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Items: 50

1.

High-resolution experimental and computational electrophysiology reveals weak β-lactam binding events in the porin PorB.

Bartsch A, Llabrés S, Pein F, Kattner C, Schön M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C.

Sci Rep. 2019 Feb 4;9(1):1264. doi: 10.1038/s41598-018-37066-9.

2.

The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB.

Mirandela GD, Tamburrino G, Hoskisson PA, Zachariae U, Javelle A.

FASEB J. 2019 Feb;33(2):1989-1999. doi: 10.1096/fj.201800782R. Epub 2018 Sep 13.

3.

Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels.

Kopec W, Köpfer DA, Vickery ON, Bondarenko AS, Jansen TLC, de Groot BL, Zachariae U.

Nat Chem. 2018 Aug;10(8):813-820. doi: 10.1038/s41557-018-0105-9. Epub 2018 Jul 20.

PMID:
30030538
4.

Merging In-Solution X-ray and Neutron Scattering Data Allows Fine Structural Analysis of Membrane-Protein Detergent Complexes.

Dias Mirandela G, Tamburrino G, Ivanović MT, Strnad FM, Byron O, Rasmussen T, Hoskisson PA, Hub JS, Zachariae U, Gabel F, Javelle A.

J Phys Chem Lett. 2018 Jul 19;9(14):3910-3914. doi: 10.1021/acs.jpclett.8b01598. Epub 2018 Jul 3.

5.

The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix.

Gundogdu M, Llabrés S, Gorelik A, Ferenbach AT, Zachariae U, van Aalten DMF.

Cell Chem Biol. 2018 May 17;25(5):513-518.e4. doi: 10.1016/j.chembiol.2018.03.004. Epub 2018 Mar 29.

6.

Ten Years of High Resolution Structural Research on the Voltage Dependent Anion Channel (VDAC)-Recent Developments and Future Directions.

Zeth K, Zachariae U.

Front Physiol. 2018 Mar 7;9:108. doi: 10.3389/fphys.2018.00108. eCollection 2018. Review.

7.

Intracellular Transfer of Na+ in an Active-State G-Protein-Coupled Receptor.

Vickery ON, Carvalheda CA, Zaidi SA, Pisliakov AV, Katritch V, Zachariae U.

Structure. 2018 Jan 2;26(1):171-180.e2. doi: 10.1016/j.str.2017.11.013. Epub 2017 Dec 14.

8.

Modulation of the Neisseria gonorrhoeae drug efflux conduit MtrE.

Tamburrino G, Llabrés S, Vickery ON, Pitt SJ, Zachariae U.

Sci Rep. 2017 Dec 6;7(1):17091. doi: 10.1038/s41598-017-16995-x.

9.

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump.

Fitzpatrick AWP, Llabrés S, Neuberger A, Blaza JN, Bai XC, Okada U, Murakami S, van Veen HW, Zachariae U, Scheres SHW, Luisi BF, Du D.

Nat Microbiol. 2017 May 15;2:17070. doi: 10.1038/nmicrobiol.2017.70.

10.

Insights into the ion-coupling mechanism in the MATE transporter NorM-VC.

Krah A, Zachariae U.

Phys Biol. 2017 Jun 29;14(4):045009. doi: 10.1088/1478-3975/aa5ee7.

PMID:
28169223
11.

Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations.

Vickery ON, Machtens JP, Zachariae U.

Curr Opin Pharmacol. 2016 Oct;30:44-50. doi: 10.1016/j.coph.2016.06.011. Epub 2016 Jul 27. Review.

12.

Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors.

Vickery ON, Machtens JP, Tamburrino G, Seeliger D, Zachariae U.

Structure. 2016 Jun 7;24(6):997-1007. doi: 10.1016/j.str.2016.04.007. Epub 2016 May 19.

13.

A role for loop G in the β1 strand in GABAA receptor activation.

Baptista-Hon DT, Krah A, Zachariae U, Hales TG.

J Physiol. 2016 Oct 1;594(19):5555-71. doi: 10.1113/JP272463. Epub 2016 Jun 27.

14.

Insights into the function of ion channels by computational electrophysiology simulations.

Kutzner C, Köpfer DA, Machtens JP, de Groot BL, Song C, Zachariae U.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1741-52. doi: 10.1016/j.bbamem.2016.02.006. Epub 2016 Feb 10. Review.

15.

Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction.

Rose AS, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW.

PLoS One. 2015 Nov 25;10(11):e0143399. doi: 10.1371/journal.pone.0143399. eCollection 2015.

16.

The Bacterial Hydrophobin BslA is a Switchable Ellipsoidal Janus Nanocolloid.

Brandani GB, Schor M, Morris R, Stanley-Wall N, MacPhee CE, Marenduzzo D, Zachariae U.

Langmuir. 2015 Oct 27;31(42):11558-63. doi: 10.1021/acs.langmuir.5b02347. Epub 2015 Oct 14.

17.

Interfacial self-assembly of a bacterial hydrophobin.

Bromley KM, Morris RJ, Hobley L, Brandani G, Gillespie RM, McCluskey M, Zachariae U, Marenduzzo D, Stanley-Wall NR, MacPhee CE.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5419-24. doi: 10.1073/pnas.1419016112. Epub 2015 Apr 13.

18.

Mechanisms of anion conduction by coupled glutamate transporters.

Machtens JP, Kortzak D, Lansche C, Leinenweber A, Kilian P, Begemann B, Zachariae U, Ewers D, de Groot BL, Briones R, Fahlke C.

Cell. 2015 Jan 29;160(3):542-53. doi: 10.1016/j.cell.2014.12.035.

19.

Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7.

Pumroy RA, Ke S, Hart DJ, Zachariae U, Cingolani G.

Structure. 2015 Feb 3;23(2):374-84. doi: 10.1016/j.str.2014.11.015. Epub 2015 Jan 15.

20.

Ion permeation in K⁺ channels occurs by direct Coulomb knock-on.

Köpfer DA, Song C, Gruene T, Sheldrick GM, Zachariae U, de Groot BL.

Science. 2014 Oct 17;346(6207):352-5. doi: 10.1126/science.1254840.

21.

Position of transmembrane helix 6 determines receptor G protein coupling specificity.

Rose AS, Elgeti M, Zachariae U, Grubmüller H, Hofmann KP, Scheerer P, Hildebrand PW.

J Am Chem Soc. 2014 Aug 13;136(32):11244-7. doi: 10.1021/ja5055109. Epub 2014 Jul 31.

PMID:
25046433
22.

Conserved structure and domain organization among bacterial Slc26 transporters.

Compton EL, Page K, Findlay HE, Haertlein M, Moulin M, Zachariae U, Norman DG, Gabel F, Javelle A.

Biochem J. 2014 Oct 15;463(2):297-307. doi: 10.1042/BJ20130619.

23.

Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition.

Kattner C, Toussi DN, Zaucha J, Wetzler LM, Rüppel N, Zachariae U, Massari P, Tanabe M.

J Struct Biol. 2014 Mar;185(3):440-7. doi: 10.1016/j.jsb.2013.12.006. Epub 2013 Dec 19.

24.

Structural determinants and mechanism of mammalian CRM1 allostery.

Dölker N, Blanchet CE, Voß B, Haselbach D, Kappel C, Monecke T, Svergun DI, Stark H, Ficner R, Zachariae U, Grubmüller H, Dickmanns A.

Structure. 2013 Aug 6;21(8):1350-60. doi: 10.1016/j.str.2013.05.015. Epub 2013 Jul 11.

25.

Quantifying disorder through conditional entropy: an application to fluid mixing.

Brandani GB, Schor M, Macphee CE, Grubmüller H, Zachariae U, Marenduzzo D.

PLoS One. 2013 Jun 10;8(6):e65617. doi: 10.1371/journal.pone.0065617. Print 2013.

26.

Effect of Protonation State on the Stability of Amyloid Oligomers Assembled from TTR(105-115).

Porrini M, Zachariae U, Barran PE, MacPhee CE.

J Phys Chem Lett. 2013 Apr 18;4(8):1233-8. doi: 10.1021/jz400372u. Epub 2013 Mar 28.

PMID:
26282135
27.

Crystal structure and functional mechanism of a human antimicrobial membrane channel.

Song C, Weichbrodt C, Salnikov ES, Dynowski M, Forsberg BO, Bechinger B, Steinem C, de Groot BL, Zachariae U, Zeth K.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4586-91. doi: 10.1073/pnas.1214739110. Epub 2013 Feb 20.

28.

Structural basis for cooperativity of CRM1 export complex formation.

Monecke T, Haselbach D, Voß B, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):960-5. doi: 10.1073/pnas.1215214110. Epub 2012 Dec 31.

29.

Identification of a cation transport pathway in Neisseria meningitidis PorB.

Kattner C, Zaucha J, Jaenecke F, Zachariae U, Tanabe M.

Proteins. 2013 May;81(5):830-40. doi: 10.1002/prot.24241. Epub 2013 Feb 25.

PMID:
23255122
30.

A designed inhibitor of a CLC antiporter blocks function through a unique binding mode.

Howery AE, Elvington S, Abraham SJ, Choi KH, Dworschak-Simpson S, Phillips S, Ryan CM, Sanford RL, Almqvist J, Tran K, Chew TA, Zachariae U, Andersen OS, Whitelegge J, Matulef K, Du Bois J, Maduke MC.

Chem Biol. 2012 Nov 21;19(11):1460-70. doi: 10.1016/j.chembiol.2012.09.017.

31.

Universal relaxation governs the nonequilibrium elasticity of biomolecules.

Kappel C, Dölker N, Kumar R, Zink M, Zachariae U, Grubmüller H.

Phys Rev Lett. 2012 Sep 14;109(11):118304. Epub 2012 Sep 14.

PMID:
23005687
32.

A molecular switch driving inactivation in the cardiac K+ channel HERG.

Köpfer DA, Hahn U, Ohmert I, Vriend G, Pongs O, de Groot BL, Zachariae U.

PLoS One. 2012;7(7):e41023. doi: 10.1371/journal.pone.0041023. Epub 2012 Jul 24.

33.

β-Barrel mobility underlies closure of the voltage-dependent anion channel.

Zachariae U, Schneider R, Briones R, Gattin Z, Demers JP, Giller K, Maier E, Zweckstetter M, Griesinger C, Becker S, Benz R, de Groot BL, Lange A.

Structure. 2012 Sep 5;20(9):1540-9. doi: 10.1016/j.str.2012.06.015. Epub 2012 Jul 26.

34.

Computational electrophysiology: the molecular dynamics of ion channel permeation and selectivity in atomistic detail.

Kutzner C, Grubmüller H, de Groot BL, Zachariae U.

Biophys J. 2011 Aug 17;101(4):809-17. doi: 10.1016/j.bpj.2011.06.010.

35.

Functional dynamics in the voltage-dependent anion channel.

Villinger S, Briones R, Giller K, Zachariae U, Lange A, de Groot BL, Griesinger C, Becker S, Zweckstetter M.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22546-51. doi: 10.1073/pnas.1012310108. Epub 2010 Dec 10.

36.

Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures.

Forwood JK, Lange A, Zachariae U, Marfori M, Preast C, Grubmüller H, Stewart M, Corbett AH, Kobe B.

Structure. 2010 Sep 8;18(9):1171-83. doi: 10.1016/j.str.2010.06.015.

37.

An unusual hydrophobic core confers extreme flexibility to HEAT repeat proteins.

Kappel C, Zachariae U, Dölker N, Grubmüller H.

Biophys J. 2010 Sep 8;99(5):1596-603. doi: 10.1016/j.bpj.2010.06.032.

38.

Hydrophilic linkers and polar contacts affect aggregation of FG repeat peptides.

Dölker N, Zachariae U, Grubmüller H.

Biophys J. 2010 Jun 2;98(11):2653-61. doi: 10.1016/j.bpj.2010.02.049.

39.

Toward a consensus model of the HERG potassium channel.

Stary A, Wacker SJ, Boukharta L, Zachariae U, Karimi-Nejad Y, Aqvist J, Vriend G, de Groot BL.

ChemMedChem. 2010 Mar 1;5(3):455-67. doi: 10.1002/cmdc.200900461.

PMID:
20104563
40.
41.

Importin-beta: structural and dynamic determinants of a molecular spring.

Zachariae U, Grubmüller H.

Structure. 2008 Jun;16(6):906-15. doi: 10.1016/j.str.2008.03.007.

42.

The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type inactivation.

Zachariae U, Schneider R, Velisetty P, Lange A, Seeliger D, Wacker SJ, Karimi-Nejad Y, Vriend G, Becker S, Pongs O, Baldus M, de Groot BL.

Structure. 2008 May;16(5):747-54. doi: 10.1016/j.str.2008.01.018.

43.

Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p.

Hartmann C, Chami M, Zachariae U, de Groot BL, Engel A, Grütter MG.

J Mol Biol. 2008 Mar 21;377(2):352-63. doi: 10.1016/j.jmb.2008.01.010. Epub 2008 Jan 15.

PMID:
18272179
44.
45.

High resolution crystal structures and molecular dynamics studies reveal substrate binding in the porin Omp32.

Zachariae U, Klühspies T, De S, Engelhardt H, Zeth K.

J Biol Chem. 2006 Mar 17;281(11):7413-20. Epub 2006 Jan 23.

46.

Multistep mechanism of chloride translocation in a strongly anion-selective porin channel.

Zachariae U, Helms V, Engelhardt H.

Biophys J. 2003 Aug;85(2):954-62.

47.

Improved 3D continuum calculations of ion flux through membrane channels.

Koumanov A, Zachariae U, Engelhardt H, Karshikoff A.

Eur Biophys J. 2003 Dec;32(8):689-702. Epub 2003 Jul 18.

PMID:
12879311
48.
49.

Picosecond time-resolved FRET in the fluorescent protein from Discosoma Red (wt-DsRed).

Schüttrigkeit TA, Zachariae U, von Feilitzsch T, Wiehler J, von Hummel J, Steipe B, Michel-Beyerle ME.

Chemphyschem. 2001 May 18;2(5):325-8. doi: 10.1002/1439-7641(20010518)2:5<325::AID-CPHC325>3.0.CO;2-P.

PMID:
23696507

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