

Zheng J, Zagotta WN.

Neuron. 2004 May 13;42(3):411-21.


Cyclic nucleotide-gated ion channels.

Matulef K, Zagotta WN.

Annu Rev Cell Dev Biol. 2003;19:23-44. Review.


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