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Items: 31

1.

Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets.

Jacobson RA, Wienholts K, Williamson AJ, Gaines S, Hyoju S, van Goor H, Zaborin A, Shogan BD, Zaborina O, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2019 Oct 11. doi: 10.1152/ajpgi.00236.2019. [Epub ahead of print]

PMID:
31604031
2.

Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.

Hyoju SK, Zaborin A, Keskey R, Sharma A, Arnold W, van den Berg F, Kim SM, Gottel N, Bethel C, Charnot-Katsikas A, Jianxin P, Adriaansens C, Papazian E, Gilbert JA, Zaborina O, Alverdy JC.

MBio. 2019 Jul 30;10(4). pii: e00903-19. doi: 10.1128/mBio.00903-19.

3.

Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station.

Urbaniak C, van Dam P, Zaborin A, Zaborina O, Gilbert JA, Torok T, Wang CCC, Venkateswaran K.

mSystems. 2019 Mar 19;4(2). pii: e00345-18. doi: 10.1128/mSystems.00345-18. eCollection 2019 Mar-Apr.

4.

Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model.

Wiegerinck M, Hyoju SK, Mao J, Zaborin A, Adriaansens C, Salzman E, Hyman NH, Zaborina O, van Goor H, Alverdy JC.

Br J Surg. 2018 Sep;105(10):1368-1376. doi: 10.1002/bjs.10859. Epub 2018 Apr 16.

PMID:
29658991
5.

De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality.

Mao J, Zaborin A, Poroyko V, Goldfeld D, Lynd NA, Chen W, Tirrell MV, Zaborina O, Alverdy JC.

ACS Biomater Sci Eng. 2017 Sep 11;3(9):2076-2085. doi: 10.1021/acsbiomaterials.7b00373. Epub 2017 Jul 17.

6.

Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis".

Krezalek MA, Hyoju S, Zaborin A, Okafor E, Chandrasekar L, Bindokas V, Guyton K, Montgomery CP, Daum RS, Zaborina O, Boyle-Vavra S, Alverdy JC.

Ann Surg. 2018 Apr;267(4):749-758. doi: 10.1097/SLA.0000000000002173.

PMID:
28187042
7.

Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa.

Hyoju SK, Klabbers RE, Aaron M, Krezalek MA, Zaborin A, Wiegerinck M, Hyman NH, Zaborina O, Van Goor H, Alverdy JC.

Ann Surg. 2018 Jun;267(6):1112-1118. doi: 10.1097/SLA.0000000000002167.

8.

Modeling Acinetobacter baumannii wound infections: The critical role of iron.

Fleming ID, Krezalek MA, Belogortseva N, Zaborin A, Defazio J, Chandrasekar L, Actis LA, Zaborina O, Alverdy JC.

J Trauma Acute Care Surg. 2017 Mar;82(3):557-565. doi: 10.1097/TA.0000000000001338.

9.

Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats.

Shakhsheer BA, Lec B, Zaborin A, Guyton K, Defnet AM, Bagrodia N, Kandel JJ, Zaborina O, Hernandez SL, Alverdy J.

Int J Colorectal Dis. 2017 Apr;32(4):539-547. doi: 10.1007/s00384-016-2737-9. Epub 2016 Dec 20.

PMID:
27999936
10.

Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress.

Zaborin A, Krezalek M, Hyoju S, Defazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G112-G122. doi: 10.1152/ajpgi.00294.2016. Epub 2016 Dec 15.

11.

Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak.

Shakhsheer BA, Versten LA, Luo JN, Defazio JR, Klabbers R, Christley S, Zaborin A, Guyton KL, Krezalek M, Smith DP, Ajami NJ, Petrosino JF, Fleming ID, Belogortseva N, Zaborina O, Alverdy JC.

J Gastrointest Surg. 2016 Oct;20(10):1744-51. doi: 10.1007/s11605-016-3237-5. Epub 2016 Aug 16.

PMID:
27530446
12.

The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury.

Krezalek MA, DeFazio J, Zaborina O, Zaborin A, Alverdy JC.

Shock. 2016 May;45(5):475-82. doi: 10.1097/SHK.0000000000000534. Review.

13.

C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.

Kanteti R, Dhanasingh I, El-Hashani E, Riehm JJ, Stricker T, Nagy S, Zaborin A, Zaborina O, Biron D, Alverdy JC, Im HK, Siddiqui S, Padilla PA, Salgia R.

Cancer Biol Ther. 2016;17(1):91-103. doi: 10.1080/15384047.2015.1108495.

14.

Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak.

Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC.

Sci Transl Med. 2015 May 6;7(286):286ra68. doi: 10.1126/scitranslmed.3010658.

15.

Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness.

Zaborin A, Smith D, Garfield K, Quensen J, Shakhsheer B, Kade M, Tirrell M, Tiedje J, Gilbert JA, Zaborina O, Alverdy JC.

MBio. 2014 Sep 23;5(5):e01361-14. doi: 10.1128/mBio.01361-14.

16.

Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa.

Shah M, Zaborin A, Alverdy JC, Scott K, Zaborina O.

FEMS Microbiol Lett. 2014 Mar;352(1):54-61. doi: 10.1111/1574-6968.12368. Epub 2014 Jan 21.

17.

Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.

Zaborin A, Defazio JR, Kade M, Kaiser BL, Belogortseva N, Camp DG 2nd, Smith RD, Adkins JN, Kim SM, Alverdy A, Goldfeld D, Firestone MA, Collier JH, Jabri B, Tirrell M, Zaborina O, Alverdy JC.

Antimicrob Agents Chemother. 2014;58(2):966-77. doi: 10.1128/AAC.02183-13. Epub 2013 Nov 25.

18.

Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.

Luong PM, Shogan BD, Zaborin A, Belogortseva N, Shrout JD, Zaborina O, Alverdy JC.

J Bacteriol. 2014 Jan;196(2):504-13. doi: 10.1128/JB.01050-13. Epub 2013 Nov 15.

19.

Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak.

Olivas AD, Shogan BD, Valuckaite V, Zaborin A, Belogortseva N, Musch M, Meyer F, Trimble WL, An G, Gilbert J, Zaborina O, Alverdy JC.

PLoS One. 2012;7(8):e44326. doi: 10.1371/journal.pone.0044326. Epub 2012 Aug 31.

20.

Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate.

Zaborin A, Gerdes S, Holbrook C, Liu DC, Zaborina OY, Alverdy JC.

PLoS One. 2012;7(4):e34883. doi: 10.1371/journal.pone.0034883. Epub 2012 Apr 13.

21.

Candida albicans isolates from the gut of critically ill patients respond to phosphate limitation by expressing filaments and a lethal phenotype.

Romanowski K, Zaborin A, Valuckaite V, Rolfes RJ, Babrowski T, Bethel C, Olivas A, Zaborina O, Alverdy JC.

PLoS One. 2012;7(1):e30119. doi: 10.1371/journal.pone.0030119. Epub 2012 Jan 13.

22.

Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration.

Babrowski T, Holbrook C, Moss J, Gottlieb L, Valuckaite V, Zaborin A, Poroyko V, Liu DC, Zaborina O, Alverdy JC.

Ann Surg. 2012 Feb;255(2):386-93. doi: 10.1097/SLA.0b013e3182331870.

23.

Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH.

Romanowski K, Zaborin A, Fernandez H, Poroyko V, Valuckaite V, Gerdes S, Liu DC, Zaborina OY, Alverdy JC.

BMC Microbiol. 2011 Sep 26;11:212. doi: 10.1186/1471-2180-11-212.

24.

Host stress and virulence expression in intestinal pathogens: development of therapeutic strategies using mice and C. elegans.

Zaborina O, Zaborin A, Romanowski K, Babrowski T, Alverdy J.

Curr Pharm Des. 2011;17(13):1254-60. Review.

25.

Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.

Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC.

Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1041-52. doi: 10.1152/ajpgi.00328.2009. Epub 2009 Oct 15.

26.

Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1.

Zaborin A, Romanowski K, Gerdes S, Holbrook C, Lepine F, Long J, Poroyko V, Diggle SP, Wilke A, Righetti K, Morozova I, Babrowski T, Liu DC, Zaborina O, Alverdy JC.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6327-32. doi: 10.1073/pnas.0813199106. Epub 2009 Apr 6.

27.

Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis.

Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J.

Surgery. 2008 Aug;144(2):189-97. doi: 10.1016/j.surg.2008.03.045.

28.

Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa.

Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC.

PLoS Pathog. 2008 Feb 8;4(2):e43. doi: 10.1371/journal.ppat.0040043.

29.

Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.

Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Turner JR, Rahme LG, Chang E, Alverdy JC.

PLoS Pathog. 2007 Mar;3(3):e35. Erratum in: PLoS Pathog. 2007 May;3(5):e67. Petroff, Elaine [corrected to Petrof, Elaine O].

30.

Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.

Wu LR, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Turner JR, Alverdy JC.

Surg Infect (Larchmt). 2005;6(2):185-95.

PMID:
16128625
31.

High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa.

Wu L, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Shapiro J, Turner JR, Wu G, Lee KY, Alverdy JC.

Gastroenterology. 2004 Feb;126(2):488-98.

PMID:
14762786

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