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Items: 16


Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.

Woodling NS, Colas D, Wang Q, Minhas P, Panchal M, Liang X, Mhatre SD, Brown H, Ko N, Zagol-Ikapitte I, van der Hart M, Khroyan TV, Chuluun B, Priyam PG, Milne GL, Rassoulpour A, Boutaud O, Manning-Boğ AB, Heller HC, Andreasson KI.

Brain. 2016 Jul;139(Pt 7):2063-81. doi: 10.1093/brain/aww117. Epub 2016 May 13.


Protein modification by adenine propenal.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ.

Chem Res Toxicol. 2014 Oct 20;27(10):1732-42. doi: 10.1021/tx500218g. Epub 2014 Sep 24.


Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.

Woodling NS, Wang Q, Priyam PG, Larkin P, Shi J, Johansson JU, Zagol-Ikapitte I, Boutaud O, Andreasson KI.

J Neurosci. 2014 Apr 23;34(17):5882-94. doi: 10.1523/JNEUROSCI.0410-14.2014.


Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA.

Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA.

Biochemistry. 2014 Apr 22;53(15):2436-41. doi: 10.1021/bi401673b. Epub 2014 Apr 11.


Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues.

Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ 2nd, Oates JA, Porter NA, Boutaud O.

ACS Med Chem Lett. 2013 Aug 8;4(8):710-714.


On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry.

Chacon A, Zagol-Ikapitte I, Amarnath V, Reyzer ML, Oates JA, Caprioli RM, Boutaud O.

J Mass Spectrom. 2011 Aug;46(8):840-6. doi: 10.1002/jms.1958.


Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies.

Zagol-Ikapitte I, Amarnath V, Jadhav S, Oates JA, Boutaud O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1098-104. doi: 10.1016/j.jchromb.2011.03.026. Epub 2011 Mar 21.


Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ 2nd, Davies SS.

Pharmaceutics. 2010 Mar;2(1):18-29.


Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte I, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts Ii LJ, Davies SS.

Pharmaceutics. 2010 Feb 1;2(1):18-29.


Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs.

Mosoni L, Balage M, Vazeille E, Combaret L, Morand C, Zagol-Ikapitte I, Boutaud O, Marzani B, Papet I, Dardevet D.

Nutrition. 2010 Nov-Dec;26(11-12):1157-62. doi: 10.1016/j.nut.2009.09.016. Epub 2010 Jan 15.


Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis.

Zagol-Ikapitte I, Amarnath V, Bala M, Roberts LJ 2nd, Oates JA, Boutaud O.

Chem Res Toxicol. 2010 Jan;23(1):240-50. doi: 10.1021/tx900407a.


Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA.

Org Biomol Chem. 2009 Dec 21;7(24):5103-12. doi: 10.1039/b912528k. Epub 2009 Oct 20.


Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ 2nd.

Biochemistry. 2006 Dec 26;45(51):15756-67. Epub 2006 Dec 6.


Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity.

Zagol-Ikapitte I, Masterson TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA.

J Neurochem. 2005 Aug;94(4):1140-5. Epub 2005 Jun 30.


Cyclooxygenase-dependent lipid-modification of brain proteins.

Boutaud O, Andreasson KI, Zagol-Ikapitte I, Oates JA.

Brain Pathol. 2005 Apr;15(2):139-42. Review.


Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine.

Zagol-Ikapitte I, Bernoud-Hubac N, Amarnath V, Roberts LJ 2nd, Boutaud O, Oates JA.

Biochemistry. 2004 May 11;43(18):5503-10.


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