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Items: 40


Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics.

Fornelli L, Srzentić K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, Thomas PM, Compton PD, Kelleher NL.

Mol Cell Proteomics. 2020 Feb;19(2):405-420. doi: 10.1074/mcp.TIR119.001638. Epub 2019 Dec 30.


Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms.

Huguet R, Mullen C, Srzentić K, Greer JB, Fellers RT, Zabrouskov V, Syka JEP, Kelleher NL, Fornelli L.

Anal Chem. 2019 Dec 17;91(24):15732-15739. doi: 10.1021/acs.analchem.9b03925. Epub 2019 Nov 22.


STORI Plots Enable Accurate Tracking of Individual Ion Signals.

Kafader JO, Beu SC, Early BP, Melani RD, Durbin KR, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Kelleher NL, Compton PD, Senko MW.

J Am Soc Mass Spectrom. 2019 Nov;30(11):2200-2203. doi: 10.1007/s13361-019-02309-0. Epub 2019 Sep 11.


Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry.

Schweppe DK, Prasad S, Belford MW, Navarrete-Perea J, Bailey DJ, Huguet R, Jedrychowski MP, Rad R, McAlister G, Abbatiello SE, Woulters ER, Zabrouskov V, Dunyach JJ, Paulo JA, Gygi SP.

Anal Chem. 2019 Mar 19;91(6):4010-4016. doi: 10.1021/acs.analchem.8b05399. Epub 2019 Feb 26.


Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.

Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL.

Anal Chem. 2018 Jul 17;90(14):8421-8429. doi: 10.1021/acs.analchem.8b00984. Epub 2018 Jun 28.


Top-Down Hydrogen-Deuterium Exchange Analysis of Protein Structures Using Ultraviolet Photodissociation.

Brodie NI, Huguet R, Zhang T, Viner R, Zabrouskov V, Pan J, Petrotchenko EV, Borchers CH.

Anal Chem. 2018 Mar 6;90(5):3079-3082. doi: 10.1021/acs.analchem.7b03655. Epub 2018 Feb 1.


Improved Precursor Characterization for Data-Dependent Mass Spectrometry.

Hebert AS, Thöing C, Riley NM, Kwiecien NW, Shiskova E, Huguet R, Cardasis HL, Kuehn A, Eliuk S, Zabrouskov V, Westphall MS, McAlister GC, Coon JJ.

Anal Chem. 2018 Feb 6;90(3):2333-2340. doi: 10.1021/acs.analchem.7b04808. Epub 2018 Jan 11.


Neprosin, a Selective Prolyl Endoprotease for Bottom-up Proteomics and Histone Mapping.

Schräder CU, Lee L, Rey M, Sarpe V, Man P, Sharma S, Zabrouskov V, Larsen B, Schriemer DC.

Mol Cell Proteomics. 2017 Jun;16(6):1162-1171. doi: 10.1074/mcp.M116.066803. Epub 2017 Apr 12.


Enhanced Dissociation of Intact Proteins with High Capacity Electron Transfer Dissociation.

Riley NM, Mullen C, Weisbrod CR, Sharma S, Senko MW, Zabrouskov V, Westphall MS, Syka JE, Coon JJ.

J Am Soc Mass Spectrom. 2016 Mar;27(3):520-31. doi: 10.1007/s13361-015-1306-8. Epub 2015 Nov 20.


Increased expression of lysosome membrane protein 2 in glomeruli of patients with idiopathic membranous nephropathy.

Rood IM, Merchant ML, Wilkey DW, Zhang T, Zabrouskov V, van der Vlag J, Dijkman HB, Willemsen BK, Wetzels JF, Klein JB, Deegens JK.

Proteomics. 2015 Nov;15(21):3722-30. doi: 10.1002/pmic.201500127. Epub 2015 Sep 28.


Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL.

Mol Cell Proteomics. 2016 Mar;15(3):776-90. doi: 10.1074/mcp.M115.053819. Epub 2015 Aug 13.


Benchmarking multiple fragmentation methods on an orbitrap fusion for top-down phospho-proteoform characterization.

Brunner AM, Lössl P, Liu F, Huguet R, Mullen C, Yamashita M, Zabrouskov V, Makarov A, Altelaar AF, Heck AJ.

Anal Chem. 2015 Apr 21;87(8):4152-8. doi: 10.1021/acs.analchem.5b00162. Epub 2015 Apr 8.


Novel parallelized quadrupole/linear ion trap/Orbitrap tribrid mass spectrometer improving proteome coverage and peptide identification rates.

Senko MW, Remes PM, Canterbury JD, Mathur R, Song Q, Eliuk SM, Mullen C, Earley L, Hardman M, Blethrow JD, Bui H, Specht A, Lange O, Denisov E, Makarov A, Horning S, Zabrouskov V.

Anal Chem. 2013 Dec 17;85(24):11710-4. doi: 10.1021/ac403115c. Epub 2013 Nov 27.


Multiplexed MS/MS for improved data-independent acquisition.

Egertson JD, Kuehn A, Merrihew GE, Bateman NW, MacLean BX, Ting YS, Canterbury JD, Marsh DM, Kellmann M, Zabrouskov V, Wu CC, MacCoss MJ.

Nat Methods. 2013 Aug;10(8):744-6. doi: 10.1038/nmeth.2528. Epub 2013 Jun 23.


Defining intact protein primary structures from saliva: a step toward the human proteome project.

Halgand F, Zabrouskov V, Bassilian S, Souda P, Loo JA, Faull KF, Wong DT, Whitelegge JP.

Anal Chem. 2012 May 15;84(10):4383-95. doi: 10.1021/ac203337s. Epub 2012 May 2.


Evaluation of front-end higher energy collision-induced dissociation on a benchtop dual-pressure linear ion trap mass spectrometer for shotgun proteomics.

Bereman MS, Canterbury JD, Egertson JD, Horner J, Remes PM, Schwartz J, Zabrouskov V, MacCoss MJ.

Anal Chem. 2012 Feb 7;84(3):1533-9. doi: 10.1021/ac203210a. Epub 2012 Jan 12.


Increased selectivity, analytical precision, and throughput in targeted proteomics.

Kiyonami R, Schoen A, Prakash A, Peterman S, Zabrouskov V, Picotti P, Aebersold R, Huhmer A, Domon B.

Mol Cell Proteomics. 2011 Feb;10(2):M110.002931. doi: 10.1074/mcp.M110.002931. Epub 2010 Jul 27.


Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry.

Halgand F, Zabrouskov V, Bassilian S, Souda P, Wong DT, Loo JA, Faull KF, Whitelegge JP.

J Am Soc Mass Spectrom. 2010 May;21(5):868-77. doi: 10.1016/j.jasms.2010.01.026. Epub 2010 Feb 1.


Dual-pressure linear ion trap mass spectrometer improving the analysis of complex protein mixtures.

Second TP, Blethrow JD, Schwartz JC, Merrihew GE, MacCoss MJ, Swaney DL, Russell JD, Coon JJ, Zabrouskov V.

Anal Chem. 2009 Sep 15;81(18):7757-65. doi: 10.1021/ac901278y.


Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer.

Bondarenko PV, Second TP, Zabrouskov V, Makarov AA, Zhang Z.

J Am Soc Mass Spectrom. 2009 Aug;20(8):1415-24. doi: 10.1016/j.jasms.2009.03.020. Epub 2009 Mar 28.


Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia.

Su X, Lucas DM, Zhang L, Xu H, Zabrouskov V, Davis ME, Knapp AR, Young DC, Payne PR, Parthun MR, Marcucci G, Grever MR, Byrd JC, Freitas MA.

Proteomics. 2009 Mar;9(5):1197-206. doi: 10.1002/pmic.200800333.


Quantification of post-translationally modified peptides of bovine alpha-crystallin using tandem mass tags and electron transfer dissociation.

Viner RI, Zhang T, Second T, Zabrouskov V.

J Proteomics. 2009 Jul 21;72(5):874-85. doi: 10.1016/j.jprot.2009.02.005. Epub 2009 Feb 24.


Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry.

Whitelegge JP, Zabrouskov V, Halgand F, Souda P, Bassilian S, Yan W, Wolinsky L, Loo JA, Wong DT, Faull KF.

Int J Mass Spectrom. 2007 Dec 1;268(2-3):190-197.


A proteomics grade electron transfer dissociation-enabled hybrid linear ion trap-orbitrap mass spectrometer.

McAlister GC, Berggren WT, Griep-Raming J, Horning S, Makarov A, Phanstiel D, Stafford G, Swaney DL, Syka JE, Zabrouskov V, Coon JJ.

J Proteome Res. 2008 Aug;7(8):3127-36. doi: 10.1021/pr800264t. Epub 2008 Jul 10.


Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry.

Zabrouskov V, Ge Y, Schwartz J, Walker JW.

Mol Cell Proteomics. 2008 Oct;7(10):1838-49. doi: 10.1074/mcp.M700524-MCP200. Epub 2008 Apr 28.


Top-down mass spectrometry of integral membrane proteins.

Whitelegge J, Halgand F, Souda P, Zabrouskov V.

Expert Rev Proteomics. 2006 Dec;3(6):585-96. Review.


Measurement of deamidation of intact proteins by isotopic envelope and mass defect with ion cyclotron resonance Fourier transform mass spectrometry.

Robinson NE, Zabrouskov V, Zhang J, Lampi KJ, Robinson AB.

Rapid Commun Mass Spectrom. 2006;20(23):3535-41.


Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry.

Zabrouskov V, Han X, Welker E, Zhai H, Lin C, van Wijk KJ, Scheraga HA, McLafferty FW.

Biochemistry. 2006 Jan 24;45(3):987-92.


Performance of a linear ion trap-Orbitrap hybrid for peptide analysis.

Yates JR, Cociorva D, Liao L, Zabrouskov V.

Anal Chem. 2006 Jan 15;78(2):493-500.


New and automated MSn approaches for top-down identification of modified proteins.

Zabrouskov V, Senko MW, Du Y, Leduc RD, Kelleher NL.

J Am Soc Mass Spectrom. 2005 Dec;16(12):2027-38. Epub 2005 Oct 25.


The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts.

Peltier JB, Cai Y, Sun Q, Zabrouskov V, Giacomelli L, Rudella A, Ytterberg AJ, Rutschow H, van Wijk KJ.

Mol Cell Proteomics. 2006 Jan;5(1):114-33. Epub 2005 Oct 4.


Infrared photodissociation spectroscopy of electrosprayed ions in a Fourier transform mass spectrometer.

Oh HB, Lin C, Hwang HY, Zhai H, Breuker K, Zabrouskov V, Carpenter BK, McLafferty FW.

J Am Chem Soc. 2005 Mar 23;127(11):4076-83.


A new approach for plant proteomics: characterization of chloroplast proteins of Arabidopsis thaliana by top-down mass spectrometry.

Zabrouskov V, Giacomelli L, van Wijk KJ, McLafferty FW.

Mol Cell Proteomics. 2003 Dec;2(12):1253-60. Epub 2003 Sep 22.


Structural analysis of phosphatidylcholines by post-source decay matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Al-Saad KA, Siems WF, Hill HH, Zabrouskov V, Knowles NR.

J Am Soc Mass Spectrom. 2003 Apr;14(4):373-82.


Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of lipids: ionization and prompt fragmentation patterns.

Al-Saad KA, Zabrouskov V, Siems WF, Knowles NR, Hannan RM, Hill HH Jr.

Rapid Commun Mass Spectrom. 2003;17(1):87-96.


Oxidative metabolism and the physiological age of seed potatoes are affected by increased alpha-linolenate content.

Zabrouskov V, Kumar GN, Spychalla JP, Knowles NR.

Physiol Plant. 2002 Oct;116(2):172-185.


Lipid metabolism during aging of high-alpha-linolenate-phenotype potato tubers.

Zabrouskov V, Knowles NR.

Arch Biochem Biophys. 2002 Jun 1;402(1):136-48.


Analysis of plant phosphatidylcholines by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Zabrouskov V, Al-Saad KA, Siems WF, Hill HH Jr, Knowles NR.

Rapid Commun Mass Spectrom. 2001;15(12):935-40.


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