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Items: 1 to 50 of 84

1.

On-Bead Peptoid Dimerization Induced by Incorporation of Glycosylated Bridging Units in Submonomer Solid-Phase Approach to Glycopeptoids.

Comegna D, Del Gatto A, Saviano M, Zaccaro L.

Org Lett. 2019 Jun 21;21(12):4454-4458. doi: 10.1021/acs.orglett.9b01242. Epub 2019 May 31.

PMID:
31150252
2.

Conformational studies of RGDechi peptide by natural-abundance NMR spectroscopy.

Farina B, Del Gatto A, Comegna D, Di Gaetano S, Capasso D, Isernia C, Saviano M, Fattorusso R, Zaccaro L, Russo L.

J Pept Sci. 2019 May;25(5):e3166. doi: 10.1002/psc.3166. Epub 2019 Mar 18.

PMID:
30884005
3.

Therapeutic Potential of a Novel αvβ₃ Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type.

Hill BS, Sarnella A, Capasso D, Comegna D, Del Gatto A, Gramanzini M, Albanese S, Saviano M, Zaccaro L, Zannetti A.

Cancers (Basel). 2019 Jan 24;11(2). pii: E139. doi: 10.3390/cancers11020139.

4.

[99mTc][Tc(N)PNP43]-Labeled RGD Peptides As New Probes for a Selective Detection of αvβ3 Integrin: Synthesis, Structure-Activity and Pharmacokinetic Studies.

Bolzati C, Salvarese N, Carpanese D, Seraglia R, Meléndez-Alafort L, Rosato A, Capasso D, Saviano M, Del Gatto A, Comegna D, Zaccaro L.

J Med Chem. 2018 Nov 8;61(21):9596-9610. doi: 10.1021/acs.jmedchem.8b01075. Epub 2018 Oct 17.

PMID:
30278131
5.

NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging.

Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML.

ACS Appl Mater Interfaces. 2017 Dec 13;9(49):43113-43126. doi: 10.1021/acsami.7b14155. Epub 2017 Dec 1.

PMID:
29148709
6.

Chemical Modification for Proteolytic Stabilization of the Selective αvβ3 Integrin RGDechi Peptide: in Vitro and in Vivo Activities on Malignant Melanoma Cells.

Comegna D, Zannetti A, Del Gatto A, de Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L.

J Med Chem. 2017 Dec 14;60(23):9874-9884. doi: 10.1021/acs.jmedchem.7b01590. Epub 2017 Dec 4.

PMID:
29144748
7.

Insights into the anticancer properties of the first antimicrobial peptide from Archaea.

Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2155-2164. doi: 10.1016/j.bbagen.2017.06.009. Epub 2017 Jun 15.

8.

A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence.

Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2342-2353. doi: 10.1016/j.bbagen.2017.04.009. Epub 2017 Apr 26.

PMID:
28454736
9.

The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism.

Persico M, Fattorusso R, Taglialatela-Scafati O, Chianese G, de Paola I, Zaccaro L, Rondinelli F, Lombardo M, Quintavalla A, Trombini C, Fattorusso E, Fattorusso C, Farina B.

Sci Rep. 2017 Apr 6;7:45485. doi: 10.1038/srep45485.

10.

The (unusual) aspartic acid in the metal coordination sphere of the prokaryotic zinc finger domain.

D'Abrosca G, Russo L, Palmieri M, Baglivo I, Netti F, de Paola I, Zaccaro L, Farina B, Iacovino R, Pedone PV, Isernia C, Fattorusso R, Malgieri G.

J Inorg Biochem. 2016 Aug;161:91-8. doi: 10.1016/j.jinorgbio.2016.05.006. Epub 2016 May 11.

PMID:
27238756
11.

A Combined NMR and Computational Approach to Determine the RGDechi-hCit-αv β3 Integrin Recognition Mode in Isolated Cell Membranes.

Farina B, de Paola I, Russo L, Capasso D, Liguoro A, Gatto AD, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L, Fattorusso R.

Chemistry. 2016 Jan 11;22(2):681-93. doi: 10.1002/chem.201503126. Epub 2015 Nov 9.

PMID:
26548575
12.

Cullin3-BTB interface: a novel target for stapled peptides.

de Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazzà D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L.

PLoS One. 2015 Apr 7;10(4):e0121149. doi: 10.1371/journal.pone.0121149. eCollection 2015.

13.

Straightforward entry to S-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics.

Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L.

Org Lett. 2015 Feb 6;17(3):640-3. doi: 10.1021/ol503664t. Epub 2015 Jan 27.

PMID:
25622618
14.

Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin.

Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B.

PLoS One. 2014 Nov 6;9(11):e112082. doi: 10.1371/journal.pone.0112082. eCollection 2014.

15.

RGDechi-hCit: αvβ3 selective pro-apoptotic peptide as potential carrier for drug delivery into melanoma metastatic cells.

Capasso D, de Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L.

PLoS One. 2014 Sep 23;9(9):e106441. doi: 10.1371/journal.pone.0106441. eCollection 2014.

16.

Zinc to cadmium replacement in the prokaryotic zinc-finger domain.

Malgieri G, Palmieri M, Esposito S, Maione V, Russo L, Baglivo I, de Paola I, Milardi D, Diana D, Zaccaro L, Pedone PV, Fattorusso R, Isernia C.

Metallomics. 2014 Jan;6(1):96-104. doi: 10.1039/c3mt00208j.

PMID:
24287553
17.

Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant.

Palmieri M, Russo L, Malgieri G, Esposito S, Baglivo I, Rivellino A, Farina B, de Paola I, Zaccaro L, Milardi D, Isernia C, Pedone PV, Fattorusso R.

J Inorg Biochem. 2014 Feb;131:30-6. doi: 10.1016/j.jinorgbio.2013.10.016. Epub 2013 Oct 29.

PMID:
24239910
18.

Structural Zn(II) implies a switch from fully cooperative to partly downhill folding in highly homologous proteins.

Palmieri M, Malgieri G, Russo L, Baglivo I, Esposito S, Netti F, Del Gatto A, de Paola I, Zaccaro L, Pedone PV, Isernia C, Milardi D, Fattorusso R.

J Am Chem Soc. 2013 Apr 3;135(13):5220-8. doi: 10.1021/ja4009562. Epub 2013 Mar 26.

PMID:
23484956
19.

In vitro activity of the αvβ3 integrin antagonist RGDechi-hCit on malignant melanoma cells.

Pisano M, DE Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C.

Anticancer Res. 2013 Mar;33(3):871-9.

PMID:
23482756
20.

Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting.

Scarì G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L.

Bioconjug Chem. 2012 Mar 21;23(3):340-9. doi: 10.1021/bc200143d. Epub 2012 Mar 9.

PMID:
22375916
21.

Structure-based design of a potent artificial transactivation domain based on p53.

Langlois C, Del Gatto A, Arseneault G, Lafrance-Vanasse J, De Simone M, Morse T, de Paola I, Lussier-Price M, Legault P, Pedone C, Zaccaro L, Omichinski JG.

J Am Chem Soc. 2012 Jan 25;134(3):1715-23. doi: 10.1021/ja208999e. Epub 2012 Jan 12.

PMID:
22191432
22.

BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury.

Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M.

Biotechnol Adv. 2012 Jan-Feb;30(1):223-32. doi: 10.1016/j.biotechadv.2011.05.008. Epub 2011 May 18.

PMID:
21620945
23.

Zinc to cadmium replacement in the A. thaliana SUPERMAN Cys₂ His₂ zinc finger induces structural rearrangements of typical DNA base determinant positions.

Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C.

Biopolymers. 2011 Nov;95(11):801-10. doi: 10.1002/bip.21680. Epub 2011 May 25.

PMID:
21618209
24.

TRPV1 modulators: structure-activity relationships using a rational combinatorial approach.

Zaccaro L, García-López MT, González-Muñiz R, García-Martínez C, Ferrer-Montiel A, Albericio F, Royo M.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3541-5. doi: 10.1016/j.bmcl.2011.04.141. Epub 2011 May 6.

PMID:
21612926
25.

Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD-cullin 3 recognition.

Pirone L, Correale S, de Paola I, Zaccaro L, De Simone G, Vitagliano L, Pedone E, Di Gaetano S.

J Pept Sci. 2011 May;17(5):373-6. doi: 10.1002/psc.1366. Epub 2011 Mar 24.

PMID:
21438081
26.

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit.

Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G.

J Transl Med. 2011 Jan 13;9:7. doi: 10.1186/1479-5876-9-7.

27.

Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor.

Cirillo G, Bianco MR, Colangelo AM, Cavaliere C, Daniele de L, Zaccaro L, Alberghina L, Papa M.

Neurobiol Dis. 2011 Mar;41(3):630-9. doi: 10.1016/j.nbd.2010.11.012. Epub 2010 Nov 25.

PMID:
21111819
28.

Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.

Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R.

Molecules. 2010 Jul 15;15(7):4924-33. doi: 10.3390/molecules15074924.

29.

AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.

Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M.

Cardiovasc Res. 2010 Oct 1;88(1):101-10. doi: 10.1093/cvr/cvq155. Epub 2010 May 28.

PMID:
20511238
30.

Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5).

Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M.

Clin Cancer Res. 2009 Aug 15;15(16):5224-33. doi: 10.1158/1078-0432.CCR-08-3270. Epub 2009 Aug 11.

31.

A new and selective radiolabeled alphavbeta3 peptide antagonist as tracer in tumor diagnosis.

De Luca S, Del Gatto A, Ruvo M, Panico MR, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L.

Adv Exp Med Biol. 2009;611:439-40. No abstract available.

PMID:
19400256
32.

Peptides for tumour therapy and diagnosis: current status and future directions.

Zaccaro L, Del Gatto A, Pedone C, Saviano M.

Curr Med Chem. 2009;16(7):780-95. Review.

PMID:
19275595
33.

A new nerve growth factor-mimetic peptide active on neuropathic pain in rats.

Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E.

J Neurosci. 2008 Mar 12;28(11):2698-709. doi: 10.1523/JNEUROSCI.5201-07.2008.

34.

The prokaryotic Cys2His2 zinc-finger adopts a novel fold as revealed by the NMR structure of Agrobacterium tumefaciens Ros DNA-binding domain.

Malgieri G, Russo L, Esposito S, Baglivo I, Zaccaro L, Pedone EM, Di Blasio B, Isernia C, Pedone PV, Fattorusso R.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17341-6. Epub 2007 Oct 23.

35.

A novel type of zinc finger DNA binding domain in the Agrobacterium tumefaciens transcriptional regulator Ros.

Esposito S, Baglivo I, Malgieri G, Russo L, Zaccaro L, D'Andrea LD, Mammucari M, Di Blasio B, Isernia C, Fattorusso R, Pedone PV.

Biochemistry. 2006 Aug 29;45(34):10394-405.

PMID:
16922516
36.

Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior.

Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M.

J Med Chem. 2006 Jun 1;49(11):3416-20.

PMID:
16722662
37.

Adoptive immunotherapy of feline immunodeficiency virus with autologous ex vivo-stimulated lymphoid cells modulates virus and T-cell subsets in blood.

Flynn JN, Pistello M, Isola P, Zaccaro L, Del Santo B, Ricci E, Matteucci D, Bendinelli M.

Clin Diagn Lab Immunol. 2005 Jun;12(6):736-45.

38.

Antiviral activity in vitro of Urtica dioica L., Parietaria diffusa M. et K. and Sambucus nigra L.

Uncini Manganelli RE, Zaccaro L, Tomei PE.

J Ethnopharmacol. 2005 Apr 26;98(3):323-7.

PMID:
15814267
39.

Evaluation of feline immunodeficiency virus ORF-A mutants as candidate attenuated vaccine.

Pistello M, Bonci F, Isola P, Mazzetti P, Merico A, Zaccaro L, Matteucci D, Bendinelli M.

Virology. 2005 Feb 20;332(2):676-90.

40.

A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: a conformational study.

De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M.

Biopolymers. 2004;76(6):459-66.

PMID:
15499565
41.

A new class of foldamers based on cis-gamma-amino-L-proline.

Farrera-Sinfreu J, Zaccaro L, Vidal D, Salvatella X, Giralt E, Pons M, Albericio F, Royo M.

J Am Chem Soc. 2004 May 19;126(19):6048-57. Erratum in: J Am Chem Soc. 2005 Jan 12;127(1):474.

PMID:
15137770
42.

AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine.

Pistello M, Matteucci D, Bonci F, Isola P, Mazzetti P, Zaccaro L, Merico A, Del Mauro D, Flynn N, Bendinelli M.

J Virol. 2003 Oct;77(20):10740-50.

43.

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.

Harwood HJ Jr, Petras SF, Shelly LD, Zaccaro LM, Perry DA, Makowski MR, Hargrove DM, Martin KA, Tracey WR, Chapman JG, Magee WP, Dalvie DK, Soliman VF, Martin WH, Mularski CJ, Eisenbeis SA.

J Biol Chem. 2003 Sep 26;278(39):37099-111. Epub 2003 Jul 3.

44.

Synthetic peptides mimicking the interleukin-6/gp130 interaction: a two-helix bundle system. Design and conformational studies.

Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C.

J Pept Sci. 2003 Feb;9(2):90-105.

PMID:
12630694
45.

NMR structure of the single QALGGH zinc finger domain from the Arabidopsis thaliana SUPERMAN protein.

Isernia C, Bucci E, Leone M, Zaccaro L, Di Lello P, Digilio G, Esposito S, Saviano M, Di Blasio B, Pedone C, Pedone PV, Fattorusso R.

Chembiochem. 2003 Mar 3;4(2-3):171-80.

PMID:
12616630
46.

Conformational features of human melanin-concentrating hormone: an NMR and computational analysis.

Vitale RM, Zaccaro L, Di Blasio B, Fattorusso R, Isernia C, Amodeo P, Pedone C, Saviano M.

Chembiochem. 2003 Jan 3;4(1):73-81.

PMID:
12512079
47.

The Arabidopsis SUPERMAN protein is able to specifically bind DNA through its single Cys2-His2 zinc finger motif.

Dathan N, Zaccaro L, Esposito S, Isernia C, Omichinski JG, Riccio A, Pedone C, Di Blasio B, Fattorusso R, Pedone PV.

Nucleic Acids Res. 2002 Nov 15;30(22):4945-51.

48.

Bcl2-negative MCF7 cells overexpress p53: implications for the cell cycle and sensitivity to cytotoxic drugs.

Poliseno L, Mariani L, Collecchi P, Piras A, Zaccaro L, Rainaldi G.

Cancer Chemother Pharmacol. 2002 Aug;50(2):127-30. Epub 2002 Jun 6.

PMID:
12172977
49.

Development of feline immunodeficiency virus ORF-A (tat) mutants: in vitro and in vivo characterization.

Pistello M, Moscardini M, Mazzetti P, Bonci F, Zaccaro L, Isola P, Freer G, Specter S, Matteucci D, Bendinelli M.

Virology. 2002 Jun 20;298(1):84-95.

50.

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