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Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study.

Adam EH, Haas V, Lindau S, Zacharowski K, Scheller B.

BMJ Open. 2020 Jan 14;10(1):e031212. doi: 10.1136/bmjopen-2019-031212.


Effectiveness of Preoperative Iron Supplementation in Major Surgical Patients with Iron Deficiency: A Prospective Observational Study.

Triphaus C, Judd L, Glaser P, Goehring MH, Schmitt E, Westphal S, Füllenbach C, Lindau S, Zacharowski K, Meybohm P, Choorapoikayil S.

Ann Surg. 2019 Nov 25. doi: 10.1097/SLA.0000000000003643. [Epub ahead of print]


[Englischer Titel: Scientific habilitations as an indicator of research productivity in Germany - a comparative analysis of several clinical specialties].

Eckle VS, Zacharowski K, Koch T, Meybohm P.

Z Evid Fortbild Qual Gesundhwes. 2020 Jan 10. pii: S1865-9217(19)30200-4. doi: 10.1016/j.zefq.2019.12.002. [Epub ahead of print] German.


Programmes for the management of preoperative anaemia: audit in ten European hospitals within the PaBloE (Patient Blood Management in Europe) Working Group.

Jung-König M, Füllenbach C, Murphy MF, Manzini P, Laspina S, Pendry K, Mühling J, Wikman A, Humbrecht C, Rigal JC, Lasocki S, Folléa G, Seifried E, Müller MM, Geisen C, Aranko K, Zacharowski K, Meybohm P; the PaBloE (Patient Blood Management in Europe) working group.

Vox Sang. 2019 Dec 26. doi: 10.1111/vox.12872. [Epub ahead of print]


Health economics of Patient Blood Management: a cost-benefit analysis based on a meta-analysis.

Meybohm P, Straub N, Füllenbach C, Judd L, Kleinerüschkamp A, Taeuber I, Zacharowski K, Choorapoikayil S.

Vox Sang. 2019 Dec 10. doi: 10.1111/vox.12873. [Epub ahead of print]


Factor XIII activity in patients requiring surgical re-exploration for bleeding after elective cardiac surgery - A prospective case control study.

Adam EH, Meier J, Klee B, Zacharowski K, Meybohm P, Weber CF, Pape A.

J Crit Care. 2019 Nov 18;56:18-25. doi: 10.1016/j.jcrc.2019.11.012. [Epub ahead of print]


Screening for iron deficiency in surgical patients based on noninvasive zinc protoporphyrin measurements.

Füllenbach C, Stein P, Glaser P, Triphaus C, Lindau S, Choorapoikayil S, Schmitt E, Zacharowski K, Hintereder G, Hennig G, Homann C, Stepp H, Spahn GH, Kaserer A, Schedler A, Meybohm P, Spahn DR.

Transfusion. 2020 Jan;60(1):62-72. doi: 10.1111/trf.15577. Epub 2019 Nov 11.


In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients.

Schmitt E, Meybohm P, Herrmann E, Ammersbach K, Endres R, Lindau S, Helmer P, Zacharowski K, Neb H.

Crit Care. 2019 Nov 22;23(1):373. doi: 10.1186/s13054-019-2618-z.


Aprotinin Relicense and Use of Nonapproved Interventions.

Royston D, De Hert S, Ouattara A, van der Linden J, Zacharowski K.

J Cardiothorac Vasc Anesth. 2019 Oct 10. pii: S1053-0770(19)31034-1. doi: 10.1053/j.jvca.2019.10.001. [Epub ahead of print] No abstract available.


Comparing Four Video Laryngoscopes and One Optical Laryngoscope with a Standard Macintosh Blade in a Simulated Trapped Car Accident Victim.

Raimann FJ, Tepperis DM, Meininger D, Zacharowski K, Schalk R, Byhahn C, Weber CF, Mutlak H.

Emerg Med Int. 2019 Oct 1;2019:9690839. doi: 10.1155/2019/9690839. eCollection 2019.


[Preoperative iron deficiency with/without anemia-an underestimated risk factor?]

Meybohm P, Neef V, Westphal S, Schnitzbauer A, Röder D, Schlegel N, Zacharowski K.

Chirurg. 2019 Sep 26. doi: 10.1007/s00104-019-01037-1. [Epub ahead of print] Review. German.


Preoperative Anaemia in Primary Hip and Knee Arthroplasty.

Meybohm P, Kohlhof H, Wirtz DC, Marzi I, Füllenbach C, Choorapoikayil S, Wittmann M, Marschall U, Thoma J, Schwendner K, Stark P, Raadts A, Friedrich J, Weigt H, Friederich P, Huber J, Gutjahr M, Schmitt E, Zacharowski K.

Z Orthop Unfall. 2019 Sep 18. doi: 10.1055/a-0974-4115. [Epub ahead of print] English, German.


Fast Interpretation of Thromboelastometry and Aggregometry in Patients Suffering from Chronic Liver Disease.

Stegewerth K, Weber CF, Moehlmann M, Adam EH, Zacharowski K, Zeuzem S, Weiler N.

Clin Lab. 2019 Aug 1;65(8). doi: 10.7754/Clin.Lab.2019.190505.


Perioperative Anemia Management as Part of PBM in Cardiac Surgery - A Narrative Updated Review.

Meybohm P, Westphal S, Ravn HB, Ranucci M, Agarwal S, Choorapoikayil S, Spahn DR, Ahmed AB, Froessler B, Zacharowski K.

J Cardiothorac Vasc Anesth. 2019 Jul 4. pii: S1053-0770(19)30639-1. doi: 10.1053/j.jvca.2019.06.047. [Epub ahead of print] Review.


[Various scenarios for billing and remuneration of preoperative management of iron deficiency anemia in the German healthcare system].

Piekarski F, Thalheimer M, Seyfried T, Kron F, Jung N, Sandow P, Isik S, Fuellenbach C, Choorapoikayil S, Marschall U, Winterhalter M, Wunderer F, Kloka J, Tellbach JH, Zacharowski K, Meybohm P.

Anaesthesist. 2019 Aug;68(8):540-545. doi: 10.1007/s00101-019-0632-9. Review. German.


Prevalence of multidrug-resistant organisms in refugee patients admitted to a German university hospital depending on duration of stay in Germany.

Reinheimer C, Abdollahi P, Zacharowski K, Meybohm P, Mutlak H, Klingebiel T, Wichelhaus TA, Kempf VAJ.

GMS Hyg Infect Control. 2019 Jun 28;14:Doc07. doi: 10.3205/dgkh000323. eCollection 2019.


Prospective Trial to Compare Direct and Indirect Laryngoscopy Using C-MAC PM® with Macintosh Blade and D-Blade® in a Simulated Difficult Airway.

Raimann FJ, Dietze PE, Cuca CE, Meininger D, Kessler P, Byhahn C, Gill-Schuster D, Zacharowski K, Mutlak H.

Emerg Med Int. 2019 Apr 1;2019:1067473. doi: 10.1155/2019/1067473. eCollection 2019.


Total Intravenous Anesthesia in GLUT1 Deficiency Syndrome Patient: A Case Report.

Kloka J, Kranepuhl S, Zacharowski K, Raimann FJ.

Am J Case Rep. 2019 May 5;20:647-650. doi: 10.12659/AJCR.914865.


Impact of a new balanced gelatine on electrolytes and pH in the perioperative care.

Marx G, Meybohm P, Schuerholz T, Lotz G, Ledinko M, Schindler AW, Rossaint R, Zacharowski K.

PLoS One. 2019 Apr 29;14(4):e0213057. doi: 10.1371/journal.pone.0213057. eCollection 2019.


Heute aus der Prämedikationsambulanz: Hernioplastik bei 10 Monate altem Kind.

Bergold M, Gill-Schuster D, Holzer L, Empting PA, Zacharowski K.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Apr;54(4):302-306. doi: 10.1055/s-0041-109752. Epub 2019 Apr 12. German. No abstract available.


TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion.

Raimann FJ, Dröse S, Bonke E, Schneider L, Tybl E, Wittig I, Heidler J, Heide H, Josipovic I, Leisegang M, Brandes RP, Roeper J, Zacharowski K, Mersmann J.

J Cardiovasc Transl Res. 2019 Oct;12(5):478-487. doi: 10.1007/s12265-019-09887-0. Epub 2019 Apr 8.


Granisetron reduces the need for uterotonics but not sympathomimetics during cesarean delivery.

Raimann FJ, Baldauf HP, Louwen F, Jennewein L, Fischer D, Zacharowski K, Weber CF.

Int J Gynaecol Obstet. 2019 Jun;145(3):361-366. doi: 10.1002/ijgo.12819. Epub 2019 Apr 15.


[Patient Blood Management: Preoperative Anemia and Case Reports from the Anemia Walk-In Clinic].

Westphal S, Isik S, Choorapoikayil S, Füllenbach C, Zacharowski K, Meybohm P.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Mar;54(3):182-193. doi: 10.1055/a-0593-4354. Epub 2019 Mar 13. German.


[Cell Salvage in Anesthesiology].

Westphal S, Zacharowski K, Choorapoikayil S, Füllenbach C, Meybohm P.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Mar;54(3):170-181. doi: 10.1055/a-0593-4377. Epub 2019 Mar 13. German.


Patient Blood Management.

Zacharowski K.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Mar;54(3):168-169. doi: 10.1055/a-0826-3236. Epub 2019 Mar 13. German. No abstract available.


Personalized medicine with IgGAM compared with standard of care for treatment of peritonitis after infectious source control (the PEPPER trial): study protocol for a randomized controlled trial.

Kalvelage C, Zacharowski K, Bauhofer A, Gockel U, Adamzik M, Nierhaus A, Kujath P, Eckmann C, Pletz MW, Bracht H, Simon TP, Winkler M, Kindgen-Milles D, Albertsmeier M, Weigand M, Ellger B, Ragaller M, Ullrich R, Marx G.

Trials. 2019 Mar 4;20(1):156. doi: 10.1186/s13063-019-3244-4.


Red blood cell transfusion and its alternatives in oncologic surgery-A critical evaluation.

Fischer D, Neb H, Choorapoikayil S, Zacharowski K, Meybohm P.

Crit Rev Oncol Hematol. 2019 Feb;134:1-9. doi: 10.1016/j.critrevonc.2018.11.011. Epub 2018 Dec 6. Review.


Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients - the study design of the LIBERAL-Trial.

Meybohm P, Lindau S, Treskatsch S, Francis R, Spies C, Velten M, Wittmann M, Gueresir E, Stoppe C, Kowark A, Coburn M, Selleng S, Baschin M, Jenichen G, Meersch M, Ermert T, Zarbock A, Kranke P, Kredel M, Helf A, Laufenberg-Feldmann R, Ferner M, Wittenmeier E, Gürtler KH, Kienbaum P, de Abreu MG, Sander M, Bauer M, Seyfried T, Gruenewald M, Choorapoikayil S, Mueller MM, Seifried E, Brosteanu O, Bogatsch H, Hasenclever D, Zacharowski K; LIBERAL Collaboration Group.

Trials. 2019 Feb 4;20(1):101. doi: 10.1186/s13063-019-3200-3.


Influence of the WOMAN trial on national wide standard operating procedures for treatment of postpartum hemorrhage.

Raimann FJ, Jennewein L, Sonntagbauer M, Raddatz LM, Möllmann CJ, Louwen F, Zacharowski K, Weber CF.

J Gynecol Obstet Hum Reprod. 2019 Apr;48(4):269-273. doi: 10.1016/j.jogoh.2019.01.010. Epub 2019 Jan 24.


Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.

Westphal S, Stoppe C, Gruenewald M, Bein B, Renner J, Cremer J, Coburn M, Schaelte G, Boening A, Niemann B, Kletzin F, Roesner J, Strouhal U, Reyher C, Laufenberg-Feldmann R, Ferner M, Brandes IF, Bauer M, Kortgen A, Stehr SN, Wittmann M, Baumgarten G, Struck R, Meyer-Treschan T, Kienbaum P, Heringlake M, Schoen J, Sander M, Treskatsch S, Smul T, Wolwender E, Schilling T, Degenhardt F, Franke A, Mucha S, Tittmann L, Kohlhaas M, Fuernau G, Brosteanu O, Hasenclever D, Zacharowski K, Meybohm P; RIPHeart-Study Collaborators.

BMC Cardiovasc Disord. 2019 Jan 24;19(1):26. doi: 10.1186/s12872-019-1002-x.


Heute aus der Gynäkologie: Neugeborenenreanimation und Notsectio.

Raimann FJ, Gill-Schuster D, Holzer L, Empting PA, Zacharowski K.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2019 Jan;54(1):74-78. doi: 10.1055/s-0042-101628. Epub 2019 Jan 8. German. No abstract available.


Cell salvage using the continuous autotransfusion device CATSmart - an observational bicenter technical evaluation.

Lindau S, Kohlhaas M, Nosch M, Choorapoikayil S, Zacharowski K, Meybohm P.

BMC Anesthesiol. 2018 Dec 12;18(1):189. doi: 10.1186/s12871-018-0651-0.


Multimodal Patient Blood Management Program Based on a Three-pillar Strategy: A Systematic Review and Meta-analysis.

Althoff FC, Neb H, Herrmann E, Trentino KM, Vernich L, Füllenbach C, Freedman J, Waters JH, Farmer S, Leahy MF, Zacharowski K, Meybohm P, Choorapoikayil S.

Ann Surg. 2019 May;269(5):794-804. doi: 10.1097/SLA.0000000000003095.


Improve hip fracture outcome in the elderly patient (iHOPE): a study protocol for a pragmatic, multicentre randomised controlled trial to test the efficacy of spinal versus general anaesthesia.

Kowark A, Adam C, Ahrens J, Bajbouj M, Bollheimer C, Borowski M, Dodel R, Dolch M, Hachenberg T, Henzler D, Hildebrand F, Hilgers RD, Hoeft A, Isfort S, Kienbaum P, Knobe M, Knuefermann P, Kranke P, Laufenberg-Feldmann R, Nau C, Neuman MD, Olotu C, Rex C, Rossaint R, Sanders RD, Schmidt R, Schneider F, Siebert H, Skorning M, Spies C, Vicent O, Wappler F, Wirtz DC, Wittmann M, Zacharowski K, Zarbock A, Coburn M; iHOPE study group.

BMJ Open. 2018 Oct 18;8(10):e023609. doi: 10.1136/bmjopen-2018-023609.


An anesthesia perspective on surgical antibiotic prophylaxis: Results of a comprehensive infectiology survey study in German hospitals.

Mutlak H, Maurer O, Zacharowski K, Schön J, Jacob M, May M.

Am J Infect Control. 2019 Feb;47(2):222-223. doi: 10.1016/j.ajic.2018.08.017. Epub 2018 Oct 15. No abstract available.


[Knowledge of German anesthetists on antibiotic stewardship].

Mutlak H, Zacharowski K, Ernst C, May M.

Anaesthesist. 2018 Oct;67(10):793-796. doi: 10.1007/s00101-018-0491-9. German. No abstract available.


Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.

Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ.

FASEB J. 2019 Feb;33(2):1711-1726. doi: 10.1096/fj.201800221R. Epub 2018 Sep 6.


[Update Mallampati : Theoretical and practical knowledge of European anesthetists on basic evaluation of airways].

Ilper H, Franz-Jäger C, Byhahn C, Klages M, Ackermann HH, Zacharowski K, Kunz T.

Anaesthesist. 2018 Oct;67(10):738-744. doi: 10.1007/s00101-018-0481-y. Epub 2018 Aug 31. German.


In Reply.

Hofland J, Ouattara A, Schaller M, Bein B, de Liefde I, Fellahi JL, Gruenewald M, Hazebroucq J, Ecoffey C, Joseph P, Heringlake M, Steib A, Coburn M, Amour J, Rozec B, Meybohm P, Preckel B, Hanouz JL, Tritapepe L, Tonner P, Benhaoua H, Roesner JP, Tenbrinck R, Bogers AJ, Mik BG, Coiffic A, Renner J, Steinfath M, Francksen H, Broch O, Haneya A, Guinet P, Daviet L, Brianchon C, Rosier S, Lehot JJ, Paarmann H, Schön J, Hanke T, Ettel J, Olsson S, Klotz S, Samet A, Laurinenas G, Thibaud A, Cristinar M, Collanges O, Levy F, Rossaint R, Stevanovic A, Schaelte G, Stoppe C, Hamou NA, Hariri S, Quessard A, Carillion A, Morin H, Silleran J, Robert D, Crouzet AS, Zacharowski K, Reyher C, Iken S, Weber NC, Hollmann M, Eberl S, Carriero G, Collacchi D, Di Persio A, Fourcade O, Bergt S, Alms A; Xenon-CABG Study Group.

Anesthesiology. 2018 Sep;129(3):611-613. doi: 10.1097/ALN.0000000000002317. No abstract available.


Patient Blood Management improves outcome in oncologic surgery.

Keding V, Zacharowski K, Bechstein WO, Meybohm P, Schnitzbauer AA.

World J Surg Oncol. 2018 Aug 7;16(1):159. doi: 10.1186/s12957-018-1456-9.


Iron supplementation in a case of severe iron deficiency anaemia.

Füllenbach C, Triphaus C, Glaser P, Ziebart A, Zacharowski K, Meybohm P, Choorapoikayil S.

Br J Anaesth. 2018 Aug;121(2):502-504. doi: 10.1016/j.bja.2018.05.004. Epub 2018 Jun 14. No abstract available.


Validation of a New Small-Volume Sodium Citrate Collection Tube for Coagulation Testing in Critically Ill Patients with Coagulopathy.

Adam EH, Zacharowski K, Hintereder G, Zierfuß F, Raimann F, Meybohm P.

Clin Lab. 2018 Jun 1;64(6):1083-1089. doi: 10.7754/Clin.Lab.2018.171008.


[Point of Care 2.0: Coagulation Monitoring Using Rotem® Sigma and Teg® 6S].

Weber CF, Zacharowski K.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2018 Jun;53(6):412-424. doi: 10.1055/s-0043-107755. Epub 2018 Jun 26. Review. German.


Point-of-Care-Gerinnungsdiagnostik: neue Methoden, neue Indikationen, neue Studienlage.

Weber CF, Zacharowski K.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2018 Jun;53(6):410-411. doi: 10.1055/a-0597-4581. Epub 2018 Jun 26. German. No abstract available.


Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells.

Kühn B, Brat C, Fettel J, Hellmuth N, Maucher IV, Bulut U, Hock KJ, Grimmer J, Manolikakes G, Rühl M, Kühn A, Zacharowski K, Matrone C, Urbschat A, Roos J, Steinhilber D, Maier TJ.

Biochem Pharmacol. 2018 Sep;155:48-60. doi: 10.1016/j.bcp.2018.06.014. Epub 2018 Jun 15.


The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury.

Fischer D, Seifen C, Baer P, Jung M, Mertens C, Scheller B, Zacharowski K, Hofmann R, Maier TJ, Urbschat A.

Front Pharmacol. 2018 Apr 27;9:369. doi: 10.3389/fphar.2018.00369. eCollection 2018.


[Physiological changes during pregnancy].

Kohlhepp LM, Hollerich G, Vo L, Hofmann-Kiefer K, Rehm M, Louwen F, Zacharowski K, Weber CF.

Anaesthesist. 2018 May;67(5):383-396. doi: 10.1007/s00101-018-0437-2. Review. German.


Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).

Welte T, Dellinger RP, Ebelt H, Ferrer M, Opal SM, Singer M, Vincent JL, Werdan K, Martin-Loeches I, Almirall J, Artigas A, Ignacio Ayestarán J, Nuding S, Ferrer R, Sirgo Rodríguez G, Shankar-Hari M, Álvarez-Lerma F, Riessen R, Sirvent JM, Kluge S, Zacharowski K, Bonastre Mora J, Lapp H, Wöbker G, Achtzehn U, Brealey D, Kempa A, Sánchez García M, Brederlau J, Kochanek M, Reschreiter HP, Wise MP, Belohradsky BH, Bobenhausen I, Dälken B, Dubovy P, Langohr P, Mayer M, Schüttrumpf J, Wartenberg-Demand A, Wippermann U, Wolf D, Torres A.

Intensive Care Med. 2018 Apr;44(4):438-448. doi: 10.1007/s00134-018-5143-7. Epub 2018 Apr 9.


Remote Ischemic Preconditioning Does Not Affect the Release of Humoral Factors in Propofol-Anesthetized Cardiac Surgery Patients: A Secondary Analysis of the RIPHeart Study.

Ney J, Hoffmann K, Meybohm P, Goetzenich A, Kraemer S, Benstöm C, Weber NC, Bickenbach J, Rossaint R, Marx G, Zacharowski K, Bernhagen J, Stoppe C.

Int J Mol Sci. 2018 Apr 5;19(4). pii: E1094. doi: 10.3390/ijms19041094.


RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow-Up.

Meybohm P, Kohlhaas M, Stoppe C, Gruenewald M, Renner J, Bein B, Albrecht M, Cremer J, Coburn M, Schaelte G, Boening A, Niemann B, Sander M, Roesner J, Kletzin F, Mutlak H, Westphal S, Laufenberg-Feldmann R, Ferner M, Brandes IF, Bauer M, Stehr SN, Kortgen A, Wittmann M, Baumgarten G, Meyer-Treschan T, Kienbaum P, Heringlake M, Schoen J, Treskatsch S, Smul T, Wolwender E, Schilling T, Fuernau G, Bogatsch H, Brosteanu O, Hasenclever D, Zacharowski K; RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study Collaborators.

J Am Heart Assoc. 2018 Mar 26;7(7). pii: e008077. doi: 10.1161/JAHA.117.008077.

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