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IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis.

Whiteside SK, Snook JP, Ma Y, Sonderegger FL, Fisher C, Petersen C, Zachary JF, Round JL, Williams MA, Weis JJ.

J Immunol. 2018 Feb 15;200(4):1457-1470. doi: 10.4049/jimmunol.1701248. Epub 2018 Jan 12.


Genetic Control of Lyme Arthritis by Borrelia burgdorferi Arthritis-Associated Locus 1 Is Dependent on Localized Differential Production of IFN-β and Requires Upregulation of Myostatin.

Paquette JK, Ma Y, Fisher C, Li J, Lee SB, Zachary JF, Kim YS, Teuscher C, Weis JJ.

J Immunol. 2017 Nov 15;199(10):3525-3534. doi: 10.4049/jimmunol.1701011. Epub 2017 Oct 6.


Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis.

Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, O'Connell RM, Weis JJ.

PLoS One. 2015 Aug 7;10(8):e0135142. doi: 10.1371/journal.pone.0135142. eCollection 2015.


Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.

Case LK, Wall EH, Osmanski EE, Dragon JA, Saligrama N, Zachary JF, Lemos B, Blankenhorn EP, Teuscher C.

Genome Biol. 2015 Feb 10;16:28. doi: 10.1186/s13059-015-0591-7.


Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production.

Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ.

J Immunol. 2014 Dec 15;193(12):6050-60. doi: 10.4049/jimmunol.1401746. Epub 2014 Nov 5.


MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi.

Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ.

PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212. eCollection 2014 Jun.


Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity.

Bramwell KK, Ma Y, Weis JH, Chen X, Zachary JF, Teuscher C, Weis JJ.

J Clin Invest. 2014 Jan;124(1):311-20. doi: 10.1172/JCI72339. Epub 2013 Dec 16.


The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease.

Case LK, Wall EH, Dragon JA, Saligrama N, Krementsov DN, Moussawi M, Zachary JF, Huber SA, Blankenhorn EP, Teuscher C.

Genome Res. 2013 Sep;23(9):1474-85. doi: 10.1101/gr.156703.113. Epub 2013 Jun 25.


Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue.

Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2012 Sep 1;189(5):2488-501. doi: 10.4049/jimmunol.1201095. Epub 2012 Jul 30.


Localized production of IL-10 suppresses early inflammatory cell infiltration and subsequent development of IFN-γ-mediated Lyme arthritis.

Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Spangrude GJ, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2012 Feb 1;188(3):1381-93. doi: 10.4049/jimmunol.1102359. Epub 2011 Dec 16.


Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system.

del Rio R, Noubade R, Saligrama N, Wall EH, Krementsov DN, Poynter ME, Zachary JF, Thurmond RL, Teuscher C.

J Immunol. 2012 Jan 15;188(2):541-7. doi: 10.4049/jimmunol.1101498. Epub 2011 Dec 5.


Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis.

Lu C, Diehl SA, Noubade R, Ledoux J, Nelson MT, Spach K, Zachary JF, Blankenhorn EP, Teuscher C.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18967-72. doi: 10.1073/pnas.1008816107. Epub 2010 Oct 18.


The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice.

Case LK, Del Rio R, Bonney EA, Zachary JF, Blankenhorn EP, Tung KS, Teuscher C.

Cell Immunol. 2010;260(2):119-27. doi: 10.1016/j.cellimm.2009.10.002.


Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12.

Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ.

Infect Immun. 2009 Aug;77(8):3302-11. doi: 10.1128/IAI.00396-09. Epub 2009 Jun 1.


Estimation of the acoustic impedance of lung versus level of inflation for different species and ages of animals.

Oelze ML, Miller RJ, Blue JP Jr, Zachary JF, O'Brien WD Jr.

J Acoust Soc Am. 2008 Oct;124(4):2340-52. doi: 10.1121/1.2973186.


A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice.

Miller JC, Ma Y, Bian J, Sheehan KC, Zachary JF, Weis JH, Schreiber RD, Weis JJ.

J Immunol. 2008 Dec 15;181(12):8492-503.


von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis.

Noubade R, del Rio R, McElvany B, Zachary JF, Millward JM, Wagner DD, Offner H, Blankenhorn EP, Teuscher C.

Am J Pathol. 2008 Sep;173(3):892-900. doi: 10.2353/ajpath.2008.080001. Epub 2008 Aug 7.


The risk of exposure to diagnostic ultrasound in postnatal subjects: thermal effects.

O'Brien WD Jr, Deng CX, Harris GR, Herman BA, Merritt CR, Sanghvi N, Zachary JF.

J Ultrasound Med. 2008 Apr;27(4):517-35; quiz 537-40. Review.


Extended three-dimensional impedance map methods for identifying ultrasonic scattering sites.

Mamou J, Oelze ML, O'Brien WD Jr, Zachary JF.

J Acoust Soc Am. 2008 Feb;123(2):1195-1208. doi: 10.1121/1.2822658.


T cell infiltration is associated with increased Lyme arthritis in TLR2-/- mice.

Wang X, Ma Y, Yoder A, Crandall H, Zachary JF, Fujinami RS, Weis JH, Weis JJ.

FEMS Immunol Med Microbiol. 2008 Jan;52(1):124-33. Epub 2007 Dec 11.


Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice.

Noubade R, Milligan G, Zachary JF, Blankenhorn EP, del Rio R, Rincon M, Teuscher C.

J Clin Invest. 2007 Nov;117(11):3507-18.


Third degree atrioventricular block and sudden death secondary to acute myocarditis in a dog.

Church WM, Sisson DD, Oyama MA, Zachary JF.

J Vet Cardiol. 2007 May;9(1):53-7. Epub 2006 Oct 16.


Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS.

Teuscher C, Subramanian M, Noubade R, Gao JF, Offner H, Zachary JF, Blankenhorn EP.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10146-51. Epub 2007 Jun 4.


Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.

Jacobson AC, Ma Y, Zachary JF, Weis JJ, Weis JH.

Infect Immun. 2007 Apr;75(4):2075-8. Epub 2007 Feb 5.


Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis.

Crandall H, Dunn DM, Ma Y, Wooten RM, Zachary JF, Weis JH, Weiss RB, Weis JJ.

J Immunol. 2006 Dec 1;177(11):7930-42.


Threshold estimation of ultrasound-induced lung hemorrhage in adult rabbits and comparison of thresholds in mice, rats, rabbits and pigs.

O'Brien WD Jr, Yang Y, Simpson DG, Frizzell LA, Miller RJ, Blue JP Jr, Zachary JF.

Ultrasound Med Biol. 2006 Nov;32(11):1793-804.


Lesions of ultrasound-induced lung hemorrhage are not consistent with thermal injury.

Zachary JF, Blue JP Jr, Miller RJ, Ricconi BJ, Eden JG, O'Brien WD Jr.

Ultrasound Med Biol. 2006 Nov;32(11):1763-70.


Examination of cancer in mouse models using high-frequency quantitative ultrasound.

Oelze ML, Zachary JF.

Ultrasound Med Biol. 2006 Nov;32(11):1639-48.


Genetic induction of tumorigenesis in swine.

Adam SJ, Rund LA, Kuzmuk KN, Zachary JF, Schook LB, Counter CM.

Oncogene. 2007 Feb 15;26(7):1038-45. Epub 2006 Sep 11.


Quantitative ultrasound assessment of the rat cervix.

McFarlin BL, O'Brien WD Jr, Oelze ML, Zachary JF, White-Traut RC.

J Ultrasound Med. 2006 Aug;25(8):1031-40.


Evidence that the Y chromosome influences autoimmune disease in male and female mice.

Teuscher C, Noubade R, Spach K, McElvany B, Bunn JY, Fillmore PD, Zachary JF, Blankenhorn EP.

Proc Natl Acad Sci U S A. 2006 May 23;103(21):8024-9. Epub 2006 May 15.


Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase.

Crandall H, Ma Y, Dunn DM, Sundsbak RS, Zachary JF, Olofsson P, Holmdahl R, Weis JH, Weiss RB, Teuscher C, Weis JJ.

Am J Pathol. 2005 Sep;167(3):775-85.


Developing a long-term surviving piglet model of neonatal hypoxic-ischemic encephalopathy.

McCulloch KM, Raju TN, Navale S, Burt CT, Roohey T, Moustogiannis A, Zachary JF.

Neurol Res. 2005 Jan;27(1):16-21.


Superthreshold behavior of ultrasound-induced lung hemorrhage in adult rats: role of pulse repetition frequency and exposure duration revisited.

O'Brien WD Jr, Simpson DG, Frizzell LA, Zachary JF.

J Ultrasound Med. 2005 Mar;24(3):339-48.


Identifying ultrasonic scattering sites from three-dimensional impedance maps.

Mamou J, Oelze ML, O'Brien WD Jr, Zachary JF.

J Acoust Soc Am. 2005 Jan;117(1):413-23.


Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease.

Wang X, Ma Y, Weis JH, Zachary JF, Kirschning CJ, Weis JJ.

Infect Immun. 2005 Jan;73(1):657-60.


Excess risk thresholds in ultrasound safety studies: statistical methods for data on occurrence and size of lesions.

Simpson DG, Ho MH, Yang Y, Zhou J, Zachary JF, O'Brien WD Jr.

Ultrasound Med Biol. 2004 Oct;30(10):1289-95.


MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.

Bolz DD, Sundsbak RS, Ma Y, Akira S, Kirschning CJ, Zachary JF, Weis JH, Weis JJ.

J Immunol. 2004 Aug 1;173(3):2003-10.


Effect of contrast agent on the incidence and magnitude of ultrasound-induced lung hemorrhage in rats.

O'Brien WD Jr, Simpson DG, Frizzell LA, Zachary JF.

Echocardiography. 2004 Jul;21(5):417-22.


Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging.

Oelze ML, O'Brien WD Jr, Blue JP, Zachary JF.

IEEE Trans Med Imaging. 2004 Jun;23(6):764-71.


Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice.

Polanczyk M, Yellayi S, Zamora A, Subramanian S, Tovey M, Vandenbark AA, Offner H, Zachary JF, Fillmore PD, Blankenhorn EP, Gustafsson JA, Teuscher C.

Am J Pathol. 2004 Jun;164(6):1915-24.


Impedance measurements of ex vivo rat lung at different volumes of inflation.

Oelze ML, Miller RJ, Blue JP Jr, Zachary JF, O'Brien WD Jr.

J Acoust Soc Am. 2003 Dec;114(6 Pt 1):3384-93.


Threshold estimates and superthreshold behavior of ultrasound-induced lung hemorrhage in adult rats: role of pulse duration.

O'Brien WD, Simpson DG, Frizzell LA, Zachary JF.

Ultrasound Med Biol. 2003 Nov;29(11):1625-34.


Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice.

Lawrenz MB, Wooten RM, Zachary JF, Drouin SM, Weis JJ, Wetsel RA, Norris SJ.

Infect Immun. 2003 Aug;71(8):4432-40.


Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi.

Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ.

Vector Borne Zoonotic Dis. 2002 Winter;2(4):275-8. No abstract available.


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