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Items: 50

1.

The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation.

Toumpanakis D, Vassilakopoulou V, Sigala I, Zacharatos P, Vraila I, Karavana V, Theocharis S, Vassilakopoulos T.

Respir Res. 2017 Dec 13;18(1):209. doi: 10.1186/s12931-017-0694-7.

2.

Inspiratory resistive breathing induces MMP-9 and MMP-12 expression in the lung.

Toumpanakis D, Noussia O, Sigala I, Litsiou E, Loverdos K, Zacharatos P, Karavana V, Michailidou T, Magkou C, Zhou Z, Theocharis S, Vassilakopoulos T.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L683-92. doi: 10.1152/ajplung.00133.2014. Epub 2015 Jan 16. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L204.

3.

Nitric oxide regulates cytokine induction in the diaphragm in response to inspiratory resistive breathing.

Sigala I, Zacharatos P, Boulia S, Toumpanakis D, Michailidou T, Parthenis D, Roussos C, Papapetropoulos A, Hussain SN, Vassilakopoulos T.

J Appl Physiol (1985). 2012 Nov;113(10):1594-603. doi: 10.1152/japplphysiol.00233.2012. Epub 2012 Sep 6.

4.

MAPKs and NF-κB differentially regulate cytokine expression in the diaphragm in response to resistive breathing: the role of oxidative stress.

Sigala I, Zacharatos P, Toumpanakis D, Michailidou T, Noussia O, Theocharis S, Roussos C, Papapetropoulos A, Vassilakopoulos T.

Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1152-62. doi: 10.1152/ajpregu.00376.2010. Epub 2011 Feb 16.

5.

Inspiratory resistive breathing induces acute lung injury.

Toumpanakis D, Kastis GA, Zacharatos P, Sigala I, Michailidou T, Kouvela M, Glynos C, Divangahi M, Roussos C, Theocharis SE, Vassilakopoulos T.

Am J Respir Crit Care Med. 2010 Nov 1;182(9):1129-36. doi: 10.1164/rccm.201001-0116OC. Epub 2010 Jul 9.

PMID:
20622034
6.

Nitric oxide stimulates interleukin-6 production in skeletal myotubes.

Makris AC, Sotzios Y, Zhou Z, Makropoulou M, Papapetropoulos N, Zacharatos P, Pyriochou A, Roussos C, Papapetropoulos A, Vassilakopoulos T.

J Interferon Cytokine Res. 2010 May;30(5):321-7. doi: 10.1089/jir.2009.0022.

PMID:
20035621
7.

First diagnosis of factor XI deficiency in a patient with subarachnoid haemorrhage.

Vasileiadis I, El-Ali M, Nanas S, Kolias S, Zacharatos P, Christopoulou-Cokkinou V, Kotanidou A.

Blood Coagul Fibrinolysis. 2009 Jun;20(4):309-13. doi: 10.1097/MBC.0b013e328329e485.

PMID:
19367158
8.

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD.

Nature. 2005 Apr 14;434(7035):907-13.

PMID:
15829965
9.

p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions.

Gorgoulis VG, Pratsinis H, Zacharatos P, Demoliou C, Sigala F, Asimacopoulos PJ, Papavassiliou AG, Kletsas D.

Lab Invest. 2005 Apr;85(4):502-11.

10.

Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population.

Gazouli M, Mantzaris G, Kotsinas A, Zacharatos P, Papalambros E, Archimandritis A, Ikonomopoulos J, Gorgoulis VG.

World J Gastroenterol. 2005 Feb 7;11(5):681-5.

11.

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.

Huyen Y, Zgheib O, Ditullio RA Jr, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD.

Nature. 2004 Nov 18;432(7015):406-11. Epub 2004 Nov 3.

PMID:
15525939
12.

E2F-1 transcription factor immunoexpression is inversely associated with tumor growth in colon adenocarcinomas.

Bramis J, Zacharatos P, Papaconstantinou I, Kotsinas A, Sigala F, Korkolis DP, Nikiteas N, Pazaiti A, Kittas C, Bastounis E, Gorgoulis VG.

Anticancer Res. 2004 Sep-Oct;24(5A):3041-7.

13.

Association of NOD2/CARD15 variants with Crohn's disease in a Greek population.

Gazouli M, Zacharatos P, Mantzaris GJ, Barbatis C, Ikonomopoulos I, Archimandritis AJ, Lukas JC, Papalambros E, Gorgoulis V.

Eur J Gastroenterol Hepatol. 2004 Nov;16(11):1177-82.

PMID:
15489579
14.

Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.

Karakaidos P, Taraviras S, Vassiliou LV, Zacharatos P, Kastrinakis NG, Kougiou D, Kouloukoussa M, Nishitani H, Papavassiliou AG, Lygerou Z, Gorgoulis VG.

Am J Pathol. 2004 Oct;165(4):1351-65.

15.

The proinflammatory phenotype of senescent cells: the p53-mediated ICAM-1 expression.

Kletsas D, Pratsinis H, Mariatos G, Zacharatos P, Gorgoulis VG.

Ann N Y Acad Sci. 2004 Jun;1019:330-2. Review.

PMID:
15247038
16.

Electron microscopy evidence that cytoplasmic localization of the p16(INK4A) "nuclear" cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas.

Evangelou K, Bramis J, Peros I, Zacharatos P, Dasiou-Plakida D, Kalogeropoulos N, Asimacopoulos PJ, Kittas C, Marinos E, Gorgoulis VG.

Biotech Histochem. 2004 Feb;79(1):5-10.

PMID:
15223748
17.

Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas.

Zacharatos P, Kotsinas A, Evangelou K, Karakaidos P, Vassiliou LV, Rezaei N, Kyroudi A, Kittas C, Patsouris E, Papavassiliou AG, Gorgoulis VG.

J Pathol. 2004 Jul;203(3):744-53.

PMID:
15221933
18.

Comparative evaluation of PCR assays for the robust molecular detection of Mycobacterium avium subsp. paratuberculosis.

Ikonomopoulos J, Gazouli M, Pavlik I, Bartos M, Zacharatos P, Xylouri E, Papalambros E, Gorgoulis V.

J Microbiol Methods. 2004 Mar;56(3):315-21.

PMID:
14967222
19.

The C3435T MDR1 gene polymorphism is not associated with susceptibility for ulcerative colitis in Greek population.

Gazouli M, Zacharatos P, Gorgoulis V, Mantzaris G, Papalambros E, Ikonomopoulos J.

Gastroenterology. 2004 Jan;126(1):367-9. No abstract available.

PMID:
14755848
20.

Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.

Mariatos G, Bothos J, Zacharatos P, Summers MK, Scolnick DM, Kittas C, Halazonetis TD, Gorgoulis VG.

Cancer Res. 2003 Nov 1;63(21):7185-9.

21.

Interferon-a2b reduces neo-microvascular density in the 'normal' urothelium adjacent to the tumor after transurethral resection of superficial bladder carcinoma.

Giannopoulos A, Adamakis I, Evangelou K, Giannopoulou M, Zacharatos P, Zsantoulis P, Perunovic B, Athanasiou A, Retalis G, Constandinidis C, Gorgoulis VG.

Onkologie. 2003 Apr;26(2):147-52.

PMID:
12771523
22.

p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner.

Gorgoulis VG, Zacharatos P, Kotsinas A, Kletsas D, Mariatos G, Zoumpourlis V, Ryan KM, Kittas C, Papavassiliou AG.

EMBO J. 2003 Apr 1;22(7):1567-78.

23.

The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein.

Gazouli M, Kokotas S, Zoumpourlis V, Zacharatos P, Mariatos G, Kletsas D, Perunovic B, Athanasiou A, Kittas C, Gorgoulis V.

Anticancer Res. 2002 Nov-Dec;22(6C):4237-41.

PMID:
12553064
25.

Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas.

Gorgoulis VG, Zacharatos P, Mariatos G, Kotsinas A, Bouda M, Kletsas D, Asimacopoulos PJ, Agnantis N, Kittas C, Papavassiliou AG.

J Pathol. 2002 Oct;198(2):142-56.

PMID:
12237873
26.

Growth index is independent of microvessel density in non-small-cell lung carcinomas.

Tsoli E, Zacharatos P, Dasiou-Plakida D, Peros J, Evangelou K, Zavras AI, Yannoukakos D, Konstantopoulou I, Asimacopoulos PJ, Kittas C, Gorgoulis VG.

Hum Pathol. 2002 Aug;33(8):812-8.

PMID:
12203214
27.

Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.

Zacharatos P, Kotsinas A, Tsantoulis P, Evangelou K, Kletsas D, Asimacopoulos PJ, Doussis-Anagnostopoulou I, Pezzella F, Gatter K, Papavassiliou AG, Kittas C, Gorgoulis VG.

Mol Med. 2001 Sep;7(9):590-7. Erratum in: Mol Med 2001 Dec;7(12):861.

28.

Expression of HLA-DR is reduced in tumor infiltrating immune cells (TIICs) and regional lymph nodes of non-small-cell lung carcinomas. A putative mechanism of tumor-induced immunosuppression?

Foukas PG, Tsilivakos V, Zacharatos P, Mariatos G, Moschos S, Syrianou A, Asimacopoulos PJ, Bramis J, Fotiadis C, Kittas C, Gorgoulis VG.

Anticancer Res. 2001 Jul-Aug;21(4A):2609-15.

PMID:
11724329
29.

Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas.

Tsoli E, Gorgoulis VG, Zacharatos P, Kotsinas A, Mariatos G, Kastrinakis NG, Kokotas S, Kanavaros P, Asimacopoulos P, Bramis J, Kletsas D, Papavassiliou AG, Kittas C.

Mol Med. 2001 Jun;7(6):418-29.

30.

Additional characterization of a hexanucleotide polymorphic site in the first intron of human H-ras gene: comparative study of its alterations in non-small cell lung carcinomas and sporadic invasive breast carcinomas.

Kotsinas A, Gorgoulis VG, Zacharatos P, Mariatos G, Kokotas S, Liloglou T, Ikonomopoulos J, Zoumpourlis V, Kyroudi A, Field JK, Asimacopoulos PJ, Kittas C.

Cancer Genet Cytogenet. 2001 Apr 15;126(2):147-54.

PMID:
11376808
31.

Sensitive differential detection of genetically related mycobacterial pathogens in archival material.

Ikonomopoulos JA, Gorgoulis VG, Kastrinakis NG, Zacharatos PV, Kokotas SN, Evangelou K, Kotsinas AG, Tsakris AG, Manolis EN, Kittas CN.

Am J Clin Pathol. 2000 Dec;114(6):940-50.

PMID:
11338484
32.

Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer.

Vassilakopoulos T, Troupis T, Sotiropoulou C, Zacharatos P, Katsaounou P, Parthenis D, Noussia O, Troupis G, Papiris S, Kittas C, Roussos C, Zakynthinos S, Gorgoulis V.

Lung Cancer. 2001 May;32(2):137-44.

PMID:
11325484
33.

A new rare allele at the CGG repeat polymorphism in the first intron of human c-H-ras gene.

Kotsinas A, Gorgoulis VG, Zacharatos P, Liloglou T, Leonardou P, Bramis J, Troupis TG, Fotiadis C, Field JK, Kittas C.

In Vivo. 2001 Jan-Feb;15(1):105-8.

PMID:
11286119
34.

Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics.

Gorgoulis VG, Zacharatos P, Mariatos G, Liloglou T, Kokotas S, Kastrinakis N, Kotsinas A, Athanasiou A, Foukas P, Zoumpourlis V, Kletsas D, Ikonomopoulos J, Asimacopoulos PJ, Kittas C, Field JK.

Cancer Res. 2001 Jan 15;61(2):538-49.

35.

Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).

Garinis GA, Gorgoulis VG, Mariatos G, Zacharatos P, Kotsinas A, Liloglou T, Foukas P, Kanavaros P, Kastrinakis NG, Vassilakopoulos T, Vogiatzi T, Field JK, Kittas C.

J Pathol. 2001 Jan;193(1):55-65.

PMID:
11169516
36.

Expression of p16(INK4A) and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: relationship with tumor growth parameters and ploidy status.

Mariatos G, Gorgoulis VG, Zacharatos P, Kotsinas A, Vogiatzi T, Rassidakis G, Foukas P, Liloglou T, Tiniakos D, Angelou N, Manolis EN, Veslemes M, Field JK, Kittas C.

Int J Cancer. 2000 Mar 20;89(2):133-41.

37.

Absence of mutations in the functional domains of the human MDM2 oncogene in non-small cell lung carcinomas.

Mariatos G, Gorgoulis VG, Kotsinas A, Zacharatos P, Kokotas S, Yannoukakos D, Kittas C.

Mutat Res. 2000 Nov 30;456(1-2):59-63.

PMID:
11087896
38.

Association of allelic imbalance at locus D13S171 (BRCA2) and p53 alterations with tumor kinetics and chromosomal instability (aneuploidy) in nonsmall cell lung carcinoma.

Gorgoulis VG, Kotsinas A, Zacharatos P, Mariatos G, Liloglou T, Tsoli E, Kokotas S, Fassoulas C, Field JK, Kittas C.

Cancer. 2000 Nov 1;89(9):1933-45.

PMID:
11064350
39.

Altered expression of the cell cycle regulatory molecules pRb, p53 and MDM2 exert a synergetic effect on tumor growth and chromosomal instability in non-small cell lung carcinomas (NSCLCs).

Gorgoulis VG, Zacharatos P, Kotsinas A, Mariatos G, Liloglou T, Vogiatzi T, Foukas P, Rassidakis G, Garinis G, Ioannides T, Zoumpourlis V, Bramis J, Michail PO, Asimacopoulos PJ, Field JK, Kittas C.

Mol Med. 2000 Mar;6(3):208-37. Erratum in: Mol Med 2001 Dec;7(12):861.

40.

c-mos immunoreactivity is an indicator of good prognosis in lung cancer.

Athanasiou A, Gorgoulis VG, Zacharatos P, Mariatos G, Kotsinas A, Liloglou T, Karameris A, Foukas P, Manolis EN, Field JK, Kittas C.

Histopathology. 2000 Jul;37(1):45-54.

PMID:
10931218
41.

Allelic imbalance at the 5q14 locus is associated with decreased apoptotic rate in non-small cell lung carcinomas (NSCLCs). Possible synergistic effect with p53 gene alterations on apoptosis.

Gorgoulis VG, Mariatos1 G, Manolis EN, Zacharatos P, Kotsinas A, Liloglou T, Vogiatzi T, Tsagkaraki A, Kokotas S, Tsoli E, Alchanatis M, Sfikakis PP, Asimacopoulos PJ, Field JK, Kittas C.

Lung Cancer. 2000 Jun;28(3):211-24.

PMID:
10812190
42.

Multiplex polymerase chain reaction for the detection of mycobacterial DNA in cases of tuberculosis and sarcoidosis.

Ikonomopoulos JA, Gorgoulis VG, Zacharatos PV, Manolis EN, Kanavaros P, Rassidakis A, Kittas C.

Mod Pathol. 1999 Sep;12(9):854-62.

PMID:
10496593
43.

Aberrant p16 expression is correlated with hemizygous deletions at the 9p21-22 chromosome region in non-small cell lung carcinomas.

Spanakis NE, Gorgoulis V, Mariatos G, Zacharatos P, Kotsinas A, Garinis G, Trigidou R, Karameris A, Tsimara-Papastamatiou H, Kouloukousa M, Manolis EN, Kittas C.

Anticancer Res. 1999 May-Jun;19(3A):1893-9.

PMID:
10470133
44.

Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1.

Zacharatos PV, Gorgoulis VG, Kotsinas A, Manolis EN, Liloglou T, Rassidakis AN, Kanavaros P, Field JD, Halazonetis T, Kittas C.

Anticancer Res. 1999 Jan-Feb;19(1A):579-87.

PMID:
10226602
45.

Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis.

Gorgoulis VG, Zacharatos P, Kotsinas A, Kyroudi A, Rassidakis AN, Ikonomopoulos JA, Barbatis C, Herrington CS, Kittas C.

Hum Pathol. 1999 Mar;30(3):274-83.

PMID:
10088545
46.

Alterations of p16-pRb pathway and chromosome locus 9p21-22 in sporadic invasive breast carcinomas.

Gorgoulis VG, Koutroumbi EN, Kotsinas A, Zacharatos P, Markopoulos C, Giannikos L, Kyriakou V, Voulgaris Z, Gogas I, Kittas C.

Mol Med. 1998 Dec;4(12):807-22.

47.

Antioxidant agent nimesulid and beta-blocker metoprolol do not exert protective effects against rat mitochondrial DNA alterations in adriamycin-induced cardiotoxicity.

Kotsinas A, Gorgoulis V, Zacharatos P, Zioris H, Triposkiadis F, Donta I, Kyriakidis M, Karayannacos P, Kittas C.

Biochem Biophys Res Commun. 1999 Jan 27;254(3):651-6.

PMID:
9920795
48.

Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression.

Gorgoulis VG, Zacharatos P, Kotsinas A, Liloglou T, Kyroudi A, Veslemes M, Rassidakis A, Halazonetis TD, Field JK, Kittas C.

Am J Pathol. 1998 Dec;153(6):1749-65.

49.

Multiplex PCR assay for the detection of mycobacterial DNA sequences directly from sputum.

Ikonomopoulos JA, Gorgoulis VG, Zacharatos PV, Kotsinas A, Tsoli E, Karameris A, Panagou P, Kittas C.

In Vivo. 1998 Sep-Oct;12(5):547-52.

PMID:
9827366
50.

Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.

Gorgoulis VG, Zacharatos PV, Manolis E, Ikonomopoulos JA, Damalas A, Lamprinopoulos C, Rassidakis GZ, Zoumpourlis V, Kotsinas A, Rassidakis AN, Halazonetis TD, Kittas C.

Br J Cancer. 1998;77(3):374-84.

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