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Items: 1 to 50 of 71

1.

Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.

Hyoju SK, Zaborin A, Keskey R, Sharma A, Arnold W, van den Berg F, Kim SM, Gottel N, Bethel C, Charnot-Katsikas A, Jianxin P, Adriaansens C, Papazian E, Gilbert JA, Zaborina O, Alverdy JC.

MBio. 2019 Jul 30;10(4). pii: e00903-19. doi: 10.1128/mBio.00903-19.

2.

Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro.

Nichols D, Pimentel MB, Borges FTP, Hyoju SK, Teymour F, Hong SH, Zaborina OY, Alverdy JC, Papavasiliou G.

Front Bioeng Biotechnol. 2019 Jun 26;7:153. doi: 10.3389/fbioe.2019.00153. eCollection 2019.

3.

Identification of Collagenolytic Bacteria in Human Samples: Screening Methods and Clinical Implications for Resolving and Preventing Anastomotic Leaks and Wound Complications.

Guyton KL, Levine ZC, Lowry AC, Lambert L, Gribovskaja-Rupp I, Hyman N, Zaborina O, Alverdy J.

Dis Colon Rectum. 2019 Aug;62(8):972-979. doi: 10.1097/DCR.0000000000001417.

PMID:
31283593
4.

Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station.

Urbaniak C, van Dam P, Zaborin A, Zaborina O, Gilbert JA, Torok T, Wang CCC, Venkateswaran K.

mSystems. 2019 Mar 19;4(2). pii: e00345-18. doi: 10.1128/mSystems.00345-18. eCollection 2019 Mar-Apr.

5.

Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.

Wiegerinck M, Hyoju SK, Mao J, Zaborin A, Adriaansens C, Salzman E, Hyman NH, Zaborina O, van Goor H, Alverdy JC.

Br J Surg. 2018 Sep;105(10):1368-1376. doi: 10.1002/bjs.10859. Epub 2018 Apr 16.

PMID:
29658991
6.

De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality.

Mao J, Zaborin A, Poroyko V, Goldfeld D, Lynd NA, Chen W, Tirrell MV, Zaborina O, Alverdy JC.

ACS Biomater Sci Eng. 2017 Sep 11;3(9):2076-2085. doi: 10.1021/acsbiomaterials.7b00373. Epub 2017 Jul 17.

7.

Media from macrophages co-incubated with Enterococcus faecalis induces epithelial cell monolayer reassembly and altered cell morphology.

Belogortseva N, Krezalek M, Guyton K, Labno C, Poroyko V, Zaborina O, Alverdy JC.

PLoS One. 2017 Aug 9;12(8):e0182825. doi: 10.1371/journal.pone.0182825. eCollection 2017.

8.

Optimum Operating Room Environment for the Prevention of Surgical Site Infections.

Gaines S, Luo JN, Gilbert J, Zaborina O, Alverdy JC.

Surg Infect (Larchmt). 2017 May/Jun;18(4):503-507. doi: 10.1089/sur.2017.020. Epub 2017 Apr 12.

9.

Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis".

Krezalek MA, Hyoju S, Zaborin A, Okafor E, Chandrasekar L, Bindokas V, Guyton K, Montgomery CP, Daum RS, Zaborina O, Boyle-Vavra S, Alverdy JC.

Ann Surg. 2018 Apr;267(4):749-758. doi: 10.1097/SLA.0000000000002173.

PMID:
28187042
10.

Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa.

Hyoju SK, Klabbers RE, Aaron M, Krezalek MA, Zaborin A, Wiegerinck M, Hyman NH, Zaborina O, Van Goor H, Alverdy JC.

Ann Surg. 2018 Jun;267(6):1112-1118. doi: 10.1097/SLA.0000000000002167.

11.

Modeling Acinetobacter baumannii wound infections: The critical role of iron.

Fleming ID, Krezalek MA, Belogortseva N, Zaborin A, Defazio J, Chandrasekar L, Actis LA, Zaborina O, Alverdy JC.

J Trauma Acute Care Surg. 2017 Mar;82(3):557-565. doi: 10.1097/TA.0000000000001338.

12.

Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats.

Shakhsheer BA, Lec B, Zaborin A, Guyton K, Defnet AM, Bagrodia N, Kandel JJ, Zaborina O, Hernandez SL, Alverdy J.

Int J Colorectal Dis. 2017 Apr;32(4):539-547. doi: 10.1007/s00384-016-2737-9. Epub 2016 Dec 20.

PMID:
27999936
13.

Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress.

Zaborin A, Krezalek M, Hyoju S, Defazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G112-G122. doi: 10.1152/ajpgi.00294.2016. Epub 2016 Dec 15.

14.

De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly(Ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas aeruginosa as a Model Intestinal Pathogen.

Yin Y, Papavasiliou G, Zaborina OY, Alverdy JC, Teymour F.

Ann Biomed Eng. 2017 Apr;45(4):1058-1068. doi: 10.1007/s10439-016-1740-1. Epub 2016 Oct 19.

15.

Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak.

Shakhsheer BA, Versten LA, Luo JN, Defazio JR, Klabbers R, Christley S, Zaborin A, Guyton KL, Krezalek M, Smith DP, Ajami NJ, Petrosino JF, Fleming ID, Belogortseva N, Zaborina O, Alverdy JC.

J Gastrointest Surg. 2016 Oct;20(10):1744-51. doi: 10.1007/s11605-016-3237-5. Epub 2016 Aug 16.

PMID:
27530446
16.

The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.

Krezalek MA, DeFazio J, Zaborina O, Zaborin A, Alverdy JC.

Shock. 2016 May;45(5):475-82. doi: 10.1097/SHK.0000000000000534. Review.

17.

C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.

Kanteti R, Dhanasingh I, El-Hashani E, Riehm JJ, Stricker T, Nagy S, Zaborin A, Zaborina O, Biron D, Alverdy JC, Im HK, Siddiqui S, Padilla PA, Salgia R.

Cancer Biol Ther. 2016;17(1):91-103. doi: 10.1080/15384047.2015.1108495.

18.

Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak.

Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC.

Sci Transl Med. 2015 May 6;7(286):286ra68. doi: 10.1126/scitranslmed.3010658.

19.

Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.

Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC.

J Trauma Acute Care Surg. 2015 Apr;78(4):823-9. doi: 10.1097/TA.0000000000000574.

20.

The opposing forces of the intestinal microbiome and the emerging pathobiome.

Defazio J, Fleming ID, Shakhsheer B, Zaborina O, Alverdy JC.

Surg Clin North Am. 2014 Dec;94(6):1151-61. doi: 10.1016/j.suc.2014.08.002. Epub 2014 Oct 7. Review.

21.

Intestinal anastomotic injury alters spatially defined microbiome composition and function.

Shogan BD, Smith DP, Christley S, Gilbert JA, Zaborina O, Alverdy JC.

Microbiome. 2014 Sep 15;2:35. doi: 10.1186/2049-2618-2-35. eCollection 2014.

22.

Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness.

Zaborin A, Smith D, Garfield K, Quensen J, Shakhsheer B, Kade M, Tirrell M, Tiedje J, Gilbert JA, Zaborina O, Alverdy JC.

MBio. 2014 Sep 23;5(5):e01361-14. doi: 10.1128/mBio.01361-14.

23.

Microscopic analysis: morphotypes and cellular appendages.

Zaborina O, Alverdy J, Shah M, Chen Y.

Methods Mol Biol. 2014;1149:99-107. doi: 10.1007/978-1-4939-0473-0_11.

PMID:
24818901
24.

Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa.

Shah M, Zaborin A, Alverdy JC, Scott K, Zaborina O.

FEMS Microbiol Lett. 2014 Mar;352(1):54-61. doi: 10.1111/1574-6968.12368. Epub 2014 Jan 21.

25.

Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.

Zaborin A, Defazio JR, Kade M, Kaiser BL, Belogortseva N, Camp DG 2nd, Smith RD, Adkins JN, Kim SM, Alverdy A, Goldfeld D, Firestone MA, Collier JH, Jabri B, Tirrell M, Zaborina O, Alverdy JC.

Antimicrob Agents Chemother. 2014;58(2):966-77. doi: 10.1128/AAC.02183-13. Epub 2013 Nov 25.

26.

Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.

Luong PM, Shogan BD, Zaborin A, Belogortseva N, Shrout JD, Zaborina O, Alverdy JC.

J Bacteriol. 2014 Jan;196(2):504-13. doi: 10.1128/JB.01050-13. Epub 2013 Nov 15.

27.

High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation.

Valuckaite V, Seal J, Zaborina O, Tretiakova M, Testa G, Alverdy JC.

J Surg Res. 2013 Aug;183(2):869-75. doi: 10.1016/j.jss.2013.02.035. Epub 2013 Mar 14.

28.

Agent-based model of epithelial host-pathogen interactions in anastomotic leak.

Stern JR, Olivas AD, Valuckaite V, Zaborina O, Alverdy JC, An G.

J Surg Res. 2013 Oct;184(2):730-8. doi: 10.1016/j.jss.2012.12.009. Epub 2013 Jan 1.

29.

Integration of TGF-β- and EGFR-based signaling pathways using an agent-based model of epithelial restitution.

Stern JR, Christley S, Zaborina O, Alverdy JC, An G.

Wound Repair Regen. 2012 Nov-Dec;20(6):862-71. doi: 10.1111/j.1524-475X.2012.00852.x. Epub 2012 Oct 30.

30.

Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak.

Olivas AD, Shogan BD, Valuckaite V, Zaborin A, Belogortseva N, Musch M, Meyer F, Trimble WL, An G, Gilbert J, Zaborina O, Alverdy JC.

PLoS One. 2012;7(8):e44326. doi: 10.1371/journal.pone.0044326. Epub 2012 Aug 31.

31.

The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis.

Babrowski T, Romanowski K, Fink D, Kim M, Gopalakrishnan V, Zaborina O, Alverdy JC.

Surgery. 2013 Jan;153(1):36-43. doi: 10.1016/j.surg.2012.06.022. Epub 2012 Aug 3.

32.

Novel model to study combined effects of microorganisms and oxidants on development of intestinal necrosis.

Carlisle EM, Liu D, Zaborina O, Alverdy JC.

Surg Infect (Larchmt). 2012 Aug;13(4):238-44. doi: 10.1089/sur.2011.055. Epub 2012 Jul 12.

PMID:
22789034
33.

Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate.

Zaborin A, Gerdes S, Holbrook C, Liu DC, Zaborina OY, Alverdy JC.

PLoS One. 2012;7(4):e34883. doi: 10.1371/journal.pone.0034883. Epub 2012 Apr 13.

34.

Candida albicans isolates from the gut of critically ill patients respond to phosphate limitation by expressing filaments and a lethal phenotype.

Romanowski K, Zaborin A, Valuckaite V, Rolfes RJ, Babrowski T, Bethel C, Olivas A, Zaborina O, Alverdy JC.

PLoS One. 2012;7(1):e30119. doi: 10.1371/journal.pone.0030119. Epub 2012 Jan 13.

35.

Pseudomonas aeruginosa potentiates the lethal effect of intestinal ischemia-reperfusion injury: the role of in vivo virulence activation.

Fink D, Romanowski K, Valuckaite V, Babrowski T, Kim M, Matthews JB, Liu D, Zaborina O, Alverdy JC.

J Trauma. 2011 Dec;71(6):1575-82. doi: 10.1097/TA.0b013e31821cb7e5.

36.

Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration.

Babrowski T, Holbrook C, Moss J, Gottlieb L, Valuckaite V, Zaborin A, Poroyko V, Liu DC, Zaborina O, Alverdy JC.

Ann Surg. 2012 Feb;255(2):386-93. doi: 10.1097/SLA.0b013e3182331870.

37.

Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH.

Romanowski K, Zaborin A, Fernandez H, Poroyko V, Valuckaite V, Gerdes S, Liu DC, Zaborina OY, Alverdy JC.

BMC Microbiol. 2011 Sep 26;11:212. doi: 10.1186/1471-2180-11-212.

38.

Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption.

Edelstein A, Fink D, Musch M, Valuckaite V, Zaborina O, Grubjesic S, Firestone MA, Matthews JB, Alverdy JC.

Shock. 2011 Nov;36(5):451-7. doi: 10.1097/SHK.0b013e31822d8de1.

39.
40.

Host stress and virulence expression in intestinal pathogens: development of therapeutic strategies using mice and C. elegans.

Zaborina O, Zaborin A, Romanowski K, Babrowski T, Alverdy J.

Curr Pharm Des. 2011;17(13):1254-60. Review.

41.

The molecular Koch's postulates and surgical infection: a view forward.

Seal JB, Morowitz M, Zaborina O, An G, Alverdy JC.

Surgery. 2010 Jun;147(6):757-65. doi: 10.1016/j.surg.2010.03.008. Review. No abstract available.

PMID:
20494210
42.

Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.

Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1041-52. doi: 10.1152/ajpgi.00328.2009. Epub 2009 Oct 15.

43.

Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1.

Zaborin A, Romanowski K, Gerdes S, Holbrook C, Lepine F, Long J, Poroyko V, Diggle SP, Wilke A, Righetti K, Morozova I, Babrowski T, Liu DC, Zaborina O, Alverdy JC.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6327-32. doi: 10.1073/pnas.0813199106. Epub 2009 Apr 6.

44.

Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement.

Chiang ET, Camp SM, Dudek SM, Brown ME, Usatyuk PV, Zaborina O, Alverdy JC, Garcia JG.

Microvasc Res. 2009 Mar;77(2):174-86. doi: 10.1016/j.mvr.2008.11.007. Epub 2008 Dec 11.

45.

Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis.

Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J.

Surgery. 2008 Aug;144(2):189-97. doi: 10.1016/j.surg.2008.03.045.

46.

Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa.

Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC.

PLoS Pathog. 2008 Feb 8;4(2):e43. doi: 10.1371/journal.ppat.0040043.

47.

Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages.

Kolli BK, Kostal J, Zaborina O, Chakrabarty AM, Chang KP.

Mol Biochem Parasitol. 2008 Apr;158(2):163-75. doi: 10.1016/j.molbiopara.2007.12.010. Epub 2007 Dec 25.

48.

Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.

Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Turner JR, Rahme LG, Chang E, Alverdy JC.

PLoS Pathog. 2007 Mar;3(3):e35. Erratum in: PLoS Pathog. 2007 May;3(5):e67. Petroff, Elaine [corrected to Petrof, Elaine O].

49.

Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.

Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G134-42. Epub 2006 Aug 10.

50.

Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier.

Zaborina O, Kohler JE, Wang Y, Bethel C, Shevchenko O, Wu L, Turner JR, Alverdy JC.

Ann Clin Microbiol Antimicrob. 2006 Jun 8;5:14.

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