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Items: 41

1.

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC).

Dhanasekaran R, Gabay-Ryan M, Baylot V, Lai I, Mosley A, Huang X, Zabludoff S, Li J, Kaimal V, Karmali P, Felsher DW.

Oncotarget. 2017 Nov 9;9(5):5517-5528. doi: 10.18632/oncotarget.22342. eCollection 2018 Jan 19.

2.

Lipid Nanoparticle-Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth.

Huang X, Magnus J, Kaimal V, Karmali P, Li J, Walls M, Prudente R, Sung E, Sorourian M, Lee R, Davis S, Yang X, Estrella H, Lee EC, Chau BN, Pavlicek A, Zabludoff S.

Mol Cancer Ther. 2017 May;16(5):905-913. doi: 10.1158/1535-7163.MCT-16-0613. Epub 2017 Feb 6.

3.

Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions.

Munthe S, Halle B, Boldt HB, Christiansen H, Schmidt S, Kaimal V, Xu J, Zabludoff S, Mollenhauer J, Poulsen FR, Kristensen BW.

J Neurooncol. 2017 Mar;132(1):45-54. doi: 10.1007/s11060-016-2356-x. Epub 2017 Jan 13.

4.

Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry.

Parsels LA, Tanska DM, Parsels JD, Zabludoff SD, Cuneo KC, Lawrence TS, Maybaum J, Morgan MA.

Cell Cycle. 2016;15(5):730-9. doi: 10.1080/15384101.2016.1148841.

5.

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.

Zhang J, Jiao J, Cermelli S, Muir K, Jung KH, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L.

Cancer Res. 2015 May 1;75(9):1859-67. doi: 10.1158/0008-5472.CAN-14-1254. Epub 2015 Mar 13.

6.

Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation.

Wagenaar TR, Zabludoff S, Ahn SM, Allerson C, Arlt H, Baffa R, Cao H, Davis S, Garcia-Echeverria C, Gaur R, Huang SM, Jiang L, Kim D, Metz-Weidmann C, Pavlicek A, Pollard J, Reeves J, Rocnik JL, Scheidler S, Shi C, Sun F, Tolstykh T, Weber W, Winter C, Yu E, Yu Q, Zheng G, Wiederschain D.

Mol Cancer Res. 2015 Jun;13(6):1009-21. doi: 10.1158/1541-7786.MCR-14-0703. Epub 2015 Mar 10.

7.

Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells.

Wagenaar TR, Tolstykh T, Shi C, Jiang L, Zhang J, Li Z, Yu Q, Qu H, Sun F, Cao H, Pollard J, Dai S, Gao Q, Zhang B, Arlt H, Cindhuchao M, Hoffmann D, Light M, Jensen K, Hopke J, Newcombe R, Garcia-Echeverria C, Winter C, Zabludoff S, Wiederschain D.

Nucleic Acids Res. 2015 Jan;43(2):1204-15. doi: 10.1093/nar/gku1367. Epub 2014 Dec 30.

8.

Anti-miR182 reduces ovarian cancer burden, invasion, and metastasis: an in vivo study in orthotopic xenografts of nude mice.

Xu X, Ayub B, Liu Z, Serna VA, Qiang W, Liu Y, Hernando E, Zabludoff S, Kurita T, Kong B, Wei JJ.

Mol Cancer Ther. 2014 Jul;13(7):1729-39. doi: 10.1158/1535-7163.MCT-13-0982. Epub 2014 May 13.

9.

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors.

Sausville E, Lorusso P, Carducci M, Carter J, Quinn MF, Malburg L, Azad N, Cosgrove D, Knight R, Barker P, Zabludoff S, Agbo F, Oakes P, Senderowicz A.

Cancer Chemother Pharmacol. 2014 Mar;73(3):539-49. doi: 10.1007/s00280-014-2380-5. Epub 2014 Jan 22.

10.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

Venkatesha VA, Parsels LA, Parsels JD, Zhao L, Zabludoff SD, Simeone DM, Maybaum J, Lawrence TS, Morgan MA.

Neoplasia. 2012 Jun;14(6):519-25.

11.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

Oza V, Ashwell S, Almeida L, Brassil P, Breed J, Deng C, Gero T, Grondine M, Horn C, Ioannidis S, Liu D, Lyne P, Newcombe N, Pass M, Read J, Ready S, Rowsell S, Su M, Toader D, Vasbinder M, Yu D, Yu Y, Xue Y, Zabludoff S, Janetka J.

J Med Chem. 2012 Jun 14;55(11):5130-42. doi: 10.1021/jm300025r. Epub 2012 Jun 4.

PMID:
22551018
12.

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.

Oza V, Ashwell S, Brassil P, Breed J, Ezhuthachan J, Deng C, Grondine M, Horn C, Liu D, Lyne P, Newcombe N, Pass M, Read J, Su M, Toader D, Yu D, Yu Y, Zabludoff S.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2330-7. doi: 10.1016/j.bmcl.2012.01.043. Epub 2012 Feb 1.

PMID:
22342147
13.

Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.

Parsels LA, Qian Y, Tanska DM, Gross M, Zhao L, Hassan MC, Arumugarajah S, Parsels JD, Hylander-Gans L, Simeone DM, Morosini D, Brown JL, Zabludoff SD, Maybaum J, Lawrence TS, Morgan MA.

Clin Cancer Res. 2011 Jun 1;17(11):3706-15. doi: 10.1158/1078-0432.CCR-10-3082. Epub 2011 Apr 11.

14.

Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.

Oza V, Ashwell S, Brassil P, Breed J, Deng C, Ezhuthachan J, Haye H, Horn C, Janetka J, Lyne P, Newcombe N, Otterbien L, Pass M, Read J, Roswell S, Su M, Toader D, Yu D, Yu Y, Valentine A, Webborn P, White A, Zabludoff S, Zheng X.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5133-8. doi: 10.1016/j.bmcl.2010.07.015. Epub 2010 Jul 29.

PMID:
20673630
15.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, Lawrence TS.

Cancer Res. 2010 Jun 15;70(12):4972-81. doi: 10.1158/0008-5472.CAN-09-3573. Epub 2010 May 25.

16.

In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, Cook JA.

Clin Cancer Res. 2010 Apr 1;16(7):2076-84. doi: 10.1158/1078-0432.CCR-09-3277. Epub 2010 Mar 16.

17.

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.

PMID:
20160494
18.

Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents.

Goteti K, Garner CE, Utley L, Dai J, Ashwell S, Moustakas DT, Gönen M, Schwartz GK, Kern SE, Zabludoff S, Brassil PJ.

Cancer Chemother Pharmacol. 2010 Jul;66(2):245-54. doi: 10.1007/s00280-009-1153-z. Epub 2009 Oct 16.

PMID:
19841922
19.

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.

Zabludoff SD, Deng C, Grondine MR, Sheehy AM, Ashwell S, Caleb BL, Green S, Haye HR, Horn CL, Janetka JW, Liu D, Mouchet E, Ready S, Rosenthal JL, Queva C, Schwartz GK, Taylor KJ, Tse AN, Walker GE, White AM.

Mol Cancer Ther. 2008 Sep;7(9):2955-66. doi: 10.1158/1535-7163.MCT-08-0492.

20.

Keeping checkpoint kinases in line: new selective inhibitors in clinical trials.

Ashwell S, Janetka JW, Zabludoff S.

Expert Opin Investig Drugs. 2008 Sep;17(9):1331-40. doi: 10.1517/13543784.17.9.1331 . Review.

PMID:
18694366
21.

DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy.

Ashwell S, Zabludoff S.

Clin Cancer Res. 2008 Jul 1;14(13):4032-7. doi: 10.1158/1078-0432.CCR-07-5138. Review.

22.

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

Janetka JW, Almeida L, Ashwell S, Brassil PJ, Daly K, Deng C, Gero T, Glynn RE, Horn CL, Ioannidis S, Lyne P, Newcombe NJ, Oza VB, Pass M, Springer SK, Su M, Toader D, Vasbinder MM, Yu D, Yu Y, Zabludoff SD.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4242-8. doi: 10.1016/j.bmcl.2008.05.016. Epub 2008 May 6.

PMID:
18547806
23.

Inhibitors of checkpoint kinases: from discovery to the clinic.

Janetka JW, Ashwell S, Zabludoff S, Lyne P.

Curr Opin Drug Discov Devel. 2007 Jul;10(4):473-86. Review.

PMID:
17659489
24.

MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.

Leszczyniecka M, Bhatia U, Cueto M, Nirmala NR, Towbin H, Vattay A, Wang B, Zabludoff S, Phillips PE.

Oncogene. 2006 Jun 8;25(24):3471-8. Epub 2006 Mar 27.

PMID:
16568094
25.

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.

Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, Wood AW, Livingston DM.

Cancer Cell. 2004 Jul;6(1):33-43.

26.

Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening.

Lyne PD, Kenny PW, Cosgrove DA, Deng C, Zabludoff S, Wendoloski JJ, Ashwell S.

J Med Chem. 2004 Apr 8;47(8):1962-8.

PMID:
15055996
27.

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors.

Towbin H, Bair KW, DeCaprio JA, Eck MJ, Kim S, Kinder FR, Morollo A, Mueller DR, Schindler P, Song HK, van Oostrum J, Versace RW, Voshol H, Wood J, Zabludoff S, Phillips PE.

J Biol Chem. 2003 Dec 26;278(52):52964-71. Epub 2003 Oct 8.

28.

Synthesis and antitumor activity of ester-modified analogues of bengamide B.

Kinder FR Jr, Versace RW, Bair KW, Bontempo JM, Cesarz D, Chen S, Crews P, Czuchta AM, Jagoe CT, Mou Y, Nemzek R, Phillips PE, Tran LD, Wang RM, Weltchek S, Zabludoff S.

J Med Chem. 2001 Oct 25;44(22):3692-9.

PMID:
11606134
29.

Male germ cells regulate transcription of the cathepsin l gene by rat Sertoli cells.

Zabludoff SD, Charron M, DeCerbo JN, Simukova N, Wright WW.

Endocrinology. 2001 Jun;142(6):2318-27.

PMID:
11356678
30.

Total syntheses of bengamides B and E.

Kinder FR Jr, Wattanasin S, Versace RW, Bair KW, Bontempo J, Green MA, Lu YJ, Marepalli HR, Phillips PE, Roche D, Tran LD, Wang R, Waykole L, Xu DD, Zabludoff S.

J Org Chem. 2001 Mar 23;66(6):2118-22.

PMID:
11300909
31.

Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects.

Sambucetti LC, Fischer DD, Zabludoff S, Kwon PO, Chamberlin H, Trogani N, Xu H, Cohen D.

J Biol Chem. 1999 Dec 3;274(49):34940-7.

32.

p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.

Zabludoff SD, Csete M, Wagner R, Yu X, Wold BJ.

Cell Growth Differ. 1998 Jan;9(1):1-11.

33.

BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.

Zabludoff SD, Wright WW, Harshman K, Wold BJ.

Oncogene. 1996 Aug 1;13(3):649-53.

PMID:
8760307
34.
35.
36.

Cyclic protein-2, a secretory product of rat Sertoli cells, is the proenzyme form of cathepsin L.

Erickson-Lawrence M, Zabludoff SD, Wright WW.

Mol Endocrinol. 1991 Dec;5(12):1789-98.

PMID:
1791830
37.

Germ cell-Sertoli cell interactions: the effect of testicular maturation on the synthesis of cyclic protein-2 by rat Sertoli cells.

Zabludoff SD, Karzai AW, Wright WW.

Biol Reprod. 1990 Jul;43(1):25-33. Erratum in: Biol Reprod 1990 Sep;43(3):following 542.

PMID:
2393690
38.

Sertoli cells, proximal convoluted tubules in the kidney, and neurons in the brain contain cyclic protein-2.

Zabludoff SD, Erickson-Lawrence M, Wright WW.

Biol Reprod. 1990 Jul;43(1):15-24. Erratum in: Biol Reprod 1990 Sep;43(3):following 542.

PMID:
2393687
39.

Germ cell-Sertoli cell interactions. Studies of cyclic protein-2 in the seminiferous tubule.

Wright WW, Zabludoff SD, Erickson-Lawrence M, Karzai AW.

Ann N Y Acad Sci. 1989;564:173-85.

PMID:
2774415
40.

Serum hormone levels associated with spawning activity in the mummichog, Fundulus heteroclitus.

Cochran RC, Zabludoff SD, Paynter KT, DiMichele L, Palmer RE.

Gen Comp Endocrinol. 1988 May;70(2):345-54. Erratum in: Gen Comp Endocrinol 1988 Sep;71(3):533.

PMID:
3384313
41.

Foraging choice in laboratory rats: Constant vs. variable delay.

Zabludoff SD, Wecker J, Caraco T.

Behav Processes. 1988 Mar;16(1-2):95-110. doi: 10.1016/0376-6357(88)90021-6.

PMID:
24896407

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