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Items: 1 to 50 of 60

1.

Using Enteroendocrine Cell-Enriched Human Enteroids to Evaluate Responses to Gut Stimuli.

Zachos NC.

Cell Mol Gastroenterol Hepatol. 2019;8(2):291-292. doi: 10.1016/j.jcmgh.2019.05.005. Epub 2019 Jun 3. No abstract available.

2.

Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model.

Ranganathan S, Doucet M, Grassel CL, Delaine-Elias B, Zachos NC, Barry EM.

Infect Immun. 2019 Mar 25;87(4). pii: e00740-18. doi: 10.1128/IAI.00740-18. Print 2019 Apr.

3.

Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors.

Pearce SC, Coia HG, Karl JP, Pantoja-Feliciano IG, Zachos NC, Racicot K.

Front Physiol. 2018 Nov 12;9:1584. doi: 10.3389/fphys.2018.01584. eCollection 2018. Review.

4.

Enterohemorrhagic E. coli (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers.

Tse CM, In JG, Yin J, Donowitz M, Doucet M, Foulke-Abel J, Ruiz-Perez F, Nataro JP, Zachos NC, Kaper JB, Kovbasnjuk O.

Toxins (Basel). 2018 Sep 1;10(9). pii: E351. doi: 10.3390/toxins10090351.

5.

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.

Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC.

Cell Host Microbe. 2018 Jun 13;23(6):775-785.e5. doi: 10.1016/j.chom.2018.05.004.

6.

Enterotoxigenic Escherichia coli is phagocytosed by macrophages underlying villus-like intestinal epithelial cells: modeling ex vivo innate immune defenses of the human gut.

Noel G, Doucet M, Nataro JP, Kaper JB, Zachos NC, Pasetti MF.

Gut Microbes. 2017 Oct 31:0. doi: 10.1080/19490976.2017.1398871. [Epub ahead of print]

7.

Gastrointestinal microphysiological systems.

Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK.

Exp Biol Med (Maywood). 2017 Oct;242(16):1633-1642. doi: 10.1177/1535370217710638. Epub 2017 May 23. Review.

8.

Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC.

Sci Rep. 2017 May 3;7:46790. doi: 10.1038/srep46790. No abstract available.

9.

Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections.

Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK.

Methods Mol Biol. 2019;1576:229-247. doi: 10.1007/7651_2017_1.

10.

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC.

Sci Rep. 2017 Mar 27;7:45270. doi: 10.1038/srep45270. Erratum in: Sci Rep. 2017 May 03;7:46790.

11.

Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.

Sci Rep. 2017 Mar 16;7:44517. doi: 10.1038/srep44517. No abstract available.

12.

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.

Cha B, Yang J, Singh V, Zachos NC, Sarker RI, Chen TE, Chakraborty M, Tse CM, Donowitz M.

J Biol Chem. 2017 May 19;292(20):8279-8290. doi: 10.1074/jbc.M116.774489. Epub 2017 Mar 10.

13.

The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.

Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M.

Annu Rev Physiol. 2017 Feb 10;79:291-312. doi: 10.1146/annurev-physiol-021115-105211. Review.

14.

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.

Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.

Sci Rep. 2017 Feb 8;7:42296. doi: 10.1038/srep42296. Erratum in: Sci Rep. 2017 Mar 16;7:44517.

15.

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.

Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E570-E579. doi: 10.1073/pnas.1615422114. Epub 2017 Jan 9.

16.

Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS.

FASEB J. 2017 Feb;31(2):751-760. doi: 10.1096/fj.201600891R. Epub 2016 Nov 8.

17.

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.

Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS.

Transl Res. 2017 Apr;182:14-26.e4. doi: 10.1016/j.trsl.2016.10.003. Epub 2016 Oct 15.

18.

Human mini-guts: new insights into intestinal physiology and host-pathogen interactions.

In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M.

Nat Rev Gastroenterol Hepatol. 2016 Nov;13(11):633-642. doi: 10.1038/nrgastro.2016.142. Epub 2016 Sep 28. Review.

19.

Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids.

In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):48-62.e3.

20.

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.

Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M.

Gastroenterology. 2016 Mar;150(3):638-649.e8. doi: 10.1053/j.gastro.2015.11.047. Epub 2015 Dec 8.

21.

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M.

J Biol Chem. 2016 Feb 19;291(8):3759-66. doi: 10.1074/jbc.R114.635995. Epub 2015 Dec 16. Review.

22.

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology.

Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK.

J Virol. 2015 Oct 7;90(1):43-56. doi: 10.1128/JVI.01930-15. Print 2016 Jan 1.

23.

Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.

Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, Wedenoja S, Baumgartner N, Vodopiutz J, Frechette-Duval MC, De Lafollie J, Persad R, Warner N, Tse CM, Sud K, Zachos NC, Sarker R, Zhu X, Muise AM, Zimmer KP, Witt H, Zoller H, Donowitz M, Müller T.

Hum Mol Genet. 2015 Dec 1;24(23):6614-23. doi: 10.1093/hmg/ddv367. Epub 2015 Sep 10.

24.

Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function.

Grant CN, Mojica SG, Sala FG, Hill JR, Levin DE, Speer AL, Barthel ER, Shimada H, Zachos NC, Grikscheit TC.

Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15;308(8):G664-77. doi: 10.1152/ajpgi.00111.2014. Epub 2015 Jan 8.

25.

NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.

Yang J, Singh V, Chen TE, Sarker R, Xiong L, Cha B, Jin S, Li X, Tse CM, Zachos NC, Donowitz M.

J Biol Chem. 2014 Jul 18;289(29):20039-53. doi: 10.1074/jbc.M114.562413. Epub 2014 May 27.

26.

Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract.

Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M.

Exp Biol Med (Maywood). 2014 Sep;239(9):1124-34. doi: 10.1177/1535370214529398. Epub 2014 Apr 9. Review.

27.

Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.

Zachos NC, Alamelumangpuram B, Lee LJ, Wang P, Kovbasnjuk O.

Cell Physiol Biochem. 2014;33(3):869-81. doi: 10.1159/000358659. Epub 2014 Mar 28.

28.

Human enteroids: preclinical models of non-inflammatory diarrhea.

Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M.

Stem Cell Res Ther. 2013;4 Suppl 1:S3. doi: 10.1186/scrt364. Epub 2013 Dec 20. Review.

29.

Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption.

Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M.

Clin Gastroenterol Hepatol. 2014 Jan;12(1):27-31. doi: 10.1016/j.cgh.2013.10.020. Epub 2013 Oct 31. Review.

30.

PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells.

Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C266-75. doi: 10.1152/ajpcell.00277.2012. Epub 2013 May 22.

31.

NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.

Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M.

J Biol Chem. 2013 Jun 7;288(23):16960-74. doi: 10.1074/jbc.M113.470799. Epub 2013 Apr 23.

32.

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.

Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M.

J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27.

33.

Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.

Zhu X, Cha B, Zachos NC, Sarker R, Chakraborty M, Chen TE, Kovbasnjuk O, Donowitz M.

J Biol Chem. 2011 Oct 7;286(40):34486-96. doi: 10.1074/jbc.M111.230219. Epub 2011 Jul 28.

34.

NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.

Murtazina R, Kovbasnjuk O, Chen TE, Zachos NC, Chen Y, Kocinsky HS, Hogema BM, Seidler U, de Jonge HR, Donowitz M.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C126-36. doi: 10.1152/ajpcell.00311.2010. Epub 2011 Mar 23.

35.

Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.

Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, Gucek M, Cole RN, Zachos NC, Salahuddin FF, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X.

Physiol Genomics. 2011 Jun 15;43(11):674-84. doi: 10.1152/physiolgenomics.00258.2010. Epub 2011 Mar 22.

36.

NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.

Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C771-82. doi: 10.1152/ajpcell.00119.2010. Epub 2010 Dec 29.

37.

Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles.

Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X.

Physiol Genomics. 2010 Nov 15;42A(3):200-10. doi: 10.1152/physiolgenomics.00001.2010. Epub 2010 Aug 24.

38.

NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.

Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M.

J Biol Chem. 2010 Nov 5;285(45):34566-78. doi: 10.1074/jbc.M110.165712. Epub 2010 Aug 24.

39.

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.

Cha B, Zhu XC, Chen W, Jones M, Ryoo S, Zachos NC, Chen TE, Lin R, Sarker R, Kenworthy AK, Tse M, Kovbasnjuk O, Donowitz M.

J Cell Sci. 2010 Jul 15;123(Pt 14):2434-43. doi: 10.1242/jcs.056713. Epub 2010 Jun 22.

40.

Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis.

Alex P, Ye M, Zachos NC, Sipes J, Nguyen T, Suhodrev M, Gonzales L, Arora Z, Zhang T, Centola M, Guggino SE, Li X.

J Immunol. 2010 Apr 1;184(7):3988-96. doi: 10.4049/jimmunol.0901657. Epub 2010 Feb 24.

41.

Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy).

Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S, Murphy S, de Vries E, Kelly DA, Maher ER.

Gastroenterology. 2010 Jun;138(7):2388-98, 2398.e1-2. doi: 10.1053/j.gastro.2010.02.010. Epub 2010 Feb 20.

42.

Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion.

Hoque KM, Woodward OM, van Rossum DB, Zachos NC, Chen L, Leung GP, Guggino WB, Guggino SE, Tse CM.

J Gen Physiol. 2010 Jan;135(1):43-58. doi: 10.1085/jgp.200910339.

43.

Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.

Zachos NC, Kovbasnjuk O, Donowitz M.

Ann N Y Acad Sci. 2009 May;1165:240-8. doi: 10.1111/j.1749-6632.2009.04055.x. Review.

44.

NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.

Zachos NC, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee LJ, Li M, de Jonge H, Donowitz M.

J Biol Chem. 2009 Aug 28;284(35):23708-18. doi: 10.1074/jbc.M109.012641. Epub 2009 Jun 17.

45.

Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.

Zachos NC, van Rossum DB, Li X, Caraveo G, Sarker R, Cha B, Mohan S, Desiderio S, Patterson RL, Donowitz M.

J Biol Chem. 2009 Jul 17;284(29):19437-44. doi: 10.1074/jbc.M109.006098. Epub 2009 May 27.

46.

NHE3 regulatory complexes.

Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X.

J Exp Biol. 2009 Jun;212(Pt 11):1638-46. doi: 10.1242/jeb.028605. Review.

47.

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M.

Cell Physiol Biochem. 2008;22(5-6):693-704. doi: 10.1159/000185553. Epub 2008 Dec 9.

48.

Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea.

Sullivan S, Alex P, Dassopoulos T, Zachos NC, Iacobuzio-Donahue C, Donowitz M, Brant SR, Cuffari C, Harris ML, Datta LW, Conklin L, Chen Y, Li X.

Inflamm Bowel Dis. 2009 Feb;15(2):261-74. doi: 10.1002/ibd.20743.

49.

Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.

Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, Centola M, Li X.

Inflamm Bowel Dis. 2009 Mar;15(3):341-52. doi: 10.1002/ibd.20753.

50.

Regulation of expression of microvillus membrane proteins by estrogen in baboon fetal ovarian oocytes.

Zachos NC, Burch MG, Billiar RB, Li C, Albrecht ED, Pepe GJ.

Biol Reprod. 2008 Dec;79(6):1160-8. doi: 10.1095/biolreprod.108.067900. Epub 2008 Aug 20.

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