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Items: 1 to 50 of 113

1.

Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters.

Bers DM, Xiang YK, Zaccolo M.

Physiology (Bethesda). 2019 Jul 1;34(4):240-249. doi: 10.1152/physiol.00002.2019.

PMID:
31165682
2.

Quantification and Comparison of Signals Generated by Different FRET-Based cAMP Reporters.

Koschinski A, Zaccolo M.

Methods Mol Biol. 2019;1947:217-237. doi: 10.1007/978-1-4939-9121-1_12.

PMID:
30969419
3.

Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79.

Musheshe N, Lobo MJ, Schmidt M, Zaccolo M.

Sensors (Basel). 2018 Jul 5;18(7). pii: E2164. doi: 10.3390/s18072164.

4.

Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.

Burdyga A, Surdo NC, Monterisi S, Di Benedetto G, Grisan F, Penna E, Pellegrini L, Zaccolo M, Bortolozzi M, Swietach P, Pozzan T, Lefkimmiatis K.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6497-E6506. doi: 10.1073/pnas.1806318115. Epub 2018 Jun 25. Erratum in: Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7882.

5.

Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity.

Liu K, Li D, Hao G, McCaffary D, Neely O, Woodward L, Ioannides D, Lu CJ, Brescia M, Zaccolo M, Tandri H, Ajijola OA, Ardell JL, Shivkumar K, Paterson DJ.

JCI Insight. 2018 May 3;3(9). pii: 98694. doi: 10.1172/jci.insight.98694.

6.

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik J.

Cell Rep. 2018 Apr 10;23(2):459-469. doi: 10.1016/j.celrep.2018.03.053.

7.

FRET-ting about RhoA signalling in heart and vasculature: a new tool in our cardiovascular toolbox.

Bruche S, Zaccolo M.

Cardiovasc Res. 2018 Apr 1;114(5):e25-e27. doi: 10.1093/cvr/cvy032. No abstract available.

PMID:
29590388
8.

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, Tarasov AI.

Diabetes. 2018 Jun;67(6):1128-1139. doi: 10.2337/db17-1102. Epub 2018 Mar 21.

9.

Using cAMP Sensors to Study Cardiac Nanodomains.

Schleicher K, Zaccolo M.

J Cardiovasc Dev Dis. 2018 Mar 13;5(1). pii: E17. doi: 10.3390/jcdd5010017. Review.

10.

cAMP: From Long-Range Second Messenger to Nanodomain Signalling.

Musheshe N, Schmidt M, Zaccolo M.

Trends Pharmacol Sci. 2018 Feb;39(2):209-222. doi: 10.1016/j.tips.2017.11.006. Epub 2017 Dec 27. Review.

PMID:
29289379
11.

Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells.

Rodrigues AL, Brescia M, Koschinski A, Moreira TH, Cameron RT, Baillie G, Beirão PSL, Zaccolo M, Cruz JS.

Life Sci. 2018 Jan 1;192:144-150. doi: 10.1016/j.lfs.2017.11.040. Epub 2017 Nov 26.

PMID:
29183797
12.
13.

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.

Monterisi S, Lobo MJ, Livie C, Castle JC, Weinberger M, Baillie G, Surdo NC, Musheshe N, Stangherlin A, Gottlieb E, Maizels R, Bortolozzi M, Micaroni M, Zaccolo M.

Elife. 2017 May 2;6. pii: e21374. doi: 10.7554/eLife.21374.

14.

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.

Surdo NC, Berrera M, Koschinski A, Brescia M, Machado MR, Carr C, Wright P, Gorelik J, Morotti S, Grandi E, Bers DM, Pantano S, Zaccolo M.

Nat Commun. 2017 Apr 20;8:15031. doi: 10.1038/ncomms15031.

15.

Components of the mitochondrial cAMP signalosome.

Monterisi S, Zaccolo M.

Biochem Soc Trans. 2017 Feb 8;45(1):269-274. doi: 10.1042/BST20160394. Review.

PMID:
28202681
16.
17.

Response to Wagner et al.: phosphodiesterase-2-anti-adrenergic friend or hypertrophic foe in heart disease?

Zoccarato A, Fields LH, Zaccolo M.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1143-1145. Epub 2016 Sep 27. No abstract available.

18.

Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.

Ivan T, Enkvist E, Viira B, Manoharan GB, Raidaru G, Pflug A, Alam KA, Zaccolo M, Engh RA, Uri A.

Bioconjug Chem. 2016 Aug 17;27(8):1900-10. doi: 10.1021/acs.bioconjchem.6b00293. Epub 2016 Jul 20.

PMID:
27389935
19.

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1.

Lobo MJ, Amaral MD, Zaccolo M, Farinha CM.

J Cell Sci. 2016 Jul 1;129(13):2599-612. doi: 10.1242/jcs.185629. Epub 2016 May 20.

20.

Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons.

Chay A, Zamparo I, Koschinski A, Zaccolo M, Blackwell KT.

PLoS Comput Biol. 2016 Feb 22;12(2):e1004735. doi: 10.1371/journal.pcbi.1004735. eCollection 2016 Feb.

21.

Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization.

Abbattiscianni AC, Favia M, Mancini MT, Cardone RA, Guerra L, Monterisi S, Castellani S, Laselva O, Di Sole F, Conese M, Zaccolo M, Casavola V.

J Cell Sci. 2016 Mar 15;129(6):1128-40. doi: 10.1242/jcs.177907. Epub 2016 Jan 28.

22.

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.

Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P.

J Clin Invest. 2015 Dec;125(12):4714-28. doi: 10.1172/JCI81975. Epub 2015 Nov 16.

23.

Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes.

Fields LA, Koschinski A, Zaccolo M.

Cell Signal. 2016 Jul;28(7):725-32. doi: 10.1016/j.cellsig.2015.10.003. Epub 2015 Oct 22.

24.

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.

Zoccarato A, Surdo NC, Aronsen JM, Fields LA, Mancuso L, Dodoni G, Stangherlin A, Livie C, Jiang H, Sin YY, Gesellchen F, Terrin A, Baillie GS, Nicklin SA, Graham D, Szabo-Fresnais N, Krall J, Vandeput F, Movsesian M, Furlan L, Corsetti V, Hamilton G, Lefkimmiatis K, Sjaastad I, Zaccolo M.

Circ Res. 2015 Sep 25;117(8):707-19. doi: 10.1161/CIRCRESAHA.114.305892. Epub 2015 Aug 4.

PMID:
26243800
25.

Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons.

Li D, Lu CJ, Hao G, Wright H, Woodward L, Liu K, Vergari E, Surdo NC, Herring N, Zaccolo M, Paterson DJ.

Hypertension. 2015 Jul;66(1):190-8. doi: 10.1161/HYPERTENSIONAHA.114.05054. Epub 2015 Apr 27.

26.

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.

Parnell E, Koschinski A, Zaccolo M, Cameron RT, Baillie GS, Baillie GL, Porter A, McElroy SP, Yarwood SJ.

Biochim Biophys Acta. 2015 Jul;1853(7):1749-58. doi: 10.1016/j.bbamcr.2015.04.009. Epub 2015 Apr 23.

27.

Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes.

Lomas O, Brescia M, Carnicer R, Monterisi S, Surdo NC, Zaccolo M.

Methods Mol Biol. 2015;1294:103-15. doi: 10.1007/978-1-4939-2537-7_8.

PMID:
25783880
28.
29.

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P.

Gastroenterology. 2015 Feb;148(2):427-39.e16. doi: 10.1053/j.gastro.2014.11.002. Epub 2014 Nov 7.

30.

cAMP signaling in subcellular compartments.

Lefkimmiatis K, Zaccolo M.

Pharmacol Ther. 2014 Sep;143(3):295-304. doi: 10.1016/j.pharmthera.2014.03.008. Epub 2014 Apr 1. Review.

31.

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

Lomas O, Zaccolo M.

Physiology (Bethesda). 2014 Mar;29(2):141-9. doi: 10.1152/physiol.00040.2013. Review.

32.

Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.

Stangherlin A, Koschinski A, Terrin A, Zoccarato A, Jiang H, Fields LA, Zaccolo M.

Methods Mol Biol. 2014;1071:59-71. doi: 10.1007/978-1-62703-622-1_5.

PMID:
24052380
33.

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.

Monterisi S, Casavola V, Zaccolo M.

Br J Pharmacol. 2013 May;169(1):1-9. doi: 10.1111/bph.12017. Review.

34.

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.

Terrin A, Monterisi S, Stangherlin A, Zoccarato A, Koschinski A, Surdo NC, Mongillo M, Sawa A, Jordanides NE, Mountford JC, Zaccolo M.

J Cell Biol. 2012 Aug 20;198(4):607-21. doi: 10.1083/jcb.201201059.

35.

Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions.

Röder IV, Strack S, Reischl M, Dahley O, Khan MM, Kassel O, Zaccolo M, Rudolf R.

PLoS One. 2012;7(7):e40860. doi: 10.1371/journal.pone.0040860. Epub 2012 Jul 16.

36.

Rapsyn mediates subsynaptic anchoring of PKA type I and stabilisation of acetylcholine receptor in vivo.

Choi KR, Berrera M, Reischl M, Strack S, Albrizio M, Röder IV, Wagner A, Petersen Y, Hafner M, Zaccolo M, Rudolf R.

J Cell Sci. 2012 Feb 1;125(Pt 3):714-23. doi: 10.1242/jcs.092361. Epub 2012 Feb 13.

37.

CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.

Monterisi S, Favia M, Guerra L, Cardone RA, Marzulli D, Reshkin SJ, Casavola V, Zaccolo M.

J Cell Sci. 2012 Mar 1;125(Pt 5):1106-17. doi: 10.1242/jcs.089086. Epub 2012 Feb 2.

38.

cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function.

Stangherlin A, Zaccolo M.

Biochem Soc Trans. 2012 Feb;40(1):11-4. doi: 10.1042/BST20110655.

PMID:
22260658
39.

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

Parnell E, Smith BO, Palmer TM, Terrin A, Zaccolo M, Yarwood SJ.

Br J Pharmacol. 2012 May;166(2):434-46. doi: 10.1111/j.1476-5381.2011.01808.x. Review.

40.

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.

Stangherlin A, Zaccolo M.

Am J Physiol Heart Circ Physiol. 2012 Jan;302(2):H379-90. doi: 10.1152/ajpheart.00766.2011. Epub 2011 Oct 28. Review.

41.

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.

Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C.

Basic Res Cardiol. 2011 Nov;106(6):1023-39. doi: 10.1007/s00395-011-0228-2. Epub 2011 Oct 20.

42.

Spatial control of cAMP signalling in health and disease.

Zaccolo M.

Curr Opin Pharmacol. 2011 Dec;11(6):649-55. doi: 10.1016/j.coph.2011.09.014. Epub 2011 Oct 13. Review.

43.

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

Mohamed TM, Oceandy D, Zi M, Prehar S, Alatwi N, Wang Y, Shaheen MA, Abou-Leisa R, Schelcher C, Hegab Z, Baudoin F, Emerson M, Mamas M, Di Benedetto G, Zaccolo M, Lei M, Cartwright EJ, Neyses L.

J Biol Chem. 2011 Dec 2;286(48):41520-9. doi: 10.1074/jbc.M111.290411. Epub 2011 Sep 29.

44.

Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases.

Stangherlin A, Zaccolo M.

J Cardiovasc Pharmacol. 2011 Oct;58(4):345-53. doi: 10.1097/FJC.0b013e3182214f2b. Review.

PMID:
21654331
45.

Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors.

Gesellchen F, Stangherlin A, Surdo N, Terrin A, Zoccarato A, Zaccolo M.

Methods Mol Biol. 2011;746:297-316. doi: 10.1007/978-1-61779-126-0_16.

PMID:
21607864
46.

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.

Wilson LS, Baillie GS, Pritchard LM, Umana B, Terrin A, Zaccolo M, Houslay MD, Maurice DH.

J Biol Chem. 2011 May 6;286(18):16285-96. doi: 10.1074/jbc.M110.217026. Epub 2011 Mar 10.

47.

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.

Sin YY, Edwards HV, Li X, Day JP, Christian F, Dunlop AJ, Adams DR, Zaccolo M, Houslay MD, Baillie GS.

J Mol Cell Cardiol. 2011 May;50(5):872-83. doi: 10.1016/j.yjmcc.2011.02.006. Epub 2011 Feb 18.

PMID:
21334344
48.

cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.

Stangherlin A, Gesellchen F, Zoccarato A, Terrin A, Fields LA, Berrera M, Surdo NC, Craig MA, Smith G, Hamilton G, Zaccolo M.

Circ Res. 2011 Apr 15;108(8):929-39. doi: 10.1161/CIRCRESAHA.110.230698. Epub 2011 Feb 17.

49.

Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.

Diskar M, Zenn HM, Kaupisch A, Kaufholz M, Brockmeyer S, Sohmen D, Berrera M, Zaccolo M, Boshart M, Herberg FW, Prinz A.

J Biol Chem. 2010 Nov 12;285(46):35910-8. doi: 10.1074/jbc.M110.155150. Epub 2010 Sep 6.

50.

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.

Oliveira RF, Terrin A, Di Benedetto G, Cannon RC, Koh W, Kim M, Zaccolo M, Blackwell KT.

PLoS One. 2010 Jul 22;5(7):e11725. doi: 10.1371/journal.pone.0011725.

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