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Items: 1 to 50 of 140

1.

Discriminative Stimulus and Low Abuse Liability Effects of Novel Endomorphin Analogs Suggest a Potential Treatment Indication for Opioid Use Disorder.

Nilges MR, Laurent M, Cable C, Arens L, Vafiades J, Zadina JE.

J Pharmacol Exp Ther. 2019 Sep;370(3):369-379. doi: 10.1124/jpet.118.253013. Epub 2019 Jun 18.

PMID:
31213481
2.
3.

Novel Endomorphin Analogs Are More Potent and Longer-Lasting Analgesics in Neuropathic, Inflammatory, Postoperative, and Visceral Pain Relative to Morphine.

Feehan AK, Morgenweck J, Zhang X, Amgott-Kwan AT, Zadina JE.

J Pain. 2017 Dec;18(12):1526-1541. doi: 10.1016/j.jpain.2017.08.007. Epub 2017 Sep 20.

PMID:
28939014
4.

Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine.

Zadina JE, Nilges MR, Morgenweck J, Zhang X, Hackler L, Fasold MB.

Neuropharmacology. 2016 Jun;105:215-227. doi: 10.1016/j.neuropharm.2015.12.024. Epub 2015 Dec 31.

PMID:
26748051
5.

PPARĪ³ activation blocks development and reduces established neuropathic pain in rats.

Morgenweck J, Griggs RB, Donahue RR, Zadina JE, Taylor BK.

Neuropharmacology. 2013 Jul;70:236-46. doi: 10.1016/j.neuropharm.2013.01.020. Epub 2013 Feb 13.

6.

Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.

Chakrabarti S, Liu NJ, Zadina JE, Sharma T, Gintzler AR.

J Pharmacol Exp Ther. 2012 Jan;340(1):56-63. doi: 10.1124/jpet.111.186874. Epub 2011 Oct 4.

7.
8.

Topography and time course of changes in spinal neuropeptide Y immunoreactivity after spared nerve injury.

Intondi AB, Zadina JE, Zhang X, Taylor BK.

Neuroscience. 2010 Feb 3;165(3):914-22. doi: 10.1016/j.neuroscience.2009.10.052. Epub 2009 Oct 30.

9.

Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus.

Greco MA, Fuller PM, Jhou TC, Martin-Schild S, Zadina JE, Hu Z, Shiromani P, Lu J.

Brain Res. 2008 Dec 15;1245:96-107. doi: 10.1016/j.brainres.2008.09.043. Epub 2008 Sep 24.

10.

Blockade of micro-opioid receptors in the medial thalamus inhibits acquisition, but not expression, of morphine-induced conditioned place preference.

Guo N, Garcia MM, Taylor BK, Zadina JE, Harlan RE.

Neuroscience. 2008 Feb 19;151(4):948-54. doi: 10.1016/j.neuroscience.2007.10.058. Epub 2007 Dec 14.

PMID:
18222040
11.
12.

Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine.

Czapla MA, Zadina JE.

Brain Res. 2005 Oct 19;1059(2):159-66. Epub 2005 Oct 11.

PMID:
16223471
13.

Mu-opioid receptor is present in dendritic targets of Endomorphin-2 axon terminals in the nuclei of the solitary tract.

Silverman MB, Hermes SM, Zadina JE, Aicher SA.

Neuroscience. 2005;135(3):887-96. Epub 2005 Sep 8.

PMID:
16154285
14.
15.
16.

Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells.

Somogyvari-Vigh A, Kastin AJ, Liao J, Zadina JE, Pan W.

Exp Brain Res. 2004 May;156(2):224-30.

17.

Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice.

Soignier RD, Vaccarino AL, Fanti KA, Wilson AM, Zadina JE.

Neurosci Lett. 2004 Aug 12;366(2):211-4.

PMID:
15276249
18.

Administration of FGF-1 through transfected cells alleviates MPTP toxicity in mice.

McLay RN, Freeman SM, Zadina JE.

Neurotox Res. 2001 Jul;3(3):249-53.

PMID:
15111249
19.

Endomorphin-2 axon terminals contact mu-opioid receptor-containing dendrites in trigeminal dorsal horn.

Aicher SA, Mitchell JL, Swanson KC, Zadina JE.

Brain Res. 2003 Jul 11;977(2):190-8.

PMID:
12834879
20.

Morphological evidence of endomorphin as an agonist for the mu-opioid receptor in the rat spinal cord.

Wang QP, Zadina JE, Guan JL, Shioda S.

Neurosci Lett. 2003 May 1;341(2):107-10.

PMID:
12686377
21.

Electron microscopic examination of the endomorphin 2-like immunoreactive neurons in the rat hypothalamus.

Wang QP, Zadina JE, Guan JL, Kastin AJ, Shioda S.

Brain Res. 2003 Apr 18;969(1-2):126-34.

PMID:
12676373
22.

Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area.

Greenwell TN, Zangen A, Martin-Schild S, Wise RA, Zadina JE.

J Comp Neurol. 2002 Dec 16;454(3):320-8.

PMID:
12442322
23.

Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants.

Abbadie C, Rossi GC, Orciuolo A, Zadina JE, Pasternak GW.

Eur J Neurosci. 2002 Sep;16(6):1075-82.

PMID:
12383236
24.

The alpha9/alpha10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear.

Lioudyno MI, Verbitsky M, Glowatzki E, Holt JC, Boulter J, Zadina JE, Elgoyhen AB, Guth PS.

Mol Cell Neurosci. 2002 Aug;20(4):695-711.

PMID:
12213449
25.

Morphological studies of the endomorphinergic neurons in the central nervous system.

Wang QP, Zadina JE, Guan JL, Shioda S.

Jpn J Pharmacol. 2002 Jul;89(3):209-15. Review.

26.

Isolation and distribution of endomorphins in the central nervous system.

Zadina JE.

Jpn J Pharmacol. 2002 Jul;89(3):203-8. Review.

28.

Endomorphin-2 immunoreactivity in the cervical dorsal horn of the rat spinal cord at the electron microscopic level.

Wang QP, Zadina JE, Guan JL, Kastin AJ, Funahashi H, Shioda S.

Neuroscience. 2002;113(3):593-605.

PMID:
12150779
29.

Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.

Sakurada S, Hayashi T, Yuhki M, Fujimura T, Murayama K, Yonezawa A, Sakurada C, Takeshita M, Sato T, Zadina JE, Kastin AJ, Sakurada T.

Peptides. 2002 May;23(5):895-901.

PMID:
12084520
30.

Role of nitric oxide in mediating vasodilator responses to opioid peptides in the rat.

Champion HC, Bivalacqua TJ, Zadina JE, Kastin AJ, Hyman AL, Kadowitz PJ.

Clin Exp Pharmacol Physiol. 2002 Mar;29(3):229-32.

PMID:
11906489
31.

Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system.

Kastin AJ, Fasold MB, Zadina JE.

Drug Metab Dispos. 2002 Mar;30(3):231-4.

PMID:
11854138
32.

Endomorphin1-like immunoreactivity in the limbic system of Syrian hamsters (Mesocricetus auratus).

Whitten RD, Martin-Schild S, Zadina JE, Albers HE.

Brain Res Bull. 2001 Dec;56(6):563-7.

PMID:
11786242
33.

The effects of endomorphin-1 on conditioned defeat in Syrian hamsters (Mesocricetus auratus).

Whitten RD, Jasnow AM, Albers HE, Martin-Schild S, Zadina JE, Huhman KL.

Brain Res. 2001 Sep 28;914(1-2):74-80.

PMID:
11578599
34.

Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.

Sakurada S, Hayashi T, Yuhki M, Orito T, Zadina JE, Kastin AJ, Fujimura T, Murayama K, Sakurada C, Sakurada T, Narita M, Suzuki T, Tan-no K, Tseng LF.

Eur J Pharmacol. 2001 Sep 21;427(3):203-10.

PMID:
11567650
36.

Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury.

Smith RR, Martin-Schild S, Kastin AJ, Zadina JE.

Neuroscience. 2001;105(3):773-8.

PMID:
11516840
37.

Saturable brain-to-blood transport of endomorphins.

Kastin AJ, Fasold MB, Smith RR, Horner KA, Zadina JE.

Exp Brain Res. 2001 Jul;139(1):70-5.

PMID:
11482845
38.

In vitro demonstration of a saturable transport system for leptin across the blood-brain barrier.

Maresh GA, Maness LM, Zadina JE, Kastin AJ.

Life Sci. 2001 May 25;69(1):67-73.

PMID:
11411806
39.

Dissociation of analgesic and rewarding effects of endomorphin-1 in rats.

Wilson AM, Soignier RD, Zadina JE, Kastin AJ, Nores WL, Olson RD, Olson GA.

Peptides. 2000 Dec;21(12):1871-4.

PMID:
11150648
40.
41.

Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone.

Sakurada S, Hayashi T, Yuhki M, Fujimura T, Murayama K, Yonezawa A, Sakurada C, Takeshita M, Zadina JE, Kastin AJ, Sakurada T.

Brain Res. 2000 Oct 20;881(1):1-8.

PMID:
11033087
42.

Differential cardiorespiratory effects of endomorphin 1, endomorphin 2, DAMGO, and morphine.

Czapla MA, Gozal D, Alea OA, Beckerman RC, Zadina JE.

Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):994-9.

PMID:
10988119
43.

Analgesic effects of endomorphin-1 and endomorphin-2 in the formalin test in mice.

Soignier RD, Vaccarino AL, Brennan AM, Kastin AJ, Zadina JE.

Life Sci. 2000 Jul 14;67(8):907-12.

PMID:
10946850
44.

Maturation of endomorphin-2 in the dorsal horn of the medulla and spinal cord of the rat.

Barr GA, Zadina JE.

Neuroreport. 1999 Dec 16;10(18):3857-60.

PMID:
10716223
45.

Comparison of active conformations of the insectatachykinin/tachykinin and insect kinin/Tyr-W-MIF-1 neuropeptide family pairs.

Nachman RJ, Moyna G, Williams HJ, Zabrocki J, Zadina JE, Coast GM, Varden Broeck J.

Ann N Y Acad Sci. 1999;897:388-400. Review.

PMID:
10676465
46.

Vasodilator responses to the endomorphin peptides, but not nociceptin/OFQ, are mediated by nitric oxide release.

Champion HC, Bivalacqua TJ, Zadina JE, Kastin AJ, Kadowitz PJ.

Ann N Y Acad Sci. 1999;897:165-72.

PMID:
10676445
47.
48.

Endomorphins: novel endogenous mu-opiate receptor agonists in regions of high mu-opiate receptor density.

Zadina JE, Martin-Schild S, Gerall AA, Kastin AJ, Hackler L, Ge LJ, Zhang X.

Ann N Y Acad Sci. 1999;897:136-44. Review.

PMID:
10676442
49.

Phe(13),Tyr(19)-melanin-concentration hormone and the blood-brain barrier: role of protein binding.

Kastin AJ, Akerstrom V, Hackler L, Zadina JE.

J Neurochem. 2000 Jan;74(1):385-91.

50.

Peptide transport system-1 (PTS-1) for Tyr-MIF-1 and Met-enkephalin differs from the receptors for either.

Maresh GA, Kastin AJ, Brown TT, Zadina JE, Banks WA.

Brain Res. 1999 Aug 28;839(2):336-40.

PMID:
10519058

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