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Items: 1 to 50 of 190

1.

Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway.

Zager RA, Johnson ACM.

Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F674-F681. doi: 10.1152/ajprenal.00571.2018. Epub 2019 Jan 30.

PMID:
30698046
2.

Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury.

Sharifian R, Okamura DM, Denisenko O, Zager RA, Johnson A, Gharib SA, Bomsztyk K.

Sci Rep. 2018 Dec 14;8(1):17870. doi: 10.1038/s41598-018-35943-x.

3.

Plasma and urinary p21: potential biomarkers of AKI and renal aging.

Johnson AC, Zager RA.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1329-F1335. doi: 10.1152/ajprenal.00328.2018. Epub 2018 Aug 1.

PMID:
30066587
4.

Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI.

Johnson ACM, Zager RA.

J Am Soc Nephrol. 2018 Aug;29(8):2157-2167. doi: 10.1681/ASN.2018030265. Epub 2018 Jul 6.

PMID:
29980651
5.

Mechanisms and consequences of oxidant-induced renal preconditioning: an Nrf2-dependent, P21-independent, anti-senescence pathway.

Johnson ACM, Zager RA.

Nephrol Dial Transplant. 2018 Nov 1;33(11):1927-1941. doi: 10.1093/ndt/gfy029.

PMID:
29522116
6.

Alpha 1 Microglobulin: A Potentially Paradoxical Anti-Oxidant Agent.

Zager RA.

Adv Tech Biol Med. 2017 Aug;5(3). pii: 238. doi: 10.4172/2379-1764.1000238. Epub 2017 Aug 24.

7.

Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury.

Johnson ACM, Delrow JJ, Zager RA.

Transl Res. 2017 Aug;186:1-18. doi: 10.1016/j.trsl.2017.05.005. Epub 2017 May 19.

PMID:
28586635
8.

An evaluation of the antioxidant protein α1-microglobulin as a renal tubular cytoprotectant.

Zager RA, Johnson AC, Frostad K.

Am J Physiol Renal Physiol. 2016 Sep 1;311(3):F640-51. doi: 10.1152/ajprenal.00264.2016. Epub 2016 May 11.

9.

Combined iron sucrose and protoporphyrin treatment protects against ischemic and toxin-mediated acute renal failure.

Zager RA, Johnson AC, Frostad KB.

Kidney Int. 2016 Jul;90(1):67-76. doi: 10.1016/j.kint.2016.01.022. Epub 2016 Mar 24.

10.

Marked protection against acute renal and hepatic injury after nitrited myoglobin + tin protoporphyrin administration.

Zager RA.

Transl Res. 2015 Nov;166(5):485-501. doi: 10.1016/j.trsl.2015.06.004. Epub 2015 Jun 10.

11.

Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes.

Mar D, Gharib SA, Zager RA, Johnson A, Denisenko O, Bomsztyk K.

Kidney Int. 2015 Oct;88(4):734-44. doi: 10.1038/ki.2015.164. Epub 2015 Jun 10.

12.

Renal cortical pyruvate as a potentially critical mediator of acute kidney injury.

Johnson AC, Zager RA.

Nephron Clin Pract. 2014;127(1-4):129-32. doi: 10.1159/000363547. Epub 2014 Sep 24. Review.

13.

Progression from acute kidney injury to chronic kidney disease: clinical and experimental insights and queries.

Zager RA.

Nephron Clin Pract. 2014;127(1-4):46-50. doi: 10.1159/000363726. Epub 2014 Sep 24. Review.

14.

Acute hepatic ischemic-reperfusion injury induces a renal cortical "stress response," renal "cytoresistance," and an endotoxin hyperresponsive state.

Zager RA, Johnson AC, Frostad KB.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F856-68. doi: 10.1152/ajprenal.00378.2014. Epub 2014 Jul 30.

15.

Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury.

Zager RA, Johnson AC, Frostad KB.

PLoS One. 2014 May 21;9(5):e98380. doi: 10.1371/journal.pone.0098380. eCollection 2014.

16.

Renal cortical pyruvate depletion during AKI.

Zager RA, Johnson AC, Becker K.

J Am Soc Nephrol. 2014 May;25(5):998-1012. doi: 10.1681/ASN.2013070791. Epub 2014 Jan 2.

17.

Renal Cortical Lactate Dehydrogenase: A Useful, Accurate, Quantitative Marker of In Vivo Tubular Injury and Acute Renal Failure.

Zager RA, Johnson AC, Becker K.

PLoS One. 2013 Jun 18;8(6):e66776. doi: 10.1371/journal.pone.0066776. Print 2013.

18.

'Biologic memory' in response to acute kidney injury: cytoresistance, toll-like receptor hyper-responsiveness and the onset of progressive renal disease.

Zager RA.

Nephrol Dial Transplant. 2013 Aug;28(8):1985-93. doi: 10.1093/ndt/gft101. Epub 2013 Jun 11. Review.

19.

Progressive endothelin-1 gene activation initiates chronic/end-stage renal disease following experimental ischemic/reperfusion injury.

Zager RA, Johnson AC, Andress D, Becker K.

Kidney Int. 2013 Oct;84(4):703-12. doi: 10.1038/ki.2013.157. Epub 2013 May 22.

20.

Post-ischemic azotemia as a partial 'brake', slowing progressive kidney disease.

Zager RA, Johnson AC, Becker K.

Nephrol Dial Transplant. 2013 Jun;28(6):1455-62. doi: 10.1093/ndt/gft040. Epub 2013 Mar 29.

21.

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease.

Ruiz S, Pergola PE, Zager RA, Vaziri ND.

Kidney Int. 2013 Jun;83(6):1029-41. doi: 10.1038/ki.2012.439. Epub 2013 Jan 16. Review.

22.

Renal cortical hemopexin accumulation in response to acute kidney injury.

Zager RA, Johnson AC, Becker K.

Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1460-72. doi: 10.1152/ajprenal.00426.2012. Epub 2012 Sep 19.

23.

Proximal tubule haptoglobin gene activation is an integral component of the acute kidney injury "stress response".

Zager RA, Vijayan A, Johnson AC.

Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F139-48. doi: 10.1152/ajprenal.00168.2012. Epub 2012 May 9.

24.

Plasma and urinary heme oxygenase-1 in AKI.

Zager RA, Johnson AC, Becker K.

J Am Soc Nephrol. 2012 Jun;23(6):1048-57. doi: 10.1681/ASN.2011121147. Epub 2012 Mar 22.

25.

Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification, and "end-stage" kidney disease.

Zager RA, Johnson AC, Becker K.

Am J Physiol Renal Physiol. 2011 Dec;301(6):F1334-45. doi: 10.1152/ajprenal.00431.2011. Epub 2011 Sep 14.

26.

HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injury.

Johnson AC, Ware LB, Himmelfarb J, Zager RA.

Clin J Am Soc Nephrol. 2011 Sep;6(9):2108-13. doi: 10.2215/CJN.02440311. Epub 2011 Jul 28.

27.

Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury.

Ware LB, Johnson AC, Zager RA.

Am J Physiol Renal Physiol. 2011 Mar;300(3):F628-38. doi: 10.1152/ajprenal.00654.2010. Epub 2010 Dec 8.

28.

MCP-1 gene activation marks acute kidney injury.

Munshi R, Johnson A, Siew ED, Ikizler TA, Ware LB, Wurfel MM, Himmelfarb J, Zager RA.

J Am Soc Nephrol. 2011 Jan;22(1):165-75. doi: 10.1681/ASN.2010060641. Epub 2010 Nov 11.

29.

Acquired cytoresistance in the setting of hematopoietic cell transplantation.

Zager RA.

Clin J Am Soc Nephrol. 2010 Dec;5(12):2150-3. doi: 10.2215/CJN.07780910. Epub 2010 Oct 21.

30.

Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury.

Johnson AC, Becker K, Zager RA.

Am J Physiol Renal Physiol. 2010 Aug;299(2):F426-35. doi: 10.1152/ajprenal.00248.2010. Epub 2010 May 26.

31.

Progressive histone alterations and proinflammatory gene activation: consequences of heme protein/iron-mediated proximal tubule injury.

Zager RA, Johnson AC.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F827-37. doi: 10.1152/ajprenal.00683.2009. Epub 2009 Dec 23.

32.

Uremia impacts renal inflammatory cytokine gene expression in the setting of experimental acute kidney injury.

Zager RA, Johnson AC, Lund S.

Am J Physiol Renal Physiol. 2009 Oct;297(4):F961-70. doi: 10.1152/ajprenal.00381.2009. Epub 2009 Aug 5.

33.

BRG1 increases transcription of proinflammatory genes in renal ischemia.

Naito M, Zager RA, Bomsztyk K.

J Am Soc Nephrol. 2009 Aug;20(8):1787-96. doi: 10.1681/ASN.2009010118. Epub 2009 Jun 25.

34.

Renal ischemia-reperfusion injury upregulates histone-modifying enzyme systems and alters histone expression at proinflammatory/profibrotic genes.

Zager RA, Johnson AC.

Am J Physiol Renal Physiol. 2009 May;296(5):F1032-41. doi: 10.1152/ajprenal.00061.2009. Epub 2009 Mar 4.

35.

Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene.

Naito M, Bomsztyk K, Zager RA.

Am J Pathol. 2009 Jan;174(1):54-62. doi: 10.2353/ajpath.2009.080602. Epub 2008 Dec 18.

36.

Uremia induces proximal tubular cytoresistance and heme oxygenase-1 expression in the absence of acute kidney injury.

Zager RA.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F362-8. doi: 10.1152/ajprenal.90645.2008. Epub 2008 Nov 26.

37.

Growth and development alter susceptibility to acute renal injury.

Zager RA, Johnson AC, Naito M, Lund SR, Kim N, Bomsztyk K.

Kidney Int. 2008 Sep;74(5):674-8. doi: 10.1038/ki.2008.251. Epub 2008 Jun 18.

38.

Endotoxin mediates recruitment of RNA polymerase II to target genes in acute renal failure.

Naito M, Bomsztyk K, Zager RA.

J Am Soc Nephrol. 2008 Jul;19(7):1321-30. doi: 10.1681/ASN.2007121368. Epub 2008 Apr 16.

39.

Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death.

Zager RA, Johnson AC, Naito M, Bomsztyk K.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F187-97. Epub 2007 Oct 17.

40.
41.

Intravenous iron therapy in peritoneal dialysis patients: short-term efficacy and long-term issues.

Zager RA.

Clin J Am Soc Nephrol. 2006 May;1(3):353-5. Epub 2006 Apr 5. Review. No abstract available.

42.

Gentamicin suppresses endotoxin-driven TNF-alpha production in human and mouse proximal tubule cells.

Zager RA, Johnson AC, Geballe A.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1373-80. Epub 2007 Aug 15.

43.
44.

'Endotoxin tolerance': TNF-alpha hyper-reactivity and tubular cytoresistance in a renal cholesterol loading state.

Zager RA, Johnson AC, Lund S.

Kidney Int. 2007 Mar;71(6):496-503. Epub 2007 Jan 17.

45.

Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury.

Zager RA, Johnson AC, Lund S, Randolph-Habecker J.

Am J Physiol Renal Physiol. 2007 Jan;292(1):F304-12. Epub 2006 Aug 1.

46.

Acute renal failure: determinants and characteristics of the injury-induced hyperinflammatory response.

Zager RA, Johnson AC, Lund S, Hanson S.

Am J Physiol Renal Physiol. 2006 Sep;291(3):F546-56. Epub 2006 Apr 25.

47.

Levosimendan protects against experimental endotoxemic acute renal failure.

Zager RA, Johnson AC, Lund S, Hanson SY, Abrass CK.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1453-62. Epub 2006 Jan 17.

48.
50.

IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride.

Berfield AK, Chait A, Oram JF, Zager RA, Johnson AC, Abrass CK.

Am J Physiol Renal Physiol. 2006 Jan;290(1):F138-47. Epub 2005 Aug 2.

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